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Volumn 32, Issue 46, 2012, Pages 16120-16128

Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MORPHINE; MU OPIATE RECEPTOR; TRANSCRIPTION FACTOR PITX3;

EID: 84869026580     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1572-12.2012     Document Type: Article
Times cited : (42)

References (73)
  • 1
    • 0025976217 scopus 로고
    • Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats
    • Acquas E, Carboni E, Di Chiara G (1991) Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats. Eur J Pharmacol 193:133-134.
    • (1991) Eur J Pharmacol , vol.193 , pp. 133-134
    • Acquas, E.1    Carboni, E.2    Di Chiara, G.3
  • 2
    • 4644271813 scopus 로고    scopus 로고
    • Brain substrates for increased drug seeking during protracted withdrawal
    • Aston-Jones G, Harris GC (2004) Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 47 [Suppl 1]: 167-179.
    • (2004) Neuropharmacology , vol.47 , Issue.SUPPL. 1 , pp. 167-179
    • Aston-Jones, G.1    Harris, G.C.2
  • 5
    • 0036069606 scopus 로고    scopus 로고
    • Presynaptic muopioid receptors regulate a late step of the secretory process in rat ventral tegmental area GABAergic neurons
    • Bergevin A, Girardot D, Bourque MJ, Trudeau LE (2002) Presynaptic muopioid receptors regulate a late step of the secretory process in rat ventral tegmental area GABAergic neurons. Neuropharmacology 42:1065-1078.
    • (2002) Neuropharmacology , vol.42 , pp. 1065-1078
    • Bergevin, A.1    Girardot, D.2    Bourque, M.J.3    Trudeau, L.E.4
  • 6
    • 0030439407 scopus 로고    scopus 로고
    • Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice
    • Bilsky EJ, Bernstein RN, Wang Z, Sadée W, Porreca F (1996) Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J Pharmacol Exp Ther 277:484-490.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 484-490
    • Bilsky, E.J.1    Bernstein, R.N.2    Wang, Z.3    Sadée, W.4    Porreca, F.5
  • 7
    • 0031012148 scopus 로고    scopus 로고
    • Increased probability of GABA release during withdrawal from morphine
    • Bonci A, Williams JT (1997) Increased probability of GABA release during withdrawal from morphine. J Neurosci 17:796-803.
    • (1997) J Neurosci , vol.17 , pp. 796-803
    • Bonci, A.1    Williams, J.T.2
  • 8
    • 0021281133 scopus 로고
    • Anatomically distinct opiate receptor fields mediate reward and physical dependence
    • Bozarth MA, Wise RA (1984) Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science 224:516-517.
    • (1984) Science , vol.224 , pp. 516-517
    • Bozarth, M.A.1    Wise, R.A.2
  • 9
    • 0029903538 scopus 로고    scopus 로고
    • Postsynaptic mechanism of depression of GABAergic synapses by oxytocin in the supraoptic nucleus of immature rat
    • Brussaard AB, Kits KS, de Vlieger TA (1996) Postsynaptic mechanism of depression of GABAergic synapses by oxytocin in the supraoptic nucleus of immature rat. J Physiol 497:495-507.
    • (1996) J Physiol , vol.497 , pp. 495-507
    • Brussaard, A.B.1    Kits, K.S.2    de Vlieger, T.A.3
  • 10
    • 0034660193 scopus 로고    scopus 로고
    • G-protein coupling of mu-opioid receptors (OP3): Elevated basal signalling activity
    • Burford NT, Wang D, Sadée W (2000) G-protein coupling of mu-opioid receptors (OP3): elevated basal signalling activity. Biochem J 348:531-537.
    • (2000) Biochem J , vol.348 , pp. 531-537
    • Burford, N.T.1    Wang, D.2    Sadée, W.3
  • 11
    • 0038560994 scopus 로고    scopus 로고
    • Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene
    • Cadet P, Mantione KJ, Stefano GB (2003) Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol 170:5118-5123.
    • (2003) J Immunol , vol.170 , pp. 5118-5123
    • Cadet, P.1    Mantione, K.J.2    Stefano, G.B.3
  • 12
    • 43449124117 scopus 로고    scopus 로고
    • Cellular neuroadaptations to chronic opioids: Tolerance, withdrawal and addiction
    • Christie MJ (2008) Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction. Br J Pharmacol 154:384-396.
    • (2008) Br J Pharmacol , vol.154 , pp. 384-396
    • Christie, M.J.1
  • 13
  • 14
    • 45849134871 scopus 로고    scopus 로고
    • Presynaptic metabotropic glutamate receptors regulate glutamatergic input to dopamine neurons in the ventral tegmental area
    • de Rover M, Meye FJ, Ramakers GM (2008) Presynaptic metabotropic glutamate receptors regulate glutamatergic input to dopamine neurons in the ventral tegmental area. Neuroscience 154:1318-1323.
    • (2008) Neuroscience , vol.154 , pp. 1318-1323
    • de Rover, M.1    Meye, F.J.2    Ramakers, G.M.3
  • 15
    • 0028798341 scopus 로고
    • Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats
    • Diana M, Pistis M, Muntoni A, Gessa G (1995) Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J Pharmacol Exp Ther 272:781-785.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 781-785
    • Diana, M.1    Pistis, M.2    Muntoni, A.3    Gessa, G.4
  • 16
    • 0033009251 scopus 로고    scopus 로고
    • Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal
    • Diana M, Muntoni AL, Pistis M, Melis M, Gessa GL (1999) Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal. Eur J Neurosci 11:1037-1041.
    • (1999) Eur J Neurosci , vol.11 , pp. 1037-1041
    • Diana, M.1    Muntoni, A.L.2    Pistis, M.3    Melis, M.4    Gessa, G.L.5
  • 17
    • 84859727772 scopus 로고    scopus 로고
    • Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively
    • Enoksson T, Bertran-Gonzalez J, Christie MJ (2012) Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively. Neuropharmacology 62:2463-2471.
    • (2012) Neuropharmacology , vol.62 , pp. 2463-2471
    • Enoksson, T.1    Bertran-Gonzalez, J.2    Christie, M.J.3
  • 18
    • 34547681422 scopus 로고    scopus 로고
    • Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement
    • Fields HL, Hjelmstad GO, Margolis EB, Nicola SM (2007) Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu Rev Neurosci 30:289-316.
    • (2007) Annu Rev Neurosci , vol.30 , pp. 289-316
    • Fields, H.L.1    Hjelmstad, G.O.2    Margolis, E.B.3    Nicola, S.M.4
  • 19
    • 0035885488 scopus 로고    scopus 로고
    • Plasmalemmal mu-opioid receptor distribution mainly in nondopaminergic neurons in the rat ventral tegmental area
    • Garzón M, Pickel VM (2001) Plasmalemmal mu-opioid receptor distribution mainly in nondopaminergic neurons in the rat ventral tegmental area. Synapse 41:311-328.
    • (2001) Synapse , vol.41 , pp. 311-328
    • Garzón, M.1    Pickel, V.M.2
  • 21
    • 0035204459 scopus 로고    scopus 로고
    • Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion
    • Gracy KN, Dankiewicz LA, Koob GF (2001) Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology 24:152-160.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 152-160
    • Gracy, K.N.1    Dankiewicz, L.A.2    Koob, G.F.3
  • 22
    • 0035111309 scopus 로고    scopus 로고
    • Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice
    • Hall FS, Sora I, Uhl GR (2001) Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice. Psychopharmacology (Berl) 154:43-49.
    • (2001) Psychopharmacology (Berl) , vol.154 , pp. 43-49
    • Hall, F.S.1    Sora, I.2    Uhl, G.R.3
  • 23
    • 12744277419 scopus 로고    scopus 로고
    • Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the mu-opioid receptor
    • Heinzen EL, Booth RG, Pollack GM (2005) Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the mu-opioid receptor. Biochem Pharmacol 69:679-688.
    • (2005) Biochem Pharmacol , vol.69 , pp. 679-688
    • Heinzen, E.L.1    Booth, R.G.2    Pollack, G.M.3
  • 25
    • 66549117005 scopus 로고    scopus 로고
    • Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area
    • Jarjour S, Bai L, Gianoulakis C (2009) Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area. Alcohol Clin Exp Res 33:1033-1043.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1033-1043
    • Jarjour, S.1    Bai, L.2    Gianoulakis, C.3
  • 26
    • 0026592638 scopus 로고
    • Opioids excite dopamine neurons by hyperpolarization of local interneurons
    • Johnson SW, North RA (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12:483-488.
    • (1992) J Neurosci , vol.12 , pp. 483-488
    • Johnson, S.W.1    North, R.A.2
  • 27
    • 0030756351 scopus 로고    scopus 로고
    • Drug abuse: Hedonic homeostatic dysregulation
    • Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52-58.
    • (1997) Science , vol.278 , pp. 52-58
    • Koob, G.F.1    Le Moal, M.2
  • 28
    • 0035199891 scopus 로고    scopus 로고
    • Drug addiction, dysregulation of reward, and allostasis
    • Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24:97-129.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 97-129
    • Koob, G.F.1    Le Moal, M.2
  • 29
    • 84861545384 scopus 로고    scopus 로고
    • Distinct roles for direct and indirect pathway striatal neurons in reinforcement
    • Kravitz AV, Tye LD, Kreitzer AC (2012) Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nat Neurosci 15:816-818.
    • (2012) Nat Neurosci , vol.15 , pp. 816-818
    • Kravitz, A.V.1    Tye, L.D.2    Kreitzer, A.C.3
  • 31
    • 79953863397 scopus 로고    scopus 로고
    • Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2
    • Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W (2011) Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2. Mol Pain 7:24.
    • (2011) Mol Pain , vol.7 , pp. 24
    • Lam, H.1    Maga, M.2    Pradhan, A.3    Evans, C.J.4    Maidment, N.T.5    Hales, T.G.6    Walwyn, W.7
  • 32
    • 1642580891 scopus 로고    scopus 로고
    • Opiate state controls bidirectional reward signaling via GABAA receptors in the ventral tegmental area
    • Laviolette SR, Gallegos RA, Henriksen SJ, van der Kooy D (2004) Opiate state controls bidirectional reward signaling via GABAA receptors in the ventral tegmental area. Nat Neurosci 7:160-169.
    • (2004) Nat Neurosci , vol.7 , pp. 160-169
    • Laviolette, S.R.1    Gallegos, R.A.2    Henriksen, S.J.3    van der Kooy, D.4
  • 33
    • 0034955327 scopus 로고    scopus 로고
    • Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment
    • Liu JG, Prather PL (2001) Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol 60:53-62.
    • (2001) Mol Pharmacol , vol.60 , pp. 53-62
    • Liu, J.G.1    Prather, P.L.2
  • 34
    • 0035851139 scopus 로고    scopus 로고
    • Constitutively active mu-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2,N-MePhe4,Glyol5] enkephalin
    • Liu JG, Ruckle MB, Prather PL (2001) Constitutively active mu-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2,N-MePhe4,Glyol5] enkephalin. J Biol Chem 276:37779-37786.
    • (2001) J Biol Chem , vol.276 , pp. 37779-37786
    • Liu, J.G.1    Ruckle, M.B.2    Prather, P.L.3
  • 36
    • 77749324825 scopus 로고    scopus 로고
    • Micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal
    • Madhavan A, He L, Stuber GD, Bonci A, Whistler JL (2010a) Micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci 30:3276-3286.
    • (2010) J Neurosci , vol.30 , pp. 3276-3286
    • Madhavan, A.1    He, L.2    Stuber, G.D.3    Bonci, A.4    Whistler, J.L.5
  • 37
    • 77958520936 scopus 로고    scopus 로고
    • Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area
    • Madhavan A, Bonci A, Whistler JL (2010b) Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci 30:14029-14035.
    • (2010) J Neurosci , vol.30 , pp. 14029-14035
    • Madhavan, A.1    Bonci, A.2    Whistler, J.L.3
  • 38
    • 0026773463 scopus 로고
    • Role of different brain structures in the expression of the physical morphine withdrawal syndrome
    • Maldonado R, Stinus L, Gold LH, Koob GF (1992) Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J Pharmacol Exp Ther 261:669-677.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 669-677
    • Maldonado, R.1    Stinus, L.2    Gold, L.H.3    Koob, G.F.4
  • 40
    • 0033178413 scopus 로고    scopus 로고
    • Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal
    • Manzoni OJ, Williams JT (1999) Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal. J Neurosci 19:6629-6636.
    • (1999) J Neurosci , vol.19 , pp. 6629-6636
    • Manzoni, O.J.1    Williams, J.T.2
  • 41
    • 0242491835 scopus 로고    scopus 로고
    • Modulation of cellular activity and synaptic transmission in the ventral tegmental area
    • Mathon DS, Kamal A, Smidt MP, Ramakers GM (2003) Modulation of cellular activity and synaptic transmission in the ventral tegmental area. Eur J Pharmacol 480:97-115.
    • (2003) Eur J Pharmacol , vol.480 , pp. 97-115
    • Mathon, D.S.1    Kamal, A.2    Smidt, M.P.3    Ramakers, G.M.4
  • 43
    • 82555174612 scopus 로고    scopus 로고
    • Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons
    • Matsui A, Williams JT (2011) Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons. J Neurosci 31:17729-17735.
    • (2011) J Neurosci , vol.31 , pp. 17729-17735
    • Matsui, A.1    Williams, J.T.2
  • 45
    • 84855656327 scopus 로고    scopus 로고
    • Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens
    • Mitchell JM, O'Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL (2012) Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens. Sci Transl Med 4: 116ra6.
    • (2012) Sci Transl Med , vol.4
    • Mitchell, J.M.1    O'Neil, J.P.2    Janabi, M.3    Marks, S.M.4    Jagust, W.J.5    Fields, H.L.6
  • 46
    • 0037083312 scopus 로고    scopus 로고
    • Ih channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain
    • Neuhoff H, Neu A, Liss B, Roeper J (2002) Ih channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J Neurosci 22:1290-1302.
    • (2002) J Neurosci , vol.22 , pp. 1290-1302
    • Neuhoff, H.1    Neu, A.2    Liss, B.3    Roeper, J.4
  • 48
    • 0035654631 scopus 로고    scopus 로고
    • Stimulation of en-dorphin eurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine
    • Olive MF, Koenig HN, Nannini MA, Hodge CW (2001) Stimulation of en-dorphin eurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. J Neurosci 21:RC184.
    • (2001) J Neurosci , vol.21
    • Olive, M.F.1    Koenig, H.N.2    Nannini, M.A.3    Hodge, C.W.4
  • 50
    • 84855445081 scopus 로고    scopus 로고
    • Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
    • Pascoli V, Turiault M, Lüscher C (2012) Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 481:71-75.
    • (2012) Nature , vol.481 , pp. 71-75
    • Pascoli, V.1    Turiault, M.2    Lüscher, C.3
  • 51
    • 84866358287 scopus 로고    scopus 로고
    • Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal
    • Radke AK, Gewirtz JC (2012) Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal. Neuropsychopharmacology 37:2405-2415.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2405-2415
    • Radke, A.K.1    Gewirtz, J.C.2
  • 52
    • 79956298602 scopus 로고    scopus 로고
    • An anatomical basis for opponent process mechanisms of opiate withdrawal
    • Radke AK, Rothwell PE, Gewirtz JC (2011) An anatomical basis for opponent process mechanisms of opiate withdrawal. J Neurosci 31:7533-7539.
    • (2011) J Neurosci , vol.31 , pp. 7533-7539
    • Radke, A.K.1    Rothwell, P.E.2    Gewirtz, J.C.3
  • 53
    • 19444361830 scopus 로고    scopus 로고
    • In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice
    • Raehal KM, Lowery JJ, Bhamidipati CM, Paolino RM, Blair JR, Wang D, Sadée W, Bilsky EJ (2005) In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 313:1150-1162.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1150-1162
    • Raehal, K.M.1    Lowery, J.J.2    Bhamidipati, C.M.3    Paolino, R.M.4    Blair, J.R.5    Wang, D.6    Sadée, W.7    Bilsky, E.J.8
  • 55
    • 12844281159 scopus 로고    scopus 로고
    • Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities
    • Sadée W, Wang D, Bilsky EJ (2005) Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci 76:1427-1437.
    • (2005) Life Sci , vol.76 , pp. 1427-1437
    • Sadée, W.1    Wang, D.2    Bilsky, E.J.3
  • 57
    • 0011276168 scopus 로고
    • Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
    • Sharma SK, Klee WA, Nirenberg M (1975) Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci U S A 72:3092-3096.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 3092-3096
    • Sharma, S.K.1    Klee, W.A.2    Nirenberg, M.3
  • 58
    • 32844470518 scopus 로고    scopus 로고
    • Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice
    • Shoblock JR, Maidment NT (2006) Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Neuropsychopharmacology 31:171-177.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 171-177
    • Shoblock, J.R.1    Maidment, N.T.2
  • 60
    • 3042709603 scopus 로고    scopus 로고
    • Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of Delta-9-tetrahydrocannabinol
    • Solinas M, Zangen A, Thiriet N, Goldberg SR (2004) Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of Delta-9-tetrahydrocannabinol. Eur J Neurosci 19:3183-3192.
    • (2004) Eur J Neurosci , vol.19 , pp. 3183-3192
    • Solinas, M.1    Zangen, A.2    Thiriet, N.3    Goldberg, S.R.4
  • 61
    • 34247480145 scopus 로고    scopus 로고
    • D1 and D2 dopaminereceptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
    • Surmeier DJ, Ding J, Day M, Wang Z, Shen W (2007) D1 and D2 dopaminereceptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci 30:228-235.
    • (2007) Trends Neurosci , vol.30 , pp. 228-235
    • Surmeier, D.J.1    Ding, J.2    Day, M.3    Wang, Z.4    Shen, W.5
  • 62
    • 0023812719 scopus 로고
    • Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays
    • Takemori AE, Ho BY, Naeseth JS, Portoghese PS (1988) Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther 246:255-258.
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 255-258
    • Takemori, A.E.1    Ho, B.Y.2    Naeseth, J.S.3    Portoghese, P.S.4
  • 63
    • 0025760593 scopus 로고
    • Ageneral role for adaptations in G-proteins and the cAMP system in mediating the chronic actions of morphine and cocaine on neuronal function
    • Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM, Nestler EJ (1991) Ageneral role for adaptations in G-proteins and the cAMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 548:100-110.
    • (1991) Brain Res , vol.548 , pp. 100-110
    • Terwilliger, R.Z.1    Beitner-Johnson, D.2    Sevarino, K.A.3    Crain, S.M.4    Nestler, E.J.5
  • 64
    • 34248382512 scopus 로고    scopus 로고
    • μ-Arrestin2 and c-Src regulate the constitutive activity and recycling of μ opioid receptors in dorsal root ganglion neurons
    • Walwyn W, Evans CJ, Hales TG (2007) μ-Arrestin2 and c-Src regulate the constitutive activity and recycling of μ opioid receptors in dorsal root ganglion neurons. J Neurosci 27:5092-5104.
    • (2007) J Neurosci , vol.27 , pp. 5092-5104
    • Walwyn, W.1    Evans, C.J.2    Hales, T.G.3
  • 65
    • 0034972443 scopus 로고    scopus 로고
    • Inverse agonists and neutral antagonists at mu opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence
    • Wang D, Raehal KM, Bilsky EJ, Sadée W (2001) Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem 77:1590-1600.
    • (2001) J Neurochem , vol.77 , pp. 1590-1600
    • Wang, D.1    Raehal, K.M.2    Bilsky, E.J.3    Sadée, W.4
  • 67
    • 0028299699 scopus 로고
    • Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence
    • Wang Z, Bilsky EJ, Porreca F, Sadée W (1994) Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci 54:PL339-PL350.
    • (1994) Life Sci , vol.54
    • Wang, Z.1    Bilsky, E.J.2    Porreca, F.3    Sadée, W.4
  • 68
    • 0030007027 scopus 로고    scopus 로고
    • 2+dependent
    • Wang Z, Arden J, Sadée W (1996) Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+dependent. FEBS Lett 387:53-57.
    • (1996) FEBS Lett , vol.387 , pp. 53-57
    • Wang, Z.1    Arden, J.2    Sadée, W.3
  • 69
    • 0035138995 scopus 로고    scopus 로고
    • Cellular and synaptic adaptations mediating opioid dependence
    • Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
    • (2001) Physiol Rev , vol.81 , pp. 299-343
    • Williams, J.T.1    Christie, M.J.2    Manzoni, O.3
  • 70
    • 0024456225 scopus 로고
    • Opiate reward: Sites and substrates
    • Wise RA (1989) Opiate reward: sites and substrates. Neurosci Biobehav Rev 13:129-133.
    • (1989) Neurosci Biobehav Rev , vol.13 , pp. 129-133
    • Wise, R.A.1
  • 71
    • 84862781072 scopus 로고    scopus 로고
    • Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 ds of morphine withdrawal
    • Wu X, Shi M, Wei C, Yang M, Liu Y, Liu Z, Zhang X, Ren W (2012) Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 ds of morphine withdrawal. J Neurosci Res 90: 1270-1283.
    • (2012) J Neurosci Res , vol.90 , pp. 1270-1283
    • Wu, X.1    Shi, M.2    Wei, C.3    Yang, M.4    Liu, Y.5    Liu, Z.6    Zhang, X.7    Ren, W.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.