Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence

Journal of Neurochemistry

Volumn 77, Issue 6, 2001, Pages 1590-1600

  Wang, Danxin ^a   Raehal, Kirsten M ^b   Bilsky, Edward J ^b   Sadée, Wolfgang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

opioid receptor; Basal signaling activity; Inverse agonists; Morphine dependence; Neutral antagonists

Indexed keywords

6ALPHA NALOXOL; 6BETA NALOXOL; 6BETA NALTREXAMINE; 7 BENZYLIDENENALTREXONE; CHLORNALTREXAMINE; CLOCINNAMOX; CYCLIC AMP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHINE; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NALMEFENE; NALOXONE; NALTREXOL; NALTREXONE; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CELL MEMBRANE; CELL STRAIN; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; HUMAN; HUMAN CELL; JUMPING; MALE; MOUSE; NARCOTIC DEPENDENCE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WITHDRAWAL SYNDROME;

ANALGESICS, OPIOID; ANIMALS; BENZYLIDENE COMPOUNDS; CELL LINE; CELL MEMBRANE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; KIDNEY; MAGNESIUM; MALE; MICE; MICE, INBRED ICR; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; SUBSTANCE WITHDRAWAL SYNDROME; SULFUR RADIOISOTOPES; TRANSFECTION; TRITIUM;

ANIMALIA;

EID: 0034972443     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00362.x     Document Type: Article

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