Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the μ-opioid receptor

Biochemical Pharmacology

Volumn 69, Issue 4, 2005, Pages 679-688

  Heinzen, Erin L ^a   Booth, Raymond G ^a   Pollack, Gary M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Opioid receptor; Constitutive activity; Morphine; Opioid tolerance; Rats

Indexed keywords

ARGININE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LEVALLORPHAN; MORPHINE SULFATE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NALORPHINE; NALOXONE; NITRIC OXIDE; RADIOLIGAND; SODIUM CHLORIDE; SULFUR 35;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG INFUSION; DRUG SCREENING; DRUG SELECTIVITY; DRUG TOLERANCE; EVALUATION; LIGAND BINDING; MALE; MOLECULE; NERVE CELL; NEUROMODULATION; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TIME;

ANALGESICS, OPIOID; ANIMALS; ARGININE; DRUG TOLERANCE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MORPHINE; NALOXONE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 12744277419     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.11.004     Document Type: Article

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