메뉴 건너뛰기




Volumn 62, Issue 8, 2012, Pages 2463-2471

Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively

Author keywords

D1 receptor; D2 receptor; Morphine; Morphine withdrawal; Nucleus accumbens

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; MORPHINE; NALOXONE;

EID: 84859727772     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.02.020     Document Type: Article
Times cited : (43)

References (57)
  • 1
    • 84862908461 scopus 로고    scopus 로고
    • An improved BAC transgenic fluorescent reporter line for sensitive and specific identification of striatonigral medium spiny neurons
    • Ade, K.K., Wan, Y., Chen, M., Gloss, B., Calakos, N., 2011. An improved BAC transgenic fluorescent reporter line for sensitive and specific identification of striatonigral medium spiny neurons. Front. Syst. Neurosci. 5, 32.
    • (2011) Front. Syst. Neurosci. , vol.5 , pp. 32
    • Ade, K.K.1    Wan, Y.2    Chen, M.3    Gloss, B.4    Calakos, N.5
  • 2
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking basal ganglia and cortex
    • Alexander, G.E., DeLong, M.R., Strick, P.L., 1986. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357-381. (Pubitemid 16055790)
    • (1986) Annual Review of Neuroscience , vol.9 , pp. 357-381
    • Alexander, G.E.1    DeLong, M.R.2    Strick, P.L.3
  • 4
    • 0026702547 scopus 로고
    • Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum
    • Berretta, S., Robertson, H.A., Graybiel, A.M., 1992. Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. J. Neurophysiol. 68, 767-777.
    • (1992) J. Neurophysiol. , vol.68 , pp. 767-777
    • Berretta, S.1    Robertson, H.A.2    Graybiel, A.M.3
  • 5
    • 45949098156 scopus 로고    scopus 로고
    • Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
    • Bertran-Gonzalez, J., Bosch, C., Maroteaux, M., Matamales, M., Hervé, D., Valjent, E., Girault, J.-A., 2008. Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J. Neurosci. 28, 5671-5685.
    • (2008) J. Neurosci. , vol.28 , pp. 5671-5685
    • Bertran-Gonzalez, J.1    Bosch, C.2    Maroteaux, M.3    Matamales, M.4    Hervé, D.5    Valjent, E.6    Girault, J.-A.7
  • 7
    • 79960221972 scopus 로고    scopus 로고
    • What is the degree of segregation between striatonigral and striatopallidal projections?
    • Bertran-Gonzalez, J., Hervé, D., Girault, J.-A., Valjent, E., 2010. What is the degree of segregation between striatonigral and striatopallidal projections? Front. Neuroanat. 4.
    • (2010) Front. Neuroanat. , pp. 4
    • Bertran-Gonzalez, J.1    Hervé, D.2    Girault, J.-A.3    Valjent, E.4
  • 9
    • 0030730282 scopus 로고    scopus 로고
    • Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area
    • Bontempi, B., Sharp, F.R., 1997. Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area. J. Neurosci. 17, 8596-8612. (Pubitemid 27461080)
    • (1997) Journal of Neuroscience , vol.17 , Issue.21 , pp. 8596-8612
    • Bontempi, B.1    Sharp, F.R.2
  • 11
    • 0032171358 scopus 로고    scopus 로고
    • Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal
    • Chieng, B., Williams, J.T., 1998. Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal. J. Neurosci. 18, 7033-7039. (Pubitemid 28388032)
    • (1998) Journal of Neuroscience , vol.18 , Issue.17 , pp. 7033-7039
    • Chieng, B.1    Williams, J.T.2
  • 12
    • 79960784151 scopus 로고    scopus 로고
    • Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area
    • Chieng, B., Azriel, Y., Mohammadi, S., Christie, M.J., 2011. Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area. J. Physiol. 589, 3775-3787.
    • (2011) J. Physiol. , vol.589 , pp. 3775-3787
    • Chieng, B.1    Azriel, Y.2    Mohammadi, S.3    Christie, M.J.4
  • 13
    • 24044457030 scopus 로고    scopus 로고
    • Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal
    • DOI 10.1097/01.wnr.0000175246.35837.5c
    • Chieng, B.C., Hallberg, C., Nyberg, F.J., Christie, M.J., 2005. Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal. Neuroreport 16, 1279-1283. (Pubitemid 41225196)
    • (2005) NeuroReport , vol.16 , Issue.12 , pp. 1279-1283
    • Chieng, B.C.H.1    Hallberg, C.2    Nyberg, F.J.3    Christie, M.J.4
  • 14
    • 0015524898 scopus 로고
    • Modification of morphine withdrawal by drugs interacting with humoral mechanisms: Some contradictions and their interpretation
    • Collier, H.O.J., Francis, D.L., Schneider, C., 1972. Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation. Nature 237, 220-223.
    • (1972) Nature , vol.237 , pp. 220-223
    • Collier, H.O.J.1    Francis, D.L.2    Schneider, C.3
  • 15
    • 0028798341 scopus 로고
    • Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats
    • Diana, M., Pistis, M., Muntoni, A., Gessa, G., 1995. Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J. Pharmacol. Exp. Ther. 272, 781-785.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 781-785
    • Diana, M.1    Pistis, M.2    Muntoni, A.3    Gessa, G.4
  • 18
    • 0029026997 scopus 로고
    • Alterations in immediate-early gene proteins in the rat forebrain induced by acute morphine injection
    • Garcia, M.M., Brown, H.E., Harlan, R.E., 1995. Alterations in immediate-early gene proteins in the rat forebrain induced by acute morphine injection. Brain Res. 692, 23-40.
    • (1995) Brain Res. , vol.692 , pp. 23-40
    • Garcia, M.M.1    Brown, H.E.2    Harlan, R.E.3
  • 19
    • 0034523717 scopus 로고    scopus 로고
    • Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved
    • DOI 10.1046/j.0953-816X.2000.01334.x
    • Georges, F., Stinus, L., Le Moine, C., 2000. Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved. Eur. J. Neurosci. 12, 4475-4486. (Pubitemid 32040927)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.12 , pp. 4475-4486
    • Georges, F.1    Stinus, L.2    Le, M.C.3
  • 20
    • 0025572196 scopus 로고
    • 2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen, C.R., Engber, T.M., Mahan, L.C., Susel, Z., Chase, T.N., Monsma Jr., F.J., Sibley, D.R., 1990. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250, 1429-1432. (Pubitemid 120031867)
    • (1990) Science , vol.250 , Issue.4986 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3    Susel, Z.4    Chase, T.N.5    Monsma Jr., F.J.6    Sibley, D.R.7
  • 22
    • 0035204459 scopus 로고    scopus 로고
    • Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion
    • Gracy, K.N., Dankiewicz, L.A., Koob, G.F., 2001. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology 24, 152-160.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 152-160
    • Gracy, K.N.1    Dankiewicz, L.A.2    Koob, G.F.3
  • 23
    • 31144443143 scopus 로고    scopus 로고
    • Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal
    • DOI 10.1016/j.neuroscience.2005.10.052, PII S0306452205011723
    • Hacker, J., Pedersen, N.P., Chieng, B.C.H., Keay, K.A., Christie, M.J., 2006. Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal. Neuroscience 137, 1389-1396. (Pubitemid 43133162)
    • (2006) Neuroscience , vol.137 , Issue.4 , pp. 1389-1396
    • Hacker, J.1    Pedersen, N.P.2    Chieng, B.C.H.3    Keay, K.A.4    Christie, M.J.5
  • 24
    • 0034810621 scopus 로고    scopus 로고
    • Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats
    • DOI 10.1016/S0028-3908(01)00101-0, PII S0028390801001010
    • Hamlin, A., Buller, K.M., Day, T.A., Osborne, P.B., 2001. Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats. Neuropharmacology 41, 574-581. (Pubitemid 32924967)
    • (2001) Neuropharmacology , vol.41 , Issue.5 , pp. 574-581
    • Hamlin, A.1    Buller, K.M.2    Day, T.A.3    Osborne, P.B.4
  • 25
    • 0025032288 scopus 로고
    • Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain
    • DOI 10.1016/0006-8993(90)90872-9
    • Hayward, M.D., Duman, R.S., Nestler, E.J., 1990. Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain. Brain Res. 525, 256-266. (Pubitemid 20257744)
    • (1990) Brain Research , vol.525 , Issue.2 , pp. 256-266
    • Hayward, M.D.1    Duman, R.S.2    Nestler, E.J.3
  • 26
    • 8144220169 scopus 로고    scopus 로고
    • Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice
    • DOI 10.1111/j.1460-9568.2004.03704.x
    • Hebb, A.L.O., Zacharko, R.M., Gauthier, M., Trudel, F., Laforest, S., Drolet, G., 2004. Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice. Eur. J. Neurosci. 20, 2415-2429. (Pubitemid 39472403)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.9 , pp. 2415-2429
    • Hebb, A.L.O.1    Zacharko, R.M.2    Gauthier, M.3    Trudel, F.4    Laforest, S.5    Drolet, G.6
  • 27
    • 0029042370 scopus 로고
    • Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system
    • Hughes, P., Dragunow, M., 1995. Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev. 47, 133-178.
    • (1995) Pharmacol. Rev. , vol.47 , pp. 133-178
    • Hughes, P.1    Dragunow, M.2
  • 28
    • 33748371601 scopus 로고    scopus 로고
    • Neural mechanisms of addiction: The role of reward-related learning and memory
    • DOI 10.1146/annurev.neuro.29.051605.113009
    • Hyman, S.E., Malenka, R.C., Nestler, E.J., 2006. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 29, 565-598. (Pubitemid 44476856)
    • (2006) Annual Review of Neuroscience , vol.29 , pp. 565-598
    • Hyman, S.E.1    Malenka, R.C.2    Nestler, E.J.3
  • 30
    • 0026592638 scopus 로고
    • Opioids excite dopamine neurons by hyperpolarization of local interneurons
    • Johnson, S.W., North, R.A., 1992. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J. Neurosci. 12, 483-488.
    • (1992) J. Neurosci. , vol.12 , pp. 483-488
    • Johnson, S.W.1    North, R.A.2
  • 31
    • 0030964773 scopus 로고    scopus 로고
    • Neostriatal cell subtypes and their functional roles
    • DOI 10.1016/S0168-0102(96)01134-0, PII S0168010296011340
    • Kawaguchi, Y., 1997. Neostriatal cell subtypes and their functional roles. Neurosci. Res. 27, 1-8. (Pubitemid 27117091)
    • (1997) Neuroscience Research , vol.27 , Issue.1 , pp. 1-8
    • Kawaguchi, Y.1
  • 32
  • 33
    • 0024310090 scopus 로고
    • Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal
    • Koob, G.F., Wall, T.L., Bloom, F.E., 1989. Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal. Psychopharmacol. (Berl.) 98, 530-534. (Pubitemid 19193903)
    • (1989) Psychopharmacology , vol.98 , Issue.4 , pp. 530-534
    • Koob, G.F.1    Wall, T.L.2    Bloom, F.E.3
  • 36
    • 77749324825 scopus 로고    scopus 로고
    • micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal
    • Madhavan, A., He, L., Stuber, G.D., Bonci, A., Whistler, J.L., 2010. micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J. Neurosci. 30, 3276-3286.
    • (2010) J. Neurosci. , vol.30 , pp. 3276-3286
    • Madhavan, A.1    He, L.2    Stuber, G.D.3    Bonci, A.4    Whistler, J.L.5
  • 37
    • 0026773463 scopus 로고
    • Role of different brain structures in the expression of the physical morphine withdrawal syndrome
    • Maldonado, R., Stinus, L., Gold, L.H., Koob, G.F., 1992. Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J. Pharmacol. Exp. Ther. 261, 669-677.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 669-677
    • Maldonado, R.1    Stinus, L.2    Gold, L.H.3    Koob, G.F.4
  • 38
    • 0033178413 scopus 로고    scopus 로고
    • Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal
    • Manzoni, O.J., Williams, J.T., 1999. Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal. J. Neurosci. 19, 6629-6636. (Pubitemid 29347462)
    • (1999) Journal of Neuroscience , vol.19 , Issue.15 , pp. 6629-6636
    • Manzoni, O.J.1    Williams, J.T.2
  • 39
    • 62849091782 scopus 로고    scopus 로고
    • Striatal medium-sized spiny neurons: Identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice
    • Matamales, M., Bertran-Gonzalez, J., Salomon, L., Degos, B., Deniau, J.-M., Valjent, E., Hervé, D., Girault, J.-A., 2009. Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice. PLoS ONE 4, e4770.
    • (2009) PLoS ONE , vol.4
    • Matamales, M.1    Bertran-Gonzalez, J.2    Salomon, L.3    Degos, B.4    Deniau, J.-M.5    Valjent, E.6    Hervé, D.7    Girault, J.-A.8
  • 40
    • 82555174612 scopus 로고    scopus 로고
    • Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons
    • Matsui, A., Williams, J.T., 2011. Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons. J. Neurosci. 31, 17729-17735.
    • (2011) J. Neurosci. , vol.31 , pp. 17729-17735
    • Matsui, A.1    Williams, J.T.2
  • 43
    • 0021326227 scopus 로고
    • DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization
    • Ouimet, C.C., Miller, P.E., Hemmings Jr., H.C., Walaas, S.I., Greengard, P., 1984. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate- regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J. Neurosci. 4, 111-124. (Pubitemid 14198292)
    • (1984) Journal of Neuroscience , vol.4 , Issue.1 , pp. 111-124
    • Ouimet, C.C.1    Miller, P.E.2    Hemmings, H.C.3
  • 44
    • 78449246412 scopus 로고    scopus 로고
    • The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: Increased high affinity state following amphetamine and in schizophrenia
    • Perreault, M.L., Hasbi, A., Alijaniaram, M., Fan, T., Varghese, G., Fletcher, P.J., Seeman, P., O'Dowd, B.F., George, S.R., 2010. The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. J. Biol. Chem. 285, 36625-36634.
    • (2010) J. Biol. Chem. , vol.285 , pp. 36625-36634
    • Perreault, M.L.1    Hasbi, A.2    Alijaniaram, M.3    Fan, T.4    Varghese, G.5    Fletcher, P.J.6    Seeman, P.7    O'Dowd, B.F.8    George, S.R.9
  • 45
    • 0025999352 scopus 로고
    • Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment
    • Pothos, E., Rada, P., Mark, G.P., Hoebel, B.G., 1991. Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment. Brain Res. 566, 348-350.
    • (1991) Brain Res. , vol.566 , pp. 348-350
    • Pothos, E.1    Rada, P.2    Mark, G.P.3    Hoebel, B.G.4
  • 46
    • 0029031798 scopus 로고
    • NMDA antagonists and clonidine block c-fos expression during morphine withdrawal
    • Rasmussen, K., Brodsky, M., Inturrisi, C.E., 1995. NMDA antagonists and clonidine block c-fos expression during morphine withdrawal. Synapse 20, 68-74.
    • (1995) Synapse , vol.20 , pp. 68-74
    • Rasmussen, K.1    Brodsky, M.2    Inturrisi, C.E.3
  • 47
    • 0024399617 scopus 로고
    • 2 receptors in the rat central nervous system
    • DOI 10.1016/0306-4522(89)90168-1
    • Richfield, E.K., Penney, J.B., Young, A.B., 1989. Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system. Neuroscience 30, 767-777. (Pubitemid 19197155)
    • (1989) Neuroscience , vol.30 , Issue.3 , pp. 767-777
    • Richfield, E.K.1    Penney, J.B.2    Young, A.B.3
  • 48
    • 0026012354 scopus 로고
    • Expression of the immediate early gene c-fos in basal ganglia: Induction by dopaminergic drugs
    • Robertson, H.A., Paul, M.L., Moratalla, R., Graybiel, A.M., 1991. Expression of the immediate early gene c-fos in basal ganglia: induction by dopaminergic drugs. Can. J. Neurol. Sci. 18, 380-383.
    • (1991) Can. J. Neurol. Sci. , vol.18 , pp. 380-383
    • Robertson, H.A.1    Paul, M.L.2    Moratalla, R.3    Graybiel, A.M.4
  • 49
    • 0026722616 scopus 로고
    • Marked inhibition of mesolimbic dopamine release: A common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
    • Rossetti, Z.L., Hmaidan, Y., Gessa, G.L., 1992. Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur. J. Pharmacol. 221, 227-234.
    • (1992) Eur. J. Pharmacol. , vol.221 , pp. 227-234
    • Rossetti, Z.L.1    Hmaidan, Y.2    Gessa, G.L.3
  • 50
    • 0025267015 scopus 로고
    • The regulation and function of c-fos and other immediate early genes in the nervous system
    • DOI 10.1016/0896-6273(90)90106-P
    • Sheng, M., Greenberg, M.E., 1990. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4, 477-485. (Pubitemid 20160837)
    • (1990) Neuron , vol.4 , Issue.4 , pp. 477-485
    • Sheng, M.1    Greenberg, M.E.2
  • 51
    • 40849085572 scopus 로고    scopus 로고
    • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia
    • DOI 10.1523/JNEUROSCI.5492-07.2008
    • Shuen, J.A., Chen, M., Gloss, B., Calakos, N., 2008. Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. J. Neurosci. 28, 2681-2685. (Pubitemid 351398859)
    • (2008) Journal of Neuroscience , vol.28 , Issue.11 , pp. 2681-2685
    • Shuen, J.A.1    Chen, M.2    Gloss, B.3    Calakos, N.4
  • 52
    • 0035010041 scopus 로고    scopus 로고
    • Mu Opiate receptor gene dose effects on different morphine actions: Evidence for differential in vivo mu receptor reserve
    • DOI 10.1016/S0893-133X(00)00252-9, PII S0893133X00002529
    • Sora, I., Elmer, G., Funada, M., Pieper, J., Li, X.F., Hall, F.S., Uhl, G.R., 2001. Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve. Neuropsychopharmacology 25, 41-54. (Pubitemid 32493821)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.1 , pp. 41-54
    • Sora, I.1    Elmer, G.2    Funada, M.3    Pieper, J.4    Li, X.-F.5    Hall, F.S.6    Uhl, G.R.7
  • 53
    • 0025063449 scopus 로고
    • Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal
    • DOI 10.1016/0306-4522(90)90106-E
    • Stinus, L., Le Moal, M., Koob, G.F., 1990. Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 37, 767-773. (Pubitemid 20282214)
    • (1990) Neuroscience , vol.37 , Issue.3 , pp. 767-773
    • Stinus, L.1    Le, M.M.2    Koob, G.F.3
  • 56
    • 0035138995 scopus 로고    scopus 로고
    • Cellular and synaptic adaptations mediating opioid dependence
    • Williams, J.T., Christie, M.J., Manzoni, O., 2001. Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev. 81, 299-343. (Pubitemid 32096178)
    • (2001) Physiological Reviews , vol.81 , Issue.1 , pp. 299-343
    • Williams, J.T.1    Christie, M.J.2    Manzoni, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.