Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy

Pathology and Oncology Research

Volumn 18, Issue 4, 2012, Pages 761-769

  Hegyi, Katalin ^a   Méhes, Gábor ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Aneuploidy; Aurora kinase; Cancer progression; Cell division; Mitotic failure

Indexed keywords

AURORA A KINASE; AURORA B KINASE; AURORA C KINASE;

ANEUPLOIDY; AURKB GENE; CANCER GROWTH; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL POPULATION; CHROMOSOME CONDENSATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE AMPLIFICATION; HISTOPATHOLOGY; HUMAN; MITOSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TUMOR GENE;

ANEUPLOIDY; HUMANS; MITOSIS; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84868445367     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9534-8     Document Type: Review

References (110)

1. Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2(1):21-32. doi:10.1038/35048096
2. Bolanos-Garcia VM (2005) Aurora kinases. Int J Biochem Cell Biol 37(8):1572-1577. doi:10.1016/j.biocel.2005.02.021
3. Katayama H, Brinkley WR, Sen S (2003) The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22(4):451-464
4. Carmena M, Ruchaud S, Earnshaw WC (2009) Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol 21(6):796-805. doi:10.1016/j.ceb.2009.09.008
5. Carvajal RD, Tse A, Schwartz GK (2006) Aurora kinases: new targets for cancer therapy. Clin Cancer Res 12(23):6869-6875. doi:10.1158/1078-0432.CCR-06- 1405
6. Carmena M, Earnshaw WC (2003) The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4(11):842-854. doi:10.1038/nrm1245
7. Salaun P, Rannou Y, Prigent C (2008) Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol 617:41-56
8. Marumoto T, Zhang D, Saya H (2005) Aurora-A - a guardian of poles. Nat Rev Cancer 5(1):42-50. doi:10.1038/nrc1526
9. Lukasiewicz KB, Lingle WL (2009) Aurora A, centrosome structure, and the centrosome cycle. Environ Mol Mutagen 50(8):602-619. doi:10.1002/em.20533
10. Mountzios G, Terpos E, Dimopoulos MA (2008) Aurora kinases as targets for cancer therapy. Cancer Treat Rev 34(2):175-182. doi:10.1016/j.ctrv.2007.09.005
11. Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y (2003) A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5(3):242-248. doi:10.1038/ncb936
12. Kufer TA, Sillje HH, Korner R, Gruss OJ, Meraldi P, Nigg EA (2002) Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol 158(4):617-623. doi:10.1083/jcb.200204155
13. Lapenna S, Giordano A (2009) Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov 8(7):547-566. doi:10.1038/nrd2907
14. Dutertre S, Cazales M, Quaranta M, Froment C, Trabut V, Dozier C, Mirey G, Bouche JP, Theis-Febvre N, Schmitt E, Monsarrat B, Prigent C, Ducommun B (2004) Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci 117(Pt 12):2523-2531. doi:10.1242/jcs.01108
15. Berdnik D, Knoblich JA (2002) Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr Biol 12(8):640-647
16. Lanni JS, Jacks T (1998) Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18(2):1055-1064
17. Meraldi P, Honda R, Nigg EA (2002) Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 21(4):483-492
18. Lengauer C, Kinzler KW, Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396(6712):643-649. doi:10.1038/25292
19. Marumoto T, Hirota T, Morisaki T, Kunitoku N, Zhang D, Ichikawa Y, Sasayama T, Kuninaka S, Mimori T, Tamaki N, Kimura M, Okano Y, Saya H (2002) Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7(11):1173-1182
20. Dieterich K, Soto Rifo R, Faure AK, Hennebicq S, Ben Amar B, Zahi M, Perrin J, Martinez D, Sele B, Jouk PS, Ohlmann T, Rousseaux S, Lunardi J, Ray PF (2007) Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Nat Genet 39(5):661-665. doi:10.1038/ng2027
21. Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-GoetzM (2010) The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. J Cell Sci 123(Pt 24):4292-4300. doi:10.1242/jcs.067447
22. Slattery SD, Mancini MA, Brinkley BR, Hall RM (2009) Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle 8(18):2984-2994
23. Kimura M, Matsuda Y, Yoshioka T, Okano Y (1999) Cell cycledependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J Biol Chem 274(11):7334-7340
24. Hu HM, Chuang CK, Lee MJ, Tseng TC, Tang TK (2000) Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1. DNA Cell Biol 19 (11):679-688. doi:10.1089/10445490050199063
25. Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, Urano T (2004) Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem 279(45):47201-47211. doi:10.1074/jbc.M403029200
26. Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague J, Butler A, Edkins S, Stevens C, Parker A, O'Meara S, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements J, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Green A, Knowles M, Leung SY, Looijenga LH, Malkowicz B, Pierotti MA, Teh BT, Yuen ST, Lakhani SR, Easton DF, Weber BL, Goldstraw P, Nicholson AG, Wooster R, Stratton MR, Futreal PA (2005) Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 65(17):7591-7595. doi:10.1158/0008-5472.CAN-05-1855
27. Fernandez-Miranda G, Trakala M, Martin J, Escobar B, Gonzalez A, Ghyselinck NB, Ortega S, Canamero M, Perez de Castro I, Malumbres M (2011) Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development 138(13):2661-2672. doi:10.1242/dev. 066381
28. Lin YS, Su LJ, Yu CT, Wong FH, Yeh HH, Chen SL, Wu JC, Lin WJ, Shiue YL, Liu HS, Hsu SL, Lai JM, Huang CY (2006) Gene expression profiles of the aurora family kinases. Gene Expr 13 (1):15-26
29. Ulisse S, Delcros JG, Baldini E, Toller M, Curcio F, Giacomelli L, Prigent C, Ambesi-Impiombato FS, D'Armiento M, Arlot-Bonnemains Y (2006) Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues. Int J Cancer 119(2):275-282. doi:10.1002/ijc.21842
30. Adams RR, Wheatley SP, Gouldsworthy AM, Kandels-Lewis SE, Carmena M, Smythe C, Gerloff DL, Earnshaw WC (2000) INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr Biol 10(17):1075-1078
31. Lens SM, Voest EE, Medema RH (2010) Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 10(12):825-841. doi:10.1038/nrc2964
32. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (2004) Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166(2):179-191. doi:10.1083/jcb.200404001
33. Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, Allis CD (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106(6):348-360
34. Ruchaud S, Carmena M, Earnshaw WC (2007) Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol 8 (10):798-812. doi:10.1038/nrm2257
35. Weaver BA, Cleveland DW (2005) Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell 8(1):7-12. doi:10.1016/j.ccr.2005.06.011
36. Dar AA, Goff LW, Majid S, Berlin J, El-Rifai W (2010) Aurora kinase inhibitors-rising stars in cancer therapeutics? Mol Cancer Ther 9(2):268-278. doi:10.1158/1535-7163.MCT-09-0765
37. Ota T, Suto S, Katayama H, Han ZB, Suzuki F, Maeda M, Tanino M, Terada Y, Tatsuka M (2002) Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res 62 (18):5168-5177
38. Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, Okawa K, Iwamatsu A, Okigaki T, Takahashi T, Inagaki M (1999) Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem 274(36):25543-25549
39. Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM, Allis CD (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102(3):279-291
40. Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002) Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22(3):874-885
41. Perez-Cadahia B, Drobic B, Davie JR (2009) H3 phosphorylation: dual role in mitosis and interphase. Biochem Cell Biol 87(5):695-709. doi:10.1139/O09-053
42. Kang TH, Park DY, Choi YH, Kim KJ, Yoon HS, Kim KT (2007) Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Mol Cell Biol 27(24):8533-8546. doi:10.1128/MCB.00018-07
43. Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D (2009) Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell 33(4):450-461. doi:10.1016/j.molcel.2009.02.003
44. Moy C, Oleykowski CA, Plant R, Greshock J, Jing J, Bachman K, Hardwicke MA, Wooster R, Degenhardt Y (2011) High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916. J Transl Med 9:110. doi:10.1186/1479-5876-9-110
45. Walsby E, Walsh V, Pepper C, Burnett A, Mills K (2008) Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts. Haematologica 93(5):662-669. doi:10.3324/haematol.12148
46. Girdler F, Sessa F, Patercoli S, Villa F, Musacchio A, Taylor S (2008) Molecular basis of drug resistance in aurora kinases. Chem Biol 15(6):552-562. doi:10.1016/j.chembiol.2008.04.013
47. Qi G, Ogawa I, Kudo Y, MiyauchiM, Siriwardena BS, Shimamoto F, Tatsuka M, Takata T (2007) Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch 450(3):297-302. doi:10.1007/s00428-006-0360-9
48. KuraiM, Shiozawa T, ShihHC, Miyamoto T, Feng YZ,Kashima H, Suzuki A, Konishi I (2005) Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma. Hum Pathol 36(12):1281-1288. doi:10.1016/j.humpath.2005. 09.014
49. Sorrentino R, Libertini S, Pallante PL, Troncone G, Palombini L, Bavetsias V, Spalletti-Cernia D, Laccetti P, Linardopoulos S, Chieffi P, Fusco A, Portella G (2005) Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab 90(2):928-935. doi:10.1210/jc.2004-1518
50. Garcia-Fernandez E, De Diego JI, Collantes-Bellido E, Mendiola M, Prim MP, Perez-Fernandez E, Miguel-Martin M, Nistal M, Hardisson D (2011) Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications. Histopathology 58(3):368-376. doi:10.1111/j.1365-2559.2011.03757.x
51. Lin ZZ, Jeng YM, Hu FC, Pan HW, Tsao HW, Lai PL, Lee PH, Cheng AL, Hsu HC (2010) Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC. BMC Cancer 10:461. doi:10.1186/1471-2407-10-461
52. Benten D, Keller G, Quaas A, Schrader J, Gontarewicz A, Balabanov S, Braig M, Wege H, Moll J, Lohse AW, Brummendorf TH (2009) Aurora kinase inhibitor PHA-739358 suppresses growth of hepatocellular carcinoma in vitro and in a xenograft mouse model. Neoplasia 11(9):934-944
53. Jantscher F, Pirker C, Mayer CE, Berger W, Sutterluety H (2011) Overexpression of Aurora-A in primary cells interferes with Sphase entry by diminishing Cyclin D1 dependent activities. Mol Cancer 10:28. doi:10.1186/1476-4598-10-28
54. Cha TL, Chuang MJ, Wu ST, Sun GH, Chang SY, Yu DS, Huang SM, Huan SK, Cheng TC, Chen TT, Fan PL, Hsiao PW (2009) Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells. Clin Cancer Res 15(3):840-850.doi:10.1158/1078- 0432.CCR-08-1918
55. Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S (2007) Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. J Cell Biochem 102(5):1318-1331. doi:10.1002/jcb.21421
56. Venoux M, Basbous J, Berthenet C, Prigent C, Fernandez A, Lamb NJ, Rouquier S (2008) ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Hum Mol Genet 17 (2):215-224. doi:10.1093/hmg/ddm298
57. Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 toMtransition. J Biol Chem 279(19):19643-19648. doi:10.1074/jbc.M311780200
58. Pugacheva EN, Golemis EA (2005) The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol 7(10):937-946. doi:10.1038/ncb1309
59. Cazales M, Schmitt E, Montembault E, Dozier C, Prigent C, Ducommun B (2005) CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle 4(9):1233-1238
60. Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T (2003) CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 5(6):853-864
61. Kim Y, Holland AJ, Lan W, Cleveland DW (2010) Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142(3):444-455. doi:10.1016/j.cell.2010.06.039
62. Huang YS, Jung MY, Sarkissian M, Richter JD (2002) N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. EMBO J 21(9):2139-2148. doi:10.1093/emboj/21.9.2139
63. Mendez R, Hake LE, Andresson T, Littlepage LE, Ruderman JV, Richter JD (2000) Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404(6775):302-307. doi:10.1038/35005126
64. Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park SY, Tanaka H, Furukawa K, Urano T (2009) Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem 284(41):28367-28381. doi:10.1074/jbc.M109.000273
65. Jang MS, Sul JW, Choi BJ, Lee SJ, Suh JH, Kim NS, Kim WH, Lim DS, Lee CW, Kim E (2008) Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. J Biol Chem 283(47):32344-32351. doi:10.1074/jbc. M804199200
66. Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM (2007) GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell 12 (5):699-712. doi:10.1016/j.devcel.2007.03.014
67. Dar AA, Belkhiri A, El-Rifai W (2009) The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene 28 (6):866-875. doi:10.1038/onc. 2008.434
68. Yang SC, Huang CH, Chen NJ, Chou CK, Lin CH (2000) Functional implication of human serine/threonine kinase, hAIK, in cell cycle progression. J Biomed Sci 7(6):484-493
69. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (2005) Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol 25 (14):5789-5800. doi:10.1128/MCB.25.14.5789- 5800.2005
70. Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G (2009) Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci 122(Pt 9):1334-1341. doi:10.1242/jcs.044321
71. Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima H (2004) The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 9 (5):383-397. doi:10.1111/j.1356-9597.2004.00732.x
72. Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (2002) MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. J Biol Chem 277(50):48714-48723. doi:10.1074/jbc.M208461200
73. Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A, Hirotsune S (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27(1):352-367. doi:10.1128/MCB.00878-06
74. Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R (2010) Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol 190(1):101-114. doi:10.1083/jcb.200908050
75. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S (2004) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 36(1):55-62. doi:10.1038/ng1279
76. Khazaei MR, Puschel AW (2009) Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity. J Biol Chem 284 (48):33571-33579. doi:10.1074/jbc.M109. 055897
77. Seki A, Coppinger JA, Jang CY, Yates JR, Fang G (2008) Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320(5883):1655-1658. doi:10.1126/science.1157425
78. Macurek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455(7209):119-123. doi:10.1038/nature07185
79. Katayama H, Zhou H, Li Q, Tatsuka M, Sen S (2001) Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 276(49):46219-46224. doi:10.1074/jbc.M107540200
80. Jang CY, Coppinger JA, Yates JR 3rd, Fang G (2011) Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3. Biochem Biophys Res Commun 408(1):174-179. doi:10.1016/j.bbrc.2011.04.004
81. Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY (2005) Identification of V23RalASer194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem 280(10):9013-9022. doi:10.1074/jbc.M411068200
82. Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol 30(2):508-523. doi:10.1128/MCB.00916-08
83. Rong R, Jiang LY, Sheikh MS, Huang Y (2007) Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1Amediatedmicrotubule interaction andM-phase cell cycle regulation. Oncogene 26(55):7700-7708. doi:10.1038/sj.onc.1210575
84. LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA (2007) Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer Res 67(11):5362-5370. doi:10.1158/0008-5472.CAN-07-0122
85. Ohishi T, Hirota T, Tsuruo T, Seimiya H (2010) TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression. Cancer Res 70(5):2041-2052. doi:10.1158/0008-5472.CAN-09-2008
86. Troiani S, Uggeri M, Moll J, Isacchi A, Kalisz HM, Rusconi L, Valsasina B (2005) Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach. J Proteome Res 4(4):1296-1303. doi:10.1021/pr050018e
87. Harper M, Tillit J, Kress M, Ernoult-Lange M (2009) Phosphorylation- dependent binding of human transcription factor MOK2 to lamin A/C. FEBS J 276(11):3137-3147. doi:10.1111/j.1742-4658.2009.07032.x
88. Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I, Inagaki M (2004) Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 279(13):12997-13003. doi:10.1074/jbc.M311128200
89. Zeitlin SG, Shelby RD, Sullivan KF (2001) CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 155(7):1147-1157. doi:10.1083/jcb.200108125
90. DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED (2006) Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127(5):969-982. doi:10.1016/j.cell.2006.09.047
91. Goto H, Yasui Y, Nigg EA, Inagaki M (2002) Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells 7(1):11-17
92. Bishop JD, Schumacher JM (2002) Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem 277(31):27577-27580. doi:10.1074/jbc.C200307200
93. Lan W, Zhang X, Kline-Smith SL, Rosasco SE, Barrett-Wilt GA, Shabanowitz J, Hunt DF, Walczak CE, Stukenberg PT (2004) Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol 14(4):273-286. doi:10.1016/j.cub.2004.01.055
94. Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao YC, Deng X, Tatsuka M, Narumiya S, May WS Jr, Nosaka T, Semba K, Inoue T, Satoh T, Inagaki M, Kitamura T (2003) Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell 4(4):549-560
95. Guse A,MishimaM, GlotzerM(2005) Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol 15(8):778-786. doi:10.1016/j.cub.2005.03.041
96. Sakita-Suto S, Kanda A, Suzuki F, Sato S, Takata T, Tatsuka M (2007) Aurora-B regulates RNA methyltransferase NSUN2. Mol Biol Cell 18(3):1107-1117. doi:10.1091/mbc.E06-11-1021
97. Tanno Y, Kitajima TS, Honda T, Ando Y, Ishiguro K, Watanabe Y (2010) Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres. Genes Dev 24 (19):2169-2179. doi:10.1101/gad.1945310
98. Wheatley SP, Henzing AJ, Dodson H, Khaled W, Earnshaw WC (2004) Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem 279(7):5655-5660. doi:10.1074/jbc.M311299200
99. Goto H, Yasui Y, Kawajiri A, Nigg EA, Terada Y, Tatsuka M, Nagata K, Inagaki M (2003) Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 278(10):8526-8530. doi:10.1074/jbc.M210892200
100. Lee EC, Frolov A, Li R, Ayala G, Greenberg NM (2006) Targeting Aurora kinases for the treatment of prostate cancer. Cancer Res 66 (10):4996-5002. doi:10.1158/0008-5472.CAN-05-2796
101. Chieffi P, Cozzolino L, Kisslinger A, Libertini S, Staibano S, Mansueto G, De Rosa G, Villacci A, Vitale M, Linardopoulos S, Portella G, Tramontano D (2006) Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation. Prostate 66(3):326-333. doi:10.1002/pros.20345
102. Chieffi P, Troncone G, Caleo A, Libertini S, Linardopoulos S, Tramontano D, Portella G (2004) Aurora B expression in normal testis and seminomas. J Endocrinol 181(2):263-270
103. Baldini E, Arlot-BonnemainsY,MottoleseM, Sentinelli S, Antoniani B, Sorrenti S, Salducci M, Comini E, Ulisse S, D'ArmientoM(2010) Deregulation of Aurora kinase gene expression in human testicular germ cell tumours. Andrologia 42(4):260-267. doi:10.1111/j.1439-0272.2009.00987.x
104. Katayama H, Ota T, Jisaki F, Ueda Y, Tanaka T, Odashima S, Suzuki F, Terada Y, Tatsuka M (1999) Mitotic kinase expression and colorectal cancer progression. J Natl Cancer Inst 91 (13):1160-1162
105. Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chan CS, Novotny M, Slamon DJ, Plowman GD (1998) A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17(11):3052-3065. doi:10.1093/emboj/17.11.3052
106. Araki K, Nozaki K, Ueba T, Tatsuka M, Hashimoto N (2004) High expression of Aurora-B/Aurora and Ipll-like midbodyassociated protein (AIM-1) in astrocytomas. J Neurooncol 67 (1-2):53-64
107. Li Y, Zhang ZF, Chen J, Huang D, Ding Y, Tan MH, Qian CN, Resau JH, Kim H, Teh BT (2010) VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma. Am J Transl Res 2(3):296-308
108. Ikezoe T, Yang J, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP, Taguchi H (2007) A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Mol Cancer Ther 6(6):1851-1857. doi:10.1158/1535-7163.MCT-07-0067
109. Hamada M, Yakushijin Y, Ohtsuka M, Kakimoto M, Yasukawa M, Fujita S (2003) Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma. Br J Haematol 121(3):439-447
110. Smith SL, Bowers NL, Betticher DC, Gautschi O, Ratschiller D, Hoban PR, Booton R, Santibanez-Koref MF, Heighway J (2005) Overexpression of aurora B kinase (AURKB) in primary nonsmall cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. Br J Cancer 93(6):719-729. doi:10.1038/sj.bjc.6602779