TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression

Cancer Research

Volumn 70, Issue 5, 2010, Pages 2041-2052

  Ohishi, Tomokazu ^a   Hirota, Toru ^b   Tsuruo, Takashi ^a   Seimiya, Hiroyuki ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; CYTOKINE; SMALL INTERFERING RNA; TANKYRASE; TELOMERIC REPEAT BINDING FACTOR 1;

ARTICLE; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; TETRAPLOIDY; WILD TYPE;

CENTROSOME; CHROMOSOMES, HUMAN; HELA CELLS; HUMANS; MITOSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TANKYRASES; TELOMERIC REPEAT BINDING PROTEIN 1; TRANSFECTION;

EID: 77950214409     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2008     Document Type: Article

References (51)

1. Marumoto T, Zhang D, Saya H. Aurora-A-a guardian of poles. Nat Rev Cancer 2005;5:42-50.
2. Hirota T, Kunitoku N, Sasayama T, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003;114:585-598
3. Kimura M, Matsuda Y, Yoshioka T, Okano Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1- related protein kinase, AIK3. J Biol Chem 1999;274:7334-7340
4. Marumoto T, Honda S, Hara T, et al. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 2003;278:51786-51795
5. Sen S, Zhou H, White RA. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 1997;14: 2195-2200
6. Bischoff JR, Anderson L, Zhu Y, et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998;17:3052-3065
7. Zhou H, Kuang J, Zhong L, et al. Tumour amplified kinase STK15/ BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998;20:189-193
8. Meraldi P, Honda R, Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 2002;21:483-492
9. Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003;3:51-62.
10. Jiang Y, Zhang Y, Lees E, Seghezzi W. AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 2003;22:8293-8301
11. Chong L, van Steensel B, Broccoli D, et al. A human telomeric protein. Science 1995;270:1663-1667
12. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005;19:2100-2110
13. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003;426:194-198
14. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015
15. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-791
16. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-352
17. van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997;385:740-743
18. Ancelin K, Brunori M, Bauwens S, et al. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol 2002;22:3474-3487
19. Smith S, Giriat I, Schmitt A, de Lange T. Tankyrase, a poly(ADPribose) polymerase at human telomeres. Science 1998;282:1484-1487
20. Chang W, Dynek JN, Smith S. TRF1 is degraded by ubiquitinmediated proteolysis after release from telomeres. Genes Dev 2003;17:1328-1333
21. Hsiao SJ, Smith S. Tankyrase function at telomeres, spindle poles, and beyond. Biochimie 2008;90:83-92.
22. Smith S, de Lange T. Tankyrase promotes telomere elongation in human cells. Curr Biol 2000;10:1299-1302
23. Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T. Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell 2005;7:25-37.
24. Seimiya H, Muramatsu Y, Smith S, Tsuruo T. Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. Mol Cell Biol 2004;24:1944-1955.
25. Seimiya H, Smith S. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem 2002;277:14116-14126
26. Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S. Protein requirements for sister telomere association in human cells. EMBO J 2007;26:4867-4878
27. De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 1997;243:518-526
28. van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998;92:401-413
29. Chang W, Dynek JN, Smith S. NuMA is a major acceptor of poly (ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochem J 2005;391: 177-184
30. Yeh TY, Sbodio JI, Chi NW. Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun 2006;350:574-579
31. Smith S, de Lange T. Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. J Cell Sci 1999;112:3649-3656
32. Chang P, Coughlin M, Mitchison TJ. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol 2005;7:1133-1139
33. Chi NW, Lodish HF. Tankyrase is a golgi-associated mitogenactivated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem 2000;275:38437-38444
34. Seimiya H. The telomeric PARP, tankyrases, as targets for cancer therapy. Br J Cancer 2006;94:341-345
35. Cook BD, Dynek JN, Chang W, Shostak G, Smith S. Role for the related poly(ADP-ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol 2002;22:332-342
36. Kim SH, Kaminker P, Campisi J. TIN2, a new regulator of telomere length in human cells. Nat Genet 1999;23:405-412
37. Ye JZ, de Lange T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet 2004;36:618-623
38. Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007;8:379-393
39. Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS. Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J 2002;21:4491-4499
40. Shen M, Haggblom C, Vogt M, Hunter T, Lu KP. Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc Natl Acad Sci U S A 1997;94: 13618-13623
41. Nakamura M, Zhou XZ, Kishi S, Kosugi I, Tsutsui Y, Lu KP. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Curr Biol 2001;11:1512-1516
42. Nakamura M, Zhou XZ, Kishi S, Lu KP. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 2002;514:193-198
43. Draviam VM, Shapiro I, Aldridge B, Sorger PK. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J 2006;25:2814-2827
44. Tirnauer JS, Grego S, Salmon ED, Mitchison TJ. EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell 2002;13:3614-3626
45. Munoz P, Blanco R, de Carcer G, et al. TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol Cell Biol 2009;29:1608-1625
46. Zhu Q, Meng L, Hsu JK, Lin T, Teishima J, Tsai RY. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. J Cell Biol 2009; 185:827-839
47. Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 2005;437: 1038-1042
48. Shang X, Burlingame SM, Okcu MF, et al. Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Mol Cancer Ther 2009;8:2461-2469
49. Zhang X, Ems-McClung SC, Walczak CE. Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. Mol Biol Cell 2008;19:2752-2765
50. Jang CY, Coppinger JA, Seki A, Yates JR III, Fang G. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci 2009;122:1334-1341
51. Keen N, Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 2004;4:927-936