메뉴 건너뛰기




Volumn 287, Issue 45, 2012, Pages 37973-37985

A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors

Author keywords

[No Author keywords available]

Indexed keywords

LIPID METABOLISMS; LIVER X RECEPTORS; METABOLIC ACTION; PROTEIN INHIBITORS; UP-REGULATION;

EID: 84868322244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.403139     Document Type: Article
Times cited : (20)

References (48)
  • 1
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR. The yin and yang of cholesterol and fat metabolism
    • Kalaany, N. Y., and Mangelsdorf, D. J. (2006) LXRS and FXR. The yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68, 159-191
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 2
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • Zelcer, N., and Tontonoz, P. (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116, 607-614 (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 3
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu, T. T., Repa, J. J., and Mangelsdorf, D. J. (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem. 276, 37735-37738
    • (2001) J. Biol. Chem. , vol.276 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 4
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • DOI 10.1146/annurev.cellbio.16.1.459
    • Repa, J. J., and Mangelsdorf, D. J. (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu. Rev. Cell Dev. Biol. 16, 459-481 (Pubitemid 32037514)
    • (2000) Annual Review of Cell and Developmental Biology , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 5
    • 0028025654 scopus 로고
    • A novel orphan receptor specific for a subset of thyroid hormone- responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
    • Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M. A., Salbert, G., and Pfahl, M. (1994) A novel orphan receptor specific for a subset of thyroid hormone- responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14, 7025-7035
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7025-7035
    • Apfel, R.1    Benbrook, D.2    Lernhardt, E.3    Ortiz, M.A.4    Salbert, G.5    Pfahl, M.6
  • 8
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the x-files
    • DOI 10.1126/science.294.5548.1866
    • Chawla, A., Repa, J. J., Evans, R. M., and Mangelsdorf, D. J. (2001) Nuclear receptors and lipid physiology. Opening the X-files. Science 294, 1866-1870 (Pubitemid 33101573)
    • (2001) Science , vol.294 , Issue.5548 , pp. 1866-1870
    • Chawta, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 9
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • Glass, C. K., and Rosenfeld, M. G. (2000) The co-regulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14, 121-141 (Pubitemid 30070977)
    • (2000) Genes and Development , vol.14 , Issue.2 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 11
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXRα
    • DOI 10.1038/383728a0
    • Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature 383, 728-731 (Pubitemid 26360651)
    • (1996) Nature , vol.383 , Issue.6602 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 12
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • DOI 10.1016/S0092-8674(00)81432-4
    • Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 93, 693-704 (Pubitemid 28257577)
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 13
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • DOI 10.1172/JCI200215593
    • Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) SREBPs. Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131 (Pubitemid 34496588)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 17
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and hepatic lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR
    • DOI 10.1074/jbc.M605023200
    • Cha, J. Y., and Repa, J. J. (2007) The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282, 743-751 (Pubitemid 47076632)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.-Y.1    Repa, J.J.2
  • 18
    • 33244482536 scopus 로고    scopus 로고
    • Combinatorial roles of nuclear receptors in inflammation and immunity
    • DOI 10.1038/nri1748, PII N1748
    • Glass, C. K., and Ogawa, S. (2006) Combinatorial roles of nuclear receptors in inflammation and immunity. Nat. Rev. Immunol. 6, 44-55 (Pubitemid 43279752)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.1 , pp. 44-55
    • Glass, C.K.1    Ogawa, S.2
  • 19
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • DOI 10.1038/nm820
    • Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., and Tontonoz, P. (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Medicine 9, 213-219 (Pubitemid 36227724)
    • (2003) Nature Medicine , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 20
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
    • DOI 10.1038/nature03988, PII N03988
    • Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., and Glass, C. K. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ. Nature 437, 759 -763 (Pubitemid 41486547)
    • (2005) Nature , vol.437 , Issue.7059 , pp. 759-763
    • Pascual, G.1    Fong, A.L.2    Ogawa, S.3    Gamliel, A.4    Li, A.C.5    Perissi, V.6    Rose, D.W.7    Willson, T.M.8    Rosenfeld, M.G.9    Glass, C.K.10
  • 21
    • 70349191359 scopus 로고    scopus 로고
    • Differential SUMOylation of LXRα and LXRα mediates transrepression of STAT1 inflammatory signaling in IFN-stimulated brain astrocytes
    • Lee, J. H., Park, S. M., Kim, O. S., Lee, C. S., Woo, J. H., Park, S. J., Joe, E. H., and Jou, I. (2009) Differential SUMOylation of LXRα and LXRα mediates transrepression of STAT1 inflammatory signaling in IFN-stimulated brain astrocytes. Mol. Cell 35, 806-817
    • (2009) Mol. Cell , vol.35 , pp. 806-817
    • Lee, J.H.1    Park, S.M.2    Kim, O.S.3    Lee, C.S.4    Woo, J.H.5    Park, S.J.6    Joe, E.H.7    Jou, I.8
  • 22
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • DOI 10.1126/science.278.5344.1803
    • Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., and Shuai, K. (1997) Specific inhibition of Stat3 signal transduction by PIAS3. Science 278, 1803-1805 (Pubitemid 27527648)
    • (1997) Science , vol.278 , Issue.5344 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 24
    • 23444461182 scopus 로고    scopus 로고
    • Regulation of gene-activation pathways by pias proteins in the immune system
    • DOI 10.1038/nri1667
    • Shuai, K., and Liu, B. (2005) Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol. 5, 593-605 (Pubitemid 41113191)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.8 , pp. 593-605
    • Shuai, K.1    Liu, B.2
  • 25
    • 0035576737 scopus 로고    scopus 로고
    • A new RING for SUMO: Wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases
    • DOI 10.1101/gad.955501
    • Jackson, P. K. (2001) A new RING for SUMO. Wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Genes Dev. 15, 3053-3058 (Pubitemid 33115672)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3053-3058
    • Jackson, P.K.1
  • 26
    • 0346100493 scopus 로고    scopus 로고
    • PIAS/SUMO: New partners in transcriptional regulation
    • DOI 10.1007/s00018-003-3129-1
    • Schmidt, D., and Müller, S. (2003) PIAS/SUMO. New partners in transcriptional regulation. Cell. Mol. Life Sci. 60, 2561-2574 (Pubitemid 38041360)
    • (2003) Cellular and Molecular Life Sciences , vol.60 , Issue.12 , pp. 2561-2574
    • Schmidt, D.1    Muller, S.2
  • 27
    • 33645514646 scopus 로고    scopus 로고
    • PIAS proteins and transcriptional regulation. More than just SUMO E3 ligases?
    • Sharrocks, A. D. (2006) PIAS proteins and transcriptional regulation. More than just SUMO E3 ligases? Genes Dev. 20, 754-758
    • (2006) Genes Dev. , vol.20 , pp. 754-758
    • Sharrocks, A.D.1
  • 28
    • 77954554653 scopus 로고    scopus 로고
    • Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice
    • Huang, P., Li, S., Shao, M., Qi, Q., Zhao, F., You, J., Mao, T., Li, W., Yan, Z., and Liu, Y. (2010) Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutr. Metab. 7, 59-68
    • (2010) Nutr. Metab. , vol.7 , pp. 59-68
    • Huang, P.1    Li, S.2    Shao, M.3    Qi, Q.4    Zhao, F.5    You, J.6    Mao, T.7    Li, W.8    Yan, Z.9    Liu, Y.10
  • 29
    • 83555172601 scopus 로고    scopus 로고
    • Ligand-dependent co-repressor acts as a novel co-repressor of thyroid hormone receptor and represses hepatic lipogenesis in mice
    • Song, Y., Shan, S., Zhang, Y., Liu, W., Ding, W., Ren, W., Xia, H., Li, X., Zhang, Q., Zhao, L., Li, X., Yan, J., and Ying, H. (2012) Ligand-dependent co-repressor acts as a novel co-repressor of thyroid hormone receptor and represses hepatic lipogenesis in mice. J. Hepatol. 56, 248-254
    • (2012) J. Hepatol. , vol.56 , pp. 248-254
    • Song, Y.1    Shan, S.2    Zhang, Y.3    Liu, W.4    Ding, W.5    Ren, W.6    Xia, H.7    Li, X.8    Zhang, Q.9    Zhao, L.10    Li, X.11    Yan, J.12    Ying, H.13
  • 30
    • 0032821886 scopus 로고    scopus 로고
    • Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency
    • DOI 10.1038/sj.gt.3300976
    • Godbey, W. T., Wu, K. K., Hirasaki, G. J., and Mikos, A. G. (1999) Improved packing of poly(ethyleneimine)-DNA complexes increases transfection efficiency. Gene Ther. 6, 1380-1388 (Pubitemid 29396726)
    • (1999) Gene Therapy , vol.6 , Issue.8 , pp. 1380-1388
    • Godbey, W.T.1    Wu, K.K.2    Hirasaki, G.J.3    Mikos, A.G.4
  • 33
    • 0018182489 scopus 로고
    • The role of malonyl-CoA in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes
    • McGarry, J. D., Takabayashi, Y., and Foster, D. W. (1978) The role of malonyl-CoA in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. J. Biol. Chem. 253, 8294-8300 (Pubitemid 9073731)
    • (1978) Journal of Biological Chemistry , vol.253 , Issue.22 , pp. 8294-8300
    • McGarry, J.D.1    Takabayashi, Y.2    Foster, D.W.3
  • 34
    • 70149108302 scopus 로고    scopus 로고
    • Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
    • Jiang, L., Wang, Q., Yu, Y., Zhao, F., Huang, P., Zeng, R., Qi, R. Z., Li, W., and Liu, Y. (2009) Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway. PloS ONE 4, e6884
    • (2009) PloS ONE , vol.4
    • Jiang, L.1    Wang, Q.2    Yu, Y.3    Zhao, F.4    Huang, P.5    Zeng, R.6    Qi, R.Z.7    Li, W.8    Liu, Y.9
  • 36
    • 0036291475 scopus 로고    scopus 로고
    • PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases
    • DOI 10.1128/MCB.22.14.5222-5234.2002
    • Kotaja, N., Karvonen, U., Jänne, O. A., and Palvimo, J. J. (2002) PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol. 22, 5222-5234 (Pubitemid 34700711)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.14 , pp. 5222-5234
    • Kotaja, N.1    Karvonen, U.2    Janne, O.A.3    Palvimo, J.J.4
  • 37
    • 0034680441 scopus 로고    scopus 로고
    • Covalent modification of p73' by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif
    • Minty, A., Dumont, X., Kaghad, M., and Caput, D. (2000) Covalent modification of p73' by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J. Biol. Chem. 275, 36316-36323
    • (2000) J. Biol. Chem. , vol.275 , pp. 36316-36323
    • Minty, A.1    Dumont, X.2    Kaghad, M.3    Caput, D.4
  • 38
    • 0035918226 scopus 로고    scopus 로고
    • SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting
    • Rodriguez, M. S., Dargemont, C., and Hay, R. T. (2001) SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J. Biol. Chem. 276, 12654-12659
    • (2001) J. Biol. Chem. , vol.276 , pp. 12654-12659
    • Rodriguez, M.S.1    Dargemont, C.2    Hay, R.T.3
  • 39
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • DOI 10.1172/JCI27794
    • Finck, B. N., and Kelly, D. P. (2006) PGC-1 co-activators. Inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116, 615-622 (Pubitemid 43326866)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 40
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • DOI 10.1016/j.cmet.2005.05.004, PII S1550413105001427
    • Lin, J., Handschin, C., and Spiegelman, B. M. (2005) Metabolic control through the PGC-1 family of transcription co-activators. Cell Metab. 1, 361-370 (Pubitemid 43960626)
    • (2005) Cell Metabolism , vol.1 , Issue.6 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 41
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP
    • DOI 10.1016/j.cell.2004.11.043, PII S009286740401147X
    • Lin, J., Yang, R., Tarr, P. T., Wu, P. H., Handschin, C., Li, S., Yang, W., Pei, L., Uldry, M., Tontonoz, P., Newgard, C. B., and Spiegelman, B. M. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β co-activation of SREBP. Cell 120, 261-273 (Pubitemid 40174768)
    • (2005) Cell , vol.120 , Issue.2 , pp. 261-273
    • Lin, J.1    Yang, R.2    Tarr, P.T.3    Wu, P.-H.4    Handschin, C.5    Li, S.6    Yang, W.7    Pei, L.8    Uldry, M.9    Tontonoz, P.10    Newgard, C.B.11    Spiegelman, B.M.12
  • 42
    • 0037088644 scopus 로고    scopus 로고
    • Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1
    • DOI 10.1074/jbc.M110761200
    • Wu, Y., Delerive, P., Chin, W. W., and Burris, T. P. (2002) Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1. J. Biol. Chem. 277, 8898-8905 (Pubitemid 34952959)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.11 , pp. 8898-8905
    • Wu, Y.1    Delerive, P.2    Chin, W.W.3    Burris, T.P.4
  • 43
    • 32644459132 scopus 로고    scopus 로고
    • Regulation of cytokine signaling pathways by PIAS proteins
    • DOI 10.1038/sj.cr.7310027, PII 7310027
    • Shuai, K. (2006) Regulation of cytokine signaling pathways by PIAS proteins. Cell Res. 16, 196-202 (Pubitemid 43247977)
    • (2006) Cell Research , vol.16 , Issue.2 , pp. 196-202
    • Shuai, K.1
  • 44
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil, G. S., and Erbay, E. (2008) Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 8, 923-934
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 45
    • 4644367257 scopus 로고    scopus 로고
    • PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
    • DOI 10.1038/ni1104
    • Liu, B., Mink, S., Wong, K. A., Stein, N., Getman, C., Dempsey, P. W., Wu, H., and Shuai, K. (2004) PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat. Immunol. 5, 891-898 (Pubitemid 39276233)
    • (2004) Nature Immunology , vol.5 , Issue.9 , pp. 891-898
    • Liu, B.1    Mink, S.2    Wong, K.A.3    Stein, N.4    Getman, C.5    Dempsey, P.W.6    Wu, H.7    Shuai, K.8
  • 47
    • 70350031566 scopus 로고    scopus 로고
    • SUMOylation attenuates the function of PGC-1alpha
    • Rytinki, M. M., and Palvimo, J. J. (2009) SUMOylation attenuates the function of PGC-1alpha. J. Biol. Chem. 284, 26184-26193
    • (2009) J. Biol. Chem. , vol.284 , pp. 26184-26193
    • Rytinki, M.M.1    Palvimo, J.J.2
  • 48
    • 33845970925 scopus 로고    scopus 로고
    • Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARγ
    • DOI 10.1016/j.molcel.2006.11.022, PII S1097276506008161
    • Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M. E., Willson, T. M., Rosenfeld, M. G., and Glass, C. K. (2007) Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ. Mol. Cell 25, 57-70 (Pubitemid 46049061)
    • (2007) Molecular Cell , vol.25 , Issue.1 , pp. 57-70
    • Ghisletti, S.1    Huang, W.2    Ogawa, S.3    Pascual, G.4    Lin, M.-E.5    Willson, T.M.6    Rosenfeld, M.G.7    Glass, C.K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.