Administration of the rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine

Cardiovascular Drugs and Therapy

Volumn 22, Issue 4, 2008, Pages 293-298

  Shibata, Itsuko ^a   Yoshitomi, Osamu ^a   Use, Tadasuke ^a   Ureshino, Hiroyuki ^a   Cho, Sungsam ^a   Maekawa, Takuji ^a   Hara, Tetsuya ^a   Sumikawa, Koji ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Fasudil; Ischemia; Reperfusion; Rho kinase; Stunned myocardium; Swine

Indexed keywords

FASUDIL; RHO KINASE; RHO KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE FIBRILLATION; NONHUMAN; PRIORITY JOURNAL; STUNNED HEART MUSCLE; SWINE; TACHYCARDIA;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; MYOCARDIUM; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; SWINE;

EID: 48349098513     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6106-y     Document Type: Article

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