Serum leptin and ghrelin levels in women with polycystic ovary syndrome: Correlation with anthropometric, metabolic, and endocrine parameters

International Journal of Fertility and Sterility

Volumn 6, Issue 2, 2012, Pages 117-126

  Houjeghani, Shiva ^a   Gargari, Bahram Pourghassem ^b   Farzadi, Laya ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ghrelin; Insulin; Leptin; Polycystic ovary syndrome

Indexed keywords

FOLLITROPIN; GHRELIN; INSULIN; LEPTIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOCRINE PRAMETERS; FEMALE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; METABOLIC PARAMETERS; OVARY POLYCYSTIC DISEASE; PARAMETERS; WAIST HIP RATIO;

EID: 84868159795     PISSN: 2008076X     EISSN: 20080778     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet. 2007; 370(9588): 685-697.
2. Dasgupta S, Reddy BM. Present status of understanding on the genetic etiology of polycystic ovary syndrome. J Postgrad Med. 2008; 54(2): 115-125.
3. Pasquali R, Casimirri F. The impact of obesity on hyper-androgenism and polycystic ovary syndrome in premeno- pau usal wnmen CC.lin EndInc rinnl 1993; 39(1):1-16
4. Ahima RS, Flier JS. Adipose tissue as an endocrine or-gan. Trends Endocrinol Metab. 2000; 11(8): 327-332.
5. Fasshauer M, Paschke R. Regulation of adipocy-tokines and insulin resistance. Diabetologia. 2003; 46(12): 1594-1603.
6. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord. 2002; 26(11): 1407-1433.
7. Salehpour S, Taherzadeh Broujeni P, Neisani Samani E. Leptin, ghrelin, adiponectin, homocysteine and insulin re-sistance related to polycystic ovary syndrome. Int J Fertil Steril. 2008; 2(3): 101-104.
8. Lazovic G, Radivojevic U, Milicevic S, Spremovic S. In-fluence of adiposity on leptin, LH and androgen levels in lean, overweight and obese PCOS patients. Int J Fertil Womens Med. 2007; 52(2-3): 82-88.
9. Atamer A, Demir B, Bayhan G, Atamer Y, Ilhan N, Akku Z. Serum levels of leptin and homocysteine in women with polycystic ovary syndrome and its relationship to endo-crine, clinical and metabolic parameters. J Int Med Res. 2008; 36(1): 96-105.
10. Mitkov M, Pehlivanov B, Orbetzova M. Serum ghrelin level in women with polycystic ovary syndrome and its relation-ship with endocrine and metabolic parameters. Gynecol Fnrdocrinol 2008 24 (11):625-630
11. Pehlivanov B, Mitkov M. Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome. Eur J Contracept Reprod Health Care. 2009; 14(2): 153-159.
12. Calvar CE, Intebi AD, Bengolea SV, Hermes R, Spinedi E.Leptin in patients with polycystic ovary syndrome. Direct correlation with insulin resistance. Medicina (B Aires). 2003; 63(6): 704-710.
13. Bideci A, Camurdan MO, Yeşilkaya E, Demirel F, Cinaz P. Serum ghrelin, leptin and resistin levels in adolescent girls with polycystic ovary syndrome. J Obstet Gynaecol Res. 2008; 34(4): 578-584.
14. Glintborg D, Andersen M, Hagen C, Frystyk J, Hulstrøm V, Flyvbjerg A, et al. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur J Endocrinol. 2006; 155(2): 337-345.
15. Dupont J, Maillard V, Coyral-Castel S, Ramé C, Froment P. Ghrelin in female and male reproduction. Int J Pept. 2010; pii: 158102.
16. Orio F Jr, Lucidi P, Palomba S, Tauchmanova L, Cascella T, Russo T, et al. Circulating ghrelin concentrations in the polycyctic ovary syndrome. J Clin Endocrinol Metab. 2003; 88(2): 942-945.
17. Waśko R, Komarowska H, Warenik-Szymankiewicz A, Sowiński J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res. 2004; 36(3): 170-173.
18. Kamal M, Mohi A, Fawzy M, EI-Sawah H. Fasting plasma ghrelin in women with and without PCOS. MEFS J. 2010; 15(2): 91-94.
19. Pasquali R, Pelusi C, Genghini S, Cacciari M, Gambin-eri A. Obesity and reproductive disorders in women. Hum Reprod Update. 2003; 9(4): 359-372.
20. Gonzalez RR, Simón C, Caballero-Campo P, Norman R, Chardonnens D, Devoto L, et al. Leptin and reproduction. Hum Reprod Update. 2000; 6(3): 290-300.
21. Barreiro ML, Tena-sempere M. Ghrelin and reproduction: a novel signal linking energy status and fertility? Mol Cell Endocrinol. 2004; 226(1-2): 1-9.
22. Rotterdam ESHRE/ASRM Sponsored PCOS consen- sus workshop group. Revised 2003 consensus on diag-nostic criteria and long-term health risks related to pol-ycystic ovary syndrome (PCOS). Hum Reprod. 2004; 19(1): 41-47.
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assess-ment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabe-tologial.1985; 28(7): 412-419.
24. Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A. Lep-tin in reproduction. Trends Endocrinol Metab. 2001; 12(2): 65-72.
25. Telli MH, Yildirim M, Noyan V. Serum leptin levels in pa-tients with polycystic ovary syndrome. Fertil Steril. 2002; 77(5): 932-935.
26. Erturk E, Kuru N, Savci V, Tuncel E, Ersoy C, Imamoglu S. Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. Fertil Steri. 2004; 82(5): 1364-1368.
27. Hautanen A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int J Obes Relat Metab Disord. 2000; 24(Suppl 2): S64-S70.
28. Von Schoultz B, Carlstörm K. On the regulation of sex-hormone-binding globulin-a challenge of an old dogma and outlines of an alternative mechanism. J Steriod Bio-chem. 1989; 32(2): 327-334.
29. Plymate SR, Matej LA, Jones RE, Friedl KE. Inhibition of sex hormone-binding globulin production in the human hepatoma (HepG2) cell line by insulin and production. J Clin Endocrinol Metab. 1988; 67(3): 460-464.
30. Nestler JE, Jakubowicz DJ. Decreases in ovarian cyto-chrome P450c17 alpha activity and serum free testoster-one after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med. 1996; 335(9): 617-623.
31. Nestler JE, Jakubowicz DJ. Lean women with polycys-tic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and se-rum androgens. J Clin Endocrinol Metab. 1997; 82(12): 4075-4079
32. Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, et al. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 2007; 117(10): 2860-2868.
33. Kieffer TJ, Habener JF. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2000; 278(1): E1-E14.
34. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes. 1996; 45(5): 695-698.
35. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, Depaoli AM, et al. Recombinant human leptin in women with hy-pothalamic amenorrhea. N Engl J Med. 2004; 351(10): 987-997.
36. Laughlin GA, Morales AJ, Yen SS. Serum leptin levels in women with polycystic ovary syndrome: the role of insu-lin resistance/hyperinsulinemia. J clin Endocrinol Metab. 1997; 82(6): 1692-1696.
37. Veldhuis JD, Pincus SM, Garcia-Rudaz MC, Ropelato MG, Escobar ME, Barontini M. Disruption of the synchro-nous secretion of leptin, LH, and ovarian androgens in nonobese adolescents with the polycystic ovarian syn-drome. J Clin Endocrinol Metab. 2001; 86(8): 3772-3778.
38. Mendonca HC, Montenegro RM Jr, Foss MC, Silva de Sá MF, Ferriani RA. Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syn-drome. Braz J Med Biol Res. 2004; 37(5): 729-736.
39. Bützow TL, Moilanen JM, Lehtovirta M, Tuomi T, Hovatta O, Siegberg R, et al. Serum and follicular fluid leptin dur-ing in vitro fertilization: relationship among leptin increase, body fat mass, and reduced ovarian response. J Clin En-docrinol Metab 1999; 84(9): 3135-3139.
40. Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the hu-man ovary. J Clin Endocrinol Metab. 1999; 84(3): 1072-1076.
41. Rouru J, Anttila L, Koskinen P, Penttilä TA, Irjala K, Hu-upponen R, et al. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1997; 82(6): 1697-1700.
42. Sih R, Morley JE, Kaiser FE, Perry HM, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 1997; 82(6): 1661-1667.
43. Behre HM, Simoni M, Nieschlag E. Strong association be-tween serum levels of leptin and testosterone in men. Clin Endocrinol (Oxf). 1997; 47(2): 237-240.
44. Haffner SM, Miettinen H, Karhapaä aä P, Mykkänen L, Laakso M. Leptin concentrations, sex hormones, and cor-tisol in nondiabetic men. J Clin Endocrinol Metab. 1997; 82(6): 1807-1809.
45. Poretsky L, Chandrasekher YA, Bai C, Liu HC, Rosen-waks Z,Giudice L. Insulin receptor mediates inhibitory effect of insulin, but not of insulin-like growth factor (IGF)-I, on IGF binding protein 1 (IGFBP-1) produc-tion in human granulosa cells. J Clin Endocrinol Metab 1996; 81(2): 493-496.
46. Rosenfield RL. Ovarian and adrenal function in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999; 28(2): 265-293.
47. Elbers JM, Asscheman H, Seidell JC, Frölich M, Meinders AE, Gooren LJ. Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab. 1997; 82(10): 3267-3270.
48. Van Rossum EF, Nicklas BJ, Dennis KE, Berman DM, Goldberg AP. Leptin responses to weight loss in post-menopausal women: relationship to sex-hormone bind-ing globulin and visceral obesity. Obes Res. 2000; 8(1): 29-35.
49. Escobar-Morreale HF, Serrano-Gotarredona J, Varela C, Garcia-Robles R, Sancho JM. Circulating leptin concen-trations in women with hirsutism. Fertil Steril. 1997; 68(5): 898-906.
50. Daghestani MH, Daghestani MH, El-Mazny A. Circulating ghrelin levels and the polycystic ovary syndrome: corre-lation with the clinical, hormonal and metabolic features. Eur J Obstet Gynecol Reprod Biol. 2011; 155(1): 65-68.
51. Schöfl C, Horn R, Schill T, Schlosser HW, Muller MJ, Brabant G. Circulating ghrelin levels in patients with poly-cystic ovary syndrome. J Clin Endocrinol Metab. 2002; 87(10): 4607-4610.
52. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insu-lin secretion in humans. J Clin Endocrinol Metab. 2001; 86(10): 5083-5086.
53. Saad MF, Bernaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E, et al. Insulin regulates plasma ghrelin concen-tration. J Clin Endocrinol Metab. 2002; 87(8): 3997-4000.
54. Caminos JE, Tena-Sempere M, Gaytan F, Sanchez-Cri-ado JE, Barreiro ML, Nogueiras R, et al. Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology. 2003: 144(4): 1594-1602.
55. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE, et al. Novel expression and func-tional role of ghrelin in rat testis. Endocrinology. 2002; 143(2): 711-725.
56. Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab. 2002; 87(12): 5625-5629