Influence of adiposity on leptin, LH and androgen levels in lean, overweight and obese PCOS patients

International Journal of Fertility and Women's Medicine

Volumn 52, Issue 2-3, 2007, Pages 82-88

  LaZovic, Gordana ^a   Radivojevic, Ubavka ^b   Milicevic, Srboljub ^a   Spremovic, Svetlana ^a  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b Institute of Mother and Child Healthcare of Serbia Dr Vukan upi   (Serbia)

Author keywords

Leptin; LH; Obesity; PCOS

Indexed keywords

ANDROSTENEDIONE; LEPTIN; LUTEINIZING HORMONE; TESTOSTERONE; THYROTROPIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD; BODY MASS; BODY WEIGHT; COMPARATIVE STUDY; FEMALE; HUMAN; METABOLISM; OBESITY; OVARY POLYCYSTIC DISEASE;

ADIPOSE TISSUE; ADULT; ANDROSTENEDIONE; BODY MASS INDEX; BODY WEIGHT; FEMALE; HUMANS; LEPTIN; LUTEINIZING HORMONE; OBESITY; POLYCYSTIC OVARY SYNDROME; TESTOSTERONE; THYROTROPIN;

EID: 42949091340     PISSN: 1534892X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Leenen R, Van der Kooy K, Seidell JC, et al: Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab 78(6): 1515-1520, 1994. (Pubitemid 24181029)
2. Ahima RS, Prabakaran D, Mantzoros C, et al: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996. (Pubitemid 26251358)
3. Barash IA, Cheung CC, Weigle DS, et al: Leptin is a metabolic signal to the reproductive system. Endocrinology 137:3144-3147, 1996. (Pubitemid 26193035)
4. Maffei M, Halaas J, Ravussin E: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1(11):1155-1161, 1995.
5. Sinha MK, Opentanova I, Ohannesian JP, et al: Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. Jrnl Clin Inves 98(6):1277-1282, 1996.
6. Licinio J, Mantzoros C, Negrao AB: Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3(5):575-579, 1997. (Pubitemid 27198660)
7. Licinio J, Negrao AB, Mantzoros C, et al: Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone and estradiol in healthy women. Proc Natl Acad Sci U.S.A. 95, 2541-2546, 1998.
8. Sinha MK, Sturis J, Ohannesian J: Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun 228(3):733-738, 1996. (Pubitemid 26421447)
9. Tartaglia, LA: The leptin receptor. J Biol Chem 272: 6093-6096, 1997.
10. Cioffi JA, Van Blerkom J, Antczak M, et al: The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 3(6):467-472, 1997. (Pubitemid 127509365)
11. Considine RV, Sinha MK, Heiman ML, et al: Serum immunoreactive leptin concentrations in normal-weight and obese humans." New Engl J Med, 334, 292-295, 1996. (Pubitemid 26033933)
12. Considine RV, Considine EL, Williams CJ: The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 19:992-994, 1996. (Pubitemid 26226765)
13. Sir-Petermann T, Piwonka V, Perez F, et al: Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? Hum Reprod 14(6):1435-1439, 1999.
14. Rosenbaum M, Leiben R: Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. J Clin Endocrinol Metab 84(6):1784-1789, 1999. (Pubitemid 30646988)
15. Kiddy DS, Sharp PS, White DM, et al: Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases." Clinic Endocrinol 32:213-220, 1990.
16. Gambineri A, Pelusi C, Vicennati V, et al: Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord 26:883-896, 2002.
17. Yen SSC, Vela P, Rankin J: Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 30:435-442, 1970.
18. Rebar R, Judd HL, Yen SSC, et al: Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 57:1320-1329, 1976.
19. Venturoli S, Porcu E, Fabbri R, et al: Episodic pulsatile secretion of FSH, LH, prolactin, oestradiol, oestrone, and LH circadian variations in polycystic ovary syndrome. Clin Endocrinol 28:93-107, 1988. (Pubitemid 18027513)
20. Couzinet B, Thomas G, Thalabard JC, et al: Effects of a pure antiandrogen on gonadotropin secretion in normal women and in polycystic ovarian disease. Fertil Steril 52:42-50, 1989. (Pubitemid 19178691)
21. Graf MA, Bielfeld P, Distter W, et al: Pulsatile luteinizing hormone secretion pattern in hyperandrogenic women. Fertil Steril 59:761-767, 1993. (Pubitemid 23104175)
22. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19-25, 2004.
23. Grulet H, Hecart AC, Delemer B, et al: Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome. Clin Endocrinol 38:621-626, 1993. (Pubitemid 23168477)
24. Holte J, Bergh T, Berne C, et al: Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin Endocrinol 41:463-471, 1994. (Pubitemid 24301279)
25. Panidis D, Rousso D, Kourtis A, et al: Serum leptin levels in normal-weight and overweight women with polycystic ovary syndrome. Clin Exp Obstet Gynecol 30(4):207-210, 2007.
26. Palmert MR, Radovick S, Boepple PA: The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab 83:1091-1096, 1998. (Pubitemid 28496375)
27. Shimizu H, Shimomura Y, Nakanishi Y, et al: Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 154:285-292, 1997. (Pubitemid 27330641)
28. Wabitsch M, Blum WF, Muche R, et al: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 100:808-813, 1997. (Pubitemid 27371698)
29. Arroyo A, Laughlin GA, Morales AJ, et al: Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. J Clin Endocrinol Metab 82:3728-3733, 1997. (Pubitemid 27509362)
30. Baker E, Flora S, Ferguson J, et al: Gonadotropin secretory dynamics in polycystic ovary syndrome. Current Opinion in Endocrinology & Diabetes 9(6):475-479, 2002. (Pubitemid 36735165)
31. Taylor AE, McCourt B, Martin KA, et al: Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab 82: 2248-2256, 1997. (Pubitemid 27287593)
32. Van Dam E, Roelfsema F, Veldhuis JD, et al: Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS. Am J Physiol Endocrinol Metab 282: E865-E872, 2002. (Pubitemid 34654748)
33. Brzechffa, PR, Jakimiuk AJ, Agarwal SK: Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 81(4166-4169), 1996.
34. Bergendahl M, Iranmanesh A, Evans WS, et al: Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy mid-luteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). J Clin Endocrinol Metab 85:207-213, 2000. (Pubitemid 32268815)