Insulin receptor mediates inhibitory effect of insulin, but not of insulin-like growth factor (IGF)-I, on IGF binding protein 1 (IGFBP-1) production in human granulosa cells

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 493-496

  Poretsky, L ^a,c   Chandrasekher, Y A ^b   Bai, C ^a   Liu, H C ^c   Rosenwaks, Z ^c   Giudice, L ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INSULIN RECEPTOR; SOMATOMEDIN C;

ARTICLE; CULTURE MEDIUM; GRANULOSA CELL; HORMONAL REGULATION; HUMAN; HUMAN CELL; HYPERINSULINEMIA; INHIBITION KINETICS; INSULIN RESISTANCE; OVARY FUNCTION; PRIORITY JOURNAL; STEROIDOGENESIS;

EID: 0030020879     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.493     Document Type: Article

References (40)

1. Giudice L. 1992 Insulin-like growth factors and ovarian follicular development. Endocr Rev. 13:641-659.
2. Poretsky L, Kalin M. 1987 The gonadotropic function of insulin. Endocr Rev. 8:132-141.
3. Adashi EY, Resnick CE, D'Ercole AJ, Svoboda ME, Van Wyk JJ. 1985 Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev. 6:400-420.
4. El-Roeiy A, Chen X, Roberts V, et al. 1994 Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries. J Clin Endocrinol Metab. 78:1488-1496.
5. Nestler JE, Clore NJ, Blackard WG. 1992 Effects of insulin on steroidogenesis in vivo. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Boston: Blackwell Scientific; 337-384.
6. Garmey JC, Day RN, Day KH, Veldhuis JD. 1993 Mechanisms of regulation of ovarian steroid metabolism by insulin-like growth factor type II: in vitro studies with swine granulosa cells. Endocrinology. 133:800-808.
7. Jones J, Clemmons D. 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 16:3-34.
8. Lowe W. 1994 Editorial: Once is not enough - Promiscuity begets diversity among the insulin-like growth factor binding proteins. Endocrinology. 135: 1719-1721.
9. Angervo M, Koistinen R, Suikkari A, Seppala M. 1991 Insulin-like growth factor binding protein-1 inhibits the DNA amplification induced by insulin-like growth factor I in human granulosa-luteal cells. Hum Reprod. 6:770-773.
10. Mason HD, Willis D, Holly JMP, Cwyfan-Hughes SC, Seppala M, Franks S. 1992 Inhibitory effects of insulin-like growth factor-binding proteins on steroidogenesis by human granulosa cells in culture. Mol Cell Endocrinol. 89: R1-R4.
11. Ui M, Shimonaka M, Shimasaki S, Ling N. 1989 An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells. Endocrinology. 125:912-916.
12. Adashi EY, Resnick CE, Ricciarelli E, et al. 1992 Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-1 hormonal action: evidence derived from the use of a truncated IGF-1 analog. J Clin Invest. 90:1593-1599.
13. Suikkari AM, Jalkanen J, Koistinen R, et al. 1989 Human granulosa cells synthesize low molecular weight insulin-like growth factor-binding protein. Endocrinology. 124:1088-1090.
14. Julkunen M, Koistinen R, Aalto-Setala K, Seppala M, Janne OA, Kontula K. 1988 Primary structure of human insulin-like growth factor-binding protein/ placental protein 12 and tissue-specific expression of its mRNA. Fed Eur Biochem Soc. 236:295-302.
15. San Roman G, Magoffin DA. 1992 Insulin-like growth factor binding proteins in ovarian follicles from women with polycystic ovarian disease: cellular source and levels in follicular fluid. J Clin Endocrinol Metab. 75:1010-1016.
16. Cataldo N, Giudice L. 1992 Follicular fluid insulin-like growth factor binding protein profiles in polycystic ovary syndrome. J Clin Endocrinol Metab. 74: 695-697.
17. Jalkanen J, Suikkari A, Koistinen R, et al. 1989 Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells. J Clin Endocrinol Metab. 69:1174-1179.
18. Suikkari AM, Koivisto VA, Koistinen R, et al. 1989 Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin. J Clin Endocrinol Metab. 68:135-140.
19. Gates GS, Bayer S, Seibel M, Poretsky L, Flier JS, Moses AC. 1987 Characterization of insulin-like growth factor I binding to human granulosa cells obtained during in vitro fertilization. J Recept Res. 7:885-902.
20. Soos MA, Field CE, Lammers R, et al. 1992 A panel of monoclonal antibodies for the Type I insulin-like growth factor receptor. J Biol Chem. 267:12955-12963.
21. Soos MA, Siddle K, Baron MD, et al. 1986 Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor. Biochem J. 235:199-208.
22. Poretsky L. 1991 On the paradox of insulin-induced hyperandrogenism in insulin resistant states. Endocr Rev. 12:3-13.
23. Poretsky L. 1993 Role of insulin resistance in the pathogenesis of polycystic ovary syndrome. In: Schats R, Schoemaker J, eds. Ovarian endocrinopathies. Parthenon Publishing Group; 8th Reinier de Graaf Symposium, Amsterdam: The Netherlands; 169-76.
24. Poretsky L. 1994 Insulin resistance and hyperandrogenism: update 1994. In: The Endocrine Pancreas, Insulin Action and Diabetes. A Negro-Vilar and L. E. Underwood, eds. Endocr Rev. 2:115-124.
25. Poretsky L, Piper B. 1994 Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis of the pathogenesis of polycystic ovary syndrome. Obstet Gynecol. 84:613-621.
26. Suikkari AM, Koivisto VA, Rutanen EM, Yki-Jarvinen H, Karonen S, Seppala M. 1988 Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein. J Clin Endocrinol Metab. 66:266-272.
27. Suikkari A, Ruutiainen K, Erkkola R, Seppala M. 1989 Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease. Hum Reprod. 4:136-139.
28. Mason H, Margara R, Winston R, Seppala M, Koistinen R, Franks S. 1993 Insulin-like growth factor-I (IGF-I) inhibits production of IGF-binding protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries. J Clin Endocrinol Metab. 76:1275-1279.
29. Mason H, Willis D, Seppala M, Franks S. 1993 Insulin inhibits insulin-like growth factor binding protein-1 (IGFBP-1) production by granulosa, theca, and stroma from human ovaries. 12th Joint Meeting of the British Endocrine Societies; March 29-April, Liverpool. J Endocrinol. 137:P-179.
30. Dor J, Costritsci N, Pariente C, et al. 1992 Insulin-like growth factor-I and follicle-stimulating hormone suppress insulin-like growth factor binding protein-1 secretion by human granulosa-luteal cells. J Clin Endocrin Metab. 75: 969-971.
31. Cahill GF. 1985 Current concepts in diabetes. In: Marble A, Krall LP, Bradley RF, Christlieb AR, Soeldner JS, eds. Joslin's diabetes mellitus, 12th edition. Philadelphia: Lea and Febiser; 1-11.
32. Flier JS, Kahn CR, Roth J. 1979 Receptors, antireceptor antibodies, and mechanism of insulin resistance. N Engl J Med. 300:413-419.
33. Diamond MP, Webster BW, Carr RK, Wentt AC, Osteen KG. 1985 Human follicular fluid insulin concentrations. J Clin Endocrinol Metab. 61:990-993.
34. Underwood LE, Van Wyk JJ. 1992 Normal and aberrant growth. Wilson JD and Foster DW, eds. In: Williams textbook of endocrinology, 8th edition. Philadelphia: WB Saunders; 1079-1138.
35. Lee PD, Suwanichkul A, DePaolis LA, Snuggs MB, Morris SL, Powell DR. 1993 Insulin-like growth factor (IGF) suppression of IGFBP-1 production: evidence for mediation by the type I IGF receptor. Regul Pept. 48:199-206.
36. Lieberman SA, Bukar J, Chen S, et al. 1992 Effects of recombinant human insulin-like growth factor-I (rhIGF-I) on total and free IGF-I concentrations, IGF-binding proteins, and glycemic response in humans. J Clin Endocrinol Metab. 75:30-36.
37. Young SC, Clemmons DR. 1994 Changes in insulin-like growth factor (IGF)-binding proteins after IGF-I injections in noninsulin-dependent diabetics. J Clin Endocrinol Metab. 78:609-614.
38. Mason HD, Willis DS, Holly J, Franks S. 1994 Insulin preincubation enhances insulin-like growth factor-II (IGF-II) action on steroidogenesis in human granulosa cells. J Clin Endocrinol Metab. 78:1265-1267.
39. Poretsky L, Glover B, Laumas V, Kalin M, Dunaif A. 1988 The effects of experimental hyperinsulinemia on steroid secretion, ovarian 125-I-insulin, and 125I-IGF-1 binding in the rat. Endocrinology. 122:581-585.
40. Poretsky L. 1989 Specificity-spillover phenomenon in the human ovary. N Engl J Med. (Letter) 321:474.