Elevated ghrelin plasma levels in patients with polycystic ovary syndrome

Hormone and Metabolic Research

Volumn 36, Issue 3, 2004, Pages 170-173

  Wasko R ^a   Komarowska, H ^a   Warenik Szymankiewicz, A ^a   Sowinski J ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Androgens; Growth hormone; Insulin; Insulin like growth factor I axis; Obesity; Women

Indexed keywords

FOLLITROPIN; GHRELIN; HORMONE; INSULIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; INSULIN BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; BODY MASS INDEX; FEMALE; HUMANS; HYPERINSULINISM; INSULIN; OSMOLAR CONCENTRATION; PEPTIDE HORMONES; POLYCYSTIC OVARY SYNDROME; SEX HORMONE-BINDING GLOBULIN;

FALLOPIA;

EID: 1942472981     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-814341     Document Type: Article

References (34)

1. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots L, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: prospective study. J Clin Endocrinol Metab 1998; 83: 3078-3082
2. Franks S. Polycystic ovary syndrome. N Engl J Med 1995; 333: 853-861
3. Gambineri A, Pagotto U, Pelusi C, Vicennati V, Pasquali R. Obesity and the polycystic ovary syndrome. Int J Obes 2002; 26: 883-896
4. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997; 18: 774-800
5. Dunaif A. Insulin action in the polycystic ovary syndrome. J Clin Endocrinol Metab 1999; 28: 340-359
6. Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF, Spielman RS, Dunaif A. Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is follistatin. Proc Natl Acad Sci 1999; 96: 8573-8578
7. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660
8. Dornonville de la Cour C, Bjorkqvist M, Sandvik AK et al. A-like cells in rat stomach contain ghrelin and do not operate under gastrin control. Regul Pept 2001; 99: 141-150
9. Date Y, Kojima M, Hosoda H et al. Ghrelin, a novel growth hormone acyclated peptide, is synthesized in the gastrointestinal tract of rats and humans. Endocrinol 2000; 141: 4255-4261
10. Kagotani Y, Sakata I, Yamazaki M, Nakamura K, Hayashi Y, Kangawa K. Localization of ghrelin-immunopositive cells in the rat hypothalamus and intestinal tract. Proceedings of the 83rd Annual Meeting of the Endocrine Society, Denver, CO. 2001: 337
11. Karbonits M, Kojima M, Kangawa K, Grossman AB. Presence of ghrelin in normal and adenomatous human pituitary. Endocrine 2001; 14: 101-104
12. Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002; 107: 63-69
13. Tena-Sempere M, Barreiro ML, Gonzales LC, Gaytan F, Zhang FP, Caminos JE, Pinilla L, Casanueva FF, Dieguez C, Aguilar E. Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002; 143: 717-725
14. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198
15. Arvat E, Di Vito L, Broglio F et al. Preeliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 2000; 23: 493-495
16. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407: 908-913
17. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance - A hypothalamic perspective. Endocrinology 2001; 142: 4163-4169
18. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50: 2540-2547
19. Ott V, Fasshauer M, Dalski A, Meier B, Perwitz N, Klein HH, Tschöp M, Klein J. Direct peripherial effects of ghrelin include suppression of adiponectin expression. Horm Metab Res 2002; 34: 640-645
20. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Ghrelin strongly stimulates growth hormone (GH) release in humans. J Clin Endocr Metab 2000; 85: 4908-4911
21. Stefan N, Stumvoll M. Adiponectin - its role in metabolism and beyond. Horm Metab Res 2002; 34: 469-474
22. Möhling M, Wegewitz U, Osterhoff M, Isken F, Ristow M, Pfeiffer AFH, Spranger J. Insulin decreases human adiponectin plasma levels. Horm Metab Res 2002; 34: 655-658
23. Barreiro ML, Pinilla L, Aguilar E, Tena-Sampere M. Expression and homologous regulation of GH secretagogue receptor m RNA in rat adrenal gland. Eur J Endocrinol 2002; 147: 677-688
24. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-709
25. Ariayasu H, Takaya K, Tagami T et al. Plasma ghrelin levels are influenced by acute and chronic feeding states in humans. Proceedings of the 83rd Annual Meeting of the Endocrine Society, Denver, CO. 2001: 336
26. Orio FJr, Lucidi P, Palomba S, Tauchmanova L, Cascella T, Russo T, Zullo F, Colao A, Lombardi G, De Feo P. Circulating ghrelin concentrations in polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88: 942-945
27. Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002; 87: 5625-5629
28. Schöfl C, Rüdiger H, Schill T, Schlösser HW, Müller MJ, Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87: 4607-4610
29. Piaditis GP, Kounadi TG, Rangou DB, Trovas GP, Kaklas NA, Tzonou AJ, Chlouverakis CS. Dysfunction of the growth hormone/insulin-like factor I axis in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 1995; 42: 635-640
30. Słowińska-Strzednicka J, Zgliczyński W, Makowska A, Jeske W, Brzezińska A, Soszyński P, Zgliczyński S. An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome due to coexistent obesity. J Clin Endocrinol Metab 1992; 74: 1432-1435
31. Lanzone A, Villa P, Fulghesu AM, Pavone V, Caruso A, Mancuso S. The growth hormone response to growth hormone - releasing hormone is blunted in polycystic ovary syndrome: relationship with obesity and hyperinsulinaemia. Hum Reprod 1995; 10: 1653-1657
32. Lee H, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution ontogeny influence of endocrine and dietary manipulations Endocrinology 2002; 143: 185-190
33. Date Y, Nakazato M, Hashiguchi S, Dezaki K, MondalMS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S. Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes 2002; 51: 124-129
34. Egido EM, Rodriguez-Gallardo J, Gutierrez E, Garcia P, Silverstre RA, Marco J. Inhibitory effect of ghrelin on insulin secretion in the rat pancreas. Diabetologia 2001; 44 (Supl. 1): A 135 (Abstract)