Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1661-1667

  Sih, Rahmawati ^a,b   Morley, John E ^a,b   Kaiser, Fran E ^a   Perry III, Horace M ^a,b   Patrick, Ping ^a   Ross, Candie ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; LEPTIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN; TESTOSTERONE;

AGED; ARTICLE; BLOOD; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HAND GRIP; HUMAN; HYPOGONADISM; IMMUNOLOGY; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TIME;

AGED; COGNITION; HAND STRENGTH; HEMOGLOBINS; HUMANS; HYPOGONADISM; LEPTIN; MALE; MIDDLE AGED; PROSTATE-SPECIFIC ANTIGEN; PROTEINS; TESTOSTERONE; TIME FACTORS;

EID: 0031157124     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.6.3988     Document Type: Article

References (49)

1. Morley JE. 1991 Endocrine factors in geriatric sexuality. Clin Geriatr Med. 7:85-94.
2. Nankin HR, Calkin JM. 1986 Decreased bioavailable testosterone in aging, normal and impotent men. J Clin Endocrinol Metab. 63:1418-1420.
3. Bremner WJ, Vitcello MV, Prinz PN. 1983 Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab. 56:1278-1281.
4. Vermeulen A, Reubens R, Verdonck L. 1972 Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab. 34:730-735.
5. Gray A, Berlin JA, McKinley JB, Longcope C. 1991 An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol. 44:671-684.
6. Korenman SG, Morley JE, Mooradian AD, et al. 1990 Secondary hvpogonadism in older men: its relationship to impotence. J Clin Endocrinol Metab. 71:963-969.
7. Mooradian AD, Morley JE, Korenman SG. 1987 Biological actions of androgens. Endocr Rev. 8:1-28.
8. Shimokata H, Tobin JD, Muler DC, Elahi D, Coon PJ, Andres R. 1989 Studies in the distribution of body fat. J. Effects of age, sex and obesity. J Gerontol Med Sci. 44:M66-M73.
9. Griggs RC, Pandya S, Florence JM, et al. 1989 Randomized controlled trial of testosterone in myotonic dystrophy. Neurology 39:219-222.
10. Griggs RC, Kingston W, Jozefowicz FR, Herr BE, Forbes G, Halliday D. 1989 Effects of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol 66:498-503.
11. Bhasin S, Storer TW, Berman N, Callegari C, et al. 1996 The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335:1-7.
12. Tenover JS. 1992 Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab. 75:1092-1098.
13. Morley JE, Perry, III, HM, Kaiser FE, et al. 1993 Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc. 41:149-152.
14. Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ. 1988 Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol. 64:1038-1044.
15. 2 max. J Appl Physiol. 65:1147-1151.
16. Shephard RJ. 1990 The scientific basis of exercise prescribing for the very old. J Am Geriatr Soc. 38:62-70.
17. Spreen O, Strauss E. 1991 A compendium of Neuropsychological Tests. Administration, Norms and Commentary. New York, Oxford University Press.
18. Borkowski TG, Benton Al, Spreen O. 1967 Word fluency and brain damage. Neuropsychologia. 5:135-140.
19. Yesavage JA, Brink TL, Rose TL, et al. 1983 Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 17:37-49.
20. Kaiser FE, Viosca SP, Morley JE, et al. 1988 Impotence and aging: clinical and hormonal factors. J Am Geriatr Soc. 36:511-519.
21. Negoro H, Morley JE, Rosenthal MJ. 1988 Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects. Am J Med. 85:360-364.
22. Carlson KE, Alston W, Feldman DJ. 1964 Electromyographic study of aging in skeletal muscle. Am J Phys Med. 43:141-145.
23. Kochakian CD, Tillotson C, Austin J, Dougherty E, Haage V, Coalson R. 1956 The effects of castration on the weight and composition of the muscles of the guinea pig. Endocrinology. 58:315-326.
24. Kochakian CD, Tillotson C. 1957 Influence of several c19 steroids on the growth of individual muscles of the guinea pig. Endocrinology. 60:607-618.
25. Ensrud KE, Nevitt MC, Yunis C, et al. 1994 Correlates of impaired function in older women. J Am Geriatr Soc. 42:481-489.
26. Sunderland A, Tinson D, Bradley L, Hewer RL. 1989 Arm function after stroke. An evaluation of grip strength as a measure of recovery and a prognostic indicator. J Neurol Neurosurg Psychiatry. 52:1267-1272.
27. Nikolaus T, Bach M, Specht-Leible N, Oster P, Schlierf G. 1995 The timed test of money counting: a short physical performance test for manual dexterity and cognitivie capacity. Age Ageing. 24:257-258.
28. Hughes SL, Gibbs J, Dunlop D, Singer R. 1995 Predictors of hand function in older persons: a two year longitudinal analysis. J Am Geriatr Soc. 43:122-129.
29. Spiegel JS, Paulus HE, Ward NB, Spiegel TM, Leake B, Kane RL. 1987 What are we measuring? An examination of walk time and grip strength. J Rheumatol. 14:80-86.
30. Laukkanen P, Era P, Heikkinen RL, Suutama T, Kauppinen M, Heikkinen E. 1994 Factors related to carrying out everyday activities among elderly people aged 80. Aging. 6:433-443.
31. Minor MA, Hewett JE. 1995 Physical fitness and work capacity in women with rheumatoid arthritis. Arthritis Care Res. 8:146-154.
32. Weber JP, Walsh PC, Peters CA, Spivak JL. 1991 Effects of reversible androgen deprivation on hemoglobin and serum immunoreactive erythropoietin in men. Am J Hematol. 36:190-194.
33. Hajjar R, Kaiser FE, Morley JE, Patrick P. 1995 Outcomes of long term testosterone treatment in older males. J Am Geriatr Soc. 43[Suppl]:SA23.
34. Janne CO, Bardin W, Jacob ST. 1975 DNA-dependent RNA polymerase I, and II from kidney. Effect of polyamines on the in vitro transcription of DNA and chromatin. Biochemistry. 14:3589-3597.
35. Wade GN, Gray JM. 1979 Theoretical review. Gonadal effects on food intake and adiposity: metabolic hypothesis. Physiol Behav. 22:583-593.
36. Nunez AA. 1982 Brief report. Dose dependent effects of testosterone on feeding and body weight in male rats. Behav Neural Biol. 34:445-449.
37. Kochakian CH, Webster JA. 1958 Effect of testosterone propionate on the appetite, body weight and composition of the normal rat. Endocrinology. 63:737-742.
38. Leshner AI, Collier G. 1973 The effects of gonadectomy on the sex differences in dietary self selection patterns and carcass compositions of rats. Physiol Behav. 11:671-676.
39. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
40. Reid IR, Wattie DJ, Evans MC, Stapleton JP. 1996 Testosterone therapy in glucocorticoid treated men. Arch Intern Med. 156:1173-1177.
41. Halaas JL, Gajiwala KS, Maffei M, et al. 1995 Weight reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
42. Considine RV, Sinha MK, Heiman ML, et al. 1996 Studies of circulating leptin by radioimmunoassay in humans with and without obesity. N Engl J Med. 334:292-295.
43. Christiansen K, Knussmann R. 1987 Sex hormones and cognitive functioning in men. Neuropsychobiology. 18:27-36.
44. Flood JF, Morley JE, Roberts E. 1992 Memory enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA. 89:1567-1571.
45. Flood JF, Farr SA, Kaiser FE, LaRegina M, Morley JE. 1995 Age related decrease of plasma testosterone in SAM-P8 mice: replacement improves age related impairment of learning and memory. Physiol Behav. 57:669-673.
46. Janowsky JS, Oviatt SK, Orwoll ES. 1994 Testosterone influences spatial cognition in older men. Behav Neurosci. 108:625-632.
47. Finkelstein JS, Klibanski A, Neer RM, et al. 1989 Increases in bone density during treatment of men with idioipathic hypogonadotropic hypogonadism J Clin Endocrinol Metab. 69:776-783.
48. Somjen D, Kaye AM, Harell A, Weisman Y. 1989 Modulation by vitamin D status of the responsiveness of rat bone to gonadal steroids. Endocrinology. 125:1870-1876.
49. Francis RM, Peacock M, Aaron JE, et al. 1986 Osteoporosis in hypogonadal men: role of decreased plasma 1,25 dihydroxyvitamin D, calcium malabsorption and low bone formation. Bone. 7:261-268.