메뉴 건너뛰기




Volumn 335, Issue 9, 1996, Pages 617-623

Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GLUCOSE; HYDROXYPROGESTERONE CAPROATE; INSULIN; LEUPRORELIN; METFORMIN; PROGESTERONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE;

EID: 0029796476     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199608293350902     Document Type: Article
Times cited : (711)

References (38)
  • 1
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Erratum, N Engl J Med 1995;333:1435
    • Franks S. Polycystic ovary syndrome. N Engl J Med 1995;333:853-61. [Erratum, N Engl J Med 1995;333:1435.]
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 3
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989;38:1165-74.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 4
    • 0025359669 scopus 로고
    • Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Green G, Futterweit W, Dobrjansky A. Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1990;70:699-704.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 699-704
    • Dunaif, A.1    Green, G.2    Futterweit, W.3    Dobrjansky, A.4
  • 5
    • 0026620885 scopus 로고
    • Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome?
    • Carmina E, Koyama T, Chang L, Stanczyk FZ, Lobo RA. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 1992;167:1807-12.
    • (1992) Am J Obstet Gynecol , vol.167 , pp. 1807-1812
    • Carmina, E.1    Koyama, T.2    Chang, L.3    Stanczyk, F.Z.4    Lobo, R.A.5
  • 7
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Xia J, Book CB, Schenker E, Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: a potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 1995;96:801-10.
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3    Schenker, E.4    Tang, Z.5
  • 8
    • 0029092780 scopus 로고
    • Insulin secretory defects in polycystic ovary syndrome: Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus
    • Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS. Insulin secretory defects in polycystic ovary syndrome: relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 1995;96:520-7.
    • (1995) J Clin Invest , vol.96 , pp. 520-527
    • Ehrmann, D.A.1    Sturis, J.2    Byrne, M.M.3    Karrison, T.4    Rosenfield, R.L.5    Polonsky, K.S.6
  • 9
    • 0028889654 scopus 로고
    • Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism
    • Apter D, Butzow T, Laughlin GA, Yen SS. Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J Clin Endocrinol Metab 1995;80:2966-73.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2966-2973
    • Apter, D.1    Butzow, T.2    Laughlin, G.A.3    Yen, S.S.4
  • 10
    • 0001223353 scopus 로고
    • Role of obesity and insulin in the development of anovulation
    • Filicori M, Flamigni C, eds. Amsterdam: Elsevier Science B.V.
    • Nestler JE. Role of obesity and insulin in the development of anovulation. In: Filicori M, Flamigni C, eds. Ovulation induction: basic science and clinical advances. Amsterdam: Elsevier Science B.V., 1994:103-14.
    • (1994) Ovulation Induction: Basic Science and Clinical Advances , pp. 103-114
    • Nestler, J.E.1
  • 11
    • 0022647650 scopus 로고
    • Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
    • Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986;62:904-10.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 904-910
    • Barbieri, R.L.1    Makris, A.2    Randall, R.W.3    Daniels, G.4    Kistner, R.W.5    Ryan, K.J.6
  • 12
    • 0023772227 scopus 로고
    • Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells
    • Cara JF, Rosenfield RL. Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells. Endocrinology 1988;123:733-9.
    • (1988) Endocrinology , vol.123 , pp. 733-739
    • Cara, J.F.1    Rosenfield, R.L.2
  • 13
    • 0027411120 scopus 로고
    • Regulation of androgen production in cultured human thecal cells by insulin-like growth factor-I and insulin
    • Bergh C, Carlsson B, Olsson JH, Selleskog U, Hillensjo T. Regulation of androgen production in cultured human thecal cells by insulin-like growth factor-I and insulin. Fertil Steril 1993;59:323-31.
    • (1993) Fertil Steril , vol.59 , pp. 323-331
    • Bergh, C.1    Carlsson, B.2    Olsson, J.H.3    Selleskog, U.4    Hillensjo, T.5
  • 14
    • 0028921511 scopus 로고
    • Metabolic regulation of androgen production by human thecal cells in vitro
    • Nahum R, Thong KJ, Hillier SG. Metabolic regulation of androgen production by human thecal cells in vitro. Hum Reprod 1995;10:75-81.
    • (1995) Hum Reprod , vol.10 , pp. 75-81
    • Nahum, R.1    Thong, K.J.2    Hillier, S.G.3
  • 15
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome
    • Nestler JE, Barlascini CO, Matt DW, et al. Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 1989;68:1027-32.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 1027-1032
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 16
    • 0023809454 scopus 로고
    • Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin
    • Plymate SR, Matej LA, Jones RE, Friedl KE. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 1988;67:460-4.
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 460-464
    • Plymate, S.R.1    Matej, L.A.2    Jones, R.E.3    Friedl, K.E.4
  • 17
    • 0026028184 scopus 로고
    • A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome
    • Nestler JE, Powers LP, Matt DW, et al. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab 1991;72:83-9.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 83-89
    • Nestler, J.E.1    Powers, L.P.2    Matt, D.W.3
  • 18
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994;43:647-54.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 19
    • 0024828508 scopus 로고
    • Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: Correlation with serum insulin and insulin-like growth factor-I
    • Oxf
    • Kiddy DS, Hamilton-Fairley D, Seppälä M, et al. Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I. Endocrinol (Oxf) 1989;31:757-63.
    • (1989) Endocrinol , vol.31 , pp. 757-763
    • Kiddy, D.S.1    Hamilton-Fairley, D.2    Seppälä, M.3
  • 20
    • 0026543775 scopus 로고
    • Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
    • Oxf
    • Kiddy DS, Hamilton-Fairley D, Bush A, et al. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 1992;36:105-11.
    • (1992) Clin Endocrinol , vol.36 , pp. 105-111
    • Kiddy, D.S.1    Hamilton-Fairley, D.2    Bush, A.3
  • 22
    • 0028588696 scopus 로고
    • Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism
    • Rosenfield RL, Barnes RB, Ehrmann DA. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1994;79:1686-92.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1686-1692
    • Rosenfield, R.L.1    Barnes, R.B.2    Ehrmann, D.A.3
  • 23
    • 0028819105 scopus 로고
    • Variations of steroid hormone metabolites in serum and urine in polycystic ovary syndrome after nafarelin stimulation: Evidence for an altered corticoid excretion
    • Luppa P, Muller B, Jacob K, et al. Variations of steroid hormone metabolites in serum and urine in polycystic ovary syndrome after nafarelin stimulation: evidence for an altered corticoid excretion. J Clin Endocrinol Metab 1995;80:280-8.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 280-288
    • Luppa, P.1    Muller, B.2    Jacob, K.3
  • 24
    • 0028938872 scopus 로고
    • Gonadotrophin and gonadal steroid response to a single dose of a long-acting agonist of gonadotrophin-releasing hormone in ovulatory and anovulatory women with polycystic ovary syndrome
    • Oxf
    • White D, Leigh A, Wilson C, Donaldson A, Franks S. Gonadotrophin and gonadal steroid response to a single dose of a long-acting agonist of gonadotrophin-releasing hormone in ovulatory and anovulatory women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 1995;42:475-81.
    • (1995) Clin Endocrinol , vol.42 , pp. 475-481
    • White, D.1    Leigh, A.2    Wilson, C.3    Donaldson, A.4    Franks, S.5
  • 25
    • 0028556840 scopus 로고
    • Source localization of androgen excess in adolescent girls
    • Ibañez L, Potau N, Zampolli M, et al. Source localization of androgen excess in adolescent girls. J Clin Endocrinol Metab 1994;79:1778-84.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1778-1784
    • Ibañez, L.1    Potau, N.2    Zampolli, M.3
  • 26
    • 0027399661 scopus 로고
    • Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects: A study of two ethnic groups
    • Nagi DK, Yudkin JS. Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects: a study of two ethnic groups. Diabetes Care 1993;16: 621-9.
    • (1993) Diabetes Care , vol.16 , pp. 621-629
    • Nagi, D.K.1    Yudkin, J.S.2
  • 27
    • 0025837055 scopus 로고
    • Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects
    • DeFronzo RA, Barzilai N, Simonson DC. Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab 1991;73:1294-301.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1294-1301
    • DeFronzo, R.A.1    Barzilai, N.2    Simonson, D.C.3
  • 28
    • 0023094932 scopus 로고
    • Polycystic ovarian disease: US features in 104 patients
    • Yeh HC, Futterweit W, Thornton JC. Polycystic ovarian disease: US features in 104 patients. Radiology 1987;163:111-6.
    • (1987) Radiology , vol.163 , pp. 111-116
    • Yeh, H.C.1    Futterweit, W.2    Thornton, J.C.3
  • 29
    • 0028328225 scopus 로고
    • Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men
    • Nestler JE, Beer NA, Jakubowicz DJ, Beer RM. Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men. J Clin Endocrinol Metab 1994;78:549-54.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 549-554
    • Nestler, J.E.1    Beer, N.A.2    Jakubowicz, D.J.3    Beer, R.M.4
  • 30
    • 0029927833 scopus 로고    scopus 로고
    • Insulin infusion amplifies 17α-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: Apparent relative impairment of 17,20-lyase activity
    • Moghetti P, Castello R, Negri C, et al. Insulin infusion amplifies 17α-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity. J Clin Endocrinol Metab 1996;81:881-6.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 881-886
    • Moghetti, P.1    Castello, R.2    Negri, C.3
  • 31
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • Unger JW, Livingston JN, Moss AM. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol 1991;36:343-62.
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 32
    • 0019443286 scopus 로고
    • Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells
    • Adashi EY, Hsueh AJW, Yen SSC. Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells. Endocrinology 1981;108:1441-9.
    • (1981) Endocrinology , vol.108 , pp. 1441-1449
    • Adashi, E.Y.1    Hsueh, A.J.W.2    Yen, S.S.C.3
  • 33
    • 0027372636 scopus 로고
    • Increased luteinizing hormone and α-subunit secretion in women with hyperandrogenic anovulation
    • Berga SL, Guzick DS, Winters SJ. Increased luteinizing hormone and α-subunit secretion in women with hyperandrogenic anovulation. J Clin Endocrinol Metab 1993;77:895-901.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 895-901
    • Berga, S.L.1    Guzick, D.S.2    Winters, S.J.3
  • 34
    • 0027169091 scopus 로고
    • Interface between extra- and intraovarian factors in polycystic ovarian syndrome
    • Yen SS, Laughlin GA, Morales AJ. Interface between extra- and intraovarian factors in polycystic ovarian syndrome. Ann N Y Acad Sci 1993;687: 98-111.
    • (1993) Ann N Y Acad Sci , vol.687 , pp. 98-111
    • Yen, S.S.1    Laughlin, G.A.2    Morales, A.J.3
  • 35
    • 0024403763 scopus 로고
    • The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects
    • Spinder T, Spijkstra JJ, van den Tweel JG, et al. The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects. J Clin Endocrinol Metab 1989;69:151-7.
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 151-157
    • Spinder, T.1    Spijkstra, J.J.2    Van Den Tweel, J.G.3
  • 36
    • 0022596436 scopus 로고
    • Do androgens directly regulate-gonadotropin secretion in the polycystic ovary syndrome?
    • Dunaif A. Do androgens directly regulate-gonadotropin secretion in the polycystic ovary syndrome? J Clin Endocrinol Metab 1986;63:215-21.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 215-221
    • Dunaif, A.1
  • 37
    • 0023574450 scopus 로고
    • Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease
    • Blankstein J, Rabinovici J, Goldenberg M, et al. Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. J Clin Endocrinol Metab 1987;65:1164-7.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1164-1167
    • Blankstein, J.1    Rabinovici, J.2    Goldenberg, M.3
  • 38
    • 0029024775 scopus 로고
    • Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women
    • Crave JC, Fimbel S, Lejeune H, Cugnardey N, Déchaud H, Pugeat M. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab 1995;80:2057-62.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2057-2062
    • Crave, J.C.1    Fimbel, S.2    Lejeune, H.3    Cugnardey, N.4    Déchaud, H.5    Pugeat, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.