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Volumn 46, Issue 2, 2012, Pages 513-521

The "janus-faced role" of autophagy in neuronal sickness: Focus on neurodegeneration

Author keywords

Acute brain damage; Autophagic flux; Autophagosomes; Celldeath; Neuronal recovery

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AUTOPHAGY PROTEIN 5; BECLIN 1; HUNTINGTIN; PARKIN; TARGET OF RAPAMYCIN KINASE;

EID: 84868145847     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8296-3     Document Type: Article
Times cited : (26)

References (76)
  • 1
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z, Klionsky DJ (2007) Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9:1102-1109 (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 2
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • Johansen T, Lamark T (2011) Selective autophagy mediated by autophagic adapter proteins. Autophagy 7:279-296
    • (2011) Autophagy , vol.7 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 3
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075 (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 4
    • 78650716872 scopus 로고    scopus 로고
    • Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
    • Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A et al (2011) Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 134:258-277
    • (2011) Brain , vol.134 , pp. 258-277
    • Yang, D.S.1    Stavrides, P.2    Mohan, P.S.3    Kaushik, S.4    Kumar, A.5
  • 5
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67-93
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 6
    • 77956179625 scopus 로고    scopus 로고
    • Regulation of macroautophagy in Saccharomyces cerevisiae
    • Inoue Y, Klionsky DJ (2010) Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol 21:664-670
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 664-670
    • Inoue, Y.1    Klionsky, D.J.2
  • 7
    • 67649467294 scopus 로고    scopus 로고
    • Dynamics and diversity in autophagy mechanisms: Lessons from yeast
    • Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10:458-467
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 458-467
    • Nakatogawa, H.1    Suzuki, K.2    Kamada, Y.3    Ohsumi, Y.4
  • 8
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • Chang YY, Neufeld TP (2009) An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 20:2004-2014
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 9
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 22:132-139
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 10
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22:124-131
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 14
    • 77957728513 scopus 로고    scopus 로고
    • The dynamic interaction of Ambra1 with the dynein motor complex regulates mammalian autophagy
    • Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G et al (2010) The dynamic interaction of Ambra1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol 191:155-168
    • (2010) J Cell Biol , vol.191 , pp. 155-168
    • Di Bartolomeo, S.1    Corazzari, M.2    Nazio, F.3    Oliverio, S.4    Lisi, G.5
  • 15
    • 79960774898 scopus 로고    scopus 로고
    • Autophagosome precursor maturation requires homotypic fusion
    • Moreau K, Ravikumar B, Renna M, Puri C, Rubinsztein DC (2011) Autophagosome precursor maturation requires homotypic fusion. Cell 146:303-317
    • (2011) Cell , vol.146 , pp. 303-317
    • Moreau, K.1    Ravikumar, B.2    Renna, M.3    Puri, C.4    Rubinsztein, D.C.5
  • 16
    • 0032545292 scopus 로고    scopus 로고
    • A new protein conjugation system in human: The counterpart of the yeast Apg12p conjugation system essential for autophagy
    • DOI 10.1074/jbc.273.51.33889
    • Mizushima N, Sugita H, Yoshimori T, Ohsumi Y (1998) A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 273:33889-33892 (Pubitemid 29008848)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 33889-33892
    • Mizushima, N.1    Sugita, H.2    Yoshimori, T.3    Ohsumi, Y.4
  • 18
    • 34250864795 scopus 로고    scopus 로고
    • Protein turnover via autophagy: Implications for metabolism
    • DOI 10.1146/annurev.nutr.27.061406.093749
    • Mizushima N, Klionsky DJ (2007) Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr 27:19-40 (Pubitemid 351373346)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 19-40
    • Mizushima, N.1    Klionsky, D.J.2
  • 20
    • 77949448601 scopus 로고    scopus 로고
    • Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes
    • Furuta N, Fujita N, Noda T, Yoshimori T, Amano A (2010) Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell 21:1001-1010
    • (2010) Mol Biol Cell , vol.21 , pp. 1001-1010
    • Furuta, N.1    Fujita, N.2    Noda, T.3    Yoshimori, T.4    Amano, A.5
  • 25
    • 78149488153 scopus 로고    scopus 로고
    • Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
    • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH (2010) Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30:14946-14954
    • (2010) J Neurosci , vol.30 , pp. 14946-14954
    • Pimplikar, S.W.1    Nixon, R.A.2    Robakis, N.K.3    Shen, J.4    Tsai, L.H.5
  • 26
    • 79955969705 scopus 로고    scopus 로고
    • Autophagy failure in Alzheimer's disease-locating the primary defect
    • Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol Dis 43:38-45
    • (2011) Neurobiol Dis , vol.43 , pp. 38-45
    • Nixon, R.A.1    Yang, D.S.2
  • 30
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar B, Duden R, Rubinsztein DC (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 11:1107-1117 (Pubitemid 34521091)
    • (2002) Human Molecular Genetics , vol.11 , Issue.9 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 32
    • 0031593675 scopus 로고    scopus 로고
    • 1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
    • Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 23:33-42 (Pubitemid 28223394)
    • (1998) Cell Structure and Function , vol.23 , Issue.1 , pp. 33-42
    • Yamamoto, A.1    Tagawa, Y.2    Yoshimori, T.3    Moriyama, Y.4    Masaki, R.5    Tashiro, Y.6
  • 33
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • DOI 10.1074/jbc.M609532200
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC (2007) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alphasynuclein. J Biol Chem 282:5641-5652 (Pubitemid 47093730)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 35
    • 77749319356 scopus 로고    scopus 로고
    • Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
    • Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M et al (2010) Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat Biotechnol 28:256-263
    • (2010) Nat Biotechnol , vol.28 , pp. 256-263
    • Bauer, P.O.1    Goswami, A.2    Wong, H.K.3    Okuno, M.4    Kurosawa, M.5
  • 36
    • 68949197599 scopus 로고    scopus 로고
    • Parkinson's disease: From molecular pathways in disease to therapeutic approaches
    • Thomas B (2009) Parkinson's disease: from molecular pathways in disease to therapeutic approaches. Antioxid Redox Signal 11:2077-2082
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2077-2082
    • Thomas, B.1
  • 37
    • 63149090431 scopus 로고    scopus 로고
    • Parkinson's disease: Frommonogenic forms to genetic susceptibility factors
    • Lesage S, BriceA (2009) Parkinson's disease: frommonogenic forms to genetic susceptibility factors. Hum Mol Genet 18:R48-R59
    • (2009) Hum Mol Genet , vol.18
    • Lesage, S.1    Brice, A.2
  • 39
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183:795-803
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 40
    • 75749156257 scopus 로고    scopus 로고
    • PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
    • Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA et al (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8:e1000298
    • (2010) PLoS Biol , vol.8
    • Narendra, D.P.1    Jin, S.M.2    Tanaka, A.3    Suen, D.F.4    Gautier, C.A.5
  • 42
    • 77951181836 scopus 로고    scopus 로고
    • PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
    • Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K et al (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189:211-221
    • (2010) J Cell Biol , vol.189 , pp. 211-221
    • Matsuda, N.1    Sato, S.2    Shiba, K.3    Okatsu, K.4    Saisho, K.5
  • 45
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • DOI 10.1126/science.1101738
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305:1292-1295 (Pubitemid 39129234)
    • (2004) Science , vol.305 , Issue.5688 , pp. 1292-1295
    • Cuervo, A.M.1    Stafanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 47
    • 84861828977 scopus 로고    scopus 로고
    • Neuronal autophagy as a mediator of life and death: Contrasting roles in chronic neurodegenerative and acute neural disorders
    • Puyal J, Ginet V, Grishchuk Y, Truttmann AC, Clarke PG (2012) Neuronal autophagy as a mediator of life and death: contrasting roles in chronic neurodegenerative and acute neural disorders. Neuroscientist 18(3):224-236
    • (2012) Neuroscientist , vol.18 , Issue.3 , pp. 224-236
    • Puyal, J.1    Ginet, V.2    Grishchuk, Y.3    Truttmann, A.C.4    Clarke, P.G.5
  • 49
    • 82255182190 scopus 로고    scopus 로고
    • Neurobiological consequences of traumatic brain injury
    • McAllister TW (2011) Neurobiological consequences of traumatic brain injury. Dialogues Clin Neurosci 13:287-300
    • (2011) Dialogues Clin Neurosci , vol.13 , pp. 287-300
    • McAllister, T.W.1
  • 52
    • 48949116105 scopus 로고    scopus 로고
    • Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury
    • Sadasivan S, Dunn WA, Hayes RL, Wang KK (2008) Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury. Biochem Biophys Res Commun 373:478-481
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 478-481
    • Sadasivan, S.1    Dunn, W.A.2    Hayes, R.L.3    Wang, K.K.4
  • 53
    • 38049064882 scopus 로고    scopus 로고
    • Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness
    • Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM, Watkins SC (2008) Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4:88-90
    • (2008) Autophagy , vol.4 , pp. 88-90
    • Clark, R.S.1    Bayir, H.2    Chu, C.T.3    Alber, S.M.4    Kochanek, P.M.5    Watkins, S.C.6
  • 54
    • 33947219280 scopus 로고    scopus 로고
    • Rapamycin is a neuroprotective treatment for traumatic brain injury
    • DOI 10.1016/j.nbd.2006.12.003, PII S0969996106003123
    • Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R (2007) Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 26:86-93 (Pubitemid 46436489)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 86-93
    • Erlich, S.1    Alexandrovich, A.2    Shohami, E.3    Pinkas-Kramarski, R.4
  • 55
    • 79956011038 scopus 로고    scopus 로고
    • Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice
    • Luo CL, Li BX, Li QQ, Chen XP, Sun YX et al (2011) Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience 184:54-63
    • (2011) Neuroscience , vol.184 , pp. 54-63
    • Luo, C.L.1    Li, B.X.2    Li, Q.Q.3    Chen, X.P.4    Sun, Y.X.5
  • 57
    • 0029664572 scopus 로고    scopus 로고
    • Thalamic metabolism and corticospinal tract integrity determine motor recovery in stroke
    • DOI 10.1002/ana.410390408
    • Binkofski F, Seitz RJ, Arnold S, Classen J, Benecke R, Freund HJ (1996) Thalamic metabolism and corticospinal tract integrity determine motor recovery in stroke. Ann Neurol 39:460-470 (Pubitemid 26118001)
    • (1996) Annals of Neurology , vol.39 , Issue.4 , pp. 460-470
    • Binkofski, F.1    Seitz, R.J.2    Arnold, S.3    Classen, J.4    Benecke, R.5    Freund, H.-J.6
  • 58
    • 84857301687 scopus 로고    scopus 로고
    • Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage
    • Viscomi MT, D'Amelio M, Cavallucci V, Latini L, Bisicchia E et al (2012) Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage. Autophagy 8:222-235
    • (2012) Autophagy , vol.8 , pp. 222-235
    • Viscomi, M.T.1    D'Amelio, M.2    Cavallucci, V.3    Latini, L.4    Bisicchia, E.5
  • 59
    • 58149483522 scopus 로고    scopus 로고
    • Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death
    • Kanno H, Ozawa H, Sekiguchi A, Itoi E (2009) Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death. Neurobiol Dis 33:143-148
    • (2009) Neurobiol Dis , vol.33 , pp. 143-148
    • Kanno, H.1    Ozawa, H.2    Sekiguchi, A.3    Itoi, E.4
  • 60
    • 80053970026 scopus 로고    scopus 로고
    • Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice
    • Kanno H, Ozawa H, Sekiguchi A, Yamaya S, Itoi E (2011) Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice. Spine (Phila Pa 1976) 36:E1427-E1434
    • (2011) Spine (Phila Pa 1976) , vol.36
    • Kanno, H.1    Ozawa, H.2    Sekiguchi, A.3    Yamaya, S.4    Itoi, E.5
  • 61
    • 84858407568 scopus 로고    scopus 로고
    • Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
    • Sekiguchi A, Kanno H,Ozawa H, Yamaya S, Itoi E (2012) Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice. J Neurotrauma 29:946-956
    • (2012) J Neurotrauma , vol.29 , pp. 946-956
    • Sekiguchi, A.1    Kanno Hozawa, H.2    Yamaya, S.3    Itoi, E.4
  • 62
    • 33846226521 scopus 로고    scopus 로고
    • The roles of autophagy in cerebral ischemia
    • Adhami F, Schloemer A, Kuan CY (2007) The roles of autophagy in cerebral ischemia. Autophagy 3:42-44
    • (2007) Autophagy , vol.3 , pp. 42-44
    • Adhami, F.1    Schloemer, A.2    Kuan, C.Y.3
  • 63
    • 41049092706 scopus 로고    scopus 로고
    • Autophagic neuron death in neonatal brain ischemia/hypoxia
    • Uchiyama Y, Koike M, Shibata M (2008) Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4:404-408 (Pubitemid 351705135)
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 404-408
    • Uchiyama, Y.1    Koike, M.2    Shibata, M.3
  • 64
    • 80052502402 scopus 로고    scopus 로고
    • Death and survival of neuronal and astrocytic cells in ischemic brain injury: A role of autophagy
    • Xu M, Zhang HL (2011) Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin 32:1089-1099
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 1089-1099
    • Xu, M.1    Zhang, H.L.2
  • 66
    • 50249189191 scopus 로고    scopus 로고
    • Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    • Wen YD, Sheng R, Zhang LS, Han R, Zhang X et al (2008) Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4:762-769
    • (2008) Autophagy , vol.4 , pp. 762-769
    • Wen, Y.D.1    Sheng, R.2    Zhang, L.S.3    Han, R.4    Zhang, X.5
  • 67
    • 38949123720 scopus 로고    scopus 로고
    • Upregulation of Beclin 1 in the ischemic penumbra
    • Rami A (2008) Upregulation of Beclin 1 in the ischemic penumbra. Autophagy 4:227-229 (Pubitemid 351231186)
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 227-229
    • Rami, A.1
  • 68
    • 36549041882 scopus 로고    scopus 로고
    • Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    • DOI 10.1016/j.nbd.2007.08.005, PII S0969996107001921
    • Rami A, Langhagen A, Steiger S (2008) Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis 29:132-141 (Pubitemid 350186114)
    • (2008) Neurobiology of Disease , vol.29 , Issue.1 , pp. 132-141
    • Rami, A.1    Langhagen, A.2    Steiger, S.3
  • 69
    • 70349647603 scopus 로고    scopus 로고
    • Targeting autophagy to prevent neonatal stroke damage
    • Puyal J, Clarke PG (2009) Targeting autophagy to prevent neonatal stroke damage. Autophagy 5:1060-1061
    • (2009) Autophagy , vol.5 , pp. 1060-1061
    • Puyal, J.1    Clarke, P.G.2
  • 71
    • 33645100937 scopus 로고    scopus 로고
    • Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
    • Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y et al (2006) Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem 96:1016-1027
    • (2006) J Neurochem , vol.96 , pp. 1016-1027
    • Zhu, C.1    Xu, F.2    Wang, X.3    Shibata, M.4    Uchiyama, Y.5
  • 72
    • 73849114180 scopus 로고    scopus 로고
    • Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms
    • Ginet V, Puyal J, Clarke PG, Truttmann AC (2009) Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms. Am J Pathol 175:1962-1974
    • (2009) Am J Pathol , vol.175 , pp. 1962-1974
    • Ginet, V.1    Puyal, J.2    Clarke, P.G.3    Truttmann, A.C.4
  • 73
    • 56349126024 scopus 로고    scopus 로고
    • Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury
    • Carloni S, Buonocore G, Balduini W (2008) Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 32:329-339
    • (2008) Neurobiol Dis , vol.32 , pp. 329-339
    • Carloni, S.1    Buonocore, G.2    Balduini, W.3
  • 74
    • 77953727786 scopus 로고    scopus 로고
    • Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia
    • Carloni S, Girelli S, Scopa C, Buonocore G, Longini M, Balduini W (2010) Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia. Autophagy 6:366-377
    • (2010) Autophagy , vol.6 , pp. 366-377
    • Carloni, S.1    Girelli, S.2    Scopa, C.3    Buonocore, G.4    Longini, M.5    Balduini, W.6
  • 75
    • 84856457651 scopus 로고    scopus 로고
    • Inhibition of rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation
    • Carloni S, Buonocore G, Longini M, Proietti F, Balduini W (2012) Inhibition of rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation. Neuroscience 203:160-169
    • (2012) Neuroscience , vol.203 , pp. 160-169
    • Carloni, S.1    Buonocore, G.2    Longini, M.3    Proietti, F.4    Balduini, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.