Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice

Journal of Neurotrauma

Volumn 29, Issue 5, 2012, Pages 946-956

  Sekiguchi, Akira ^a   Kanno, Haruo ^a,b   Ozawa, Hiroshi ^a   Yamaya, Seiji ^a   Itoi, Eiji ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

autophagy; Beclin 1; LC3; mTOR; rapamycin; SCI

Indexed keywords

BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PROTEIN LC3; PROTEIN P70S6K; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL LOSS; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MOTOR DYSFUNCTION; MOUSE; NERVOUS TISSUE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TISSUE INJURY; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MOTOR ACTIVITY; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; SIROLIMUS; SPINAL CORD INJURIES;

EID: 84858407568     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1919     Document Type: Article

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