메뉴 건너뛰기




Volumn 7, Issue 10, 2012, Pages

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYTOCHROME P450; ICOSANOID; ICOSATRIENOIC ACID; LINOLEOYL COENZYME A DESATURASE; LIPOXYGENASE; MESSENGER RNA; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PROSTAGLANDIN D2; PROSTAGLANDIN E2; SAFFLOWER OIL;

EID: 84868118479     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047567     Document Type: Article
Times cited : (50)

References (48)
  • 1
    • 79952432817 scopus 로고    scopus 로고
    • Cancer drugs: remedy required
    • Editorial
    • Editorial (2011) Cancer drugs: remedy required. Nature 17: 231-232.
    • (2011) Nature , vol.17 , pp. 231-232
  • 2
    • 79952409338 scopus 로고    scopus 로고
    • Targeting the missing links for cancer therapy
    • Polyak K, Garber J, (2011) Targeting the missing links for cancer therapy. Nat Med 17: 283-284.
    • (2011) Nat Med , vol.17 , pp. 283-284
    • Polyak, K.1    Garber, J.2
  • 3
    • 79952366279 scopus 로고    scopus 로고
    • Metabolism unhinged: IDH mutations in cancer
    • Prensner JR, Chinnaiyan AM, (2011) Metabolism unhinged: IDH mutations in cancer. Nat Med 17: 291-293.
    • (2011) Nat Med , vol.17 , pp. 291-293
    • Prensner, J.R.1    Chinnaiyan, A.M.2
  • 4
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC, (2011) Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17: 320-329.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 5
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang D, DuBois RN, (2010) Eicosanoids and cancer. Nat Rev Cancer 10: 181-193.
    • (2010) Nat Rev Cancer , vol.10 , pp. 181-193
    • Wang, D.1    DuBois, R.N.2
  • 6
    • 23844478668 scopus 로고    scopus 로고
    • Rethinking lipid mediators in physiology and pathophysiology
    • Weylandt KH, Kang JX, (2005) Rethinking lipid mediators in physiology and pathophysiology. Lancet 366: 618-620.
    • (2005) Lancet , vol.366 , pp. 618-620
    • Weylandt, K.H.1    Kang, J.X.2
  • 7
    • 58149292278 scopus 로고    scopus 로고
    • Modulation of inflammatory cytokines by omega-3 Fatty acids
    • Kang JX, Weylandt KH, (2008) Modulation of inflammatory cytokines by omega-3 Fatty acids. Subcell Biochem 49: 133-143.
    • (2008) Subcell Biochem , vol.49 , pp. 133-143
    • Kang, J.X.1    Weylandt, K.H.2
  • 8
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarinomas
    • Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, et al. (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarinomas. Gastroenterology 107: 1183-1188.
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3    Giardiello, F.M.4    Ferrenbach, S.5
  • 9
    • 32544442362 scopus 로고    scopus 로고
    • COX inhibitors and breast cancer
    • Mazhar D, Ang R, Waxman J, (2006) COX inhibitors and breast cancer. Br J Cancer 94: 346-350.
    • (2006) Br J Cancer , vol.94 , pp. 346-350
    • Mazhar, D.1    Ang, R.2    Waxman, J.3
  • 10
    • 23844547173 scopus 로고    scopus 로고
    • 15(S)-Hydroxyeicosatetraenoic acid induces angiogenesisvia activation of PI3K-Akt-mTOR-S6K1 signaling
    • Zhang B, Cao H, Rao GN, (2005) 15(S)-Hydroxyeicosatetraenoic acid induces angiogenesisvia activation of PI3K-Akt-mTOR-S6K1 signaling. Cancer Res 65: 7283-7291.
    • (2005) Cancer Res , vol.65 , pp. 7283-7291
    • Zhang, B.1    Cao, H.2    Rao, G.N.3
  • 11
    • 34547092185 scopus 로고    scopus 로고
    • Cytochrome p450 epoxygenase promotes human cancer metastasis
    • Jiang JG, Ning YG, Chen C, Ma D, Liu ZJ, et al. (2007) Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Res 67: 6665-6674.
    • (2007) Cancer Res , vol.67 , pp. 6665-6674
    • Jiang, J.G.1    Ning, Y.G.2    Chen, C.3    Ma, D.4    Liu, Z.J.5
  • 12
    • 79953055619 scopus 로고    scopus 로고
    • Chemoprevention: First line of defence
    • Gravitz L, (2011) Chemoprevention: First line of defence. Nature 471: S5-S7.
    • (2011) Nature , vol.471
    • Gravitz, L.1
  • 13
    • 0023276149 scopus 로고
    • A new era for science in nutrition
    • Leaf A, Weber PC, (1987) A new era for science in nutrition. Am J Clin Nutr 45: 1048-1053.
    • (1987) Am J Clin Nutr , vol.45 , pp. 1048-1053
    • Leaf, A.1    Weber, P.C.2
  • 14
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos AP, (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med 233: 674-688.
    • (2008) Exp Biol Med , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 15
    • 18144454187 scopus 로고    scopus 로고
    • A simplified method for analysis of polyunsaturated fatty acids
    • Kang JX, Wang J, (2005) A simplified method for analysis of polyunsaturated fatty acids. BMC Biochem 6: 5.
    • (2005) BMC Biochem , vol.6 , pp. 5
    • Kang, J.X.1    Wang, J.2
  • 16
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us
    • Hlatky L, Hahnfeldt P, Folkman J, (2002) Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 94: 883-893.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 17
    • 0030057431 scopus 로고    scopus 로고
    • A quantitative assay using basement membrane extracts to study tumor angiogenesis in vivo
    • Ito Y, Iwamoto Y, Tanaka K, Okuyama K, Sugioka Y, (1996) A quantitative assay using basement membrane extracts to study tumor angiogenesis in vivo. Int J Cancer 67: 148-152.
    • (1996) Int J Cancer , vol.67 , pp. 148-152
    • Ito, Y.1    Iwamoto, Y.2    Tanaka, K.3    Okuyama, K.4    Sugioka, Y.5
  • 18
    • 0032929070 scopus 로고    scopus 로고
    • Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase
    • Cho HP, Nakamura MT, Clarke SD, (1999) Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem 274: 471-477.
    • (1999) J Biol Chem , vol.274 , pp. 471-477
    • Cho, H.P.1    Nakamura, M.T.2    Clarke, S.D.3
  • 19
  • 20
    • 0032819001 scopus 로고    scopus 로고
    • Essential fatty acids in health and chronic disease
    • Simopoulos AP, (1999) Essential fatty acids in health and chronic disease. Am J Clin Nutr 70: 560S-569S.
    • (1999) Am J Clin Nutr , vol.70
    • Simopoulos, A.P.1
  • 21
    • 80052052129 scopus 로고    scopus 로고
    • The Omega-6/Omega-3 Fatty Acid Ratio in Chronic Diseases: Animal Models and Molecular Aspects
    • Kang JX, (2011) The Omega-6/Omega-3 Fatty Acid Ratio in Chronic Diseases: Animal Models and Molecular Aspects. World Rev Nutr Diet 102: 22-29.
    • (2011) World Rev Nutr Diet , vol.102 , pp. 22-29
    • Kang, J.X.1
  • 22
    • 67650938102 scopus 로고    scopus 로고
    • The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential
    • Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, et al. (2009) The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Eur J Cancer 45: 2077-2086.
    • (2009) Eur J Cancer , vol.45 , pp. 2077-2086
    • Spencer, L.1    Mann, C.2    Metcalfe, M.3    Webb, M.4    Pollard, C.5
  • 23
    • 27244445146 scopus 로고    scopus 로고
    • Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
    • Burdge GC, Calder PC, (2005) Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 45: 581-597.
    • (2005) Reprod Nutr Dev , vol.45 , pp. 581-597
    • Burdge, G.C.1    Calder, P.C.2
  • 24
    • 0033215186 scopus 로고    scopus 로고
    • Differential Metabolism of Exogenous and Endogenous Arachidonic Acid in Human Neutrophils
    • Sala A, Zarini S, Folco G, Murphy RC, Henson PM, (1999) Differential Metabolism of Exogenous and Endogenous Arachidonic Acid in Human Neutrophils. J Biol Chem 274: 28264-28269.
    • (1999) J Biol Chem , vol.274 , pp. 28264-28269
    • Sala, A.1    Zarini, S.2    Folco, G.3    Murphy, R.C.4    Henson, P.M.5
  • 25
    • 33645772227 scopus 로고    scopus 로고
    • Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
    • Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, et al. (2006) Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 9: 287-300.
    • (2006) Cancer Cell , vol.9 , pp. 287-300
    • Sun, L.1    Hui, A.M.2    Su, Q.3    Vortmeyer, A.4    Kotliarov, Y.5
  • 26
    • 2542454682 scopus 로고    scopus 로고
    • Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
    • Zhao H, Langerød A, Ji Y, Nowels KW, Nesland JM, et al. (2004) Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell 15: 2523-2536.
    • (2004) Mol Biol Cell , vol.15 , pp. 2523-2536
    • Zhao, H.1    Langerød, A.2    Ji, Y.3    Nowels, K.W.4    Nesland, J.M.5
  • 28
    • 39549117982 scopus 로고    scopus 로고
    • Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    • Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, et al. (2008) Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res 68: 1003-1011.
    • (2008) Cancer Res , vol.68 , pp. 1003-1011
    • Furuta, E.1    Pai, S.K.2    Zhan, R.3    Bandyopadhyay, S.4    Watabe, M.5
  • 29
    • 0034718771 scopus 로고    scopus 로고
    • Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
    • Swinnen JV, Heemers H, Deboel L, Foufelle F, Heyns W, et al. (2000) Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene 19: 5173-5181.
    • (2000) Oncogene , vol.19 , pp. 5173-5181
    • Swinnen, J.V.1    Heemers, H.2    Deboel, L.3    Foufelle, F.4    Heyns, W.5
  • 31
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: advances in eicosanoid biology
    • Funk CD, (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875.
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 33
    • 33751504296 scopus 로고    scopus 로고
    • Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions
    • Ruegg C, (2006) Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. J Leukoc Biol 80: 682-684.
    • (2006) J Leukoc Biol , vol.80 , pp. 682-684
    • Ruegg, C.1
  • 34
    • 34548150402 scopus 로고    scopus 로고
    • Angiogenesis and chronic inflammation: cause or consequence?
    • Costa C, Incio J, Soares R, (2007) Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis 10: 149-166.
    • (2007) Angiogenesis , vol.10 , pp. 149-166
    • Costa, C.1    Incio, J.2    Soares, R.3
  • 35
    • 54249155141 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates tumor angiogenesis in prostate cancer
    • Jain S, Chakraborty G, Raja R, Kale S, Kundu GC, (2008) Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. Cancer Res 68: 7750-7759.
    • (2008) Cancer Res , vol.68 , pp. 7750-7759
    • Jain, S.1    Chakraborty, G.2    Raja, R.3    Kale, S.4    Kundu, G.C.5
  • 36
    • 38349183605 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    • Finetti F, Solito R, Morbidelli L, Giachetti A, Ziche M, et al. (2008) Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1. J Biol Chem 283: 2139-2146.
    • (2008) J Biol Chem , vol.283 , pp. 2139-2146
    • Finetti, F.1    Solito, R.2    Morbidelli, L.3    Giachetti, A.4    Ziche, M.5
  • 37
    • 77950398950 scopus 로고    scopus 로고
    • 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression
    • Kundumani-Sridharan V, Niu J, Wang D, Van Quyen D, Zhang Q, et al. (2010) 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression. Blood 115: 2105-2116.
    • (2010) Blood , vol.115 , pp. 2105-2116
    • Kundumani-Sridharan, V.1    Niu, J.2    Wang, D.3    Van Quyen, D.4    Zhang, Q.5
  • 38
    • 67651114089 scopus 로고    scopus 로고
    • The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8
    • Cheranov SY, Wang D, Kundumani-Sridharan V, Karpurapu M, Zhang Q, et al. (2009) The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8. Blood 113: 6023-6033.
    • (2009) Blood , vol.113 , pp. 6023-6033
    • Cheranov, S.Y.1    Wang, D.2    Kundumani-Sridharan, V.3    Karpurapu, M.4    Zhang, Q.5
  • 39
    • 33745873484 scopus 로고    scopus 로고
    • Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells
    • Nie D, Krishnamoorthy S, Jin R, Tang K, Chen Y, et al. (2006) Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. J Biol Chem 281: 18601-18609.
    • (2006) J Biol Chem , vol.281 , pp. 18601-18609
    • Nie, D.1    Krishnamoorthy, S.2    Jin, R.3    Tang, K.4    Chen, Y.5
  • 40
    • 1142310943 scopus 로고    scopus 로고
    • Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    • Kang JX, Wang J, Wu L, Kang ZB, (2004) Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature 427: 504.
    • (2004) Nature , vol.427 , pp. 504
    • Kang, J.X.1    Wang, J.2    Wu, L.3    Kang, Z.B.4
  • 41
    • 33747620742 scopus 로고    scopus 로고
    • Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids
    • Xia S, Lu Y, Wang J, He C, Hong S, et al. (2006) Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci USA 103: 12499-12504.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12499-12504
    • Xia, S.1    Lu, Y.2    Wang, J.3    He, C.4    Hong, S.5
  • 42
    • 34848875143 scopus 로고    scopus 로고
    • Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    • Nowak J, Weylandt KH, Habbel P, Wang J, Dignass A, et al. (2007) Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 28: 1991-1995.
    • (2007) Carcinogenesis , vol.28 , pp. 1991-1995
    • Nowak, J.1    Weylandt, K.H.2    Habbel, P.3    Wang, J.4    Dignass, A.5
  • 43
    • 45549085184 scopus 로고    scopus 로고
    • Reduced colitis-associated colon cancer in fat-1 (n-3 fatty acid desaturase) transgenic mice
    • Jia Q, Lupton JR, Smith R, Weeks BR, Callaway E, et al. (2008) Reduced colitis-associated colon cancer in fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res 68: 3985-3991.
    • (2008) Cancer Res , vol.68 , pp. 3985-3991
    • Jia, Q.1    Lupton, J.R.2    Smith, R.3    Weeks, B.R.4    Callaway, E.5
  • 44
    • 34447121230 scopus 로고    scopus 로고
    • Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    • Berquin IM, Min Y, Wu R, Wu J, Perry D, et al. (2007) Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest 117: 1866-1875.
    • (2007) J Clin Invest , vol.117 , pp. 1866-1875
    • Berquin, I.M.1    Min, Y.2    Wu, R.3    Wu, J.4    Perry, D.5
  • 45
    • 79958204979 scopus 로고    scopus 로고
    • Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- α
    • Weylandt KH, Krause LF, Gomolka B, Chiu CY, Bilal S, et al. (2011) Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- α. Carcinogenesis 32: 897-903.
    • (2011) Carcinogenesis , vol.32 , pp. 897-903
    • Weylandt, K.H.1    Krause, L.F.2    Gomolka, B.3    Chiu, C.Y.4    Bilal, S.5
  • 46
    • 70949100689 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2
    • Lim K, Han C, Dai Y, Shen M, Wu T, (2009) Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther 8: 3046-3055.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3046-3055
    • Lim, K.1    Han, C.2    Dai, Y.3    Shen, M.4    Wu, T.5
  • 47
    • 55749110745 scopus 로고    scopus 로고
    • Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation
    • Lu Y, Nie D, Witt WT, Chen Q, Shen M, et al. (2008) Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. Mol Cancer Ther 7: 3203-3211.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3203-3211
    • Lu, Y.1    Nie, D.2    Witt, W.T.3    Chen, Q.4    Shen, M.5
  • 48
    • 77955513412 scopus 로고    scopus 로고
    • The non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model
    • Griffitts J, Saunders D, Tesiram YA, Reid GE, Salih A, et al. (2010) The non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model. Biochim Biophys Acta 1801: 1133-1144.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 1133-1144
    • Griffitts, J.1    Saunders, D.2    Tesiram, Y.A.3    Reid, G.E.4    Salih, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.