Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 157-166

  Obukowicz, Mark G ^a,d   Welsch, Dean J ^b   Salsgiver, William J ^b   Martin Berger, Cynthia L ^c   Chinn, Kevin S ^a   Duffin, Kevin L ^d   Raz, Amiram ^e   Needleman, Philip ^a  

^a Discovery Pharmacology   (United States)

^b Biochemistry and Molecular Biology   (United States)

^c Cardiovascular Diseases Research   (United States)

^d MONSANTO COMPANY   (United States)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; CARRAGEENAN; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; ESSENTIAL FATTY ACID; INDOMETACIN; METHYLCELLULOSE; OLEIC ACID; POLYSORBATE 20; SC 26196; UNCLASSIFIED DRUG; LINOLEIC ACID; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENZYME INHIBITION; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID DESATURATION; FEMALE; INFLAMMATION; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; REFEEDING; ANIMAL; BAGG ALBINO MOUSE; DRUG ANTAGONISM; EDEMA; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; EDEMA; ENZYME INHIBITORS; FATTY ACID DESATURASES; FATTY ACIDS, ESSENTIAL; FEMALE; LINOLEIC ACID; MALE; MICE; MICE, INBRED BALB C; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032219604     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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