Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis

Cancer Letters

Volumn 175, Issue 2, 2002, Pages 157-163

  Hansen Petrik, Melissa B ^a   McEntee, Michael F ^a   Johnson, Benjamin T ^a   Obukowicz, Mark G ^b   Masferrer, Jaime ^b   Zweifel, Ben ^b   Chiu, Chun Hung ^a   Whelan, Jay ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b PFIZER INC   (United States)

Author keywords

6 Desaturase; ApcMin + mouse; Arachidonic acid; HT 29 cell; Intestinal tumor; SC 26196

Indexed keywords

ARACHIDONIC ACID; LINOLEIC ACID; LINOLEOYL COENZYME A DESATURASE; OXYGENASE INHIBITOR; PHOSPHOLIPID; SC 26196; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CANCER INHIBITION; CANCER SIZE; COLON CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID COMPOSITION; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; ANTICARCINOGENIC AGENTS; ENZYME INHIBITORS; FATTY ACID DESATURASES; INTESTINAL NEOPLASMS; LINOLEOYL-COA DESATURASE; MALE; MICE; MICE, INBRED C57BL; PIPERAZINES;

MUS MUSCULUS;

EID: 0037168955     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00715-7     Document Type: Article

References (21)

1. Biochemistry of essential fatty acids
2. Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase
3. Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer
4. Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice
5. Studying cancer in the mouse
6. Lessons from hereditary colorectal cancer
7. Reduced tumor growth of the human colonic cancer cell lines COLO-320 and HT-29 in vivo by dietary n-3 lipids
8. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128)
9. Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis
10. Min/+ mice
11. Dietary arachidonic and linoleic acids: Comparative effects on tissue lipids
12. Antithetic relationship of dietary arachidonic acid and eicosapentaenoic acid on eicosanoid production in vivo
13. Min/+ mice
14. Min-induced tumorigenesis
15. Transcriptional regulation of cyclooxygenase-2 gene expression: Novel effects of nonsteroidal anti-inflammatory drugs
16. 6-Desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or ω3 fatty acids
17. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
18. The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the Min mouse model of adenomatous polyposis
19. Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice
20. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis
21. Δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)