Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model. Omega-3 fatty acids prevent liver neoplasia

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 10, 2010, Pages 1133-1144

  Griffitts, J ^a,b   Saunders, D ^a   Tesiram, Y A ^a   Reid, G E ^c,d   Salih, A ^c   Liu, S ^c   Lydic, T A ^c   Busik, J V ^c   Kang, J X ^e   Towner, R A ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Michigan State University   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

HCC; Liver cancer; Omega 3 fatty acids; TGF c myc; Transgenic mouse model

Indexed keywords

OMEGA 3 FATTY ACID; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; FAT 1 GENE; GENE; GENE MUTATION; HISTOLOGY; LIVER CARCINOGENESIS; LIVER TUMOR; MOUSE; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARCINOMA, HEPATOCELLULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; FATTY ACID DESATURASES; FATTY ACIDS; FATTY ACIDS, OMEGA-3; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; LIVER; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR BURDEN;

MAMMALIA; MUS; MUS MUSCULUS;

EID: 77955513412     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.06.008     Document Type: Article

References (44)

1. World Cancer Report. Lyon: World Health Organization; 2003.
2. Cotran R.S., Kumar V., Collins T. Robbins Pathologic Basis of Disease 1999, W.B. Saunders Company, Philadelphia. sixth ed.
3. Co Wen A.E., Campbell C.B. Bile salt metabolism. I. The physiology of bile salts. Aust. N.Z. J. Med. 1977, 7:579-586.
4. Abel S., Smuts C.M., de Villiers C., Gelderblom W.C. Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis. Carcinogenesis 2001, 22:795-804.
5. Ntambi J.M., Bené H. Polyunsaturated fatty acid regulation of gene expression. J. Molecular Neuroscience 2001, 16:273-278.
6. Begin M.E., Das U.N., Ells G., Horrobin D.F. Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukotrienes Med. 1985, 19:177-186.
7. Hughes-Fulford M., Li C.F., Boonyaratanakornkit J., Sayyah S. Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer Res. 2006, 66:1427-1433.
8. Hudert C.A., Weylandt K.H., Lu Y., Wang J., Hong S., Dignass A., Serhan C.N., Kang J.X. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc. Natl Acad. Sci. 2006, 103:11276-11281.
9. Kang J.X. Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot. Essent. Fatty Acids 2007, 77:263-267.
10. Kang J.X. From fat to Fat-1: a tale of omega-3 fatty acids. J. Membrane Biol. 2005, 206:165-172.
11. Schmocker C., Weylandt K.H., Kahlke L., Wang J., Lobeck H., Tiegs G., Berg T., Kang J.X. Omega-3 fatty acids alleviate D-GaIN/LPS induced acute hepatitis by suppression of cytokines. Hepatology 2007, 45:864-869.
12. Stehr S.N., Heller A.R. Omega-3 fatty acid effects on biochemical indices following cancer surgery. Clin. Chim. Acta 2006, 373:1-8.
13. Spychalla J.P., Kinney A.J., Browse J. Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proc. Natl Acad. Sci. 1997, 94:1142-1147.
14. Dixon R.M. NMR studies of phospholipid metabolism in hepatic lymphoma. NMR Biomed. 1998, 11:370-379.
15. 31P magnetic resonance spectroscopy in vivo and in vitro. Br. J. Cancer 1994, 69:633-640.
16. 31P magnetic resonance spectroscopy study. Br. J. Cancer 1993, 67:1303-1309.
17. Daly P.F., Cohen J.S. Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: a review. Cancer Res. 1989, 49:770-779.
18. Taylor-Robinson S.D. Applications of magnetic resonance spectroscopy to chronic liver disease. Clin. Med. 2001, 1:54-60.
19. 1H MRS markers of tumour growth in intrasplenic tumours and liver metastasis induced by injection of HT-29 cells in nude mice spleen. NMR Biomed. 1998, 11:93-106.
20. Li C.W., Kuo Y.C., Chen C.Y., Kuo Y.T., Chiu Y.Y., She F.O., Liu G.C. Quantification of choline compounds in human hepatic tumors by proton MR spectroscopy at 3T. Magn. Reson. Med. 2005, 53:770-776.
21. Foley L.M., Towner R.A., Painter D.M. In vivo image-guided 1H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model. Biochim. Biophys. Acta 2001, 1526:230-236.
22. Murakami H., Sanderson N.D., Nagy P., Marino P.A., Merlino G., Thoreirsson S.S. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor α in hepatic oncogenesis. Cancer Res. 1993, 53:1719-1723.
23. Calvisi D.F., Thorgeirsson S.S. Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer. Toxicol. Pathol. 2005, 33:181-184.
24. Griffitts J., Tesiram Y., Reid G.E., Saunders D., Floyd R.A., Towner R.A. In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model. J. Lipid Res. 2009, 50:611-622.
25. Tesiram Y.A., Saunders D., Towner R.A. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim. Biophys. Acta 2005, 1737:61-68.
26. Savitzky A., Golay M.J.E. Smoothing and differentiation of data by simplified least squares procedures. Anal. Chem. 1964, 36:1627-1629.
27. Folch J., Lees M., Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1956, 226:497-509.
28. Chen P.S., Toribara T.Y., Warner H. Microdetermination of phosphorus. Anal. Chem. 1956, 28:1756-1758.
29. Koivusalo M., Haimi P., Heikinheimo L., Kostiainen R., Somerharju P. Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response. J. Lipid Res. 2001, 42:663-672.
30. Han X., Yang K., Yang J., Fikes K.N., Cheng H., Gross R.W. Factors influencing the electrospray intrasource separation and selective ionization of glycerophospholipids. J. Am. Soc. Mass Spectrom. 2006, 17:264-274.
31. Lydic T.A., Renis R., Busik J.V., Reid G.E. Analysis of retina and erythrocyte glycerophospholipid alterations in a rat model of type 1 diabetes. JALA 2009, 14:383-399.
32. Haimi P., Uphoff A., Hermansson M., Somerharju P. Software tools for analysis of mass spectrometric lipidome data. Anal. Chem. 2006, 78:8324-8331.
33. Wang Y., Botolin D., Xu J., Christian B., Mitchell E., Jayaprakasam B., Nair M.G., Peters J.M., Busik J.V., Olson L.K., Jump D.B. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J. Lipid Res. 2006, 47:2028-2041.
34. Simon R.M., Korn E.L., McShane L.M., Radmacher M.D., Wright G.W., Zhao Y. Design and analysis of DNA microarray investigations 2003, Springer-Verlag, New York.
35. Korn E.L., Troendle J.F., McShane L.M., Simon R. Controlling the number of false discoveries: application to high-dimensional genomic data. J. Statistical Planning Inference 2004, 124:379-398.
36. Wright G.W., Simon R. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003, 19:2448-2455.
37. Kang J.X., Weylandt K.H. Modulation of inflammatory cytokines by omega-3 fatty acids. Sucell. Biochem. 2008, 49:133-143.
38. Weylandt K.H., Nadolny A., Kahike L., Köhnke T., Schmöcker C., Wang J., Lauwers G.Y., Glickman J.N., Kang J.X. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim. Biophys. Acta 2008, 1782:634-641.
39. Nowak J., Weylandt K.H., Habbel P., Wang J., Dignass A., Glickman J.N., Kang J.X. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 2007, 28:1991-1995.
40. Jia Q., Lupton J.R., Smith R., Weeks B.R., Callaway E., Davidson L.A., Kim W., Fan Y.Y., Yang P., Newman R.A., Kang J.X., McMurray D.N., Chapkin R.S. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res. 2008, 68:3985-3991.
41. Factor V., Oliver A.L., Panta G.R., Thorgeirsson S.S., Sonenshein G.E., Arsra M. Roles of Akt/PKB and IKK complex in constitutive induction of NFκB in hepatocellular carcinomas of transforming growth factor α/c-myc transgenic mice. Hepatology 2001, 34:32-41.
42. Cavin L.G., Wang F., Factor V.M., Kaur S., Venkatraman M., Thorgeirsson S.S., Arsura M. Transforming growth factor-α inhibits the intrinsic pathway of c-myc-induced apoptosis through activation of nuclear factor-κB in murine hepatocellular carcinomas. Mol. Cancer Res. 2005, 3:403-412.
43. Floyd R.A., Kotake Y., Towner R.A., Guo W.-X., Nakae D., Konishi Y. Nitric oxide and cancer development. J. Toxicol. Pathol. 2007, 20:77-92.
44. Lim K., Han C., Dai Y., Shen M., Wu T. Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol. Cancer Ther. 2009, 8:3046-3055.