Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-β phosphorylation

Molecular Cancer Therapeutics

Volumn 7, Issue 10, 2008, Pages 3203-3211

  Lu, Yi ^a   Nie, Daibang ^a,c   Witt, William T ^b   Chen, Qiuyan ^a   Shen, Miaoda ^b   Xie, Haiyang ^b   Lai, Liangxue ^c   Dai, Yifan ^a,b   Zhang, Jian ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASPASE 3; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; ACYL COENZYME A DESATURASE; CAENORHABDITIS ELEGANS PROTEIN; FAT 1 PROTEIN, C ELEGANS; FAT-1 PROTEIN, C ELEGANS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FAT 1 GENE; GENE EXPRESSION; GENE FUNCTION; GENE TRANSFER; GENETIC TRANSFECTION; GENOME; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR GROWTH; ANIMAL; CAENORHABDITIS ELEGANS; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BETA CATENIN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOWN-REGULATION; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MICE; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; TRANSFECTION;

EID: 55749110745     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0494     Document Type: Article

References (28)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
2. Weisburger JH. Nakahara memorial lecture. Application of the mechanisms of nutritional carcinogenesis to the prevention of cancer. Princess Takamatsu Symp 1985;16:11-26.
3. Wargovich MJ, Baer AR. Basic and clinical investigations of dietary calcium in the prevention of colorectal cancer. Prev Med 1989;18:672-9.
4. Ozasa K, Watanabe Y, Ito Y, et al. Dietary habits and risk of lung cancer death in a large-scale cohort study (JACC Study) in Japan by sex and smoking habit. Jpn J Cancer Res 2001;92:1259-69.
5. Udilova N, Jurek D, Marian B, et al. Induction of lipid peroxidation in biomembranes by dietary oil components. Food Chem Toxicol 2003;41:1481-9.
6. Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA 2007;297:986-94.
7. Ritch CR, Wan RL, Stephens LB, et al. Dietary fatty acids correlate with prostate cancer biopsy grade and volume in Jamaican men. J Urol 2007;177:97-101; discussion.
8. Lai L, Kang JX, Li R, et al. Generation of cloned transgenic pigs rich in ω-3 fatty acids. Nat Biotechnol 2006;24:435-6.
9. Kang JX. From fat to fat-1: a tale of ω-3 fatty acids. J Membr Biol 2005;206:165-72.
10. Simopoulos AP. Importance of the ratio of ω-6/ω-3 essential fatty acids: evolutionary aspects. World Rev Nutr Diet 2003;92:1-22.
11. Abel S, De Kock M, Smuts CM, et al. Dietary modulation of fatty acid profiles and oxidative status of rat hepatocyte nodules: effect of different n-6/n-3 fatty acid ratios. Lipids 2004;39:963-76.
12. Xia SH, Wang J, Kang JX. Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Carcinogenesis 2005;26:779-84.
13. Schley PD, Jijon HB, Robinson LE, et al. Mechanisms of ω-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat 2005;92:187-95.
14. 2. Clin Cancer Res 2006;12:4662-70.
15. Xia S, Lu Y, Wang J, et al. Melanoma growth is reduced in fat-1 transgenic mice: impact of ω-6/ω-3 essential fatty acids. Proc Natl Acad Sci U S A 2006;103:12499-504.
16. Kim Y, Ji SK, Choi H. Modulation of liver microsomal monooxygenase system by dietary n-6/n-3 ratios in rat hepatocarcinogenesis. Nutr Cancer 2000;37:65-72.
17. Connolly JM, Coleman M, Rose DP. Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice. Nutr Cancer 1997;29:114-9.
18. Nowak J, Weylandt KH, Habbel P, et al. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 2007;28:1991-5.
19. Berquin IM, Min Y, Wu R, et al. Modulation of prostate cancer genetic risk by ω-3 and ω-6 fatty acids. J Clin Invest 2007;117:1866-75.
20. Ge Y, Chen Z, Kang ZB, et al. Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Anticancer Res 2002;22:537-43.
21. Zhang J, Dai J, Qi Y, et al. Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest 2001;107:1235-44.
22. Davol PA, Frackelton AR, Jr. Targeting human prostatic carcinoma through basic fibroblast growth factor receptors in an animal model: characterizing and circumventing mechanisms of tumor resistance. Prostate 1999;40:178-91.
23. Salas TR, Kim J, Vakar-Lopez F, et al. Glycogen synthase kinase-3β is involved in the phosphorylation and suppression of androgen receptor activity. J Biol Chem 2004;279:19191-200.
24. Wallner L, Dai J, Escara-Wilke J, et al. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res 2006;66:3087-95.
25. Ding VW, Chen RH, McCormick F. Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling. J Biol Chem 2000;275:32475-81.
26. 2 activates β-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by ω-3 polyunsaturated fatty acids. Cancer Res 2008;68:553-60.
27. Sharma M, Chuang WW, Sun Z. Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation. J Biol Chem 2002;277:30935-41.
28. Persad S, Troussard AA, McPhee TR, et al. Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 2001;153:1161-74.