Acute and chronic viral hepatitis

MacSween's Pathology of the Liver

Volumn , Issue , 2012, Pages 361-401

  Theise, Neil D ^a   Bodenheimer, Henry C ^a   Ferrell, Linda D ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84868087854     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7020-3398-8.00007-6     Document Type: Chapter

References (346)

1. Shiffman ML Management of acute hepatitis B. Clin Liver Dis 2010, 14:75-91.
2. Sass DA, Shakil AO Fulminant hepatic failure. Liver Transpl 2005, 11:594-605.
3. Schiødt FV, Ostapowicz G, Murray N, Satyanarana R Alpha-fetoprotein and prognosis in acute liver failure. Liver Transpl 2006, 12:1776-1781.
4. Schiødt FV, Bangert K, Shakil AO, McCashland T Predictive value of actin-free Gc-globulin in acute liver failure. Liver Transpl 2007, 13:1324-1329.
5. Parekh NK, Hynan LS, De Lemos J, Lee WM Elevated troponin I levels in acute liver failure: is myocardial injury an integral part of acute liver failure?. Hepatology 2007, 45:1489-1495.
6. Gazzard BG, Henderson JM, Williams R Factor VII levels as a guide to prognosis in fulminant hepatic failure. Gut 1976, 17:489-491.
7. Yamagishi Y, Saito H, Ebinuma H, et al. A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis. J Gastroenterol 2009, 44:615-623.
8. Valla D, Flejou JF, Lebrec D, et al. Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. Hepatology 1989, 10:482-487.
9. Lauff JJ, Kasper ME, Wu TW, et al. Isolation and preliminary characterization of a fraction of bilirubin in serum that is firmly bound to protein. Clin Chem 1982, 28:629-637.
10. Bruguera M, Bordas J, Rodes J Atlas of laparoscopy and biopsy of the liver 1979, WB Saunders, Philadelphia.
11. Poff JA, Coakley FV, Qayyum A, et al. Frequency and histopathologic basis of hepatic surface nodularity in patients with fulminant hepatic failure. Radiol 2008, 249:518-523.
12. Gazzard BG, Portmann B, Murray-Lyon IM, Williams R Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. Q J Med 1975, 44:615-626.
13. Rappaport AM The microcirculatory acinar concept of normal and pathological hepatic structure. Beitr Pathol 1976, 157:215-243.
14. De Groote J, Desmet V, Gedigk P, et al. A classification of chronic hepatitis. Lancet 1968, ii:626-628.
15. Thaler H Die Virushepatitis. Leberbiopsie 1969, 51. Springer, Berlin. H. Thaler (Ed.).
16. Ferrell L, Wright T, Roberts J, et al. Pathology of hepatitis C viral infection in liver transplant recipients. Hepatology 1992, 16:865-876.
17. Ranek L Cytophotometric studies of the DNA, nucleic acid and protein content of human liver cell nuclei. Acta Cytol 1976, 20:151-157.
18. Inuzuka S, Ueno T, Torimura T, et al. Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis. Hepatology 1990, 12:249-256.
19. Nonomura A, Mizukami Y, Matsubara F, Kobayashi K Clinicopathological study of lymphocyte attachment to endothelial cells (endothelialitis) in various liver diseases. Liver 1991, 11:78-88.
20. Hengeveld P, Zuyderhoudt FM, Jobsis AC, van Gool J Some aspects of iron metabolism during acute viral hepatitis. Hepatogastroenterology 1982, 29:138-141.
21. Hashimoto E, Kojimahara N, Noguchi S, et al. Immunohistochemical characterization of hepatic lymphocytes in acute hepatitis A, B, and C. J Clin Gastroenterol 1996, 23:199-202.
22. Mietkiewski JM, Scheuer PJ Immunoglobulin-containing plasma cells in acute hepatitis. Liver 1985, 5:84-88.
23. Sciot R, Van Damme B, Desmet VJ Cholestatic features in hepatitis A. J Hepatol 1986, 3:172-181.
24. Tordjmann T, Grimbert S, Genestie C, et al. Hépatite à cellules multinuclées de l'adulte: étude chez 17 malades. Gastroenterol Clin Biol 1998, 22:305-310.
25. Boyer JL, Klatskin G Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis). N Engl J Med 1970, 283:1063-1071.
26. Ware AJ, Eigenbrodt EH, Combes B Prognostic significance of subacute hepatic necrosis in acute hepatitis. Gastroenterology 1975, 68:519-524.
27. Spitz RD, Keren DF, Boitnott JK, Maddrey WC Bridging hepatic necrosis. Etiology and prognosis. Am J Dig Dis 1978, 23:1076-1078.
28. Nisman RM, Ganderson AP, Vlahcevic ZR, Gregory DH Acute viral hepatitis with bridging hepatic necrosis. An overview. Arch Intern Med 1979, 139:1289-1291.
29. Scheuer PJ, Maggi G Hepatic fibrosis and collapse: histological distinction by orcein staining. Histopathology 1980, 4:487-490.
30. Hanau C, Munoz SJ, Rubin R Histopathological heterogeneity in fulminant hepatic failure. Hepatology 1995, 21:345-351.
31. Thung SN, Gerber MA The formation of elastic fibers in livers with massive hepatic necrosis. Arch Pathol Lab Med 1982, 106:468-469.
32. Horney JT, Galambos JT The liver during and after fulminant hepatitis. Gastroenterology 1977, 73:639-645.
33. Phillips MJ, Poucell S Modern aspects of the morphology of viral hepatitis. Hum Pathol 1981, 12:1060-1084.
34. Theise ND, Saxena R, Portmann BC, et al. The canals of Hering and hepatic stem cells in humans. Hepatology 1999, 30:1425-1430.
35. Milandri M, Gaub J, Ranek L Evidence for liver cell proliferation during fatal acute liver failure. Gut 1980, 21:423-427.
36. Smedile A, Farci P, Verme G, et al. Influence of delta infection on severity of hepatitis B. Lancet 1982, 2:945-947.
37. Omata M, Ehata T, Yokosuka O, et al. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991, 324:1699-1704.
38. Liang TJ, Hasegawa K, Rimon N, et al. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991, 324:1705-1709.
39. Diseases of the liver and biliary tract. Standardization of nomenclature, diagnostic criteria, and prognosis 1994, Raven Press, New York. C. Leevy, S. Sherlock, N. Tygstrup, R. Zetterman (Eds.).
40. Shikata T, Karasawa T, Abe K Two distinct types of hepatitis in experimental hepatitis B virus infection. Am J Pathol 1980, 99:353-367.
41. Hølund B, Poulsen H, Schlichting P Reproducibility of liver biopsy diagnosis in relation to the size of the specimen. Scand J Gastroenterol 1980, 15:329-335.
42. Pawlotsky JM Use and interpretation of virological tests for hepatitis C. Hepatology 2002, 36:s65-s73.
43. Nakanuma Y Necroinflammatory changes in hepatic lobules in primary biliary cirrhosis with less well-defined cholestatic changes. Hum Pathol 1993, 24:378-383.
44. Danan G, Benichou C Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993, 46:1323-1330.
45. Derby L, Gutthann SP, Jick H, Dean A Liver disorders in receiving chlorpromazine or isoniazid. Pharmacotherapy 1993, 13:354-358.
46. Estes JD, Stoplman D, Olyaei A, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg 2003, 138:852-858.
47. Levitsky J, Mailliard ME Diagnosis and therapy of alcoholic liver disease. Sem Liver Dis 2004, 24:233-247.
48. Czaja AJ, Freese DK Diagnosis and treatment of autoimmune hepatitis. Hepatology 2002, 36:479-497.
49. Karvountzis GG, Redeker AG, Peters RL Long term follow-up studies of patients surviving fulminant viral hepatitis. Gastroenterology 1974, 67:870-877.
50. Thaler H Hepatitis and cirrhosis. Dtsch Med Wochenschr 1975, 100:1018-1025.
51. Wanless I, Wong F, Blendis L, et al. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995, 21:1238-1247.
52. Macias J, Berenguer J, Japon M, Giron J Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency/hepatitis C virus. Hepatology 2009, 50:1056-1063.
53. Maheshwari A, Ray S, Thuluvath PJ Acute hepatitis C. Lancet 2008, 372:321-332.
54. Lok ASF, McMahon BJ AASLD Guidelines: Chronic hepatitis B; Update 2009. Hepatology 2009, 50:1-36.
55. Alberti A, Noventa F, Benvegnu L, et al. Prevalence of liver disease in population of asymptomatic persons with hepatitis C virus infection. Ann Int Med 2000, 137:961-965.
56. Kyrlagitsis I, Portmann B, Smith H, et al. Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT. Am J Gastroenterol 2003, 98:1588-1593.
57. Hui CK, Belaye T, Montegrande K, Wright TL A comparison in the progression of liver fibrosis in chronic hepatitis C between persistently normal and elevated transaminase. J Hepatol 2003, 38:511-517.
58. Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. J Hepatol 2003, 38:518-526.
59. Mehta SH, Lau B, Afdhal NH, Thomas DL Exceeding the limits of liver histology markers. J Hepatol 2009, 50:36-41. Jan.
60. Freisdrich-Rust M, Ong MF, Martens S, Sarrazin C Performance of transient elastography for the staging of liver fibrosis: a metanalysis. Gastroenterology 2008, 134:960-974. Apr.
61. Groote JD, Desmet V, Gedigk P, et al. A classification of chronic hepatitis. Lancet 1968, ii:626-628.
62. Bonacini M, Govindarajan S, Kohla M, et al. Intrahepatic lymphocyte phenotypes in hepatitis C virus infection: a comparison between cirrhotic and non-cirrhotic livers. Minerva Gastroenterol Dietol 2007, 53:1-7.
63. Kasper HU, Ligum D, Cucus J, et al. Liver distribution of gammadelta-T-cells in patients with chronic hepatitis of different etiology. APMIS 2009, 117:779-785.
64. Walewska-Zielecka B, Madalinski K, Jablonska J, et al. Composition of inflammatory infiltrate and its correlation with HBV/HCV antigen expression. World J Gastroenterol 2008, 14:4040-4046.
65. Bach N, Thung SN, Schaffner F The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis. Hepatology 1992, 15:572-577.
66. Souza P, Prihoda TJ, Hoyumpa AM, Sharkey FE Morphologic features resembling transplant rejection in core biopsies of native livers from patients with Hepatitis C. Hum Pathol 2009, 40:92-97.
67. Scheuer PJ, Ashrafzadeh P, Sherlock S, et al. The pathology of hepatitis C. Hepatology 1992, 15:567-571.
68. Wanless IR, Wong F, Blendis LM, et al. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995, 21:1238-1247.
69. Popper H, Paronetto F, Schaffner F Immune processes in the pathogenesis of liver disease. Ann NY Acad Sci 1965, 124:781-799.
70. Ibuki N, Yamamoto K, Yabushita K, et al. In situ expression of granzyme B and Fas-ligand in the liver of viral hepatitis. Liver 2002, 22:198-204.
71. Eddleston AL, Mondelli M Immunopathological mechanisms of liver cell injury in chronic hepatitis B virus infection. J Hepatol 1986, 3(Suppl. 2):S17-S23.
72. Antonaci S, Schiraldi O Costimulatory molecules and cytotoxic T cells in chronic hepatitis C: defence mechanisms devoted to host integrity or harmful events favouring liver injury progression? A review. Immunopharmacol Immunotoxicol 1998, 20:455-472.
73. Pianko S, Patella S, Ostapowicz G, et al. Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat 2001, 8:406-413.
74. Kerr JF, Cooksley WG, Searle J, et al. The nature of piecemeal necrosis in chronic active hepatitis. Lancet 1979, 2:827-828.
75. Chen NL, Bai L, Li L, et al. Apoptosis pathway of liver cells in chronic hepatitis. World J Gastroenterol 2004, 10:3201-3204.
76. Calabrese F, Pontisso P, Pettenazzo E, et al. Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV-RNA levels. Hepatology 2000, 31:1153-1159.
77. Popper H Changing concepts of the evolution of chronic hepatitis and the role of piecemeal necrosis. Hepatology 1983, 3:758-762.
78. Liaw YF, Chu CM, Chen TJ, et al. Chronic lobular hepatitis: a clinicopathological and prognostic study. Hepatology 1982, 2:258-262.
79. Cooksley WG, Bradbear RA, Robinson W, et al. The prognosis of chronic active hepatitis without cirrhosis in relation to bridging necrosis. Hepatology 1986, 6:345-348.
80. Chen TJ, Liaw YF The prognostic significance of bridging hepatic necrosis in chronic type B hepatitis: a histopathologic study. Liver 1988, 8:10-16.
81. Falkowski O, An HJ, Ianus IA, et al. Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells. J Hepatol 2003, 39:357-364.
82. Clouston AD, Powell EE, Walsh MJ, et al. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 2005, 41:809-818.
83. Schuppan D, Krebs A, Bauer M, Hahn EG Hepatitis C and liver fibrosis. Cell Death Differ 2003, 10:S59-S67.
84. Giannelli G, Antonaci S Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection. Histol Histopathol 2005, 20:939-944.
85. Arif A, Levine RA, Sanderson SO, et al. Regression of fibrosis in chronic hepatitis C after therapy with interferon and ribavirin. Dig Dis Sci 2003, 48:1425-1430.
86. Friedman SL, Bansal MB Reversal of hepatic fibrosis - fact or fantasy?. Hepatology 2006, 43(2 Suppl 1):S82-S88.
87. Poynard T, McHutchison J, Manns M, et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002, 122:1303-1313.
88. Wanless IR, Nakashima E, Sherman M Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 2000, 124:1599-1607.
89. Garcia-Tsao G, Friedman S, Iredale J, Pinzani M Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis. Hepatology 2010, 51:1445-1449.
90. Dufour JF, DeLellis R, Kaplan MM Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment. Dig Dis Sci 1998, 43:2573-2576.
91. Poynard T, McHutchison J, Davis GL, et al. Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C. Hepatology 2000, 32:1131-1137.
92. Ray MB Regression of cirrhosis. A timely topic. Arch Pathol Lab Med 2000, 124:1589-1590. discussion 1592-3.
93. Geller SA Coming or going? What is cirrhosis?. Arch Pathol Lab Med 2000, 124:1587-1588. discussion 1592-3.
94. Chejfec G Controversies in pathology. Is cirrhosis of the liver a reversible disease?. Arch Pathol Lab Med 2000, 124:1585-1586. discussion 1592-3.
95. Chedid A Regression of human cirrhosis. Arch Pathol Lab Med 2000, 124:1591. discussion 1592-3.
96. Wanless IR In reply. Arch Pathol Lab Med 2000, 124:1592-1593.
97. Guidotti LG, Chisari FV Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathhol Mech Dis 2006, 1:23-61.
98. Chisari FV, Isogawa M, Wieland SF Pathogenesis of hepatitis B virus infection. Pathol Biol 2010, 58:258-266.
99. Tang H, Grise H Cellular and molecular biology of HCV infection and hepatitis. Clinical Science 2009, 117:49-65.
100. Diepolder HM New insights into the immunopathogenesis of chronic hepatitis C. Antiviral Research 2009, 82:103-109.
101. Taylor JM Hepatitis delta virus. Virology 2006, 344:71-76.
102. Rosenberg W Mechanisms of immune escape in viral hepatitis. Gut 1999, 44:759-764.
103. Einav S, Koziel MJ Immunopathogenesis of hepatitis C virus in the immunosuppressed host. Transpl Infect Dis 2002, 4:85-92.
104. Liaw YF Hepatitis viruses under immunosuppressive agents. J Gastroenterol Hepatol 1998, 13:14-20.
105. Tsai WL, Chung RT Viral hepatocarcinogenesis. Oncogene 2010, 29:2309-2324.
106. Theise ND Cirrhosis and hepatocellular neoplasia: more like cousins than like parent and child. Gastroenterology 1996, 111:526-528.
107. Franco E, Giambi C, Ialacci R, Maurici M Prevention of hepatitis A by vaccination. Expert Opin Biol Ther 2003, 3:965-974.
108. Mele A Progress in prevention and control of hepatitis B: a congress reviewing the first ten years since the introduction of mass vaccination in Italy. J Med Virol 2002, 67:432.
109. Chi ZC, Ma SZ Rheumatologic manifestations of hepatic diseases. Hepatobiliary Pancreat Dis Int 2003, 2:32-37.
110. Vassilopoulos D, Manolakopoulos S Rheumatic manifestations of hepatitis. Curr Opin Rheumatol 2010, 22:91-96.
111. Ramos-Casals M, Muñoz S, Medina F, et al. HISPAMEC Study Group. Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry). J Rheumatol 2009, 36:1442-1448.
112. Exley MA, Koziel MJ To be or not to be NKT: natural killer T cells in the liver. Hepatology 2004, 40:1033-1040.
113. Alatrakchi N, Koziel M Regulatory T cells and viral liver disease. J Viral Hepat 2009, 16:223-229.
114. Lisman T, Porte RJ The role of platelets in liver inflammation and regeneration. Semin Thromb Hemost 2010, 36:170-174.
115. Jiao J, Friedman SL, Aloman C Hepatic fibrosis. Curr Opin Gastroenterol 2009, 25:223-229.
116. Brenner DA Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc 2009, 120:361-368.
117. Paradis V, Kollinger M, Fabre M, et al. In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 1997, 26:135-142.
118. Rockey DC Current and future anti-fibrotic therapies for chronic liver disease. Clin Liver Dis 2008, 12:939-962.
119. Han YP Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol 2006, 21(Suppl. 3):S88-S91.
120. Shukla NB, Poles MA Hepatitis B virus infection: co-infection with hepatitis C virus, hepatitis D virus, and human immunodeficiency virus. Clin Liver Dis 2004, 8:445-460.
121. Bradley DW, Maynard JE, McCaustland KA, et al. Non-A, non-B hepatitis in chimpanzees: interference with acute hepatitis A virus and chronic hepatitis B virus infections. J Med Virol 1983, 11:207-213.
122. Pontisso P, Gerotto M, Ruvoletto MG, et al. Hepatitis C genotypes in patients with dual hepatitis B and C virus infection. J Med Virol 1996, 48:157-160.
123. Guido M, Rugge M, Colombari R, et al. Prompt hepatitis C virus suppression following hepatitis B virus superinfection in chronic untreated hepatitis C. Ital J Gastroenterol Hepatol 1998, 30:414-417.
124. Colombari R, Dhillon AP, Piazzola E, et al. Chronic hepatitis in multiple virus infection: histopathological evaluation. Histopathology 1993, 22:319-325.
125. Guido M, Thung SN, Fattovich G, et al. Intrahepatic expression of hepatitis B virus antigens: effect of hepatitis C virus infection. Mod Pathol 1999, 12:599-603.
126. Lefkowitch JH The liver in AIDS. Semin Liver Dis 1997, 17:335-344.
127. Soriano V, Vispo E, Labarga P, et al. Viral hepatitis and HIV co-infection. Antiviral Res 2010, 85:303-315.
128. Colson P, Dhiver C, Gérolami R Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection. Clin Microbiol Infect 2008, 14:1176-1180.
129. Rosenberg PM, Farrell JJ, Abraczinskas DR, et al. Rapidly progressive fibrosing cholestatic hepatitis - hepatitis C virus in HIV coinfection. Am J Gastroenterol 2002, 97:478-483.
130. Tolan DJ, Davies MH, Millson CE Fibrosing cholestatic hepatitis after liver transplantation in a patient with hepatitis C and HIV infection. N Engl J Med 2001, 345:1781.
131. Fang JW, Wright TL, Lau JY Fibrosing cholestatic hepatitis in patient with HIV and hepatitis B. Lancet 1993, 342:1175.
132. Housset C, Pol S, Carnot F, et al. Interactions between human immunodeficiency virus-1, hepatitis delta virus and hepatitis B virus infections in 260 chronic carriers of hepatitis B virus. Hepatology 1992, 15:578-583.
133. Sabin CA, Walker AS, Dunn D HIV/HCV coinfection, HAART, and liver-related mortality. Lancet 2004, 364:757-758. author reply.
134. Rullier A, Trimoulet P, Neau D, et al. Fibrosis is worse in HIV-HCV patients with low-level immunodepression referred for HCV treatment than in HCV-matched patients. Hum Pathol 2004, 35:1088-1094.
135. Theise ND Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach. Modern Pathology 2007, 20:S3-S14.
136. Hansen KE, Arnason J, Bridges AJ Autoantibodies and common viral illnesses. Semin Arthritis Rheum 1998, 27:263-271.
137. Trepo C, Guillevin L Polyarteritis nodosa and extrahepatic manifestations of HBV infection: The case against autoimmune intervention in pathogenesis. J Autoimmunity 2001, 16:269-274.
138. Kayali Z, Buckwold VE, Zimmerman B, Schmidt WN Hepatitis C, cryoglobulinemia and cirrhosis a meta-analysis. Hepatology 2002, 36:978-985.
139. Cesur S, Akin K, Kurt H The significance of cryoglobulinemia in patients with chronic hepatitis B and C virus infection. Hepatogastroenterology 2003, 50:1487-1489.
140. Propst T, Propst A, Dietze O, et al. High prevalence of viral infection in adults with homozygous and heterozygous alpha 1-antitrypsin deficiency and chronic liver disease. Ann Intern Med 1992, 117:641-645.
141. Mak CM, Lam CW Diagnosis of Wilson's disease: a comprehensive review. Crit Rev Clin Lab Sci 2008, 45:263-290.
142. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981, 1:431-435.
143. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22:696-699.
144. Batts KP, Ludwig J Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995, 19:1409-1417.
145. Lefkowitch JH Liver biopsy assessment in chronic hepatitis. Arch Med Res 2007, 38:634-643.
146. Desmet VJ, Gerber M, Hoofnagle JH, et al. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994, 19:1513-1520.
147. Bedossa P, Poynard T An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996, 24:289-293.
148. Hui AY, Liew CT, Go MY, et al. Quantitative assessment of fibrosis in liver biopsies from patients with chronic hepatitis B. Liver Int 2004, 24:611-618.
149. Maduli E, Andorno S, Rigamonti C, et al. Evaluation of liver fibrosis in chronic hepatitis C with a computer-assisted morphometric method. Ann Ital Med Int 2002, 17:242-247.
150. Smith JO, Sterling RK Systematic review: non-invasive methods of fibrosis analysis in chronic hepatitis C. Aliment Pharmacol Ther 2009, 30:557-576.
151. Almasio PL, Niero M, Angioli D, et al. Experts' opinions on the role of liver biopsy in HCV infection: a Delphi survey by the Italian Association of Hospital Gastroenterologists (A. I. G. O.). J Hepatol 2005, 43:381-387.
152. Guido M, Rugge M Liver biopsy sampling in chronic viral hepatitis. Semin Liver Dis 2004, 24:89-97.
153. Fanning L, Loane J, Kenny-Walsh E, et al. Tissue viral load variability in chronic hepatitis C. Am J Gastroenterol 2001, 96:3384-3389.
154. Regev A, Berho M, Jeffers LJ, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002, 97:2614-2618.
155. Persico M, Palmentieri B, Vecchione R, et al. Diagnosis of chronic liver disease: reproducibility and validation of liver biopsy. Am J Gastroenterol 2002, 97:491-492.
156. Siddique I, El-Naga HA, Madda JP, et al. Sampling variability on percutaneous liver biopsy in patients with chronic hepatitis C virus infection. Scand J Gastroenterol 2003, 38:427-432.
157. Bedossa P, Dargere D, Paradis V Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003, 38:1449-1457.
158. Goldstein NS, Hastah F, Galan MV, Gordon SC Fibrosis heterogeneity in nonalcoholic steatohepatitis and hepatitis C virus needle core biopsy specimens. Am J Clin Pathol 2005, 123:382-387.
159. Winkfield B, Aube C, Burtin P, Cales P Inter-observer and intra-observer variability in hepatology. Eur J Gastroenterol Hepatol 2003, 15:959-966.
160. The French METAVIR Cooperative Study Group Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994, 20:15-20.
161. Goldin RD, Goldin JG, Burt AD, et al. Intra-observer and inter-observer variation in the histopathological assessment of chronic viral hepatitis. J Hepatol 1996, 25:649-654.
162. Scheuer PJ, Standish RA, Dhillon AP Scoring of chronic hepatitis. Clin Liver Dis 2002, 6:335-347.
163. Cross SS Grading and scoring in histopathology. Histopathology 1998, 33:99-106.
164. Macnaughton RJ Numbers, scales, and qualitative research. Lancet 1996, 347:1099-1100.
165. Brunt EM Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2010, 7:195-203.
166. Tiniakos DG, Vos MB, Brunt EM Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010, 5:145-171.
167. Isom HC, McDevitt EI, Moon MS Elevated hepatic iron: a confounding factor in chronic hepatitis C. Biochim Biophys Acta 2009, 1790:650-662.
168. Fiel MI, Schiano TD, Guido M, et al. Increased hepatic iron deposition resulting from treatment of chronic hepatitis C with ribavirin. Am J Clin Pathol 2000, 113:35-39.
169. Hytiroglou P, Park YN, Krinsky G, Theise ND Hepatic precancerous lesions and small hepatocellular carcinoma. Gastroenterol Clin North Am 2007, 36:867-887.
170. Ikeda H, Sasaki M, Sato Y, et al. Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion. Hum Pathol 2009, 40:1774-1782.
171. Kim H, Oh BK, Roncalli M, et al. Large liver cell change in hepatitis B virus-related liver cirrhosis. Hepatology 2009, 50:752-762.
172. Hytiroglou P Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis 2004, 24:65-75.
173. Chang O, Yano Y, Masuzawa A, et al. The cytological characteristics of small cell change of dysplasia in small hepatic nodules. Oncol Rep 2010, 23:1229-1232.
174. Turlin B, Deugnier Y Evaluation and interpretation of iron in the liver. Semin Diagn Pathol 1998, 15:237-245.
175. Deugnier YM, Charalambous P, Le Quilleuc D, et al. Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: a study of 185 patients. Hepatology 1993, 18:1363-1369.
176. Feinstone S, Kapikian A, Purcell R Hepatitis A: detection by immune electron microscopy of a virus-like antigen associated with acute illness. Science 1973, 182:1026-1028.
177. Mathiesen LR, Fauerholdt L, Moller AM, et al. Immunofluorescence studies for hepatitis A virus and hepatitis B surface and core antigen in liver biopsies from patients with acute viral hepatitis. Gastroenterology 1979, 77:623-628.
178. Shimizu YK, Shikata T, Beninger PR, et al. Detection of hepatitis A antigen in human liver. Infect Immun 1982, 36:320-324.
179. Fagan E, Yousef G, Brahm J, et al. Persistence of hepatitis A virus in fulminant hepatitis and after liver transplantation. J Med Virol 1990, 30:131-136.
180. Tilzey AJ, Banatvala JE Hepatitis A (editorial). Br Med J 1991, 302:1552-1553.
181. Villari D, Raimondo G, Attard L, et al. Polyphasic type A hepatitis: histological features. Infection 1993, 21:46-48.
182. Masada CT, Shaw BW, et al. Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection. J Clin Gastroenterol 1993, 17:158-162.
183. Gane E, Sallie R, Saleh M, et al. Clinical recurrence of hepatitis A following liver transplantation for acute liver failure. J Med Virol 1995, 45:35-39.
184. Inoue K, Yoshiba M, Yotsuyanagi H, et al. Chronic hepatitis A with persistent viral replication. J Med Virol 1996, 50:322-324.
185. McDonald GS, Courtney MG, Shattock AG, Weir DG Prolonged IgM antibodies and histopathological evidence of chronicity in hepatitis A. Liver 1989, 9:223-228.
186. Vento S, Garofano T, Di Perri G, et al. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Lancet 1991, 337:183-187.
187. Abe H, Beninger PR, Ikejiri N, et al. Light microscopic findings of liver biopsy specimens from patients with hepatitis type A and comparison with type B. Gastroenterology 1982, 82:938-947.
188. Teixeira MR, Weller IV, Murray A, et al. The pathology of hepatitis A in man. Liver 1982, 2:53-60.
189. Okuno T, Sano A, Deguchi T, et al. Pathology of acute hepatitis A in humans. Comparison with acute hepatitis B. Am J Clin Pathol 1984, 81:162-169.
190. Ponz E, Garcia-Pagan JC, Bruguera M, et al. Hepatic fibrin-ring granulomas in a patient with hepatitis A. Gastroenterology 1991, 100:268-270.
191. Yamamoto T, Ishii M, Nagura H, et al. Transient hepatic fibrin-ring granulomas in a patient with acute hepatitis A. Liver 1995, 15:276-279.
192. Ruel M, Sevestre H, Henry-Biabaud E, et al. Fibrin ring granulomas in hepatitis A. Dig Dis Sci 1992, 37:1915-1917.
193. Vallbracht A, Maier K, Stierhof YD, et al. Liver-derived cytotoxic T cells in hepatitis A virus infection. J Infect Dis 1989, 160:209-217.
194. Muller C, Godl I, Gottlicher J, et al. Phenotypes of peripheral blood lymphocytes during acute hepatitis A. Acta Paediatr Scand 1991, 80:931-937.
195. Te HS, Jensen DM Epidemiology of hepatitis B and C viruses: a global overview. Clin Liver Dis 2010, 14:1-21.
196. McMahon BJ The natural history of chronic hepatitis B virus infection. Hepatology 2009, 49(5 Suppl):S45-S55.
197. Davison F, Alexander GJ, Trowbridge R, et al. Detection of hepatitis B virus DNA in spermatozoa, urine, saliva and leucocytes, of chronic HBsAg carriers. A lack of relationship with serum markers of replication. J Hepatol 1987, 4:37-44.
198. Candotti D, Allain JP Transfusion-transmitted hepatitis B virus infection. J Hepatol 2009, 51:798-809.
199. Dane DS, Cameron CH, Briggs M Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. Lancet 1970, 1:695-698.
200. Locarnini S Molecular virology of hepatitis B virus. Semin Liver Dis 2004, 24(Suppl. 1):3-10.
201. Blumberg BS, Alter HJ, Visnich S A 'new' antigen in leukemia sera. JAMA 1965, 191:541-546.
202. Wen YM Structural and functional analysis of full-length hepatitis B virus genomes in patients: implications in pathogenesis. J Gastroenterol Hepatol 2004, 19:485-489.
203. Lee JY, Locarnini S Hepatitis B virus: pathogenesis, viral intermediates, and viral replication. Clin Liver Dis 2004, 8:301-320.
204. Servoss JC, Friedman LS Serologic and molecular diagnosis of hepatitis B virus. Clin Liver Dis 2004, 8:267-281.
205. Nair S, Perrillo RP Hepatitis B and D. Hepatology: a textbook of liver disease 2003, vol. 2:959-1017. WB Saunders, Philadelphia, PA. 4th edn.
206. McMahon BJ The natural history of chronic hepatitis B virus infection. Semin Liver Dis 2004, 24(Suppl. 1):17-21.
207. Liaw YF, Tai DI, Chu CM, Chen TJ The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology 1988, 8:493-496.
208. McMahon BJ, Alberts SR, Wainwright RB, et al. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med 1990, 150:1051-1054.
209. Chotiyaputta W, Lok AS Hepatitis B virus variants. Nat Rev Gastroenterol Hepatol 2009, 6:453-462.
210. Ghany MG, Doo EC Antiviral resistance and hepatitis B therapy. Hepatology 2009, 49(5 Suppl):S174-S184.
211. Si Ahmed SN, Zoulim F Pathobiology of HBV mutants and clinical impact for treatment monitoring. Expert Rev Anti Infect Ther 2009, 7:309-320.
212. Nijhuis M, van Maarseveen NM, Boucher CA Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases. Handb Exp Pharmacol 2009, 189:299-320.
213. Sheldon J, Soriano V Hepatitis B virus escape mutants induced by antiviral therapy. J Antimicrob Chemother 2008, 61:766-768.
214. Liaw YF Natural history of chronic hepatitis B virus infection and long-term outcome under treatment. Liver Int 2009, 29(Suppl. 1):100-107.
215. Xiao SY, Lu L, Wang HL Fibrosing cholestatic hepatitis: clinicopathologic spectrum, diagnosis and pathogenesis. Int J Clin Exp Pathol 2008, 1:396-402.
216. Nayak NC, Sachdeva R Localization of hepatitis B surface antigen in conventional paraffin sections of the liver. Comparison of immunofluorescence, immunoperoxidase, and orcein staining methods with regard to their specificity and reliability as antigen marker. Am J Pathol 1975, 81:479-492.
217. Lefkowitch JH, Lobritto SJ, Brown RS, et al. Ground-glass, polyglucosan-like hepatocellular inclusions: A 'new' diagnostic entity. Gastroenterology 2006, 131:713-718.
218. Bianchi L, Gudat F Sanded nuclei in hepatitis B: eosinophilic inclusions in liver cell nuclei due to excess in hepatitis B core antigen formation. Lab Invest 1976, 35:1-5.
219. Chu CM, Liaw YF Immunohistological study of intrahepatic expression of hepatitis B core and E antigens in chronic type B hepatitis. J Clin Pathol 1992, 45:791-795.
220. Trevisan A, Gudat F, Busachi C, et al. An improved method for HBcAg demonstration in paraffin-embedded liver tissue. Liver 1982, 2:331-339.
221. Chu CM, Yeh CT, Chien RN, et al. The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflect the level of viral replication in chronic hepatitis B virus infection. J Clin Microbiol 1997, 35:102-105.
222. Ballare M, Lavarini C, Brunetto MR, et al. Relationship between the
223. Park YN, Han KH, Kim KS, et al. Cytoplasmic expression of hepatitis B core antigen in chronic hepatitis B virus infection: role of precore stop mutants. Liver 1999, 19:199-205.
224. McDonald JA, Harris S, Waters JA, Thomas HC Effect of human immunodeficiency virus (HIV) infection on chronic hepatitis B hepatic viral antigen display. J Hepatol 1987, 4:337-342.
225. Callea F Immunohistochemical techniques for the demonstration of viral antigens in liver tissue. Ric Clin Lab 1988, 18:223-231.
226. Wang WL, London WT, Lega L, Feitelson MA HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology 1991, 14:29-37.
227. Azam F, Koulaouzidis A Hepatitis B virus and hepatocarcinogenesis. Ann Hepatol 2008, 7:125-129.
228. Hoofnagle JH, Shafritz DA, Popper H Chronic type B hepatitis and the 'healthy' HBsAg carrier state. Hepatology 1987, 7:758-763.
229. Kakimi K, Isogawa M, Chung J, et al. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J Virol 2002, 76:8609-8620.
230. Guidotti LG The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection. Vaccine 2002, 20(Suppl. 4):A80-A82.
231. Dandri M, Lutgehetmann M, Volz T, Petersen J Small animal model systems for studying hepatitis B virus replication and pathogenesis. Semin Liver Dis 2006, 26:181-191.
232. Wang FS, Zhang Z Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus. Expert Rev Gastroenterol Hepatol 2009, 3:499-512.
233. Koziel MJ Cytokines in viral hepatitis. Semin Liver Dis 1999, 19:157-169.
234. Shi YH, Shi CH Molecular characteristics and stages of chronic hepatitis B virus infection. World J Gastroenterol 2009, 15:3099-3105.
235. Bracebridge S, Irwin D, Millership S Prevention of perinatal hepatitis B transmission in a health authority area: an audit. Commun Dis Public Health 2004, 7:138-141.
236. Guidotti LG, Chisari FV Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001, 19:65-91.
237. Guidotti LG, Morris A, Mendez H, et al. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. J Virol 2002, 76:2617-2621.
238. Guidotti LG, Rochford R, Chung J, et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999, 284:825-829.
239. Rehermann B, Ferrari C, Pasquinelli C, Chisari FV The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996, 2:1104-1108.
240. Maini MK, Schurich M The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J Hepatol 2010, 52:616-619.
241. McCarron B, Main J, Thomas HC HIV and hepatotropic viruses: interactions and treatments. Int J STD AIDS 1997, 8:739-746.
242. Jung MC, Pape GR Immunology of hepatitis B infection. Lancet Infect Dis 2002, 2:43-50.
243. Pawlotsky JM Pathophysiology of hepatitis C virus infection and related liver disease. Trends Microbiol 2004, 12:96-102.
244. Penin F, Dubuisson J, Rey FA, et al. Structural biology of hepatitis C virus. Hepatology 2004, 39:5-19.
245. Andre P, Perlemuter G, Budkowska A, et al. Hepatitis C virus particles and lipoprotein metabolism. Semin Liver Dis 2005, 25:93-104.
246. Simmonds P Genetic diversity and evolution of hepatitis C virus - 15 years on. J Gen Virol 2004, 85:3173-3188.
247. Myrmel H, Ulvestad E, Asjø B The hepatitis C virus enigma. APMIS 2009, 117:427-439.
248. Zuure F, Davidovich U, Kok G, Depla AC Evaluation of a risk assessment questionnaire to assist hepatitis C screening in the general population. Euro Surveill 2010, 15:19539.
249. Scott C, Day S, Low E, et al. Unselected hepatitis C screening of men who have sex with men attending sexual health clinics. J Infect 2010, 60:351-353.
250. Urbanus AT, van de Laar TJ, Stolte IG, et al. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009, 23:F1-F7.
251. Mast EE, Hwang LY, Seto DS, et al. Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy. J Infect Dis 2005, 192:1880-1889.
252. Miranda AE, Figueiredo NC, Schmidt R, Page-Shafer K A population-based survey of the prevalence of HIV, syphilis, hepatitis B and hepatitis C infections, and associated risk factors among young women in Vitória, Brazil. AIDS Behav 2008, 12:S25-S31.
253. Feitelson MA Hepatitis C Virus: From laboratory to clinic 2002, Cambridge University Press, Cambridge.
254. Orland JR, Wright TL, Cooper S Acute hepatitis C. Hepatology 2001, 33:321-327.
255. Hoofnagle JH Hepatitis C: the clinical spectrum of disease. Hepatology 1997, 26:15S-20S.
256. Bowen DG, Walker CM Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005, 436:946-952.
257. El-Serag HB Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 2002, 36:S74-S83.
258. Kobayashi K, Hashimoto E, Ludwig J, et al. Liver biopsy features of acute hepatitis C compared with hepatitis A, B, and non-A, non-B, non-C. Liver 1993, 13:69-72.
259. Fabris P, Fleming VM, Giordani MT, Barnes E Acute hepatitis C: clinical aspects, diagnosis, and outcome of acute HCV infection. Curr Pharm Des 2008, 14:1661-1665.
260. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology 2000, 32:11-16.
261. Haber MM, West AB, Haber AD, Reuben A Relationship of aminotransferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 1995, 90:1250-1257.
262. Kyrlagkitsis I, Portmann B, Smith H, et al. Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT. Am J Gastroenterol 2003, 98:1588-1593.
263. Kaji K, Nakanuma Y, Sasaki M, et al. Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies. Mod Pathol 1994, 7:937-945.
264. Lefkowitch JH, Schiff ER, Davis GL, et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology 1993, 104:595-603.
265. Mosnier JF, Degott C, Marcellin P, et al. The intraportal lymphoid nodule and its environment in chronic active hepatitis C: an immunohistochemical study. Hepatology 1993, 17:366-371.
266. Khakoo SI, Soni PN, Savage K, et al. Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity. Am J Pathol 1997, 150:963-970.
267. Fartoux L, Poujol-Robert A, Guechot J, et al. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005, 54:1003-1008.
268. Moucari R, Asselah T, Cazals-Hatem D, et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology 2008, 134:416-423.
269. Monto A, Dove LM, Bostrom A, et al. Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfection. Hepatology 2005, 42:310-316.
270. Fillipowicz EA, Xiao S, Sower LE, et al. Detection of HCV in bile duct epithelium by laser capture microdissection (LCM). In Vivo 2005, 19:737-739.
271. Kaji K, Nakanuma Y, Harada K, et al. Hemosiderin deposition in portal endothelial cells is a histologic marker predicting poor response to interferon-alpha therapy in chronic hepatitis C. Pathol Int 1997, 47:347-352.
272. Boucher E, Bourienne A, Adams P, et al. Liver iron concentration and distribution in chronic hepatitis C before and after interferon treatment. Gut 1997, 41:115-120.
273. Chiaverini C, Halimi G, Ouzan D, et al. Porphyria cutanea tarda, C282Y, H63D and S65C HFE gene mutations and hepatitis C infection: a study from southern France. Dermatology 2003, 206:212-216.
274. Deugnier Y, Turlin B, le Quilleuc D, et al. A reappraisal of hepatic siderosis in patients with end-stage cirrhosis: practical implications for the diagnosis of hemochromatosis. Am J Surg Pathol 1997, 21:669-675.
275. Schluger LK, Sheiner PA, Thung SN, et al. Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology 1996, 23:971-976.
276. Ruggieri A, Harada T, Matsuura Y, Miyamura T Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 1997, 229:68-76.
277. Chisari FV Unscrambling hepatitis C virus-host interactions. Nature 2005, 436:930-932.
278. Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005, 11:791-796.
279. Bissig KD, Wieland SF, Tran P, et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 2010, 120:924-930.
280. Sakai A, Kaneko S, Honda M, et al. Quasispecies of hepatitis C virus in serum and in three different parts of the liver of patients with chronic hepatitis. Hepatology 1999, 30:556-561.
281. Pachiadakis I, Pollara G, Chain BM, Naoumov NV Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence?. Lancet Infect Dis 2005, 5:296-304.
282. Bortolami M, Kotsafti A, Cardin R, Farinati F Fas / FasL system, IL-1beta expression and apoptosis in chronic HBV and HCV liver disease. J Viral Hepat 2008, 15:515-522.
283. Hayashi N, Mita E Involvement of Fas system-mediated apoptosis in pathogenesis of viral hepatitis. J Viral Hepat 1999, 6:357-365.
284. Sene D, Limal N, Cacoub P Hepatitis C virus-associated extrahepatic manifestations: a review. Metab Brain Dis 2004, 19:357-381.
285. Cacoub P, Poynard T, Ghillani P, et al. Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 1999, 42:2204-2212.
286. Vassilopoulos D, Younossi ZM, Hadziyannis E, et al. Study of host and virological factors of patients with chronic HCV infection and associated laboratory or clinical autoimmune manifestations. Clin Exp Rheumatol 2003, 21:S101-S111.
287. Roboz GJ Hepatitis C and B-cell lymphoma. AIDS Patient Care STDS 1998, 12:605-609.
288. Safdar K, Schiff ER Alcohol and hepatitis C. Semin Liver Dis 2004, 24:305-315.
289. Schiff ER, Ozden N Hepatitis C and alcohol. Alcohol Res Health 2003, 27:232-239.
290. Jerrells TR Association of alcohol consumption and exaggerated immunopathologic effects in the liver induced by infectious organism. Front Biosci 2002, 7:d1487-d1493.
291. Anderson S, Nevins CL, Green LK, et al. Assessment of liver histology in chronic alcoholics with and without hepatitis C virus infection. Dig Dis Sci 2001, 46:1393-1398.
292. Mas VR, Fassnacht R, Archer KJ, Maluf D Molecular mechanisms involved in the interaction effects of alcohol and HCV in liver cirrhosis. Mol Med 2010, 16:287-297.
293. Hourigan LF, Macdonald GA, Purdie D, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 1999, 29:1215-1219.
294. Rizzetto M, Canese MG, Arico S, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut 1977, 18:997-1003.
295. Bean P Latest discoveries on the infection and coinfection with hepatitis D virus. Am Clin Lab 2002, 21:25-27.
296. Karayiannis P Hepatitis D virus. Rev Med Virol 1998, 8:13-24.
297. Taylor JM Replication of human hepatitis delta virus: recent developments. Trends Microbiol 2003, 11:185-190.
298. Diener TO Hepatitis delta virus-like agents: an overview. Prog Clin Biol Res 1993, 382:109-115.
299. Macnaughton TB, Li YI, Doughty AL, Lai MM Hepatitis delta virus RNA encoding the large delta antigen cannot sustain replication due to rapid accumulation of mutations associated with RNA editing. J Virol 2003, 77:12048-12056.
300. Taylor JM Replication of the hepatitis delta virus RNA genome. Adv Virus Research 2009, 74:103-121.
301. Li YJ, Macnaughton T, Gao L, Lai MM RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies. J Virol 2006, 80:6478-6486.
302. Gaeta GB, Stroffolini T, Chiaramonte M, et al. Chronic hepatitis D: a vanishing Disease? An Italian multicenter study. Hepatology 2000, 32:824-827.
303. Rizetto M Hepatitis D: thirty years later. J Hepatol 2009, 50:1043-1050.
304. Caredda F, Rossi E, d'Arminio Monforte A, et al. Hepatitis B virus-associated coinfection and superinfection with delta agent: indistinguishable disease with different outcome. J Infect Dis 1985, 151:925-928.
305. Negro F, Rizzetto M Diagnosis of hepatitis delta virus infection. J Hepatol 1995, 22:136-139.
306. Farci P, Smedile A, Lavarini C, et al. Delta hepatitis in inapparent carriers of hepatitis B surface antigen. A disease simulating acute hepatitis B progressive to chronicity. Gastroenterology 1983, 85:669-673.
307. Moreno A, Ramon y Cajal S, Marazuela M, et al. Sanded nuclei in delta patients. Liver 1989, 9:367-371.
308. Ohashi K, Marion PL, Nakai H, et al. Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses. Nat Med 2000, 6:327-331.
309. Guilhot S, Huang SN, Xia YP, et al. Expression of the hepatitis delta virus large and small antigens in transgenic mice. J Virol 1994, 68:1052-1058.
310. Netter HJ, Kajino K, Taylor JM Experimental transmission of human hepatitis delta virus to the laboratory mouse. J Virol 1993, 67:3357-3362.
311. Cole SM, Gowans EJ, Macnaughton TB, et al. Direct evidence for cytotoxicity associated with expression of hepatitis delta virus antigen. Hepatology 1991, 13:845-851.
312. Popper H, Thung SN, Gerber MA, et al. Histologic studies of severe delta agent infection in Venezuelan Indians. Hepatology 1983, 3:906-912.
313. Khuroo MS Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med 1980, 68:818-824.
314. Asher LV, Innis BL, Shrestha MP, et al. Virus-like particles in the liver of a patient with fulminant hepatitis and antibody to hepatitis E virus. J Med Virol 1990, 31:229-233.
315. Arankalle VA, Ticehurst J, Sreenivasan MA, et al. Aetiological association of a virus-like particle with enterically transmitted non-A, non-B hepatitis. Lancet 1988, i:550-554.
316. Panda SK, Datta R, Kaur J, et al. Enterically transmitted non-A, non-B hepatitis: recovery of virus-like particles from an epidemic in south Delhi and transmission studies in rhesus monkeys. Hepatology 1989, 10:466-472.
317. Zuckerman AJ Hepatitis E virus. The main cause of enterically transmitted non-A, non-B hepatitis. Br Med J 1990, 300:1475-1476.
318. Reyes G, Purdy M, Kim J, et al. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 1990, 247:1335-1339.
319. Soe S, Uchida T, Suzuki K, et al. Enterically transmitted non-A, non-B hepatitis in cynomolgus monkeys: morphology and probable mechanism of hepatocellular necrosis. Liver 1989, 9:135-145.
320. Takahashi K, Kang JH, Ohnishi S, et al. Full-length sequences of six hepatitis E virus isolates of genotypes III and IV from patients with sporadic acute or fulminant hepatitis in Japan. Intervirology 2003, 46:308-318.
321. Burcell RH, Everson SU Hepatitis E: an emerging awareness of an old disease. J Hepatol 2008, 48:494-503.
322. Purdy MA, Carson D, McCaustland KA, et al. Viral specificity of hepatitis E virus antigens identified by fluorescent antibody assay using recombinant HEV proteins. J Med Virol 1994, 44:212-214.
323. Krawczynski K Hepatitis E. Hepatology 1993, 17:932-941.
324. Harrison T Hepatitis E virus - an update. Liver 1999, 19:171-176.
325. Ramalingaswami V, Purcell RH Waterborne non-A, non-B hepatitis. Lancet 1988, 1:571-573.
326. Skidmore SJ, Yarbough PO, Gabor KA, et al. Imported hepatitis E in UK. Lancet 1991, 337:1541.
327. Johansson PJ, Mushahwar IK, Norkrans G, et al. Hepatitis E virus infections in patients with acute hepatitis non-A-D in Sweden. Scand J Infect Dis 1995, 27:543-546.
328. Clemente-Casares P, Pina S, Buti M, et al. Hepatitis E virus epidemiology in industrialized countries. Emerg Infect Dis 2003, 9:448-454.
329. Malcolm P, Dalton H, Hussaini HS, Mathew J The histology of autochthonous hepatitis E virus infection. Histopathology 2007, 51:190-194.
330. Khuroo MS, Teli MR, Skidmore S, et al. Incidence and severity of viral hepatitis in pregnancy. Am J Med 1981, 70:252-255.
331. Le Cann P, Tong MJ, Werneke J, Coursaget P Detection of antibodies to hepatitis E virus in patients with autoimmune chronic active hepatitis and primary biliary cirrhosis. Scand J Gastroenterol 1997, 32:387-389.
332. Wang CH, Tschen SY Hepatitis E virus and primary biliary cirrhosis. Q J Med 1997, 90:154-155.
333. Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 2008, 358:811-817.
334. Sylvan SP, Hellstrom UB, Hampl H, et al. Hepatitis E in patients with chronic autoimmune liver disease. JAMA 1995, 273:377-378.
335. Peron JM, Danjoux M, Kamar N, et al. Liver histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France. Virchows Arch 2007, 450:405-410.
336. Uchida T Hepatitis E: review. Gastroenterol Jpn 1992, 27:687-696.
337. Wendum D, Nachury M, Yver M, et al. Acute hepatitis E: a cause of lymphocytic destructive cholangitis. Hum Pathol 2005, 36:436-438.
338. Fagan EA, Ellis DS, Tovey GM, et al. Toga virus-like particles in acute liver failure attributed to sporadic non-A, non-B hepatitis and recurrence after liver transplantation. J Med Virol 1992, 38:71-77.
339. Deka N, Sharma M, Mukerjee R Isolation of the novel agent from human stool samples that is associated with sporadic non-A, non-B hepatitis. J Virol 1994, 68:7810-7815.
340. Simons J, Leary T, Dawson G, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nature Med 1995, 1:564-569.
341. Kao JH, Chen PJ, Lai MY, et al. GB virus-C/hepatitis G virus infection in an area endemic for viral hepatitis, chronic liver disease, and liver cancer. Gastroenterology 1997, 112:1265-1270.
342. Kaiser T, Tillmann HL GB virus C infection: is there a clinical relevance for patients infected with the human immunodeficiency virus?. AIDS Rev 2005, 7:3-12.
343. Barbosa AJ, Baggio-Zappia GL, Dobo C, et al. Analysis of GB virus C infection among HIV-HCV coinfected patients. Rev Soc Bras Med Tropo 2009, 42:591-593.
344. Burra P, Masier A, Boldrin C, et al. Torque Teno Virus: any pathological role in liver tranplanted patients?. Transplant International 2008, 21:972-979.
345. Umemura T, Tanaka E, Ostapowicz G, et al. Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis. J Infect Dis 2003, 188:1545-1552.
346. Moriyama M, Mikuni M, Matsumura H, et al. SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis. Liver Int 2005, 25:226-235.