The role of platelets in liver inflammation and regeneration

Seminars in Thrombosis and Hemostasis

Volumn 36, Issue 2, 2010, Pages 170-174

  Lisman, Ton ^a   Porte, Robert J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Hepatectomy; Hepatitis; Inflammation; Ischemia reperfusion; Liver; Platelet; Regeneration; Serotonin

Indexed keywords

APOPTOSIS; CYTOTOXIC T LYMPHOCYTE; HEPATITIS; HUMAN; KNOCKOUT MOUSE; LIVER DISEASE; LIVER INJURY; LIVER ISCHEMIA; LIVER REGENERATION; LIVER RESECTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICROCIRCULATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; VIRUS INFECTION;

BLOOD PLATELETS; HEPATITIS; HUMANS; LIVER CIRCULATION; LIVER REGENERATION; REPERFUSION INJURY; SEROTONIN;

EID: 77951599552     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0030-1251501     Document Type: Review

References (32)

1. Wagner D D., Burger P C. Platelets in inflammation and thrombosis. Arterioscler Thromb Vasc Biol 2003 23 (12) 2131-2137
2. Nurden A T., Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci 2008 13 3532-3548 (Pubitemid 351594702)
3. Borsig L. The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 2008 8 (8) 1247-1255
4. Italiano J E. Jr, Richardson J L., Patel-Hett S et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008 111 (3) 1227-1233 (Pubitemid 351213404)
5. Langer H F., Gawaz M. Platelets in regenerative medicine. Basic Res Cardiol 2008 103 (4) 299-307
6. Lev E I., Estrov Z, Aboulfatova K et al. Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix. Thromb Haemost 2006 96 (4) 498-504 (Pubitemid 44560686)
7. Diacovo T G., Roth S J., Buccola J M., Bainton D F., Springer T A. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood 1996 88 (1) 146-157
8. Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev 2009 23 (4) 177-189
9. Zimmerman G A., Weyrich A S. Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol 2008 28 (3) s17-s24
10. Witters P, Freson K, Verslype C et al. Review article: blood platelet number and function in chronic liver disease and cirrhosis. Aliment Pharmacol Ther 2008 27 (11) 1017-1029 (Pubitemid 351614886)
11. Goulis J, Chau T N., Jordan S et al. Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 1999 44 (5) 754-758 (Pubitemid 29195930)
12. Hugenholtz G G., Porte R J., Lisman T. The platelet and platelet function testing in liver disease. Clin Liver Dis 2009 13 (1) 11-20
13. Lisman T, Bongers T N., Adelmeijer J et al. Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 2006 44 (1) 53-61 (Pubitemid 44049138)
14. Cywes R, Packham M A., Tietze L et al. Role of platelets in hepatic allograft preservation injury in the rat. Hepatology 1993 18 (3) 635-647 (Pubitemid 23259965)
15. Sindram D, Porte R J., Hoffman M R., Bentley R C., Clavien P A. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000 118 (1) 183-191 (Pubitemid 30020386)
16. Khandoga A, Biberthaler P, Enders G et al. P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock 2002 18 (6) 529-535
17. Yadav S S., Howell D N., Steeber D A., Harland R C., Tedder T F., Clavien P A. P-Selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. Hepatology 1999 29 (5) 1494-1502
18. Cywes R, Mullen J B., Stratis M A. et al. Prediction of the outcome of transplantation in man by platelet adherence in donor liver allografts. Evidence of the importance of prepreservation injury. Transplantation 1993 56 (2) 316-323 (Pubitemid 23239431)
19. Sindram D, Porte R J., Hoffman M R., Bentley R C., Clavien P A. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000 118 (1) 183-191 (Pubitemid 30020386)
20. Sindram D, Porte R J., Hoffman M R., Bentley R C., Clavien P A. Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury. FASEB J 2001 15 (7) 1230-1232
21. Nocito A, Georgiev P, Dahm F et al. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 2007 45 (2) 369-376 (Pubitemid 46374593)
22. Nakamura M, Shibazaki M, Nitta Y, Endo Y. Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-1 and tumour necrosis factor: the role of Kupffer cells. J Hepatol 1998 28 (6) 991-999 (Pubitemid 28275978)
23. Endo Y, Nakamura M. The effect of lipopolysaccharide, interleukin-1 and tumour necrosis factor on the hepatic accumulation of 5-hydroxytryptamine and platelets in the mouse. Br J Pharmacol 1992 105 (3) 613-619
24. Clavien P A. Liver regeneration: a spotlight on the novel role of platelets and serotonin. Swiss Med Wkly 2008 138 (25-26) 361-370
25. Lesurtel M, Graf R, Aleil B et al. Platelet-derived serotonin mediates liver regeneration. Science 2006 312 (5770) 104-107
26. Murata S, Hashimoto I, Nakano Y, Myronovych A, Watanabe M, Ohkohchi N. Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats. Ann Surg 2008 248 (5) 821-828
27. Murata S, Ohkohchi N, Matsuo R, Ikeda O, Myronovych A, Hoshi R. Platelets promote liver regeneration in early period after hepatectomy in mice. World J Surg 2007 31 (4) 808-816 (Pubitemid 46496239)
28. Alkozai E M., Nijsten M, de Jong K P. et al. Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection. Ann Surg 2010 251 (2) 300-306
29. Lesurtel M, Graf R, Aleil B et al. Platelet-derived serotonin mediates liver regeneration. Science 2006 312 (5770) 104-107
30. Matondo R B., Punt C, Homberg J et al. Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration. Am J Physiol Gastrointest Liver Physiol 2009 296 (4) G963-G968
31. Iannacone M, Sitia G, Isogawa M et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 2005 11 (11) 1167-1169 (Pubitemid 43093662)
32. Lang P A., Contaldo C, Georgiev P et al. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 2008 14 (7) 756-761 (Pubitemid 351951519)