Torque Teno virus: Any pathological role in liver transplanted patients?

Transplant International

Volumn 21, Issue 10, 2008, Pages 972-979

  Burra, Patrizia ^a,b   Masier, Annalisa ^b   Boldrin, Caterina ^b   Calistri, Arianna ^b   Andreoli, Elisabetta ^c   Senzolo, Marco ^b   Zorzi, Manuel ^d   Sgarabotto, Dino ^b   Guido, Maria ^b   Cillo, Umberto ^b   Canova, Daniele ^b   Bendinelli, Mauro ^c   Pistello, Mauro ^c   Maggi, Fabrizio ^c   Palù, Giorgio ^b  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

Histological damage; Liver transplantation; TTV genogroups; TTV infection; Viral hepatitis

Indexed keywords

ACICLOVIR; ADEFOVIR DIPIVOXIL; ANTIVIRUS AGENT; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; LAMIVUDINE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PEGINTERFERON; PREDNISONE; RAPAMYCIN; RIBAVIRIN; STEROID; TACROLIMUS; VIRUS DNA;

ACUTE GRAFT REJECTION; ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ARTICLE; BLOOD ANALYSIS; CHRONIC HEPATITIS; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DELTA AGENT HEPATITIS; DRUG DOSE INCREASE; FEMALE; GENOTYPE; GRAFT REJECTION; HEPATITIS B; HEPATITIS C; HERPES VIRUS INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTRANSAMINASEMIA; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER DISEASE; LIVER GRAFT; LIVER INJURY; MALE; MONOTHERAPY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; TORQUE TENO VIRUS; TREATMENT OUTCOME; VIREMIA; VIRUS LOAD;

ADULT; AGED; BIOPSY; DNA VIRUS INFECTIONS; DNA, VIRAL; FEMALE; GENOTYPE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSION; ITALY; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; TORQUE TENO VIRUS;

EID: 51349155647     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2008.00714.x     Document Type: Article

References (31)

1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in post-transfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 1997 41 : 92.
2. Bendinelli M, Pistello M, Maggi F, Fornai C, Freer G, Vatteroni ML. Molecular properties, biology and clinical implication of TT virus, a recently identified widespread infectious agent of humans. Clin Microbiol Rev 2001 1 : 98.
3. Peng YH, Nishizawa T, Takahashi M, Ishikawa T, Yoshikawa A, Okamoto H. Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants. Arch Virol 2002 147 : 21.
4. Hu ZJ, Lang ZW, Zhou YS, et al. Clinicopathological study on TTV infection in hepatitis of unknown etiology. World J Gastroenterol 2002 8 : 288.
5. Gallian P, Berland Y, Olmer M, et al. TT virus infection in French hemodialysis patients: study of prevalence and risk factors. J Clin Microbiol 1999 37 : 2538.
6. Burra P, Mioni D, Cecchetto A, et al. Histological features after liver transplantation in alcoholic cirrhotics. J Hepatol 2001 34 : 716.
7. Targhetta S, Villamil F, Inturri P, et al. Protocol liver biopsies in the long term management of patients transplanted for hepatitis B-related liver disease. World J Gastroenterol 2006 12 : 1706.
8. Roche B, Samuel D. Treatment of hepatitis B and C after liver transplantation Part 1, hepatitis B. Transpl Int 2005 17 : 746.
9. Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991 13 : 372.
10. Burra P, Targhetta S, Pevere S, et al. Antiviral therapy for hepatitis C virus recurrence following liver transplantation: long-term results from a single center experience. Transplant Proc 2006 38 : 1127.
11. Willems M, Metselaar HJ, Tilanus HW, Schalm SW, de Man RA. Liver transplantation and hepatitis C. Transpl Int. 2002 15 : 61 (Epub 9 March 2002).
12. Lucey MR, Merion RM, Henley KS, et al. Selection for and outcome of liver transplantation in alcoholic liver disease. Gastroenterology 1992 102 : 1736.
13. Okamoto H, Takahashi M, Nishizawa T, et al. Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and non coding regions. Virology 1999 259 : 428.
14. Maggi F, Pifferi M, Fornai C, et al. TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol 2003 77 : 2418.
15. Maggi F, Andreoli E, Lanini L, et al. Relationships between total plasma load of TorqueTenoVirus (TTV) and TTV genogroups carried. J Clin Microbiol 2005 43 : 4807.
16. International Group Review. Alcoholic liver disease: morphological manifestations. Lancet 1981 1 : 707.
17. Pappo O, Ramo H, Starzl TE, Fung JJ, Demetris AJ. Structural integrity and identification of causes of liver allograft dysfunction occurring 5 years after transplantation. Am J Surg Pathol 1995 19 : 192.
18. Demetrius AJ, Batts KP, Yamabe H. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997 25 : 658.
19. Shang D, Lin YH, Rigopoulou I, Chen B, Alexander GJ, Allain JP. Detection of TT virus DNA in patients with liver disease and recipients of liver transplant. J Med Virol 2000 61 : 455.
20. Genovese D, Dettori S, Argentini C, et al. Molecular characterisation of SENV and TTV infections in hepatopathic liver-transplant patients. Arch Virol 2004 149 : 1423.
21. Love A, Stanzeit B, Li L, et al. TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels. Transfusion 2000 40 : 306.
22. Biagini P, Gallian P, Touinssi M, et al. High prevalence of TT virus infection in French blood donors revealed by the use of three PCR systems. Transfusion 2000 40 : 590.
23. Simmonds P, Davidson F, Lycett C, et al. Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet 1998 352 : 191.
24. Desai SM, Muerhoff AS, Leary TP, et al. Prevalence of TT virus infection in US blood donors and populations at risk for acquiring parenterally transmitted viruses. J Infect Dis 1999 179 : 1242.
25. Saback FL, Palmer TE, Sabino RR, et al. Infection with hepatitis A and TT viruses and socioeconomic status in Rio de Janeiro, Brazil. Scand J Infect Dis 2001 33 : 121.
26. Lin CL, Kyono W, Tongson J, et al. Fecal excretion of a novel human circovirus, TT virus, in healthy children. Clin Diagn Lab Immunol 2000 7 : 960.
27. Szl'adek G., Juh'asz A., Asztalos L., et al. Persisting TT virus (TTV) genogroup 1 variants in renal transplant recipients. Arch Virol 2003 48 : 841.
28. Lai YC, Hu RT, Yang SS, Wu CH. Coinfection of TT virus and response to interferon therapy in patients with chronic hepatitis B or C. World J Gastroenterol 2002 8 : 567.
29. Moen EM, Sagedal S, Bjoro K, Degre M, Opstad PK, Grinde B. Effect of immune modulation on TT virus (TTV) and TTV-like mini-virus (TLMV) viremia. J Med Virol 2003 70 : 177.
30. Maggi F., Pifferi M., Tempestini E., et al. TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases. J Virol 2003 77 : 9081.
31. Horváth R, Studeník P, Benedík J, Dendis M, Cerný J. TT virus infection in liver transplant recipients with cryptogenic cirrhosis. Vnitr Lek 2002 48 : 177.