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Volumn 3, Issue 5, 2009, Pages 499-512

Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus

Author keywords

Antiviral therapy; Disease progression; Hepatitis B virus; Host immunity; Immune therapy

Indexed keywords

ADEFOVIR DIPIVOXIL; ADENINE NUCLEOTIDE DERIVATIVE; ALPHA INTERFERON; DENDRITIC CELL VACCINE; EMTRICITABINE; GENE PRODUCT; HEPATITIS B VIRUS X PROTEIN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; HLA A2 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; LAMIVUDINE; PEGINTERFERON; PROGRAMMED CELL DEATH 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VIRUS DNA;

EID: 70449724811     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.09.50     Document Type: Review
Times cited : (67)

References (124)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM. Hepatitis B virus infection. N. Engl. J. Med. 337, 1733-1745 (1997).
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 2
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B Virus Infection - Natural History and Clinical Consequences
    • DOI 10.1056/NEJMra031087
    • Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N. Engl. J. Med. 350, 1118-1129 (2004). (Pubitemid 38298992)
    • (2004) New England Journal of Medicine , vol.350 , Issue.11 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 3
    • 33847701354 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 45, 507-539 (2007).
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.1    McMahon, B.J.2
  • 4
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag JL. Hepatitis B virus infection. N. Engl. J. Med. 359, 1486-1500 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 5
  • 6
    • 35348838379 scopus 로고    scopus 로고
    • Clinical immune characterization of hepatitis B virus infection and implications for immune intervention: Progress and challenges
    • Wang FS. Clinical immune characterization of hepatitis B virus infection and implications for immune intervention: progress and challenges. Hepatol. Res. 37(Suppl. 3), S339-S346 (2007).
    • (2007) Hepatol. Res. , vol.37 , Issue.SUPPL. 3
    • Wang, F.S.1
  • 7
    • 33846085749 scopus 로고    scopus 로고
    • Immunopathogenesis of hepatitis B virus infection
    • Chang JJ, Lewin SR. Immunopathogenesis of hepatitis B virus infection. Immunol. Cell Biol. 85, 16-23 (2007).
    • (2007) Immunol. Cell Biol. , vol.85 , pp. 16-23
    • Chang, J.J.1    Lewin, S.R.2
  • 8
    • 44949180106 scopus 로고    scopus 로고
    • Understanding the immunopathogenesis of chronic hepatitis B virus: An Asian prospective
    • DOI 10.1111/j.1440-1746.2008.05385.x
    • Tan AT, Koh S, Goh V, Bertoletti A. Understanding the immunopathogenesis of chronic hepatitis B virus: an Asian prospective. J. Gastroenterol. Hepatol. 23, 833-843 (2008). (Pubitemid 351806581)
    • (2008) Journal of Gastroenterology and Hepatology , vol.23 , Issue.6 , pp. 833-843
    • Tan, A.T.1    Koh, S.2    Goh, V.3    Bertoletti, A.4
  • 9
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Excellent and updated review that includes virological and immunological novel concepts regarding hepatitis B virus (HBV) infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5, 215-229 (2005). •• Excellent and updated review that includes virological and immunological novel concepts regarding hepatitis B virus (HBV) infection.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 10
    • 0036461318 scopus 로고    scopus 로고
    • Immunology of hepatitis B infection
    • Jung MC, Pape GR. Immunology of hepatitis B infection. Lancet Infect. Dis. 2, 43-50 (2002).
    • (2002) Lancet Infect. Dis. , vol.2 , pp. 43-50
    • Jung, M.C.1    Pape, G.R.2
  • 11
    • 0027919071 scopus 로고
    • Acute liver failure
    • Lee WM. Acute liver failure. N. Engl. J. Med. 329, 1862-1872 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1862-1872
    • Lee, W.M.1
  • 14
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • DOI 10.1126/science.284.5415.825
    • Guidotti LG, Rochford R, Chung J et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 284, 825-829 (1999). (Pubitemid 29291352)
    • (1999) Science , vol.284 , Issue.5415 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 16
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro P, Valdatta C, Boni C et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 58(7), 974-982 (2009).
    • (2009) Gut , vol.58 , Issue.7 , pp. 974-982
    • Fisicaro, P.1    Valdatta, C.2    Boni, C.3
  • 17
    • 35948985622 scopus 로고    scopus 로고
    • Innate immune response and hepatic inflammation
    • DOI 10.1055/s-2007-991511
    • Szabo G, Mandrekar P, Dolganiuc A. Innate immune response and hepatic inflammation. Semin. Liver Dis. 27, 339-350 (2007). (Pubitemid 350071835)
    • (2007) Seminars in Liver Disease , vol.27 , Issue.4 , pp. 339-350
    • Szabo, G.1    Mandrekar, P.2    Dolganiuc, A.3
  • 18
    • 3242711262 scopus 로고    scopus 로고
    • Innate sensing of viruses by Toll-like receptors
    • DOI 10.1128/JVI.78.15.7867-7873.2004
    • Boehme KW, Compton T. Innate sensing of viruses by Toll-like receptors. J. Virol. 78, 7867-7873 (2004). (Pubitemid 38944272)
    • (2004) Journal of Virology , vol.78 , Issue.15 , pp. 7867-7873
    • Boehme, K.W.1    Compton, T.2
  • 20
    • 0033998463 scopus 로고    scopus 로고
    • Intrahepatic induction of α/β interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    • Wieland SF, Guidotti LG, Chisari FV. Intrahepatic induction of α/β interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J. Virol. 74, 4165-4173 (2000).
    • (2000) J. Virol. , vol.74 , pp. 4165-4173
    • Wieland, S.F.1    Guidotti, L.G.2    Chisari, F.V.3
  • 21
    • 65449117568 scopus 로고    scopus 로고
    • Hepatitis B virus suppresses Toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
    • Wu J, Meng Z, Jiang M et al. Hepatitis B virus suppresses Toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 49, 1132-1140 (2009).
    • (2009) Hepatology , vol.49 , pp. 1132-1140
    • Wu, J.1    Meng, Z.2    Jiang, M.3
  • 22
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • DOI 10.1128/JVI.79.11.7269-7272.2005
    • Isogawa M, Robek MD, Furuichi Y, Chisari FV. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J. Virol. 79, 7269-7272 (2005). (Pubitemid 40677357)
    • (2005) Journal of Virology , vol.79 , Issue.11 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 23
    • 37749050365 scopus 로고    scopus 로고
    • Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice
    • Wu J, Lu M, Meng Z et al. Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice. Hepatology 46, 1769-1778 (2007).
    • (2007) Hepatology , vol.46 , pp. 1769-1778
    • Wu, J.1    Lu, M.2    Meng, Z.3
  • 24
    • 58149517671 scopus 로고    scopus 로고
    • Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
    • Guo H, Jiang D, Ma D et al. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J. Virol. 83, 847-858 (2009).
    • (2009) J. Virol. , vol.83 , pp. 847-858
    • Guo, H.1    Jiang, D.2    Ma, D.3
  • 26
    • 0033951066 scopus 로고    scopus 로고
    • Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines
    • DOI 10.1128/JVI.74.5.2255-2264.2000
    • McClary H, Koch R, Chisari FV, Guidotti LG. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74, 2255-2264 (2000). (Pubitemid 30091480)
    • (2000) Journal of Virology , vol.74 , Issue.5 , pp. 2255-2264
    • Mcclary, H.1    Koch, R.2    Chisari, F.V.3    Guidotti, L.G.4
  • 27
    • 0036097046 scopus 로고    scopus 로고
    • Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte culturest
    • DOI 10.1128/JVI.76.11.5646-5653.2002
    • Pasquetto V, Wieland SF, Uprichard SL, Tripodi M, Chisari FV. Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures. J. Virol. 76, 5646-5653 (2002). (Pubitemid 34517915)
    • (2002) Journal of Virology , vol.76 , Issue.11 , pp. 5646-5653
    • Pasquetto, V.1    Wieland, S.F.2    Uprichard, S.L.3    Tripodi, M.4    Chisari, F.V.5
  • 28
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • DOI 10.1016/S1074-7613(00)80295-2
    • Guidotti LG, Ishikawa T, Hobbs MV et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4, 25-36 (1996). (Pubitemid 26054933)
    • (1996) Immunity , vol.4 , Issue.1 , pp. 25-36
    • Guidotti, L.G.1    Ishikawa, T.2    Hobbs, M.V.3    Matzke, B.4    Schreiber, R.5    Chisari, F.V.6
  • 29
    • 33644544110 scopus 로고    scopus 로고
    • The liver as an immunological organ
    • Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology 43, S54-S62 (2006).
    • (2006) Hepatology , vol.43
    • Racanelli, V.1    Rehermann, B.2
  • 30
    • 42449088897 scopus 로고    scopus 로고
    • Natural killer cell recognition of missing self
    • DOI 10.1038/ni0508-477, PII NI0508-477
    • Karre K. Natural killer cell recognition of missing self. Nat. Immunol. 9, 477-480 (2008). (Pubitemid 351560515)
    • (2008) Nature Immunology , vol.9 , Issue.5 , pp. 477-480
    • Karre, K.1
  • 31
    • 0034596944 scopus 로고    scopus 로고
    • Natural killer T cell activation inhibits hepatitis B virus replication in vivo
    • DOI 10.1084/jem.192.7.921
    • Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192, 921-930 (2000). (Pubitemid 30765686)
    • (2000) Journal of Experimental Medicine , vol.192 , Issue.7 , pp. 921-930
    • Kakimi, K.1    Guidotti, L.G.2    Koezuka, Y.3    Chisari, F.V.4
  • 32
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to γ-2/interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • DOI 10.1084/jem.194.12.1755
    • Kakimi K, Lane TE, Wieland S et al. Blocking chemokine responsive to γ-2/ interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J. Exp. Med. 194, 1755-1766 (2001). (Pubitemid 34028655)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1755-1766
    • Kakimi, K.1    Lane, T.E.2    Wieland, S.3    Asensio, V.C.4    Campbell, I.L.5    Chisari, F.V.6    Guidotti, L.G.7
  • 33
    • 0036839012 scopus 로고    scopus 로고
    • Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice
    • Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J. Immunol. 169, 5188-5195 (2002). (Pubitemid 35217189)
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 5188-5195
    • Kimura, K.1    Kakimi, K.2    Wieland, S.3    Guidotti, L.G.4    Chisari, F.V.5
  • 34
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23, 275-306 (2005).
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 35
    • 33847752705 scopus 로고    scopus 로고
    • Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion
    • DOI 10.1002/hep.21457
    • Kingham TP, Chaudhry UI, Plitas G et al. Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion. Hepatology 45, 445-454 (2007). (Pubitemid 46374601)
    • (2007) Hepatology , vol.45 , Issue.2 , pp. 445-454
    • Kingham, T.P.1    Chaudhry, U.I.2    Plitas, G.3    Katz, S.C.4    Raab, J.5    Dematteo, R.P.6
  • 36
    • 14844309280 scopus 로고    scopus 로고
    • Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2)
    • DOI 10.1111/j.1440-1746.2004.03529.x
    • Duan XZ, Zhuang H, Wang M et al. Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2). J. Gastroenterol. Hepatol. 20, 234-242 (2005). (Pubitemid 40343275)
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.2 , pp. 234-242
    • Duan, X.-Z.1    Zhuang, H.2    Wang, M.3    Li, H.-W.4    Liu, J.-C.5    Wang, F.-S.6
  • 40
    • 0037213545 scopus 로고    scopus 로고
    • + T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • + T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 77, 68-76 (2003).
    • (2003) J. Virol. , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3
  • 41
    • 33645220927 scopus 로고    scopus 로고
    • + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection
    • + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J. Virol. 80, 3532-3540 (2006).
    • (2006) J. Virol. , vol.80 , pp. 3532-3540
    • Boettler, T.1    Panther, E.2    Bengsch, B.3
  • 42
    • 0036892605 scopus 로고    scopus 로고
    • + lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C
    • + lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J. Virol. 76, 12423-12434 (2002).
    • (2002) J. Virol. , vol.76 , pp. 12423-12434
    • Urbani, S.1    Boni, C.2    Missale, G.3
  • 43
    • 2442684151 scopus 로고    scopus 로고
    • Memory CD8 T-cell differentiation during viral infection
    • DOI 10.1128/JVI.78.11.5535-5545.2004
    • Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J. Virol. 78, 5535-5545 (2004). (Pubitemid 38661640)
    • (2004) Journal of Virology , vol.78 , Issue.11 , pp. 5535-5545
    • Wherry, E.J.1    Ahmed, R.2
  • 44
    • 44649166448 scopus 로고    scopus 로고
    • Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    • One of the first articles to define the dynamics of programmed cell death (PD)-1 expression associated with the outcome of acute HBV infection
    • Zhang Z, Zhang JY, Wherry EJ et al. Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology 134, 1938-1949 (2008). • One of the first articles to define the dynamics of programmed cell death (PD)-1 expression associated with the outcome of acute HBV infection.
    • (2008) Gastroenterology , vol.134 , pp. 1938-1949
    • Zhang, Z.1    Zhang, J.Y.2    Wherry, E.J.3
  • 45
    • 67349172179 scopus 로고    scopus 로고
    • Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients
    • One of the first articles to define the dynamics of PD-1 expression associated with the outcome of acute HBV infection
    • Zhang Z, Jin B, Zhang JY et al. Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients. J. Hepatol. 50, 1163-1173 (2009). • One of the first articles to define the dynamics of PD-1 expression associated with the outcome of acute HBV infection.
    • (2009) J. Hepatol. , vol.50 , pp. 1163-1173
    • Zhang, Z.1    Jin, B.2    Zhang, J.Y.3
  • 46
    • 22544479154 scopus 로고    scopus 로고
    • + T cell effector functions after antigen recognition in the liver
    • + T cell effector functions after antigen recognition in the liver. Immunity 23, 53-63 (2005).
    • (2005) Immunity , vol.23 , pp. 53-63
    • Isogawa, M.1    Furuichi, Y.2    Chisari, F.V.3
  • 49
    • 69249113887 scopus 로고    scopus 로고
    • Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections
    • Oliviero B, Varchetta S, Paudice E et al. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 137(3), 1151-1160 (2009).
    • (2009) Gastroenterology , vol.137 , Issue.3 , pp. 1151-1160
    • Oliviero, B.1    Varchetta, S.2    Paudice, E.3
  • 51
    • 58249123434 scopus 로고    scopus 로고
    • Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression
    • Du J, Liang X, Liu Y et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell Death Differ. 16, 219-229 (2009).
    • (2009) Cell Death Differ. , vol.16 , pp. 219-229
    • Du, J.1    Liang, X.2    Liu, Y.3
  • 52
    • 0037270978 scopus 로고    scopus 로고
    • Hepatic T cells and liver tolerance
    • Useful paper describing the association between the immune microenvironment and immune tolerance in the liver
    • Crispe IN. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51-62 (2003). •• Useful paper describing the association between the immune microenvironment and immune tolerance in the liver.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 51-62
    • Crispe, I.N.1
  • 53
    • 0037302569 scopus 로고    scopus 로고
    • Dendritic cells and immune regulation in the liver
    • Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut 52, 307-314 (2003).
    • (2003) Gut , vol.52 , pp. 307-314
    • Lau, A.H.1    Thomson, A.W.2
  • 54
    • 1542319876 scopus 로고    scopus 로고
    • Interleukin-10 Secretion Differentiates Dendritic Cells from Human Liver and Skin
    • Goddard S, Youster J, Morgan E, Adams DH. Interleukin-10 secretion differentiates dendritic cells from human liver and skin. Am. J. Pathol. 164, 511-519 (2004). (Pubitemid 38364667)
    • (2004) American Journal of Pathology , vol.164 , Issue.2 , pp. 511-519
    • Goddard, S.1    Youster, J.2    Morgan, E.3    Adams, D.H.4
  • 55
    • 0036623462 scopus 로고    scopus 로고
    • Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases
    • DOI 10.1016/S0168-8278(02)00062-4, PII S0168827802000624
    • Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A. Phenotypic ana lysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases. J. Hepatol. 36, 734-741 (2002). (Pubitemid 35177401)
    • (2002) Journal of Hepatology , vol.36 , Issue.6 , pp. 734-741
    • Kunitani, H.1    Shimizu, Y.2    Murata, H.3    Higuchi, K.4    Watanabe, A.5
  • 57
    • 0034812992 scopus 로고    scopus 로고
    • Antigen-presenting cells at the liver tissue in patients with chronic viral liver diseases: CD83-positive mature dendritic cells at the vicinity of focal and confluent necrosis
    • DOI 10.1016/S1386-6346(01)00084-5
    • Tanimoto K, Akbar SM, Michitaka K, Horiike N, Onji M. Antigen-presenting cells at the liver tissue in patients with chronic viral liver diseases: CD83-positive mature dendritic cells at the vicinity of focal and confluent necrosis. Hepatol. Res. 21, 117-125 (2001). (Pubitemid 32899082)
    • (2001) Hepatology Research , vol.21 , Issue.2 , pp. 117-125
    • Tanimoto, K.1    Akbar, S.K.M.F.2    Michitaka, K.3    Horiike, N.4    Onji, M.5
  • 58
    • 33846083817 scopus 로고    scopus 로고
    • Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B
    • DOI 10.1016/j.clim.2006.09.006, PII S1521661606008783
    • Zhang Z, Chen D, Yao J et al. Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B. Clin. Immunol. 122, 173-180 (2007). (Pubitemid 46073893)
    • (2007) Clinical Immunology , vol.122 , Issue.2 , pp. 173-180
    • Zhang, Z.1    Chen, D.2    Yao, J.3    Zhang, H.4    Jin, L.5    Shi, M.6    Zhang, H.7    Wang, F.-S.8
  • 59
    • 48449101734 scopus 로고    scopus 로고
    • Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-onchronic hepatitis B liver failure
    • Zhang Z, Zou ZS, Fu JL et al. Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-onchronic hepatitis B liver failure. J. Hepatol. 49, 396-406 (2008).
    • (2008) J. Hepatol. , vol.49 , pp. 396-406
    • Zhang, Z.1    Zou, Z.S.2    Fu, J.L.3
  • 60
    • 0034678435 scopus 로고    scopus 로고
    • + cells in liver damage and viral control during persistent hepatitis B virus infection
    • + cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 191, 1269-1280 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3
  • 62
    • 43049112084 scopus 로고    scopus 로고
    • Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
    • Provides explanations for HBV-specific CD8 T-cell depletion in chronic HBV infection
    • Lopes AR, Kellam P, Das A et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835-1845 (2008). • Provides explanations for HBV-specific CD8 T-cell depletion in chronic HBV infection.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1835-1845
    • Lopes, A.R.1    Kellam, P.2    Das, A.3
  • 64
    • 18844366609 scopus 로고    scopus 로고
    • Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans
    • DOI 10.1007/s10875-004-6249-y
    • Duan XZ, Wang M, Li HW et al. Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans. J. Clin. Immunol. 24, 637-646 (2004). (Pubitemid 40933115)
    • (2004) Journal of Clinical Immunology , vol.24 , Issue.6 , pp. 637-646
    • Duan, X.-Z.1    Wang, M.2    Li, H.-W.3    Zhuang, H.4    Xu, D.5    Wang, F.-S.6
  • 65
    • 2442665419 scopus 로고    scopus 로고
    • Selective functional deficit in dendritic cell - T cell interaction is a crucial mechanism in chronic hepatitis B virus infection
    • DOI 10.1111/j.1365-2893.2004.00497.x
    • Zheng BJ, Zhou J, Qu D et al. Selective functional deficit in dendritic cell - T cell interaction is a crucial mechanism in chronic hepatitis B virus infection. J. Viral Hepat. 11, 217-224 (2004). (Pubitemid 38658446)
    • (2004) Journal of Viral Hepatitis , vol.11 , Issue.3 , pp. 217-224
    • Zheng, B.J.1    Zhou, J.2    Qu, D.3    Siu, K.L.4    Lam, T.W.5    Lo, H.Y.6    Lee, S.S.7    Wen, Y.M.8
  • 67
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • Stoop JN, van der Molen RG, Baan CC et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41, 771-778 (2005).
    • (2005) Hepatology , vol.41 , pp. 771-778
    • Stoop, J.N.1    Van Der Molen, R.G.2    Baan, C.C.3
  • 68
    • 14744271751 scopus 로고    scopus 로고
    • + regulatory T cells in patients with hepatitis B virus infection
    • + regulatory T cells in patients with hepatitis B virus infection. J. Virol. 79, 3322-3328 (2005).
    • (2005) J. Virol. , vol.79 , pp. 3322-3328
    • Franzese, O.1    Kennedy, P.T.2    Gehring, A.J.3
  • 69
    • 34548796457 scopus 로고    scopus 로고
    • Tumor necrosis factor a inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response
    • Stoop JN, Woltman AM, Biesta PJ et al. Tumor necrosis factor a inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response. Hepatology 46, 699-705 (2007).
    • (2007) Hepatology , vol.46 , pp. 699-705
    • Stoop, J.N.1    Woltman, A.M.2    Biesta, P.J.3
  • 70
    • 33745323050 scopus 로고    scopus 로고
    • + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J. Immunol. 177, 739-747 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 739-747
    • Xu, D.1    Fu, J.2    Jin, L.3
  • 72
    • 34248185086 scopus 로고    scopus 로고
    • B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B
    • Chen L, Zhang Z, Chen W et al. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J. Immunol. 178, 6634-6641 (2007). (Pubitemid 46717448)
    • (2007) Journal of Immunology , vol.178 , Issue.10 , pp. 6634-6641
    • Chen, L.1    Zhang, Z.2    Chen, W.3    Zhang, Z.4    Li, Y.5    Shi, M.6    Zhang, J.7    Chen, L.8    Wang, S.9    Wang, F.-S.10
  • 74
    • 51049123791 scopus 로고    scopus 로고
    • Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
    • Das A, Hoare M, Davies N et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J. Exp. Med. 205, 2111-2124 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2111-2124
    • Das, A.1    Hoare, M.2    Davies, N.3
  • 76
    • 35348819908 scopus 로고    scopus 로고
    • Autoimmune diseases of the liver, autoimmune hepatitis and primary biliary cirrhosis: Unfinished business
    • Mackay IR. Autoimmune diseases of the liver, autoimmune hepatitis and primary biliary cirrhosis: unfinished business. Hepatol. Res. 37(Suppl. 3), S357-S364 (2007).
    • (2007) Hepatol. Res. , vol.37 , Issue.SUPPL. 3
    • Mackay, I.R.1
  • 77
    • 0029986179 scopus 로고    scopus 로고
    • Proteasome complex as a potential cellular target of hepatitis B virus X protein
    • Huang J, Kwong J, Sun EC, Liang TJ. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J. Virol. 70, 5582-5591 (1996). (Pubitemid 26240735)
    • (1996) Journal of Virology , vol.70 , Issue.8 , pp. 5582-5591
    • Huang, J.1    Kwong, J.2    Sun, E.C.-Y.3    Liang, T.J.4
  • 78
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Bouchard MJ, Schneider RJ. The enigmatic X gene of hepatitis B virus. J. Virol. 78, 12725-12734 (2004).
    • (2004) J. Virol. , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 79
    • 65349104743 scopus 로고    scopus 로고
    • Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-κB and the mitochondrial permeability transition pore
    • Clippinger AJ, Gearhart TL, Bouchard MJ. Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-κB and the mitochondrial permeability transition pore. J. Virol. 83, 4718-4731 (2009).
    • (2009) J. Virol. , vol.83 , pp. 4718-4731
    • Clippinger, A.J.1    Gearhart, T.L.2    Bouchard, M.J.3
  • 80
    • 47049100688 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    • Clippinger AJ, Bouchard MJ. Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J. Virol. 82, 6798-6811 (2008).
    • (2008) J. Virol. , vol.82 , pp. 6798-6811
    • Clippinger, A.J.1    Bouchard, M.J.2
  • 81
    • 0142151773 scopus 로고    scopus 로고
    • Exploring the Biological Basis of Hepatitis B e Antigen in Hepatitis B Virus Infection
    • DOI 10.1053/jhep.2003.50453
    • Milich D, Liang TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 38, 1075-1086 (2003). (Pubitemid 37314815)
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1075-1086
    • Milich, D.1    Liang, T.J.2
  • 82
    • 67449110843 scopus 로고    scopus 로고
    • Interaction of the hepatitis B core antigen and the innate immune system
    • Lee BO, Tucker A, Frelin L et al. Interaction of the hepatitis B core antigen and the innate immune system. J. Immunol. 182, 6670-6681 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 6670-6681
    • Lee, B.O.1    Tucker, A.2    Frelin, L.3
  • 83
    • 0030959049 scopus 로고    scopus 로고
    • Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B
    • Indicated, for the first time, that a IFN-a therapy-induced immune response is key to clear the virus in vivo
    • Rossol S, Marinos G, Carucci P et al. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99, 3025-3033 (1997). • Indicated, for the first time, that a IFN-a therapy-induced immune response is key to clear the virus in vivo.
    • (1997) J. Clin. Invest. , vol.99 , pp. 3025-3033
    • Rossol, S.1    Marinos, G.2    Carucci, P.3
  • 84
    • 33645229491 scopus 로고    scopus 로고
    • Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection
    • Untergasser A, Zedler U, Langenkamp A et al. Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection. Hepatology 43, 539-547 (2006).
    • (2006) Hepatology , vol.43 , pp. 539-547
    • Untergasser, A.1    Zedler, U.2    Langenkamp, A.3
  • 86
    • 0034533209 scopus 로고    scopus 로고
    • + T cells results in antigen-specific T-cell tolerance
    • + T cells results in antigen-specific T-cell tolerance. Nat. Med. 6, 1348-1354 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 1348-1354
    • Limmer, A.1    Ohl, J.2    Kurts, C.3
  • 89
    • 38549182325 scopus 로고    scopus 로고
    • A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients
    • Liu HG, Fan ZP, Chen WW et al. A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients. Clin. Exp. Immunol. 151, 441-447 (2008).
    • (2008) Clin. Exp. Immunol. , vol.151 , pp. 441-447
    • Liu, H.G.1    Fan, Z.P.2    Chen, W.W.3
  • 90
    • 36148963701 scopus 로고    scopus 로고
    • The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope
    • Liu HG, Chen WW, Fan ZP et al. The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope. Clin. Immunol. 125, 337-345 (2007).
    • (2007) Clin. Immunol. , vol.125 , pp. 337-345
    • Liu, H.G.1    Chen, W.W.2    Fan, Z.P.3
  • 91
    • 0036787682 scopus 로고    scopus 로고
    • Imbalanced intrahepatic expression of interleukin 12, interferon γ, and interleukin 10 in fulminant hepatitis B
    • Leifeld L, Cheng S, Ramakers J et al. Imbalanced intrahepatic expression of interleukin 12, interferon γ, and interleukin 10 in fulminant hepatitis B. Hepatology 36, 1001-1008 (2002).
    • (2002) Hepatology , vol.36 , pp. 1001-1008
    • Leifeld, L.1    Cheng, S.2    Ramakers, J.3
  • 92
    • 33745882961 scopus 로고    scopus 로고
    • Reduced monocyte HLA-DR expression: A novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure
    • Antoniades CG, Berry PA, Davies ET et al. Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology 44, 34-43 (2006).
    • (2006) Hepatology , vol.44 , pp. 34-43
    • Antoniades, C.G.1    Berry, P.A.2    Davies, E.T.3
  • 93
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-2250 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 94
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor- Related apoptosis-inducing ligand
    • DOI 10.1038/75045
    • Jo M, Kim TH, Seol DW et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med. 6, 564-567 (2000). (Pubitemid 30305907)
    • (2000) Nature Medicine , vol.6 , Issue.5 , pp. 564-567
    • Jo, M.1    Kim, T.-H.2    Seol, D.-W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6    Strom, S.C.7
  • 96
    • 1642367212 scopus 로고    scopus 로고
    • Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection
    • Lee JY, Chae DW, Kim SM et al. Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection. J. Viral Hepat. 11, 130-135 (2004).
    • (2004) J. Viral Hepat. , vol.11 , pp. 130-135
    • Lee, J.Y.1    Chae, D.W.2    Kim, S.M.3
  • 97
    • 61949335187 scopus 로고    scopus 로고
    • Fibrogenesis in pediatric cholestatic liver disease: Role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment
    • Ramm GA, Shepherd RW, Hoskins AC et al. Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment. Hepatology 49, 533-544 (2009).
    • (2009) Hepatology , vol.49 , pp. 533-544
    • Ramm, G.A.1    Shepherd, R.W.2    Hoskins, A.C.3
  • 99
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • Zhang JP, Yan J, Xu J et al. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 50, 980-989 (2009).
    • (2009) J. Hepatol. , vol.50 , pp. 980-989
    • Zhang, J.P.1    Yan, J.2    Xu, J.3
  • 101
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • DOI 10.1016/j.ccr.2006.06.016, PII S1535610806002145
    • Budhu A, Forgues M, Ye QH et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10, 99-111 (2006). (Pubitemid 44202603)
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.-H.3    Jia, H.-L.4    He, P.5    Zanetti, K.A.6    Kammula, U.S.7    Chen, Y.8    Qin, L.-X.9    Tang, Z.-Y.10    Wang, X.W.11
  • 102
    • 66149162007 scopus 로고    scopus 로고
    • Benefits and risks of interferon therapy for hepatitis B
    • Perrillo R. Benefits and risks of interferon therapy for hepatitis B. Hepatology 49, S103-S111 (2009).
    • (2009) Hepatology , vol.49
    • Perrillo, R.1
  • 108
    • 33750610311 scopus 로고    scopus 로고
    • Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV
    • DOI 10.1002/hep.21340
    • van der Molen RG, Sprengers D, Biesta PJ, Kusters JG, Janssen HL. Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV. Hepatology 44, 907-914 (2006). (Pubitemid 46489555)
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 907-914
    • Van Der Molen, R.G.1    Sprengers, D.2    Biesta, P.J.3    Kusters, J.G.4    Janssen, H.L.A.5
  • 109
    • 34047266620 scopus 로고    scopus 로고
    • Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B
    • Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, Janssen HL. Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B. Virology 361, 141-148 (2007).
    • (2007) Virology , vol.361 , pp. 141-148
    • Stoop, J.N.1    Van Der Molen, R.G.2    Kuipers, E.J.3    Kusters, J.G.4    Janssen, H.L.5
  • 110
    • 51349132036 scopus 로고    scopus 로고
    • Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion
    • Evans A, Riva A, Cooksley H et al. Programmed death 1 expression during antiviral treatment of chronic hepatitis B: impact of hepatitis B e-antigen seroconversion. Hepatology 48, 759-769 (2008).
    • (2008) Hepatology , vol.48 , pp. 759-769
    • Evans, A.1    Riva, A.2    Cooksley, H.3
  • 111
    • 20444436447 scopus 로고    scopus 로고
    • + T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection
    • + T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection. J. Hepatol. 43, 45-52 (2005).
    • (2005) J. Hepatol. , vol.43 , pp. 45-52
    • Tang, T.J.1    Kwekkeboom, J.2    Mancham, S.3
  • 113
    • 14844304318 scopus 로고    scopus 로고
    • Persistence of HBV-DNA in children with chronic hepatitis B who seroconverted to anti-HBs antibodies after interferon-α therapy: Correlation with specific IgG subclass responses to HBsAg
    • DOI 10.1016/j.jhep.2004.11.036
    • Gregorek H, Dzierzanowska-Fangrat K, Woynarowski M et al. Persistence of HBV-DNA in children with chronic hepatitis B who seroconverted to anti-HBs antibodies after interferon-α therapy: correlation with specific IgG subclass responses to HBsAg. J. Hepatol. 42, 486-490 (2005). (Pubitemid 40342926)
    • (2005) Journal of Hepatology , vol.42 , Issue.4 , pp. 486-490
    • Gregorek, H.1    Dzierzanowska-Fangrat, K.2    Woynarowski, M.3    Jozwiak, P.4    Witkowska-Vogtt, E.5    Socha, J.6    Syczewska, M.7    Madalinski, K.8
  • 114
    • 35748936151 scopus 로고    scopus 로고
    • Response to interferon-α treatment correlates with recovery of blood plasmacytoid dendritic cells in children with chronic hepatitis B
    • DOI 10.1016/j.jhep.2007.07.019, PII S0168827807004710
    • Zhang Z, Zhang H, Chen D et al. Response to interferon-α treatment correlates with recovery of blood plasmacytoid dendritic cells in children with chronic hepatitis B. J. Hepatol. 47, 751-759 (2007). (Pubitemid 350051116)
    • (2007) Journal of Hepatology , vol.47 , Issue.6 , pp. 751-759
    • Zhang, Z.1    Zhang, H.2    Chen, D.3    Yao, J.4    Fu, J.5    Jin, L.6    Wang, F.-S.7
  • 115
    • 66149171762 scopus 로고    scopus 로고
    • Monitoring during and after antiviral therapy for hepatitis B
    • Andersson KL, Chung RT. Monitoring during and after antiviral therapy for hepatitis B. Hepatology 49, S166-S173 (2009).
    • (2009) Hepatology , vol.49
    • Andersson, K.L.1    Chung, R.T.2
  • 116
    • 33744502624 scopus 로고    scopus 로고
    • Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection
    • Akbar SM, Horiike N, Onji M. Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection. World J. Gastroenterol. 12, 2876-2883 (2006). (Pubitemid 43805457)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.19 , pp. 2876-2883
    • Akbar, Sk.Md.F.1    Horiike, N.2    Onji, M.3
  • 117
    • 67349100632 scopus 로고    scopus 로고
    • Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection
    • Shi M, Fu J, Shi F et al. Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection. Clin. Immunol. 132, 43-54 (2009).
    • (2009) Clin. Immunol. , vol.132 , pp. 43-54
    • Shi, M.1    Fu, J.2    Shi, F.3
  • 118
    • 44649136845 scopus 로고    scopus 로고
    • Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells
    • Provides evidence that adoptive mesenchymal stem cell treatment may represent a new therapeutic approach for patients with liver disease
    • Kuo TK, Hung SP, Chuang CH et al. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 134, 2111-2121 (2008). •• Provides evidence that adoptive mesenchymal stem cell treatment may represent a new therapeutic approach for patients with liver disease.
    • (2008) Gastroenterology , vol.134 , pp. 2111-2121
    • Kuo, T.K.1    Hung, S.P.2    Chuang, C.H.3
  • 119
    • 56549113250 scopus 로고    scopus 로고
    • The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis
    • Dai LJ, Li HY, Guan LX, Ritchie G, Zhou JX. The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis. Stem Cell Res. 2, 16-25 (2009).
    • (2009) Stem Cell Res. , vol.2 , pp. 16-25
    • Dai, L.J.1    Li, H.Y.2    Guan, L.X.3    Ritchie, G.4    Zhou, J.X.5
  • 120
    • 70349733505 scopus 로고    scopus 로고
    • Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A Phase I-II clinical trial
    • Kharaziha P, Hellstrom PM, Noorinayer B et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a Phase I-II clinical trial. Eur. J. Gastroenterol. Hepatol. 21(10), 1199-1205 (2009).
    • (2009) Eur. J. Gastroenterol. Hepatol. , vol.21 , Issue.10 , pp. 1199-1205
    • Kharaziha, P.1    Hellstrom, P.M.2    Noorinayer, B.3
  • 122
    • 70449714637 scopus 로고    scopus 로고
    • Bringing the antiviral therapy home for chronic hepatitis B patients: Host immunity influences the efficacy and disease prognosis
    • Wang FS, Zhang JY. Bringing the antiviral therapy home for chronic hepatitis B patients: host immunity influences the efficacy and disease prognosis. Zhonghua Gan Zang Bing Za Zhi 17, 164-166 (2009).
    • (2009) Zhonghua Gan Zang Bing Za Zhi , vol.17 , pp. 164-166
    • Wang, F.S.1    Zhang, J.Y.2
  • 123
    • 33749364107 scopus 로고    scopus 로고
    • Hepatitis B virus replication and liver disease progression: The impact of antiviral therapy
    • Liaw YF. Hepatitis B virus replication and liver disease progression: the impact of antiviral therapy. Antivir. Ther. 11, 669-679 (2006).
    • (2006) Antivir. Ther. , vol.11 , pp. 669-679
    • Liaw, Y.F.1
  • 124
    • 34249993791 scopus 로고    scopus 로고
    • Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: Preclinical studies in the woodchuck model
    • DOI 10.1517/13543784.16.6.787
    • Lu M, Menne S, Yang D, Xu Y, Roggendorf M. Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model. Expert. Opin. Investig. Drugs 16, 787-801 (2007). (Pubitemid 46882354)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.6 , pp. 787-801
    • Lu, M.1    Menne, S.2    Yang, D.3    Yu, Y.4    Roggendorf, M.5


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