Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice

Journal of Virology

Volumn 76, Issue 6, 2002, Pages 2617-2621

  Guidotti, Luca G ^a   Morris, Amber ^a   Mendez, Heike ^a   Koch, Rick ^a   Silverman, Robert H ^a   Williams, Bryan R G ^a   Chisari, Francis V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; GENE PRODUCT; INTERFERON REGULATORY FACTOR 1; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE; RIBONUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEPATITIS; HEPATITIS B VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VIRUS REPLICATION;

ANIMALS; DNA-BINDING PROTEINS; EIF-2 KINASE; ENDORIBONUCLEASES; GENE EXPRESSION REGULATION, VIRAL; HEPATITIS B; HEPATITIS B VIRUS; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE II; INTERFERON-GAMMA, RECOMBINANT; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOPROTEINS; POLY I-C; VIRUS REPLICATION;

EID: 0036187835     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.6.2617-2621.2002     Document Type: Article

References (34)

1. iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1
2. Inhibition of hepatitis B virus (HBV) replication during adenovirus and cytomegalovirus infections in HBV transgenic mice
3. Interleukin-12 inhibits hepatitis B virus (HBV) replication in HBV transgenic mice
4. Hepatitis B virus immunopathogenesis
5. Inhibition of cell-free protein synthesis by pppA2′p5′A2′p5′A: A novel oligonucleotide synthesized by interferon-treated L cell extracts
6. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
7. Functional classification of interferon-stimulated genes identified using microarrays
8. Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replication
9. Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver
10. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
11. High-level hepatitis B virus replication in transgenic mice
12. Mx proteins: Mediators of innate resistance to RNA viruses
13. Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A
14. An overview of the interferon system: Signal transduction and mechanisms of action
15. pppA2′p5′A2′p5′A: An inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells
16. Involvement of the IRF-1 transcription factor in antiviral responses to interferons
17. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-kappaB
18. RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection
19. The role of transgenic knockout models in defining the pathogenesis of viral heart disease
20. Regulation of human immunodeficiency virus replication by 2′,5′-oligoadenylate-dependent RNase L
21. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines
22. Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth
23. Reoviruses and the interferon system
24. Interferon-induced proteins and the antiviral state
25. How cells respond to interferons
26. How hepatitis C virus counteracts the interferon response: The jury is still out on NS5A
27. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
28. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
29. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
30. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
31. Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
32. Interferon action and apoptosis are defective in mice devoid of 2′,5′- oligoadenylate-dependent RNase L
33. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways
34. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs