Increased hepatic iron deposition resulting from treatment of chronic hepatitis C with ribavirin

American Journal of Clinical Pathology

Volumn 113, Issue 1, 2000, Pages 35-39

  Fiel, M Isabel ^a   Schiano, Thomas D ^b   Guido, Maria ^a   Thung, Swan N ^a   Lindsay, Karen L ^c   Davis, Gary L ^d   Lewis, James H ^e   Seeff, Leonard B ^f   Bodenheimer Jr , Henry C ^b,g  

^a Lillian Henry M Stratton Hans P   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Hemosiderosis; Hepatitis C virus; Interferon; Viral hepatitis

Indexed keywords

ALPHA INTERFERON; IRON; PLACEBO; RIBAVIRIN;

ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INDUCED DISEASE; HEMOLYSIS; HEMOLYTIC ANEMIA; HEMOSIDEROSIS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IRON STORAGE; KUPFFER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER INJURY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0034005999     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/2grw-bq0e-6kyq-9gmf     Document Type: Article

References (30)

1. Bacon BR. Diagnosis and management of hemochromatosis. Gastroenterology. 1997;13:995-999.
2. Di Bisceglie AM, Bacon BR, Kleiner DE, et al. Increase in hepatic iron stores following prolonged therapy with ribavirin in patients with chronic hepatitis C. J Hepatol. 1994;21:1109-1112.
3. Olynyk JK, Reddy KR, Di Bisceglie AM, et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology. 1995;108:1104-1109.
4. Barton AL, Banner BF, Cable EE, et al. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol. 1995;103:419-424.
5. Clemente MG, Congia M, Lai ME, et al. Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C. J Pediatr. 1994;125:123-128.
6. Hayashi H, Takikawa T, Nishimura N, et al. Improvement of serum aminotransferase levels after phlebotomy in patients with chonic active hepatitis C and excess hepatic iron. Am J Gastroenterol. 1994;89:986-988.
7. Patterson JL, Fernandez-Larsson R. Molecular mechanisms of action of ribavirin. Rev Infect Dis. 1990;12:1139-1146.
8. Fried MW, Fong T-L, Swain MG, et al. Therapy of chronic hepatitis B with a 6-month course of ribavirin. J Hepatol. 1994;21:145-150.
9. Di Bisceglie AM, Shindo M, Fong T-L, et al. A pilot study of ribavirin therapy for chronic hepatitis C. Hepatology. 1992;16:649-654.
10. Di Bisceglie AM, Conjeevaran HS, Fried MW, et al. Ribavirin as therapy for chronic hepatitis C. Ann Intern Med. 1995;121:897-903.
11. Dusheiko G, Main J, Thomas H, et al. Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study. J Hepatol. 1996;25:591-598.
12. Bodenheimer HC, Lindsay KL, Davis GL, et al. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multicenter trial. Hepatology. 1997;26:473-477.
13. Brillanti S, Garson J, Mauro F, et al. A pilot study of combination therapy with ribavirin plus interferon-alpha for interferon-alpha resistant chronic hepatitis C. Gastroenterology. 1994;107:812-817.
14. Schvarcz R, Yun ZB, Sonnenberg A, et al. Combined treatment with interferon alpha 2b and ribavirin for chronic hepatitis C in patients with a previous non-response or nonsustained response to interferon alone. J Med Virol. 1995;46:43-47.
15. Bizollon T, Palazzo U, Ducerf C, et al. Pilot study of the combination of interferon alfa and ribavirin therapy of recurrent hepatitis C after liver transplantation. Hepatology. 1997;26:500-504.
16. Reichard O, Schvarcz R, Weiland O. Therapy of hepatitis C: alpha-interferon and ribavirin. Hepatology. 1997;26(suppl):108S-111S.
17. Camps J, Garcia N, Riezu-Boz JI, et al. Ribavirin in the treatment of chronic hepatitis C unresponsive to alfa interferon. J Hepatol. 1995;19:408-412.
18. Kakumu S, Yoshioka K, Wakita T, et al. A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C. Gastroenterology. 1993;105:507-512.
19. Reichard O, Andersson J, Schvarez R, et al. Ribavirin treatment for chronic hepatitis C. Lancet. 1991; 557:1058-1061.
20. Schulman NR. Assessment of hematologic effects of ribavirin in humans. In: Smith RA, Knight V, Smith JA, eds. Clinical Applications of Ribavirin. Orlando, FL: Academic Press; 1984:79-92.
21. Canonico PG, Kende M, Huggins JW. The toxicology and pharmacology of ribavirin in experimental animals. In: Smith RA, Knight V, Smith JA, eds. Clinical applications of Ribavirin. Orlando, FL: Academic Press; 1984:65-77.
22. Canonico PG, Kastello MD, Cosgriff TM, et al. Hematological and bone marrow effects of ribavirin in Rhesus monkeys. Toxicol Appl Pharmacol. 1984;74:163-172.
23. Brissot P, Bourel M, Herry D, et al. Assessment of liver iron content in 271 patients: a reevaluation of direct and indirect methods. Gastroenterology. 1981;80:557-565.
24. Davis GL, Lau JJ, Lim HL. Therapy for chronic hepatitis C. Gastroenterol Clin North Am. 1994;23:603-613.
25. Davis GL, Balant LA, Schiff ER, et al. Treatment of chronic hepatitis C with recombinant interferon alfa: a multicenter randomized controlled trial. N Engl J Med. 1989;321:1501-1506.
26. Chemello L, Cavaletto L, Bernardinello E, et al. The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C. J Hepatol. 1995;23(suppl):8-12.
27. Braconer J, Paulsen O, Engman K, et al. Combined alpha-interferon and ribavirin treatment for chronic hepatitis C virus infection. Scand J Infect Dis. 1995;27:325-329.
28. Gilbert BE, Knight V. Biochemistry and clinical applications of ribavirin. Antimicrob Agents Chemother. 1986;30:201-205.
29. Sibille J-C, Kondo H, Aisen P. Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein. Hepatology. 1988;8:296-301.
30. Piperno A, Fargion S, D'Alba R, et al. Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection. J Hepatol. 1992;16:364-368.