Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV-RNA levels

Hepatology

Volumn 31, Issue 5, 2000, Pages 1153-1159

  Calabrese, Fiorella ^a   Pontisso, Patrizia ^a   Pettenazzo, Elena ^a   Benvegnù, Luisa ^a   Vario, Alessandro ^a   Chemello, Liliana ^a   Alberti, Alfredo ^a,b   Valente, Marialuisa ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CD8 ANTIGEN; VIRUS RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL INFILTRATION; FEMALE; GENOTYPE; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNE MEDIATED INJURY; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS LOAD;

EID: 0034053796     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/he.2000.7123     Document Type: Article

References (9)

1. Alter MJ, Margolis HS, Krawcynski K, Judson FN, Mares A, Alexander WJ, Hu PY, et al. The natural history of community-acquired hepatitis C in the United States. N Engl J Med 1992;327:1899-1905.
2. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997;349:825-832.
3. Hayashi N, Mita E, Iio S, Takehara T, Kasahara A, Fusamoto H, Kamada T. Fas system and apoptosis in viral hepatitis. J Gastroenterol Hepatol 1997;12 (suppl):S223-S226.
4. Ando K, Hiroishi K, Kaneko T, Moriyama T, Muto Y, Kayagaki N, Yagita H, et al. Perform, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. J Immunol 1997;158:5283-5291.
5. Lau JYN, Xie X, Lai M, Wu PC. Apoptosis and viral hepatitis. Semin Liv Dis 1998;18:169-176.
6. Williams GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell 1993;74:777-779.
7. Searle J, Harmon BV, Bishop CJ, Kerr JFR. The significance of cell death by apoptosis in hepatobiliary disease. J Gastroenterol Hepatol 1987;2:77-96.
8. Kerr JFR, Cooksley WGE, Searle J, Halliday JW, Halliday WJ, Holder L, Roberts I, et al. The nature of piecemeal necrosis in chronic active hepatitis. Lancet 1979;2:827-828.
9. Hiramatsu N, Hayashi N, Katayama K, Mochizuki K, Kawanishi Y, Kasahara A, Fusamoto H, et al. T. Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C. HEPATOLOGY 1994;19:1354-1359.