The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities

Cytokine

Volumn 60, Issue 3, 2012, Pages 653-660

  Tormo, Aurélie Jeanne ^a   Letellier, Marie Claude ^a   Lissilaa, Rami ^b,d   Batraville, Laurie Anne ^a   Sharma, Mukut ^c,e   Ferlin, Walter ^b   Elson, Greg ^b   Crabé, Sandrine ^a,c,e   Gauchat, Jean François ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NOVIMMUNE SA   (Switzerland)

^c KCVA Medical Center   (United States)

^d Glenmark Pharmaceuticals SA   (Switzerland)

^e Wittycell   (France)

Author keywords

Cardiotrophin like cytokine; Ciliary neurotrophic factor; Interleukin 6; Interleukin 6 receptor; T cells

Indexed keywords

CARDIOTROPHIN LIKE CYTOKINE; CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA; CYTOKINE; CYTOKINE LIKE FACTOR 1; GAMMA INTERFERON; GLYCOPROTEIN GP 130; INTERLEUKIN 11 RECEPTOR ALPHA; INTERLEUKIN 6 RECEPTOR ALPHA; PROTEIN LIFRBETA; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT; CYTOKINE RECEPTOR GP130; CYTOKINES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-11 RECEPTOR ALPHA SUBUNIT; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER;

MUS; RODENTIA;

EID: 84867985480     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.08.014     Document Type: Article

References (60)

1. Elson G.C., Lelievre E., Guillet C., Chevalier S., Plun-Favreau H., Froger J., et al. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci 2000, 3:867-872.
2. Lelievre E., Plun-Favreau H., Chevalier S., Froger J., Guillet C., Elson G.C., et al. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J Biol Chem 2001, 276:22476-22484.
3. Davis S., Aldrich T.H., Stahl N., Pan L., Taga T., Kishimoto T., et al. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 1993, 260:1805-1808.
4. Davis S., Aldrich T.H., Valenzuela D.M., Wong V.V., Furth M.E., Squinto S.P., et al. The receptor for ciliary neurotrophic factor. Science 1991, 253:59-63.
5. Ip N.Y., McClain J., Barrezueta N.X., Aldrich T.H., Pan L., Li Y., et al. The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 1993, 10:89-102.
6. Ip N.Y., Nye S.H., Boulton T.G., Davis S., Taga T., Li Y., et al. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992, 69:1121-1132.
7. Stockli K.A., Lillien L.E., Naher-Noe M., Breitfeld G., Hughes R.A., Raff M.C., et al. Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J Cell Biol 1991, 115:447-459.
8. Sleeman M.W., Anderson K.D., Lambert P.D., Yancopoulos G.D., Wiegand S.J. The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 2000, 74:265-272.
9. Jones J.L., Anderson J.M., Phuah C.L., Fox E.J., Selmaj K., Margolin D., et al. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain 2010, 133:2232-2247.
10. Miller R.G., Petajan J.H., Bryan W.W., Armon C., Barohn R.J., Goodpasture J.C., et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS study group. Ann Neurol 1996, 39:256-260.
11. Miller R.G., Bryan W.W., Dietz M.A., Munsat T.L., Petajan J.H., Smith S.A., et al. Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis. Neurology 1996, 47:1329-1331.
12. Lambert P.D., Anderson K.D., Sleeman M.W., Wong V., Tan J., Hijarunguru A., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 2001, 98:4652-4657.
13. Sleeman M.W., Garcia K., Liu R., Murray J.D., Malinova L., Moncrieffe M., et al. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc Natl Acad Sci USA 2003, 100:14297-14302.
14. Bays H.E. Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obes Res 2004, 12:1197-1211.
15. Ettinger M.P., Littlejohn T.W., Schwartz S.L., Weiss S.R., McIlwain H.H., Heymsfield S.B., et al. Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 2003, 289:1826-1832.
16. Stockli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Gotz R., et al. Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature 1989, 342:920-923.
17. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet 1994, 7:79-84.
18. Hoffmann V., Pohlau D., Przuntek H., Epplen J.T., Hardt C. A null mutation within the ciliary neurotrophic factor (CNTF)-gene: implications for susceptibility and disease severity in patients with multiple sclerosis. Genes Immun 2002, 3:53-55.
19. Giess R., Maurer M., Linker R., Gold R., Warmuth-Metz M., Toyka K.V., et al. Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. Arch Neurol 2002, 59:407-409.
20. Giess R., Holtmann B., Braga M., Grimm T., Muller-Myhsok B., Toyka K.V., et al. Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. Am J Hum Genet 2002, 70:1277-1286.
21. Giess R., Goetz R., Schrank B., Ochs G., Sendtner M., Toyka K. Potential implications of a ciliary neurotrophic factor gene mutation in a German population of patients with motor neuron disease. Muscle Nerve 1998, 21:236-238.
22. Herholz J., Meloni A., Marongiu M., Chiappe F., Deiana M., Herrero C.R., et al. Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders. Eur J Hum Genet 2011, 19:525-533.
23. Crisponi L., Crisponi G., Meloni A., Toliat M.R., Nurnberg G., Usala G., et al. Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. Am J Hum Genet 2007, 80:971-981.
24. Dagoneau N., Bellais S., Blanchet P., Sarda P., Al-Gazali L.I., Di Rocco M., et al. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. Am J Hum Genet 2007, 80:966-970.
25. Hahn A.F., Jones D.L., Knappskog P.M., Boman H., McLeod J.G. Cold-induced sweating syndrome A report of two cases and demonstration of genetic heterogeneity. J Neurol Sci 2006.
26. Knappskog P.M., Majewski J., Livneh A., Nilsen P.T., Bringsli J.S., Ott J., et al. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Am J Hum Genet 2003, 72:375-383.
27. Rousseau F, McLeod JG, Chevalier S, Guillet C, Guilhot F, Cognet I, et al. Inactivation of Cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. PNAS; 2006.
28. Jung C., Dagoneau N., Baujat G., Le Merrer M., David A., Di Rocco M., et al. Stuve-Wiedemann syndrome: long-term follow-up and genetic heterogeneity. Clin Genet 2010, 77:266-272.
29. McCarthy E.T., Sharma M., Savin V.J. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2010, 5:2115-2121.
30. Schmidt-Ott K.M., Yang J., Chen X., Wang H., Paragas N., Mori K., et al. Novel regulators of kidney development from the tips of the ureteric bud. J Am Soc Nephrol 2005, 16:1993-2002.
31. Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., et al. Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem 2003, 278:9528-9535.
32. Elson G.C., Graber P., Losberger C., Herren S., Gretener D., Menoud L.N., et al. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol 1998, 161:1371-1379.
33. Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S., et al. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci USA 1999, 96:11458-11463.
34. Shi Y., Wang W., Yourey P.A., Gohari S., Zukauskas D., Zhang J., et al. Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. Biochem Biophys Res Commun 1999, 262:132-138.
35. Senaldi G., Stolina M., Guo J., Faggioni R., McCabe S., Kaufman S.A., et al. Regulatory effects of novel neurotrophin-1/b cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function. J Immunol 2002, 168:5690-5698.
36. Metcalfe S.M. LIF in the regulation of T-cell fate and as a potential therapeutic. Genes Immun 2011, 12:157-168.
37. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
38. Diehl S., Anguita J., Hoffmeyer A., Zapton T., Ihle J.N., Fikrig E., et al. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 2000, 13:805-815.
39. Kuhlmann T., Remington L., Cognet I., Bourbonniere L., Zehntner S., Guilhot F., et al. Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis. Am J Pathol 2006, 169:584-598.
40. Crabe S., Guay-Giroux A., Tormo A.J., Duluc D., Lissilaa R., Guilhot F., et al. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J Immunol 2009, 183:7692-7702.
41. Fuhlbrigge R.C., Fine S.M., Unanue E.R., Chaplin D.D. Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA. Proc Natl Acad Sci USA 1988, 85:5649-5653.
42. Cognet I., Guilhot F., Chevalier S., Guay-Giroux A., Bert A., Elson G.C., et al. Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities. Eur Cytokine Network 2004, 15:255-262.
43. Lissilaa R., Buatois V., Magistrelli G., Williams A.S., Jones G.W., Herren S., et al. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. J Immunol 2010, 185:5512-5521.
44. Gearing D.P., Ziegler S.F., Comeau M.R., Friend D., Thoma B., Cosman D., et al. Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci USA 1994, 91:1119-1123.
45. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002, 16:779-790.
46. Picard C., Casanova J.L. Inherited disorders of cytokines. Curr Opin Pediatr 2004, 16:648-658.
47. Scheinecker C., Smolen J., Yasothan U., Stoll J., Kirkpatrick P. Tocilizumab Nat Rev Drug Discov 2009, 8:273-274.
48. Batten M., Ghilardi N. The biology and therapeutic potential of interleukin 27. J Mol Med 2007, 85:661-672.
49. Kastelein R.A., Hunter C.A., Cua D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007, 25:221-242.
50. Chen Q., Ghilardi N., Wang H., Baker T., Xie M.H., Gurney A., et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 2000, 407:916-920.
51. Plun-Favreau H., Elson G., Chabbert M., Froger J., deLapeyriere O., Lelievre E., et al. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. Embo J 2001, 20:1692-1703.
52. Davis S., Aldrich T.H., Ip N.Y., Stahl N., Scherer S., Farruggella T., et al. Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses. Science 1993, 259:1736-1739.
53. Korn T., Bettelli E., Oukka M., Kuchroo V.K. IL-17 and Th17 Cells. Annu Rev Immunol 2009, 27:485-517.
54. Axtell R.C., de Jong B.A., Boniface K., van der Voort L.F., Bhat R., De Sarno P., et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010, 16:406-412.
55. Krakowski M., Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 1996, 26:1641-1646.
56. Tran E.H., Prince E.N., Owens T. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 2000, 164:2759-2768.
57. Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007, 13:1173-1175.
58. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005, 201:233-240.
59. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141.
60. Linker R.A., Maurer M., Gaupp S., Martini R., Holtmann B., Giess R., et al. CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nat Med 2002, 8:620-624.