Potential implications of a ciliary neurotrophic factor gene mutation in a German population of patients with motor neuron disease

Muscle and Nerve

Volumn 21, Issue 2, 1998, Pages 236-238

  Giess, Ralf ^a   Goetz, Rudolf ^a   Schrank, Bertold ^a   Ochs, Guenter ^a   Sendtner, Michael ^a   Toyka, Klaus ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Ciliary neurotrophic factor; Motor neuron disease; Mutation; Neurotrophic factors

Indexed keywords

CILIARY NEUROTROPHIC FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; FASCICULATION; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MOTOR NEURON DISEASE; MUSCLE ATROPHY; MUSCLE WEAKNESS; POINT MUTATION; PRIORITY JOURNAL; SPASTIC PARAPLEGIA; SPINAL MUSCULAR ATROPHY;

EID: 0031890907     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4598(199802)21:2<236::aid-mus12>3.0.co;2-%23     Document Type: Article

References (9)

1. ALS CNTF Treatment Study (A.C.T.S.) Group: A double-blind placebo controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. Neurology 1996;46:1244-1249.
2. Arakawa Y, Sendtner M. Thoenen H: Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci 1990;10:3507-3515.
3. Brooks BR: El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors. J Neurol Sci 1994;124(suppl):96-107.
4. Elliott JL, Snider WD: Motor neuron growth factors. Neurology 1996;47(suppl 2):S47-S53.
5. Lam A, Fuller F, Miller J, Kloss J, Manthorpe M, Varon S, et al.: Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 1991;102:271-276.
6. Li M, Sendtner M, Smith A: Essential function of LIF receptor in motor neurons. Nature 1995;378:724-727.
7. Lin L-F, Mismer D, Lile JD, Armes LG, Butler ET III, Vannice JL, et al. Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science 1989;246:1023-1025.
8. Magal E, Burnham P, Varon S: Effects of ciliary neuronotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low-affinity nerve growth factor receptors. Dev Brain Res 1991;63:141-150.
9. Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H: Disruption of the CNTF gene results in motor neuron degeneration. Nature 1993;365:27-32.