Association of a null mutation in the CNTF gene with early onset of multiple sclerosis

Archives of Neurology

Volumn 59, Issue 3, 2002, Pages 407-409

  Giess, Ralf ^a   Mäurer, Mathias ^a   Linker, Ralf ^a   Gold, Ralf ^a   Warmuth Metz, Monika ^a   Toyka, Klaus V ^a   Sendtner, Michael ^a   Rieckmann, Peter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; DNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; GENE; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0036191226     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.59.3.407     Document Type: Article

References (11)

1. Cytokines and the pathogenesis of multiple sclerosis
2. HLA-DR15 is associated with lower age at onset in multiple sclerosis
3. Ciliary neurotrophic factor
4. Multiple extracellular signals are required for long-term oligodendrocyte survival
5. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death
6. A null mutation in the human CNTF gene is not causally related to neurological diseases
7. Combined magnetization transfer and proton spectoscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis
8. Potential Implications of a ciliary neurotrophic factor gene mutation in a German population of patients with motor neuron disease
9. CNTF-deficiency deteriorates clinical course and histopathology a murine model of experimental autoimmune encephalomyelitis: A neurotrophic factor as outcome determinator of neuroinflammation
10. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
11. Detection of ventricular enlargement in patients at the earliest clinical stage of MS