Gene-environment interaction and susceptibility to pediatric brain tumors

Environmental Factors, Genes, and the Development of Human Cancers

Volumn , Issue , 2010, Pages 223-252

  Kunkle, Brian ^a   Sandberg, David ^b   Jayakar, Prasanna ^b   Felty, Quentin ^a   Roy, Deodutta ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Environment; Gene environment interactions; Individual susceptibility; Mitochondrial nuclear signaling; Pediatric brain tumors (pBTs)

Indexed keywords

EID: 84867973981     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-6752-7_9     Document Type: Chapter

References (139)

1. Adinolfi M. 1985. The development of the human blood-CSF-brain barrier. Dev Med Child Neurol 27:532-537.
2. Aleardi AM, Benard G, Augereau O, Malgat M, Talbot JC, Mazat JP, et al. 2005. Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release. J Bioenerg Biomembr 37:207-225.
3. Anderson LM, Diwan BA, Fear NT, Roman E. 2000. Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models. Environ Health Perspect 108(Suppl 3):573-594.
4. Autrup H. 1993. Transplacental transfer of genotoxins and transplacental carcinogenesis. Environ Health Perspect 101(Suppl 2):33-38.
5. Bailey P, Cushing H. 1925. Medulloblastoma cerebelli: a common type of midcerebellar glioma of childhood. Arch Neurol Psychiatry 14:192-223.
6. Baldwin RT, Preston-Martin S. 2004. Epidemiology of brain tumors in childhood-a review. Toxicol Appl Pharmacol 199:118-131.
7. Bar EE, Chaudhry A, Farah MH, Eberhart CG. 2007. Hedgehog signaling promotes medulloblastoma survival via Bc/II. Am J Pathol 170:347-355.
8. Barnette P, Scholl R, Blandford M, Ballard L, Tsodikov A, Magee J, et al. 2004. High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. Cancer Epidemiol Biomarkers Prev 13:304-313.
9. Birch JM, Alston RD, Kelsey AM, Quinn MJ, Babb P, McNally RJ. 2002. Classification and incidence of cancers in adolescents and young adults in England 1979-1997. Br J Cancer 87:1267-1274.
10. Branstetter DG, Stoner GD, Schut HA, Senitzer D, Conran PB, Goldblatt PJ. 1987. Ethylnitrosourea-induced transplacental carcinogenesis in the mouse: tumor response, DNA binding, and adduct formation. Cancer Res 47:348-352.
11. Brodeur GM, Castleberry RP. 1997. Neuroblastoma. In: Principles and practice of pediatric oncology (Pizzo PA, Poplack DG, eds.). Philadelphia, PA: Lippincott, 761-797.
12. Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, et al. 2007. Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 12:328-341.
13. Bunin GR. 2004. Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies. Toxicol Appl Pharmacol 199:91-103.
14. Buonocore G, Perrone S, Bracci R. 2001. Free radicals and brain damage in the newborn. Biol Neonate 79:180-186.
15. Cadieux B, Ching TT, Vanden Berg SR, Costello JF. 2006. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 66:8469-8476.
16. Calabrese V, Copani A, Testa D, Ravagna A, Spadaro F, Tendi E, et al. 2000. Nitric oxide synthase induction in astroglial cell cultures: effect on heat shock protein 70 synthesis and oxidant/antioxidant balance. J Neurosci Res 60:613-622.
17. Carew JS, Huang P. 2002. Mitochondrial defects in cancer. Mol Cancer 1:9.
18. Copeland WC, Wachsman JT, Johnson FM, Penta JS. 2002. Mitochondrial DNA alterations in cancer. Cancer Invest 20:557-569.
19. Cottrell DA, Ince PG, Blakely EL, Johnson MA, Chinnery PF, Hanna M, et al. 2000. Neuropathological and histochemical changes in a multiple mitochondrial DNA deletion disorder. J Neuropathol Exp Neurol 59:621-627.
20. Delsite RL, Rasmussen LJ, Rasmussen AK, Kalen A, Goswami PC, Singh KK. 2003. Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis 18:497-503.
21. Dietert RR, Etzel RA, Chen D, Halonen M, Holladay SD, Jarabek AM, et al. 2000. Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environ Health Perspect 108(Suppl 3):483-490.
22. Dirks P. 2007. Bmi1 and cell of origin determinants of brain tumor phenotype. Cancer Cell 12:295-297.
23. Doll R, Wakeford R. 1997. Risk of childhood cancer from fetal irradiation. Br J Radiol 70:130-139.
24. Dukhande VV, Malthankar-Phatak GH, Hugus JJ, Daniels CK, Lai JC. 2006. Manganeseinduced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells. Neurochem Res 31:1349-1357.
25. Duthie SJ, Dobson VL. 1999. Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. Eur J Nutr 38:28-34.
26. Enns R, Criddle RS. 1977. Investigation of the structural arrangement of the protein subunits of mitochondrial ATPase. Arch Biochem Biophys 183:742-752.
27. Erecinska M, Cherian S, Silver IA. 2004. Energy metabolism in mammalian brain during development. Prog Neurobiol 73:397-445.
28. Evans AR, Limp-Foster M, Kelley MR. 2000. Going APE over ref-1. Mutat Res 461:83-108.
29. Ezer R, Alonso M, Pereira E, Kim M, Allen JC, Miller DC, et al. 2002. Identification of glutathione S-transferase (GST) polymorphisms in brain tumors and association with susceptibility to pediatric astrocytomas. J Neurooncol 59:123-134.
30. Fear NT, Roman E, Ansell P, Bull D. 2001. Malignant neoplasms of the brain during childhood: the role of prenatal and neonatal factors (United Kingdom). Cancer Causes Control 12:443-449.
31. Ferrer I, Tortosa A, Condom E, Blanco R, Macaya A, Planas A. 1994. Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat. Neurosci Lett 179:13-16.
32. Folkerth RD, Haynes RL, Borenstein NS, Belliveau RA, Trachtenberg F, Rosenberg PA, et al. 2004. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol 63:990-999.
33. Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA. 2001. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Res 891:54-68.
34. Gottfried Y, Voldavsky E, Yodko L, Sabo E, Ben-Itzhak O, Larisch S. 2004. Expression of the proapoptotic protein ARTS in astrocytic tumors: correlation with malignancy grade and survival rate. Cancer 101:2614-2621.
35. Grimmer MR, Weiss WA. 2006. Childhood tumors of the nervous system as disorders of normal development. Curr Opin Pediatr 18:634-638.
36. Gunter KK, Gunter TE. 1994. Transport of calcium by mitochondria. J Bioenerg Biomembr 26:471-485.
37. Gunther C, Von Hadeln K, Muller-Thomsen T, Alberici A, Binetti G, Hock C, et al. 2004. Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease. Neurosci Lett 369:219-223.
38. Gurney JG, Smith MA, Bunin GR. 1999a. CNS and miscellaneous intracranial and intraspinal neoplasms (ICCC III). Online NIH Pub. no. 99-4649. Bethesda, MD: Cancer Statistics Branch, Cancer Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute.
39. Gurney JG, Wall DA, Jukich PJ, Davis FG. 1999b. The contribution of nonmalignant tumors to CNS tumor incidence rates among children in the United States. Cancer Causes Control 10:101-105.
40. Halperin EC, Miranda ML, Watson DM, George SL, Stanberry M. 2004. Medulloblastoma and birth date: evaluation of 3 U. S. datasets. Arch Environ Health 59:26-30.
41. Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, De Alboran IM, Olson JM, et al. 2006. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 66:8655-8661.
42. Hjalmars U, Kulldorff M, Wahlqvist Y, Lannering B. 1999. Increased incidence rates but no spacetime clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors. Cancer 85:2077-2090.
43. Hoffman S, Schellinger KA, Propp JM, McCarthy BJ, Campbell RT, Davis FG. 2007. Seasonal variation in incidence of pediatric medulloblastoma in the United States, 1995-2001. Neuroepidemiology 29:89-95.
44. Humphrey ML, Cole MP, Pendergrass JC, Kiningham KK. 2005. Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH). Neurotoxicology 26:407-416.
45. IARC. 1998. In: International incidence of childhood cancer (Parkin DM, Kramarova E, Draper GJ, Masuyer E, Michaelis J, Neglia JP, et al., eds.). Lyon: International Agency for Research on Cancer.
46. Jirtle RL, Skinner MK. 2007. Environmental epigenomics and disease susceptibility. Nat Rev Genet 8:253-262.
47. Jukich PJ, McCarthy BJ, Surawicz TS, Freels S, Davis FG. 2001. Trends in incidence of primary brain tumors in the United States, 1985-1994. Neuro Oncol 3:141-151.
48. Kafadar AM, Yilmaz H, Kafadar D, Ergen A, Zeybek U, Bozkurt N, et al. 2006. C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and highgrade gliomas. Anticancer Res 26:2445-2449.
49. Kaiser J. 1999. No meeting of minds on childhood cancer. Science 286:1832-1834.
50. Kang D, Kim SH, Hamasaki N. 2007. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7:39-44.
51. Katayam M, Yoshida K, Ishimori H, Katayama M, Kawase T, Motoyama J, et al. 2002. Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy. J Neurooncol 59:107-115.
52. Khan MA, Van DJ, Yeung IW, Hill RP. 2003. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol 66:95-102.
53. Kiebish MA, Seyfried TN. 2005. Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors. BMC Cancer 5:102.
54. Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, et al. 2007. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 67:6314-6324.
55. Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B. 1988. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332:371-374.
56. Kirches E, Michael M, Woy C, Schneider T, Warich-Kirches M, Schneider-Stock R, et al. 1999. Loss of heteroplasmy in the displacement loop of brain mitochondrial DNA in astrocytic tumors. Genes Chromosomes Cancer 26:80-83.
57. Kontush A. 2001. Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease. Free Radic Biol Med 31:1120-1131.
58. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, et al. 2004. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 103:252-257.
59. Kulawiec M, Safina A, Desouki MM, Still I, Matsui SI, Bakin A, et al. 2008. Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol Ther 7(11):1732-1743.
60. Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner VF, et al. 2004. Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Mol Cancer Res 2:433-441.
61. Lai R, Crevier L, Thabane L. 2005. Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. Cancer Epidemiol Biomarkers Prev 14:1784-1790.
62. Larsson NG, Luft R. 1999. Revolution in mitochondrial medicine. FEBS Lett 455:199-202.
63. Lee WC, Choi CH, Cha SH, Oh HL, Kim-YK. 2005. Role of ERK in hydrogen peroxide-induced cell death of human glioma cells. Neurochem Res 30:263-270.
64. Lemasters GK, Perreault SD, Hales BF, Hatch M, Hirshfield AN, Hughes CL, et al. 2000. Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary. Environ Health Perspect 108(Suppl 3):505-509.
65. Lerman-Sagie T, Leshinsky-Silver E, Watemberg N, Luckman Y, Lev D. 2005. White matter involvement in mitochondrial diseases. Mol Genet Metab 84:127-136.
66. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, et al. 2004. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol 63:499-509.
67. Linet MS, Ries LA, Smith MA, Tarone RE, Devesa SS. 1999. Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States. J Natl Cancer Inst 91:1051-1058.
68. Magnani C, Dalmasso P, Pastore G, Terracini B, Martuzzi M, Mosso ML, et al. 2003. Increasing incidence of childhood leukemia in Northwest Italy, 1975-98. Int J Cancer 105:552-557.
69. Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JC. 2004. Differential lowering by manganese treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with manganeseinduced cell death. Neurochem Res 29:709-717.
70. Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH. 2006. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15:1437-1449.
71. Manshande JP, Van TJ, Coppens M, Casaer P. 1985. Seasonal variation in incidence of cerebellar medulloblastoma. Brain Dev 7:525-526.
72. Marino S. 2005. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 11:17-22.
73. Maris JM. 2005. The biologic basis for neuroblastoma heterogeneity and risk stratification. Curr Opin Pediatr 17:7-13.
74. Marks N, Berg MJ. 1999. Recent advances on neuronal caspases in development and neurodegeneration. Neurochem Int 35:195-220.
75. Mavelli I, Rigo A, Federico R, Ciriolo MR, Rotilio G. 1982. Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain. Biochem J 204:535-540.
76. McNally RJ, Kelsey AM, Cairns DP, Taylor GM, Eden OB, Birch JM. 2001. Temporal increases in the incidence of childhood solid tumors seen in Northwest England (1954-1998) are likely to be real. Cancer 92:1967-1976.
77. McNeil DE, Cote TR, Clegg L, Rorke LB. 2002. Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results. Med Pediatr Oncol 39:190-194.
78. Meadows AT, Baum E, Fossati-Bellani F, Green D, Jenkin RD, Marsden B, et al. 1985. Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 3:532-538.
79. Mealey J Jr., Hall PV. 1977. Medulloblastoma in children. Survival and treatment. J Neurosurg 46:56-64.
80. Melov S, Lithgow GJ, Fischer DR, Tedesco PM, Johnson TE. 1995. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res 23:1419-1425.
81. Modica-Napolitano JS, Singh KK. 2002. Mitochondria as targets for detection and treatment of cancer. Expert Rev Mol Med 4:1-19.
82. Montanini L, Regna-Gladin C, Eoli M, Albarosa R, Carrara F, Zeviani M, et al. 2005. Instability of mitochondrial DNA and MRI and clinical correlations in malignant gliomas. J Neurooncol 74:87-89.
83. National Cancer Institute NIoNDaS. 2000. Report of the Brain Tumor Progress Review Group. NIH Publication Number 01-4902.
84. National Institutes of Health. 2002. What you need to know about brain tumors. Bethesda, MD: National Cancer Institute.
85. Neglia JP, Meadows AT, Robison LL, Kim TH, Newton WA, Ruymann FB, et al. 1991. Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 325:1330-1336.
86. Neri M, Fucic A, Knudsen LE, Lando C, Merlo F, Bonassi S. 2003. Micronuclei frequency in children exposed to environmental mutagens: a review. Mutat Res 544:243-254.
87. Neri M, Ugolini D, Bonassi S, Fucic A, Holland N, Knudsen LE, et al. 2006. Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysis. Mutat Res 612:14-39.
88. Ohta S. 2006. Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs. Oncogene 25:4768-4776.
89. Olshan AF, Anderson L, Roman E, Fear N, Wolff M, Whyatt R, et al. 2000. Workshop to identify critical windows of exposure for children's health: cancer work group summary. Environ Health Perspect 108(Suppl 3):595-597.
90. Park SY, Chang I, Kim J, Kang SW, Park S, Singh K, et al. 2004. Resistance of mitochondrial DNA-depleted cells against cell death. J Biol Chem 279:7512-7520.
91. Penta JS, Johnson FM, Wachsman JT, Copeland WC. 2001. Mitochondrial DNA in human malignancy. Mutat Res 488:119-133.
92. Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, et al. 2002. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol Biomarkers Prev 11:1134-1137.
93. Pouliquen D, Olivier C, Hervouet E, Pedelaborde F, Debien E, Le Cabellec MT, et al. 2008. Dietary prevention of malignant glioma aggressiveness, implications in oxidant stress and apoptosis. Int J Cancer 123:288-295.
94. Preston-Martin S, Munir R, Chakrabarti I. 2006. Neoplasms of the nervous system. In: Cancer Epidemiology and Prevention (Schottenfield D, Fraumeni JF, eds.). New York, NY: Oxford University Press.
95. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD. 1993. Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262:695-700.
96. Rahman S, Hargreaves I, Clayton P, Heales S. 2001. Neonatal presentation of coenzyme Q10 deficiency. J Pediatr 139:456-458.
97. Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, et al. 2006. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 15:2514-2520.
98. Rao G, Pedone CA, Del VL, Reiss K, Holland EC, Fults DW. 2004. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 23:6156-6162.
99. Rasmussen AK, Chatterjee A, Rasmussen LJ, Singh KK. 2003. Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. Nucleic Acids Res 31:3909-3917.
100. Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. 2006. The neurobiology of neurooncology. Ann Neurol 60:3-11.
101. Reed JC. 1997. Bcl-2 family proteins and the hormonal control of cell life and death in normalcy and neoplasia. Vitam Horm 53:99-138.
102. Rice JM. 2006. Inducible and transmissible genetic events and pediatric tumors of the nervous system. J Radiat Res (Tokyo) 47(Suppl B):B1-B11.
103. Rice JM, Ward JM. 1982. Age dependence of susceptibility to carcinogenesis in the nervous system. Ann N Y Acad Sci 381:274-289.
104. Rice JM, Wilbourn JD. 2000. Tumors of the nervous system in carcinogenic hazard identification. Toxicol Pathol 28:202-214.
105. Robertson JD, Gogvadze V, Kropotov A, Vakifahmetoglu H, Zhivotovsky B, Orrenius S. 2004. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep 5:643-648.
106. Robertson CL, Soane L, Siegel ZT, Fiskum G. 2006. The potential role of mitochondria in pediatric traumatic brain injury. Dev Neurosci 28:432-446.
107. Rodier PM. 1995. Developing brain as a target of toxicity. Environ Health Perspect 103(Suppl 6):73-76.
108. Ron E, Modan B, Boice JD Jr., Alfandary E, Stovall M, Chetrit A, et al. 1988. Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033-1039.
109. Roy D, Cai Q, Felty Q, Narayan S. 2007. Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. J Toxicol Environ Health B Crit Rev 10:235-257.
110. Rustin P. 2002. Mitochondria, from cell death to proliferation. Nat Genet 30:352-353.
111. Sadler TW. 2000. Susceptible periods during embryogenesis of the heart and endocrine glands. Environ Health Perspect 108(Suppl 3):555-561.
112. Samuelsen SO, Bakketeig LS, Tretli S, Johannesen TB, Magnus P. 2006. Head circumference at birth and risk of brain cancer in childhood: a population-based study. Lancet Oncol 7:39-42.
113. Scarpulla RC. 2008. Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y Acad Sci 1147:321-334.
114. Schoenberg BS, Schoenberg DG, Christine BW, Gomez MR. 1976. The epidemiology of primary intracranial neoplasms of childhood. A population study. Mayo Clin Proc 51:51-56.
115. Schuller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, et al. 2008. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shhinduced medulloblastoma. Cancer Cell 14:123-134.
116. Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, et al. 2007. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev 16:559-565.
117. Searles NS, Mueller BA, De Roos AJ, Viernes HM, Farin FM, Checkoway H. 2005. Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1). Environ Health Perspect 113:909-913.
118. Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui S. 2005. Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene 354:140-146.
119. Sirachainan N, Wongruangsri S, Kajanachumpol S, Pakakasama S, Visudtibhan A, Nuchprayoon I, et al. 2008. Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children. Cancer Detect Prev 32:72-78.
120. Slikker W III, Mei N, Chen T. 2004. N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults. Toxicol Sci 81:112-120.
121. Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta SG, Singh KK. 2008. A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther 7:1182-1190.
122. Smith MA, Freidlin B, Ries LA, Simon R. 1998. Trends in reported incidence of primary malignant brain tumors in children in the United States. J Natl Cancer Inst 90:1269-1277.
123. Stavrovskaya IG, Kristal BS. 2005. The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death? Free Radic Biol Med 38:687-697.
124. Steliarova-Foucher E, Stiller C, Kaatsch P, Berrino F, Coebergh JW, Lacour B, et al. 2004. Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCISproject): an epidemiological study. Lancet 364:2097-2105.
125. Suliman HB, Carraway MS, Welty-Wolf KE, Whorton AR, Piantadosi CA. 2003. Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. J Biol Chem 278:41510-41518.
126. Taanman JW. 1999. The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta 1410:103-123.
127. Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. 2006. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a casecontrol study. BMC Cancer 6:148.
128. Thannickal VJ, Fanburg BL. 2000. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279:L1005-L1028.
129. Thompson JR, Gerald PF, Willoughby ML, Armstrong BK. 2001. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 358:1935-1940.
130. Van RH, Salvador C, Yang H, Huang TT, Epstein CJ, Richardson A. 1999. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch Biochem Biophys 363:91-97.
131. Vasko MR, Guo C, Kelley MR. 2005. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) 4:367-379.
132. Vega A, Salas A, Gamborino E, Sobrido MJ, Macaulay V, Carracedo A. 2004. mtDNA mutations in tumors of the central nervous system reflect the neutral evolution of mtDNA in populations. Oncogene 23:1314-1320.
133. Von BJ, Reynolds P. 2003. Birth characteristics and brain cancers in young children. Int J Epidemiol 32:248-256.
134. Wong-Riley MT. 1989. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci 12:94-101.
135. Wright J. 1910. Neurocytoma and neuroblastomas, a kind of tumor not generally recognized. J Exp Med 12:556-561.
136. Xanthoudakis S, Curran T. 1996. Redox regulation of AP-1: a link between transcription factor signaling and DNA repair. Adv Exp Med Biol 387:69-75.
137. Yamakawa Y, Fukui M, Kinoshita K, Ohgami S, Kitamura K. 1979. Seasonal variation in incidence of cerebellar medulloblastoma by month of birth. Fukuoka Igaku Zasshi 70:295-300.
138. Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, et al. 2008. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14:135-145.
139. Zhong W, Oberley LW, Oberley TD, Yan T, Domann FE, St Clair DK. 1996. Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ 7:1175-1186.