Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children

Cancer Detection and Prevention

Volumn 32, Issue 1, 2008, Pages 72-78

  Sirachainan, Nongnuch ^a   Wongruangsri, Siranee ^a   Kajanachumpol, Saowanee ^a   Pakakasama, Samart ^a   Visudtibhan, Anannit ^a   Nuchprayoon, Issarang ^b   Lusawat, Apasri ^c   Phudhicharoenrat, Suchart ^a   Shuangshoti, Shanop ^b   Hongeng, Suradej ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b KING CHULALONGKORN MEMORIAL HOSPITAL   (Thailand)

^c PRASAT NEUROLOGICAL INSTITUTE   (Thailand)

Author keywords

Case control study; Central nervous system tumors; Folate metabolism; Folate pathway; Pediatric brain tumors; Polymorphisms; Thai children; Thailand

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; GENOMIC DNA;

ARTICLE; ASTROCYTOMA; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; EMBRYONAL CARCINOMA; EPENDYMOMA; FEMALE; FOLATE METABOLISM; GENETIC POLYMORPHISM; GENETIC RISK; GERM CELL TUMOR; GLIOMA; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MENINGIOMA; NEUROECTODERM TUMOR; OLIGODENDROGLIOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PINEAL BODY TUMOR; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; THAILAND;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; FEMALE; FOLIC ACID; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; THAILAND; THYMIDYLATE SYNTHASE;

EID: 42749091125     PISSN: 0361090X     EISSN: 15251500     Source Type: Journal    
DOI: 10.1016/j.cdp.2008.02.004     Document Type: Article

References (43)

1. Hjalmars U., Kulldorff M., Wahlqvist Y., and Lannering B. Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992. Cancer 85 (1999) 2077-2090
2. McNeil D.E., Coté T.R.M.D., Clegg L., and Rorke L.B. Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Med Pediatr Oncol 39 (2002) 190-194
3. Kleihues P., Aguzzi A., and Ohgaki H. Genetic and environmental factors in the etiology of human brain tumors. Toxicol Lett 82/83 (1995) 601-605
4. Schuz J., Bohler E., Berg G., Schlehofer B., Schlehofer B., Hettinger I., et al. Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group Germany). Am J Epidemiol 163 (2006) 512-520
5. Searles Nielsen S., Mueller B.A., De Roos A.J., Viernes H.M., Farin F.M., and Checkoway H. Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1). Environ Health Perspect 113 (2005) 909-913
6. Dietrich M., Block G., Pogoda J.M., Buffler P., Hecht S., and Preston-Martin S. A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors. Cancer Causes Control 16 (2005) 619-635
7. Rodvall Y., Pershagen G., Hrubec Z., Ahlbom A., Pedersen N.L., and Boice J.D. Prenatal X-ray exposure and childhood cancer in Swedish twins. Int J Cancer 46 (1990) 362-365
8. Rimm I.J., Li F.C., Tarbell N.J., Winston K.R., and Sallan S.E. Brain tumors after cranial irradiation for childhood acute lymphoblastic leukaemia. A 13-year experience from the Dana-Farber Cancer Institute and the Children's Hospital. Cancer 59 (1987) 1506-1508
9. Sharp L., and Little J. Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159 (2004) 423-443
10. Duthie S.J. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 55 (1999) 578-592
11. Ames B.N. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475 (2001) 7-20
12. Navarro Silvera S.A., Jain M., Howe G.R., Miller A.B., and Rohan T.E. Dietary folate consumption and risk of ovarian cancer: a prospective cohort study. Eur J Cancer Prev 15 (2006) 511-515
13. Pelucchi C., Galeone C., Talamini R., Negri E., Parpinel M., Franceschi S., et al. Dietary folate and risk of prostate cancer in Italy. Cancer Epidemiol Biomakers Prev 14 (2005) 944-948
14. Krajinovic M., Lamothe S., Labuda D., Lemieux-Blanchard E., Theoret Y., Moghrabi A., et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 103 (2004) 252-257
15. Thompson J.R., Gerald P.F., Willoughby M.L., and Armstrong B.K. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukemia in childhood: a case-control study. Lancet 358 (2001) 1935-1940
16. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71 (2000) 121-138
17. van der Put N.M., Gabreels F., Stevens E.M., Stevens E.M., Smeitink J.A., Trijbels F.J., et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet 62 (1998) 1044-1051
18. Weisberg I., Tran P., Christensen B., Sibani S., and Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTFHR) associated with decreased enzyme activity. Mol Genet Metab 64 (1998) 169-172
19. van der Put N.M., van der Molen E.F., Kluijtmans L.A., Heil S.G., Trijbels J.M., Eskes T.K., et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. QJM 90 (1997) 511-517
20. Luo H.R., Lu X.M., Yao Y.G., Horie N., Takeishi K., Jorde L.B., et al. Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochem Genet 40 (2002) 41-51
21. Horie N., Aiba H., Oguro K., Hojo H., and Takeishi K. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 20 (1995) 191-197
22. Chango A., Emery-Fillon N., de Courcy G.P., Lambert D., Pfister M., Rosenblatt D.S., et al. A polymorphism (80G → A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab 70 (2000) 310-315
23. Gemmati D., Ongaro A., Scapoli G.L., Della Porta M., Tognazzo S., Serino M.L., et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 13 (2004) 787-794
24. Wiemels J.L., Smith R.N., Taylor G.M., Eden O.B., Alexander F.E., and Greaves M.F. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukaemia. Proc Natl Acad Sci USA 98 (2001) 4004-4009
25. Xu W.H., Shrubsole M.J., Xi Y.B., Cai Q., Zhao G.M., Ruan Z.X., et al. Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 16 (2007) 281-287
26. Henao O.L., Piyathilake C.J., Waterbor J.W., Funkhouser E., Johanning G.L., Heimburger D.C., et al. Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. Int J Cancer 113 (2005) 991-997
27. Ma J., Stampfer M.J., Giovannucci E., Artigas C., Hunter D.J., Fuchs C., et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57 (1997) 1098-1102
28. Li D., Ahmed M., Li Y., Jiao L., Chou T.H., Wolff R.A., et al. 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 14 (2005) 1470-1476
29. Skibola C.F., Forrest M.S., Coppede F., Agana L., Hubbard A., Smith M.T., et al. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood 104 (2004) 2155-2162
30. Wang L., Chen W., Wang J., Tan Y., Zhou Y., Ding W., et al. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur J Cancer 42 (2006) 3206-3211
31. Gotze T., Rocken C., Rohl F.W., Wex T., Hoffman J., Westphal S., et al. Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett 251 (2007) 228-236
32. Relton C.L., Wilding C.S., Pearce M.S., Laffling A.J., Jonas P.A., Lynch S.A., et al. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. J Med Genet 41 (2004) 256-260
33. Grimmer M.R., and Weiss W.A. Childhood tumors of the nervous system as disorders of normal development. Curr Opin Pediatr 18 (2006) 634-638
34. Kafadar A.M., Yilmaz H., Kafadar D., Ergen A., Zeybek U., Bozkurt N., et al. C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas. Anticancer Res 26 (2006) 2445-2449
35. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
36. Ulrich C.M., Bigler J., Bostick R., Fosdick L., and Potter J.D. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res 62 (2002) 3361-3364
37. Martin D.N., Boersma B.J., Howe T.M., Goodman J.E., Mechanic L.E., Chanock S.J., et al. Association of MTHFR gene polymorphisms with breast cancer survival. BMC Cancer 6 (2006) 257
38. Ho G.Y., Eikelboom J.W., Hankey G.J., Wong C.R., Tan S.L., Chan J.B., et al. Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients. Stroke 37 (2006) 456-460
39. Shi Q., Zhang Z., Li G., Pillow P.C., Hernandez L.M., Spitz M.R., et al. Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis. Pharmacogenet Genomics 15 (2005) 547-555
40. Matsuo K., Hamajima N., Hirai T., Inoue M., Takezaki T., and Tajima K. Methionine synthase reductase gene A66G polymorphism is associated with risk of colorectal cancer. Asian Pac J Cancer Prev 3 (2002) 353-359
41. Marsh S., Collie-Duguid E.S., Li T., Liu X., and McLeod H.L. Ethnic variation in the thymidylate synthase enhancer region polymorphism among caucasian and Asian populations. Genomics 58 (1999) 310-312
42. Rady P.L., Szucs S., Matalon R.K., Grady J., Hudnall S.D., Kellner L.H., et al. Genetic polymorphism (G80A) of reduced folate carrier gene in ethnic populations. Mol Genet Metab 73 (2001) 285-286
43. Bunin G.R., Kuijten R.R., Buckley J.D., Rorke L.B., and Meadows A.T. Relation between maternal diet and subsequent primitive neuroectodermal brain tumors in young children. N Engl J Med 329 (1993) 536-541