Loss of heteroplasmy in the displacement loop of brain mitochondrial DNA in astrocytic tumors

Genes Chromosomes and Cancer

Volumn 26, Issue 1, 1999, Pages 80-83

  Kirches, Elmar ^a   Michael, Matthias ^a   Woy, Cornelia ^a   Schneider, Thomas ^a   Warich Kirches, Michaela ^a   Schneider Stock, Regine ^a   Winkler, Kirstin ^a   Wittig, Holger ^a   Dietzmann, Knut ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; HETERODUPLEX; PLASMID VECTOR;

ADULT; AGED; ARTICLE; ASTROCYTOMA; BRAIN MITOCHONDRION; BRAIN TUMOR; CLINICAL ARTICLE; FEMALE; GENE SEQUENCE; GLIOBLASTOMA; HUMAN; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD;

ADULT; AGED; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; DNA, MITOCHONDRIAL; FEMALE; GLIOBLASTOMA; HETERODUPLEX ANALYSIS; HUMANS; MALE; MIDDLE AGED; NUCLEIC ACID CONFORMATION; VARIATION (GENETICS);

EID: 0032838427     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199909)26:1<80::AID-GCC11>3.0.CO;2-4     Document Type: Article

References (5)

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2. Jazin EE, Cavelier L, Eriksson I, Oreland L, Gyllenstein U. 1996. Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc Natl Acad Sci USA 93:12382-12387.
3. Kleihues P, Burger PC, Scheithauer BW. 1993. Histological typing of tumors of the central nervous system. Berlin: Springer.
4. Marchington DR, Hartshorne GM, Barlow D, Poulton J. 1997. Homopolymeric tract heteroplasmy in mtDNA from tissues and single oozytes: support for a genetic bottleneck. Am J Hum Genet 60:408-416.
5. Szibor R, Plate I, Kirches E, Krause D. 1995. Mixing and thermic treatment of mitochondrial PCR fragments reveal sequence differences by heteroduplex formation: a rapid method for forensic identity testing. Adv Foren Haemogen 6:14-16.