Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells

Neurochemical Research

Volumn 31, Issue 11, 2006, Pages 1349-1357

  Dukhande, Vikas V ^a   Malthankar Phatak, Gauri H ^a   Hugus, Jeremy J ^a,b   Daniels, Christopher K ^a   Lai, James C K ^a,c  

^a IDAHO STATE UNIVERSITY   (United States)

^b NORTHWEST NAZARENE UNIVERSITY   (United States)

^c Moutam States Med Res Institute   (United States)

Author keywords

Astrocytoma and neuroblastoma cells; BSO; Glutathione; Glutathione depletion; Manganese; Mn neurotoxicity; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BUTHIONINE SULFOXIMINE; DYE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HOE 33342; MANGANESE CHLORIDE; PROPIDIUM IODIDE;

APOPTOSIS; ARTICLE; ASTROCYTOMA CELL; CANCER CELL CULTURE; CELL DEATH; CELL SPECIFICITY; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NEUROCHEMISTRY; NEUROPATHOLOGY; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTIMETABOLITES; ASTROCYTOMA; BRAIN NEOPLASMS; BUTHIONINE SULFOXIMINE; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; MANGANESE POISONING; NERVE DEGENERATION; NEUROBLASTOMA;

EID: 33751292156     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9179-7     Document Type: Article

References (41)

1. Lai JCK, Chan AWK, Minski MJ, Lim L (1985) Roles of metal ions in brain development and aging. In: Gabay S, Harris J, Ho BT (eds) Metal ions in neurology and psychiatry. Alan Liss, New York, pp 49-67
2. Lai JCK, Chan AWK, Leung TKC, Minski MJ, Lim L (1992) Neurochemical changes in rats chronically treated with a high concentration of manganese chloride. Neurochem Res 17:841-847
3. Cotzias GC, Horiuchi K, Fuenzalida S, Mena I (1968) Chronic manganese poisoning: clearance of tissue manganese concentrations with persistance of the neurological picture. Neurology 18:376-382
4. Erikson KM, Dobson AW, Dorman DC, Aschner M (2004) Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ 334-335:409-416
5. Lai JCK, Minski MJ, Chan AWK, Lim L (2000) Interrelations between manganese and other metal ions in health and disease. In: Sigel A, Sigel H (eds) Metal ions in biological systems. Dekker, New York, pp 123-156
6. Lai JCK, Chan AWK, Minski MJ, Leung TKC, Lim L, Davison AN (1985) Application of instrumental neutron activation analysis to the study of trace metals in brain and metal toxicity. In: Gabay S, Harris J, Ho BT (eds) Metal ions in neurology and psychiatry, Alan Liss, New York, pp 323-343
7. Zhang S, Fu J, Zhou Z (2004) In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. Toxicol In Vitro 18:71-77
8. Galvani P, Fumagalli P, Santagostino A (1995) Vulnerability of mitochondrial complex I in PC12 cells exposed to manganese. Eur J Pharmacol 293:377-383
9. Donaldson J, LaBella FS, Gesser D (1981) Enhanced autooxidation of dopamine as a possible basis of manganese neurotoxicity. Neurotoxicology 2:53-64
10. Lai JCK, Minski MJ, Chan AWK, Leung TKC, Lim L (1999) Manganese mineral interactions in brain. Neurotoxicology 20:433-444
11. Desole MS, Esposito G, Migheli R, Fresu L, Sircana S, Miele M, De Natale G, Miele E (1995) Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci Lett 192:73-76
12. Worley CG, Bombick D, Allen JW, Suber RL, Aschner M (2002) Effects of manganese on oxidative stress in CATH.a cells. Neurotoxicology 23:159-164
13. Weber S, Dorman DC, Lash LH, Erikson K, Vrana KE, Aschner M (2002) Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints. Neurotoxicology 23:169-175
14. Meister A (1995) Glutathione metabolism. Methods Enzymol 251:3-7
15. Dröge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47-95
16. Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254:7558-7560
17. Schulz JB, Lindenau J, Seyfried J, Dichgans J (2000) Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 267:4904-4911
18. Verity MA (1999) Manganese neurotoxicity: a mechanistic hypothesis. Neurotoxicology 20:489-497
19. Stokes AH, Lewis DY, Lash LH, Jerome WG III, Grant KW, Aschner M, Vrana KE (2000) Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosis. Brain Res 858:1-8
20. Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JCK (2004) Differential lowering by manganese treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with manganese-induced cell death. Neurochem Res 29:709-717
21. Lai JCK, Leung TKC, Lim L (1984) Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy. Neurotoxicology 5:37-47
22. Miele M, Serra PA, Esposito G, Delogu MR, Migheli R, Rocchitta G, Desole MS (2000) Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese. Aging 12:393-397
23. Wedler FC, Ley BW (1990) Ca(II) and Zn(II) ions alter the dynamics and distribution of Mn(II) in chick cultured glial cells. Neurochem Res 15:1221-1228
24. Normandin L, Hazell AS (2002) Manganese Neurotoxicity: an update of pathophysiologic mechanisms. Metab Brain Dis 17:375-387
25. Raps SP, Lai JCK, Hertz L, Cooper AJL (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res 493:398-401
26. Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJL (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 62:45-53
27. Mossman T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
28. White MG, Emery M, Nonner D, Barrett JN (2003) Caspase activation contributes to delayed death of heat-stressed striatal neurons. J Neurochem 87:958-968
29. Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207-212
30. Takeda A (2003) Manganese action in brain function. Brain Res Rev 41:79-87
31. Olanow CW, Good PF, Shinotoh H, Hewitt KA, Vingerhoets F, Snow BJ, Beal MF, Calne DB, Perl DP (1996) Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. Neurology 46:492-498
32. Krieger D, Krieger S, Jansen O, Gass P, Theilmann L, Lichtnecker H (1995) Manganese and chronic hepatic encephalopathy. Lancet 346:270-274
33. Nelson K, Golnick J, Korn T, Angle C (1993) Manganese encephalopathy: utility of early magnetic resonance imaging. Br J Ind Med 50:510-513
34. Yamada M, Ohno S, Okayasu I, Okeda R, Hatakeyama S, Watanabe H, Ushio K, Tsukagoshi H (1986) Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain. Acta Neuropathol (Berl) 70:273-278
35. Hazell AS, Normandin L, Norenberg MD, Kennedy G, Yi JH (2005) Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett 396:167-171
36. Lai JCK, Leung TKC, Lim L (1985) Effects of metal ions on neurotransmitter function and metabolism. In: Gabay S, Harris J, Ho BT (eds) Metal ions in neurology and psychiatry. Alan Liss, New York, pp 177-197
37. Jain A, Martensson J, Stole E, Auld PA, Meister A (1991) Glutathione deficiency leads to mitochondrial damage in brain PNAS 88:1913-1917
38. Meister A (1995) Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271:35-42
39. Desole MS, Esposito G, Migheli R, Sircana S, Delogu MR, Fresu L, Miele M, de Natale G, Miele E (1997) Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells. Pharmacol Res 36:285-292
40. Aschner M, Gannon M, Kimelberg HK (1992) Manganese uptake and efflux in cultured rat astrocytes. J Neurochem 58:730-735
41. Zatta P, Lucchini R, Van Rensburg SJ, Taylor A (2003) The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. Brain Res Bull 62:15-28