Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells

Brain Research

Volumn 891, Issue 1-2, 2001, Pages 54-68

  Garcia, S J ^a   Seidler, F J ^a   Crumpton, T L ^a   Slotkin, T A ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Adenylyl cyclase; AP 1; C6 cell; Chlorpyrifos; Differentiation; DNA synthesis; Nuclear transcription factor; Oxidative stress; Sp1

Indexed keywords

CHLORPYRIFOS; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHOLINERGIC NERVE CELL; CONCENTRATION RESPONSE; CONTRAST ENHANCEMENT; DNA SYNTHESIS; ENZYME ACTIVITY; GLIOMA CELL; MACROMOLECULE; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TARGET CELL;

ADENYLATE CYCLASE; ANIMALS; BRAIN; CHLORPYRIFOS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INSECTICIDES; MACROMOLECULAR SUBSTANCES; NEUROGLIA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0035830772     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03189-9     Document Type: Article

References (105)

1. The DNA-binding efficiency of Sp1 is affected by redox changes
2. αs isoforms in PC12 cells: Relationship to neurite outgrowth
3. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
4. Glial cells in neurotoxicity development
5. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: Implications for neurotoxicity
6. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides
7. In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides
8. Vulnerable processes of nervous system development: A review of markers and methods
9. Effects of α-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: Critical perinatal periods for regional selectivity
10. Cell proliferation in growing cultures of dissociated embryonic mouse brain: Macromolecule and ornithine decarboxylase synthesis and regulation by hormones and drugs
11. Effect of peroxynitrite on the mitochondrial respiratory chain: Susceptibility of neurones and astocytes in primary culture
12. Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat
13. Chlorpyrifos interferes with cell development in rat brain regions
14. Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats
15. Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats
16. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats
17. Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat
18. Effects of valproic acid on β-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells
19. Corticosterone exacerbates cyanide-induced cell death in hippocampal cultures: Role of astrocytes
20. Biochemical aspects of cardiac muscle differentiation
21. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: Effects on nuclear transcription factor involved in cell replication and differentiation
22. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
23. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways
24. Developmental neurotoxicity of chlorpyrifos: Delayed targeting of DNA synthesis after repeated administration
25. Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes
26. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity
27. Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: Is acetylcholinesterase inhibition the site of action?
28. Exposures from indoor spraying of chlorpyrifos pose greater health risks to children than currently estimated
29. Enzyme induction and regulation of protein synthesis
30. Neurotransmitters and neurotrophins collaborate to influence brain development
31. Potential exposure and health risks of infants following indoor residential pesticide applications
32. Strong c-Jun/AP-1 immunoreactivity is restricted to apoptotic cells following intracerebral ibotenic acid injection in developing rats
33. Effect of the tricyclic antidepressant desipramine in β-adrenergic receptor in cultured rat C6 glioma cells
34. Effect of growth factors on the in vitro growth and differentiation of early and late passage C6 glioma cells
35. Alcohol, astroglia, and brain development
36. Association between the increase of cAMP content and the trans-synaptic induction of tyrosine hydroxylase in rat adrenal medulla
37. Monitoring intracellular nitric oxide formation by chlorofluorescein in neuronal cells
38. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children
39. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
40. Ethanol, oxidative stress, reactive aldehydes and the fetus
41. β-Adrenergic receptors regulate astrogliosis and cell proliferation in the central nervous system in vivo
42. In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase
43. Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum
44. Cyclic AMP, early response gene expression, and DNA synthesis in rat smooth muscle cells
45. Structure, mechanism, and regulation of mammalian adenylyl cyclase
46. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chlorpyrifos
47. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells: N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade
48. Elevated AP-1 transcription factor DNA binding activity at the onset of functional plasticity during development of rat sensory cortical areas
49. Hyperoxia induces the differentiated neuronal phenotype of PC12 cells by producing reactive oxygen species
50. Regulation of mRNAs for three enzymes in the glial cell model C6 cell line
51. Pesticides and inner-city children: Exposures, risks, and prevention
52. Gestational exposure to chlorpyrifos: Apparent protection of the fetus?
53. Signal transduction processes in the developing brain: Perturbations of G protein α-subunit abundances by perinatal hypothyroidism
54. Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells
55. Mn-uncoupling of the catecholamine sensitive adenylate cyclase system of rat reticulocytes
56. 3H]hemicholinium-3 binding in rat brain
57. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion
58. Regulation of insulin-like growth factor I production in rat C6 glioma cells: Possible role as an autocrine/paracrine growth factor
59. Protein measurement with the Folin phenol reagent
60. Effects of lithium on signal transduction in humans
61. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
62. Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain
63. Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway
64. Common mechanism of toxicity: A case study of organophosphorus pesticides
65. Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures
66. Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors
67. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats
68. Embryotoxicity and neurotoxicity in rats associated with prenatal exposure to Dursban®
69. Elevated basal AP-1 DNA binding activity in developing rat brain
70. Pharmacological regulation of AP-1 transcription factor DNA binding activity
71. DNA binding activity of CREB transcription factors during ontogeny of the central nervous system
72. Lead-induced developmental changes in AP-1 DNA binding in rat brain
73. Neonatal noradrenaline depletion prevents the transition of Bergmann glia in the developing cerebellum
74. Organophosphorus pesticides: Do they all have the same mechanism of toxicity?
75. Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures
76. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides
77. Chlorpyrifos: Assessment of potential for delayed neurotoxicity by repeated dosing in adult hens with monitoring of brain acetylcholinesterase, brain and lymphocyte neurotoxic esterase and plasma butyrylcholinesterase activities
78. Oxidative stress-induced cell damage in the CNS
79. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos
80. Developmental expression of Sp1 in the mouse
81. Maintenance of neuronal glutathion by glial cells
82. Forskolin: Its biological and chemical properties
83. Interference between DNA binding activities of AP-1 and GR transcription factors in rat thymocytes undergoing dexamethasone-induced apoptosis
84. Locus coeruleus (LC) - Target interaction and cAMP in control of LC development
85. Developmental cholinotoxicants: Nicotine and chlorpyrifos
86. β-Adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells
87. Glucocorticoid administration discoordinates nuclear transcription factors in fetal rat brain: Implications for the use of antenatal steroids
88. Tonic suppression of adrenal AP-1 activity by glucocorticoids
89. Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade
90. Modeling the developmental neurotoxicity of chlorpyrifos in vitro: Macromolecule synthesis in PC12 cells
91. Neuronal death: Is there a role for astrocytes?
92. Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species
93. Effect of nerve growth factor on AP-1, NF-kappa-B, and Oct DNA binding activity in apoptotic PC12 cells: Extrinsic and intrinsic elements
94. Lithium attenuates nerve growth factor-induced activation of AP-1 DNA binding activity in PC12 cells
95. Dexamethasone attenuates kainate-induced AP-1 activation in rat brain
96. Rapid arrest of DNA synthesis by N6, O2′-dibutyryl cyclic adenosine 3′,5′-monophosphate in cultured hepatoma cells
97. Glucocorticoid control of glial gene expression
98. Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex
99. Regulation of differentiated properties of oligodendrocytes
100. Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms
101. Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression
102. Ontogeny of regulatory mechanisms for β-adrenoceptor control of rat cardiac adenylyl cyclase: Targeting of G-proteins and the cyclase catalytic subunit
103. Agonist-induced sensitization of β-adrenoceptor signaling in neonatal rat heart: Expression and catalytic activity of adenylyl cyclase
104. Ontogeny of G-protein expression: Control by β-adrenoceptors