Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity

Toxicology and Applied Pharmacology

Volumn 264, Issue 3, 2012, Pages 404-412

  Toyooka, Tatsushi ^a   Shinmen, Takuya ^a   Aarts, Jac M M J G ^b   Ibuki, Yuko ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

H2AX; 9,10 Phenanthrenequinone; Genotoxicity; NAC; NQO1; ROS

Indexed keywords

ACETYLCYSTEINE; ACTIN; HISTONE H2AX; OXIDOREDUCTASE; PHENANTHRENEQUINONE; PROTEIN NQO1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ENZYME ACTIVITY; EXHAUST GAS; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TISSUE SPECIFICITY;

ACETYLCYSTEINE; ANIMALS; CELL LINE; CRICETINAE; FIBROBLASTS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KERATINOCYTES; NAD(P)H DEHYDROGENASE (QUINONE); PHENANTHRENES;

EID: 84867861457     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.017     Document Type: Article

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