Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells

Free Radical Biology and Medicine

Volumn 44, Issue 8, 2008, Pages 1645-1655

  Taguchi, Keiko ^a   Shimada, Megumi ^a   Fujii, Sayako ^a   Sumi, Daigo ^a   Pan, Xiaoqing ^a   Yamano, Shigeru ^b   Nishiyama, Takahito ^c   Hiratsuka, Akira ^c   Yamamoto, Masayuki ^a   Cho, Arthur K ^d   Froines, John R ^d   Kumagai, Yoshito ^a,d  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

9,10 Phenanthraquinone; Detoxification; Free radicals; Glucuronidation; Redox activity

Indexed keywords

5' DIPHOSPHATE GLUCURONOSYLTRANSFERASE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A6; MONOGLUCURONIDE; PHENANTHRENEQUINONE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DETOXIFICATION; EPITHELIUM CELL; GENE DELETION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; EPITHELIAL CELLS; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARTICULATE MATTER; PHENANTHRENES; SUBSTRATE SPECIFICITY;

EID: 41149155769     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.01.024     Document Type: Article

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