N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct

Free Radical Biology and Medicine

Volumn 44, Issue 6, 2008, Pages 1069-1074

  Lambert, Joshua D ^a   Sang, Shengmin ^a   Yang, Chung S ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

( ) Epigallocatechin 3 gallate; Apoptosis; Lung cancer; N Acetylcysteine

Indexed keywords

ACETYLCYSTEINE; EPIGALLOCATECHIN GALLATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LUNG CANCER; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANTIOXIDANTS; APOPTOSIS; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLOW CYTOMETRY; HUMANS; LUNG NEOPLASMS; MICE; RADIATION-PROTECTIVE AGENTS;

MURINAE;

EID: 39949085226     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.12.016     Document Type: Article

References (28)

1. Lambert J.D., and Yang C.S. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat. Res. 523-524 (2003) 201-208
2. Lambert J.D., Hong J., Yang G.Y., Liao J., and Yang C.S. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am. J. Clin. Nutr. 81 (2005) 284S-291S
3. Hou Z., Lambert J.D., Chin K.V., and Yang C.S. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutat. Res 555 (2004) 3-19
4. Higdon J.V., and Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 43 (2003) 89-143
5. Hong J., Lu H., Meng X., Ryu J.H., Hara Y., and Yang C.S. Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells. Cancer Res. 62 (2002) 7241-7246
6. Sang S., Lee M.J., Hou Z., Ho C.T., and Yang C.S. Stability of tea polyphenol (-)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions. J. Agric. Food Chem. 53 (2005) 9478-9484
7. Yang C.S., Hong J., Hou Z., and Sang S. Green tea polyphenols: antioxidative and prooxidative effects. J. Nutr. 134 (2004) 3181S
8. Yang C.S., Sang S., Lambert J.D., Hou Z., Ju J., and Lu G. Possible mechanisms of the cancer-preventive activities of green tea. Mol. Nutr. Food Res. 50 (2006) 170-175
9. Chan M.M., Soprano K.J., Weinstein K., and Fong D. Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility. J. Cell. Physiol. 207 (2006) 389-396
10. Hou Z., Sang S., You H., Lee M.J., Hong J., Chin K.V., and Yang C.S. Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer Res. 65 (2005) 8049-8056
11. Vittal R., Selvanayagam Z.E., Sun Y., Hong J., Liu F., Chin K.V., and Yang C.S. Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. Mol. Cancer Ther. 3 (2004) 1091-1099
12. Yang G.Y., Liao J., Kim K., Yurkow E.J., and Yang C.S. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 19 (1998) 611-616
13. Hou Z., Xiao H., Lambert J., You H., and Yang C.S. Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces oxidative stress and DNA damage in cancer cell lines, xenograft tumors, and mouse liver. Proc. Am. Assoc. Cancer Res. 47 (2006) 1150
14. Sang S., Lambert J.D., Hong J., Tian S., Lee M.J., Stark R.E., Ho C.T., and Yang C.S. Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice. Chem. Res. Toxicol. 18 (2005) 1762-1769
15. Galati G., Lin A., Sultan A.M., and O'Brien P.J. Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radic. Biol. Med. 40 (2006) 570-580
16. Bold R.J., Virudachalam S., and McConkey D.J. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J. Surg. Res. 100 (2001) 11-17
17. Hong J., Lambert J.D., Lee S.H., Sinko P.J., and Yang C.S. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem. Biophys. Res. Commun. 310 (2003) 222-227
18. Lee M.J., Prabhu S., Meng X., Li C., and Yang C.S. An improved method for the determination of green and black tea polyphenols in biomatrices by high-performance liquid chromatography with coulometric array detection. Anal. Biochem. 279 (2000) 164-169
19. Yang G.Y., Liao J., Li C., Chung J., Yurkow E.J., Ho C.T., and Yang C.S. Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21 (2000) 2035-2039
20. Monks T.J., Jones D.C., Bai F., and Lau S.S. The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity. Ther. Drug Monit. 26 (2004) 132-136
21. Bai F., Lau S.S., and Monks T.J. Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity. Chem. Res. Toxicol. 12 (1999) 1150-1157
22. Reddy B.S., Wang C.X., Kong A.N., Khor T.O., Zheng X., Steele V.E., Kopelovich L., and Rao C.V. Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats. Cancer Res. 66 (2006) 4542-4546
23. Chauhan D., Li G., Podar K., Hideshima T., Shringarpure R., Catley L., Mitsiades C., Munshi N., Tai Y.T., Suh N., Gribble G.W., Honda T., Schlossman R., Richardson P., Sporn M.B., and Anderson K.C. The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood 103 (2004) 3158-3166
24. Stadheim T.A., Suh N., Ganju N., Sporn M.B., and Eastman A. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. J. Biol. Chem. 277 (2002) 16448-16455
25. Izzotti A., Bagnasco M., Cartiglia C., Longobardi M., Balansky R.M., Merello A., Lubet R.A., and De Flora S. Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung. Eur. J. Cancer 41 (2005) 1864-1874
26. Vanisree A.J., and Shyamaladevi C.S. The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells-in vitro. Life Sci. 79 (2006) 654-659
27. Thanopolou E., Baltayiannis N., and Lykogianni V. Nutritional aspects regarding lung cancer chemoprevention. J. Buon. 11 (2006) 7-20
28. Lambert J.D., and Yang C.S. Mechanisms of cancer prevention by tea constituents. J. Nutr. 133 (2003) 3262S-3267S