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Volumn 323, Issue 1-2, 2012, Pages 25-32

Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease

Author keywords

Brain hypoperfusion; Cerebral ischemia; Epigenetic modifications; Free radicals; Oxidative stress; Vascular factors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANGIOTENSIN 1B RECEPTOR; APOLIPOPROTEIN E4; CORTICOSTERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DEXAMETHASONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MYOCARDIN; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PROOPIOMELANOCORTIN; REACTIVE OXYGEN METABOLITE; RIBOSOME DNA; SERUM RESPONSE FACTOR;

EID: 84867842594     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2012.09.010     Document Type: Review
Times cited : (33)

References (136)
  • 1
    • 33749177143 scopus 로고    scopus 로고
    • A hundred years of Alzheimer's disease research
    • J. Hardy A hundred years of Alzheimer's disease research Neuron 52 2006 3 13
    • (2006) Neuron , vol.52 , pp. 3-13
    • Hardy, J.1
  • 2
    • 34547775843 scopus 로고    scopus 로고
    • Molecular pathology and pharmacogenomics in Alzheimer's disease: Polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression
    • R. Cacabelos Molecular pathology and pharmacogenomics in Alzheimer's disease: polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression Methods Find Exp Clin Pharmacol 29 Suppl. A 2007 1 91
    • (2007) Methods Find Exp Clin Pharmacol , vol.29 , Issue.SUPPL. A , pp. 1-91
    • Cacabelos, R.1
  • 4
    • 33747875649 scopus 로고    scopus 로고
    • Systemic inflammatory markers and risk of dementia
    • T. Dziedzic Systemic inflammatory markers and risk of dementia Am J Alzheimers Dis Other Demen 21 2006 258 262
    • (2006) Am J Alzheimers Dis Other Demen , vol.21 , pp. 258-262
    • Dziedzic, T.1
  • 5
    • 77449143860 scopus 로고    scopus 로고
    • Pharmacogenomic protocols in CNS disorders and dementia
    • R. Cacabelos Pharmacogenomic protocols in CNS disorders and dementia Neurodegener Dis 7 2010 167 169
    • (2010) Neurodegener Dis , vol.7 , pp. 167-169
    • Cacabelos, R.1
  • 6
    • 3042727913 scopus 로고    scopus 로고
    • Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease
    • W. Kalback, C. Esh, E.M. Castano, A. Rahman, T. Kokjohn, and D.C. Luehrs Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease Neurol Res 26 2004 525 539
    • (2004) Neurol Res , vol.26 , pp. 525-539
    • Kalback, W.1    Esh, C.2    Castano, E.M.3    Rahman, A.4    Kokjohn, T.5    Luehrs, D.C.6
  • 7
    • 24644456470 scopus 로고    scopus 로고
    • Calcium dysregulation in Alzheimer's disease: Recent advances gained from genetically modified animals
    • I.F. Smith, K.N. Green, and F.M. LaFeria Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals Cell Calcium 38 2005 427 437
    • (2005) Cell Calcium , vol.38 , pp. 427-437
    • Smith, I.F.1    Green, K.N.2    Laferia, F.M.3
  • 8
    • 27544484846 scopus 로고    scopus 로고
    • Are mitochondria critical in the pathogenesis of Alzheimer's disease?
    • P.H. Reddy, and M.F. Beal Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res Brain Res Rev 49 2005 618 632
    • (2005) Brain Res Brain Res Rev , vol.49 , pp. 618-632
    • Reddy, P.H.1    Beal, M.F.2
  • 9
    • 34648834538 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in aging and Alzheimer's disease: Strategies to protect neurons
    • P.H. Reddy Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons Antioxid Redox Signal 9 2007 1647 1658
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1647-1658
    • Reddy, P.H.1
  • 10
    • 33947138841 scopus 로고    scopus 로고
    • The dysregulation of the cell cycle and the diagnosis of Alzheimer's disease
    • Z. Nagy The dysregulation of the cell cycle and the diagnosis of Alzheimer's disease Biochim Biophys Acta 1772 2007 402 408
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 402-408
    • Nagy, Z.1
  • 13
    • 0037111287 scopus 로고    scopus 로고
    • Similarities between Alzheimer's disease and vascular dementia
    • R. Kalaria Similarities between Alzheimer's disease and vascular dementia J Neurol Sci 203-204 2002 29 34
    • (2002) J Neurol Sci , vol.203-204 , pp. 29-34
    • Kalaria, R.1
  • 14
    • 80053189523 scopus 로고    scopus 로고
    • Can stroke cause neurodegenerative dementia?
    • T.B. Cumming, and A. Brodtmann Can stroke cause neurodegenerative dementia? Int J Stroke 6 2011 416 424
    • (2011) Int J Stroke , vol.6 , pp. 416-424
    • Cumming, T.B.1    Brodtmann, A.2
  • 15
    • 5644248024 scopus 로고    scopus 로고
    • Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial
    • H. Engelberg Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial Dement Geriatr Cogn Disord 18 2004 278 298
    • (2004) Dement Geriatr Cogn Disord , vol.18 , pp. 278-298
    • Engelberg, H.1
  • 16
    • 33845505233 scopus 로고    scopus 로고
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
    • X. Sun, G. He, H. Qing, W. Zhou, F. Dobie, and F. Cai Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression Proc Natl Acad Sci U S A 103 2006 18727 18732
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18727-18732
    • Sun, X.1    He, G.2    Qing, H.3    Zhou, W.4    Dobie, F.5    Cai, F.6
  • 19
    • 39349089972 scopus 로고    scopus 로고
    • Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension
    • W. Dai, O.L. Lopez, O.T. Carmichael, J. Becker, L.H. Kuller, and M. Gach Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension Stroke 39 2008 349 354
    • (2008) Stroke , vol.39 , pp. 349-354
    • Dai, W.1    Lopez, O.L.2    Carmichael, O.T.3    Becker, J.4    Kuller, L.H.5    Gach, M.6
  • 20
    • 33947134956 scopus 로고    scopus 로고
    • Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
    • B.R. Reed, D.M. Mungas, J.H. Kramer, W. Ellis, H.V. Vinters, and C. Zarow Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease Brain 130 2007 731 739
    • (2007) Brain , vol.130 , pp. 731-739
    • Reed, B.R.1    Mungas, D.M.2    Kramer, J.H.3    Ellis, W.4    Vinters, H.V.5    Zarow, C.6
  • 21
    • 24344482925 scopus 로고    scopus 로고
    • Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    • N.D. Prins, E.J. van Dijk, T. den Heijer, S.E. Vermeer, J. Jolles, and P.J. Koudstaal Cerebral small-vessel disease and decline in information processing speed, executive function and memory Brain 128 2007 2034 2041
    • (2007) Brain , vol.128 , pp. 2034-2041
    • Prins, N.D.1    Van Dijk, E.J.2    Den Heijer, T.3    Vermeer, S.E.4    Jolles, J.5    Koudstaal, P.J.6
  • 22
    • 33748951370 scopus 로고    scopus 로고
    • How do heart disease and stroke become risk factors for Alzheimer's disease?
    • J.C. de la Torre How do heart disease and stroke become risk factors for Alzheimer's disease? Neurol Res 28 2006 637 644
    • (2006) Neurol Res , vol.28 , pp. 637-644
    • De La Torre, J.C.1
  • 23
    • 12544254102 scopus 로고    scopus 로고
    • Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    • T. den Heijer, L.J. Launer, N.D. Prins, E.J. van Dijk, S.E. Vermeer, and A. Hofman Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe Neurology 64 2005 263 267
    • (2005) Neurology , vol.64 , pp. 263-267
    • Den Heijer, T.1    Launer, L.J.2    Prins, N.D.3    Van Dijk, E.J.4    Vermeer, S.E.5    Hofman, A.6
  • 24
    • 7644223380 scopus 로고    scopus 로고
    • Risk factors for vascular dementia and Alzheimer disease
    • P.B. Gorelick Risk factors for vascular dementia and Alzheimer disease Stroke 25 11 Suppl. 1 2004 2620 2622
    • (2004) Stroke , vol.25 , Issue.11 SUPPL. 1 , pp. 2620-2622
    • Gorelick, P.B.1
  • 25
    • 17844385791 scopus 로고    scopus 로고
    • Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation
    • M. Koistinaho, and J. Koistinaho Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation Brain Res Brain Res Rev 48 2005 240 250
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 240-250
    • Koistinaho, M.1    Koistinaho, J.2
  • 26
    • 38049034539 scopus 로고    scopus 로고
    • Cerebral ischemia and Alzheimer's disease: The expression of amyloid-beta and apolipoprotein e in human hippocampus
    • J.P. Qi, H. Wu, Y. Yang, D.D. Wang, Y.X. Chen, and Y.H. Gu Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus J Alzheimers Dis 12 2007 335 341
    • (2007) J Alzheimers Dis , vol.12 , pp. 335-341
    • Qi, J.P.1    Wu, H.2    Yang, Y.3    Wang, D.D.4    Chen, Y.X.5    Gu, Y.H.6
  • 27
    • 0141819900 scopus 로고    scopus 로고
    • Vascular factors in Alzheimer's disease
    • R.N. Kalaria Vascular factors in Alzheimer's disease Int Psychogeriatr 15 Suppl. 1 2003 47 52
    • (2003) Int Psychogeriatr , vol.15 , Issue.SUPPL. 1 , pp. 47-52
    • Kalaria, R.N.1
  • 28
    • 0037442177 scopus 로고    scopus 로고
    • Alzheimer's disease and angiogenesis
    • A.H. Vagnucci Jr., and W.W. Li Alzheimer's disease and angiogenesis Lancet 361 2003 605 608
    • (2003) Lancet , vol.361 , pp. 605-608
    • Vagnucci Jr., A.H.1    Li, W.W.2
  • 29
    • 0344737582 scopus 로고    scopus 로고
    • Vascular pathology in Alzheimer disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    • D.R. Thal, E. Ghebremedhin, M. Orantes, and O.D. Wiestler Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline J Neuropathol Exp Neurol 62 2003 1287 1301
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1287-1301
    • Thal, D.R.1    Ghebremedhin, E.2    Orantes, M.3    Wiestler, O.D.4
  • 30
    • 0036447681 scopus 로고    scopus 로고
    • Vascular basis of Alzheimer's pathogenesis
    • J.C. de la Torre Vascular basis of Alzheimer's pathogenesis Ann N Y Acad Sci 977 2002 196 215
    • (2002) Ann N y Acad Sci , vol.977 , pp. 196-215
    • De La Torre, J.C.1
  • 32
    • 33750022878 scopus 로고    scopus 로고
    • Vascular determinants of cholinerigic deficits in Alzheimer disease and vascular dementia
    • G.C. Román, and R.N. Kalaria Vascular determinants of cholinerigic deficits in Alzheimer disease and vascular dementia Neurobiol Aging 27 2006 1769 1785
    • (2006) Neurobiol Aging , vol.27 , pp. 1769-1785
    • Román, G.C.1    Kalaria, R.N.2
  • 33
    • 34147183707 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
    • R. Deane, and B.V. Zlokovic Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Curr Alzheimer Res 4 2007 191 197
    • (2007) Curr Alzheimer Res , vol.4 , pp. 191-197
    • Deane, R.1    Zlokovic, B.V.2
  • 34
    • 0036259003 scopus 로고    scopus 로고
    • Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss
    • J.J. Kril, S. Patel, A.J. Harding, and G.M. Halliday Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss J Neurol Neurosurg Psychiatry 72 2002 747 751
    • (2002) J Neurol Neurosurg Psychiatry , vol.72 , pp. 747-751
    • Kril, J.J.1    Patel, S.2    Harding, A.J.3    Halliday, G.M.4
  • 35
    • 34047276804 scopus 로고    scopus 로고
    • Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease
    • H. Kitaguchi, M. Ihara, H. Saiki, R. Takahashi, and H. Tomimoto Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease Neurosci Lett 417 2007 128 131
    • (2007) Neurosci Lett , vol.417 , pp. 128-131
    • Kitaguchi, H.1    Ihara, M.2    Saiki, H.3    Takahashi, R.4    Tomimoto, H.5
  • 36
    • 37349042862 scopus 로고    scopus 로고
    • Genes endothelial function and cerebral small vessel disease in man
    • H.S. Markus Genes endothelial function and cerebral small vessel disease in man Exp Physiol 93 2008 121 127
    • (2008) Exp Physiol , vol.93 , pp. 121-127
    • Markus, H.S.1
  • 39
    • 28244470262 scopus 로고    scopus 로고
    • Cerebrovascular gene linked to Alzheimer's disease pathology
    • J.C. de la Torre Cerebrovascular gene linked to Alzheimer's disease pathology Trends Mol Med 11 2005 534 536
    • (2005) Trends Mol Med , vol.11 , pp. 534-536
    • De La Torre, J.C.1
  • 40
    • 0037319288 scopus 로고    scopus 로고
    • Converging pathogenic mechanisms in vascular and neurodegenerative dementia
    • C. Iadecola, and P.B. Gorelick Converging pathogenic mechanisms in vascular and neurodegenerative dementia Stroke 34 2003 335 337
    • (2003) Stroke , vol.34 , pp. 335-337
    • Iadecola, C.1    Gorelick, P.B.2
  • 41
    • 1842528072 scopus 로고    scopus 로고
    • Cerebral infarctions and the likelihood dementia from Alzheimer disease pathology
    • J.A. Schneider, R.S. Wilson, J.L. Bienias, D.A. Evans, and D.A. Bennett Cerebral infarctions and the likelihood dementia from Alzheimer disease pathology Neurology 62 2004 1148 1155
    • (2004) Neurology , vol.62 , pp. 1148-1155
    • Schneider, J.A.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Bennett, D.A.5
  • 43
    • 22144451172 scopus 로고    scopus 로고
    • The age-dependent relation of blood pressure to cognitive function and dementia
    • C. Qiu, B. Winblad, and L. Fratiglioni The age-dependent relation of blood pressure to cognitive function and dementia Lancet Neurol 4 2005 487 499
    • (2005) Lancet Neurol , vol.4 , pp. 487-499
    • Qiu, C.1    Winblad, B.2    Fratiglioni, L.3
  • 44
    • 7644223663 scopus 로고    scopus 로고
    • Atherosclerosis of cerebral arteries in Alzheimer's disease
    • A.E. Roher, C. Esh, A. Rahman, T.A. Kokjohn, and T.G. Beach Atherosclerosis of cerebral arteries in Alzheimer's disease Stroke 35 11 Suppl. 1 2004 2623 2627
    • (2004) Stroke , vol.35 , Issue.11 SUPPL. 1 , pp. 2623-2627
    • Roher, A.E.1    Esh, C.2    Rahman, A.3    Kokjohn, T.A.4    Beach, T.G.5
  • 45
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • B.V. Zlokovic Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci 28 2005 202 208
    • (2005) Trends Neurosci , vol.28 , pp. 202-208
    • Zlokovic, B.V.1
  • 46
    • 0036449823 scopus 로고    scopus 로고
    • Vascular pathology in Alzheimer's disease
    • T. Miyakawa Vascular pathology in Alzheimer's disease Ann N Y Acad Sci 977 2002 303 305
    • (2002) Ann N y Acad Sci , vol.977 , pp. 303-305
    • Miyakawa, T.1
  • 48
    • 23844522541 scopus 로고    scopus 로고
    • Aggregation of vascular risk factors and risk of incident Alzheimer disease
    • J.A. Luchsinger, C. Reitz, L.S. Honig, M.X. Tang, S. Shea, and R. Mayeux Aggregation of vascular risk factors and risk of incident Alzheimer disease Neurology 65 2005 545 551
    • (2005) Neurology , vol.65 , pp. 545-551
    • Luchsinger, J.A.1    Reitz, C.2    Honig, L.S.3    Tang, M.X.4    Shea, S.5    Mayeux, R.6
  • 50
    • 0036447662 scopus 로고    scopus 로고
    • Hypertension and related factors in the etiology of Alzheimer's disease
    • I. Skoog, and D. Gustafson Hypertension and related factors in the etiology of Alzheimer's disease Ann N Y Acad Sci 977 2002 29 36
    • (2002) Ann N y Acad Sci , vol.977 , pp. 29-36
    • Skoog, I.1    Gustafson, D.2
  • 52
    • 36348997143 scopus 로고    scopus 로고
    • Acute hypertensive crisis may be a risk factor for Alzheimer's disease induction and progression
    • S. Gharibzadeh, S.S. Hoseini, and S. Mahdavi Acute hypertensive crisis may be a risk factor for Alzheimer's disease induction and progression J Neuropsychiatry Clin Neurosci 19 2007 483 484
    • (2007) J Neuropsychiatry Clin Neurosci , vol.19 , pp. 483-484
    • Gharibzadeh, S.1    Hoseini, S.S.2    Mahdavi, S.3
  • 53
    • 16644370316 scopus 로고    scopus 로고
    • The significance of arterial hypertension for the development of dementia
    • J. Schrader The significance of arterial hypertension for the development of dementia MMW Fortschr Med 146 2004 40 42
    • (2004) MMW Fortschr Med , vol.146 , pp. 40-42
    • Schrader, J.1
  • 54
    • 34848891873 scopus 로고    scopus 로고
    • Assessment of endothelial function in Alzheimer's disease: Is Alzheimer's disease a vascular disease?
    • D.S. Dede, B. Yavuz, B.B. Yavuz, M. Cankurtaran, M. Halil, and Z. Ulger Assessment of endothelial function in Alzheimer's disease: is Alzheimer's disease a vascular disease? J Am Geriatr Soc 55 2007 1613 1617
    • (2007) J Am Geriatr Soc , vol.55 , pp. 1613-1617
    • Dede, D.S.1    Yavuz, B.2    Yavuz, B.B.3    Cankurtaran, M.4    Halil, M.5    Ulger, Z.6
  • 56
    • 0036327648 scopus 로고    scopus 로고
    • Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer's disease
    • O.C. Suter, T. Sunthorn, R. Kraftsik, J. Straubel, P. Darekar, and K. Khalilii Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer's disease Stroke 33 2002 1986 1992
    • (2002) Stroke , vol.33 , pp. 1986-1992
    • Suter, O.C.1    Sunthorn, T.2    Kraftsik, R.3    Straubel, J.4    Darekar, P.5    Khalilii, K.6
  • 58
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • B.V. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci 12 2011 723 738
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 59
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • R.D. Bell, E.A. Winkler, A.P. Sagare, I. Singh, B. LaRue, and R. Deane Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron 68 2010 409 427
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    Larue, B.5    Deane, R.6
  • 60
    • 33846471269 scopus 로고    scopus 로고
    • Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype
    • N. Chow, R.D. Bell, R. Deane, J.W. Streb, J. Chen, and A. Brooks Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype PNAS 104 2007 823 828
    • (2007) PNAS , vol.104 , pp. 823-828
    • Chow, N.1    Bell, R.D.2    Deane, R.3    Streb, J.W.4    Chen, J.5    Brooks, A.6
  • 61
    • 59649110562 scopus 로고    scopus 로고
    • SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells
    • R.D. Bell, R. Deane, N. Chow, X. Long, A. Sagare, and I. Singh SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells Nat Cell Biol 11 2009 143 153
    • (2009) Nat Cell Biol , vol.11 , pp. 143-153
    • Bell, R.D.1    Deane, R.2    Chow, N.3    Long, X.4    Sagare, A.5    Singh, I.6
  • 62
    • 24744457932 scopus 로고    scopus 로고
    • Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
    • Z. Wu, H. Guo, N. Chow, J. Sallstrom, R.D. Bell, and R. Deane Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med 11 2005 959 965
    • (2005) Nat Med , vol.11 , pp. 959-965
    • Wu, Z.1    Guo, H.2    Chow, N.3    Sallstrom, J.4    Bell, R.D.5    Deane, R.6
  • 63
    • 34948888151 scopus 로고    scopus 로고
    • Clearance of amyloid-β by circulating lipoprotein receptors
    • A. Sagare, R. Deane, R.D. Bell, B. Johnson, K. Hamm, and R. Pendu Clearance of amyloid-β by circulating lipoprotein receptors Nat Med 13 2007 1029 1031
    • (2007) Nat Med , vol.13 , pp. 1029-1031
    • Sagare, A.1    Deane, R.2    Bell, R.D.3    Johnson, B.4    Hamm, K.5    Pendu, R.6
  • 64
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
    • R. Deane, Z. Wu, A. Sagare, J. Davis, S. Du Yan, and K. Hamm LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron 43 2004 333 344
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3    Davis, J.4    Du Yan, S.5    Hamm, K.6
  • 65
    • 0036227489 scopus 로고    scopus 로고
    • Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood
    • O.R. Monro, J.B. Mackic, S. Yamada, M.B. Segal, J. Ghiso, and C. Maurer Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood Neurobiol Aging 23 2002 405 412
    • (2002) Neurobiol Aging , vol.23 , pp. 405-412
    • Monro, O.R.1    MacKic, J.B.2    Yamada, S.3    Segal, M.B.4    Ghiso, J.5    Maurer, C.6
  • 66
    • 0022371325 scopus 로고
    • Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: Kinetics of unidirectional influx, carrier specificity and effects of glucagon
    • G.E. Mann, B.V. Zlokovic, and Yuclilevich Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon Biochim Biophys Acta 819 1985 241 248
    • (1985) Biochim Biophys Acta , vol.819 , pp. 241-248
    • Mann, G.E.1    Zlokovic, B.V.2    Yuclilevich3
  • 67
    • 0030933273 scopus 로고    scopus 로고
    • Cellular and molecular neurosurgery: Pathways from concept to reality-part I: Target disorders and concept approaches to gene therapy of the central nervous system
    • [discussion 803-804]
    • B.V. Zlokovic, and M.L. Appuzzo Cellular and molecular neurosurgery: pathways from concept to reality-part I: target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery 40 1997 789 803 [discussion 803-804]
    • (1997) Neurosurgery , vol.40 , pp. 789-803
    • Zlokovic, B.V.1    Appuzzo, M.L.2
  • 68
    • 37349054326 scopus 로고    scopus 로고
    • Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease
    • E. Hamel, N. Nicolakakis, T. Aboulkassim, B. Ongali, and X.K. Tong Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease Exp Physiol 93 2008 116 120
    • (2008) Exp Physiol , vol.93 , pp. 116-120
    • Hamel, E.1    Nicolakakis, N.2    Aboulkassim, T.3    Ongali, B.4    Tong, X.K.5
  • 69
    • 1342285214 scopus 로고    scopus 로고
    • Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease
    • G. Aliev, M.A. Smith, M.E. Obrenovich, J.C. de la Torre, and G. Perry Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease Neurotox Res 5 2003 491 504
    • (2003) Neurotox Res , vol.5 , pp. 491-504
    • Aliev, G.1    Smith, M.A.2    Obrenovich, M.E.3    De La Torre, J.C.4    Perry, G.5
  • 70
    • 29144467473 scopus 로고    scopus 로고
    • Hypoperfusion, mitochondria failure, oxidative stress and Alzheimer disease
    • G. Aliev, M.E. Obrenovich, M.A. Smith, and G. Perry Hypoperfusion, mitochondria failure, oxidative stress and Alzheimer disease J Biomed Biotechnol 3 2003 162 163
    • (2003) J Biomed Biotechnol , vol.3 , pp. 162-163
    • Aliev, G.1    Obrenovich, M.E.2    Smith, M.A.3    Perry, G.4
  • 71
    • 0036266871 scopus 로고    scopus 로고
    • Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: Window of treatment
    • E. Farkas, M.C. de Wilde, A.J. Kiliaan, and P.G. Luiten Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatment Drugs Today (Barc) 38 2002 365 376
    • (2002) Drugs Today (Barc) , vol.38 , pp. 365-376
    • Farkas, E.1    De Wilde, M.C.2    Kiliaan, A.J.3    Luiten, P.G.4
  • 72
    • 38749107038 scopus 로고    scopus 로고
    • The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease-facts and hypotheses
    • D. Zádori, Z. Datki, and B. Penke The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease-facts and hypotheses Ideggyogy Sz 60 2007 428 437
    • (2007) Ideggyogy Sz , vol.60 , pp. 428-437
    • Zádori, D.1    Datki, Z.2    Penke, B.3
  • 73
    • 33745168653 scopus 로고    scopus 로고
    • Leukoaraiosis and ischemia: Beyond the myth
    • D.G. Munoz Leukoaraiosis and ischemia: beyond the myth Stroke 37 2006 1348 1349
    • (2006) Stroke , vol.37 , pp. 1348-1349
    • Munoz, D.G.1
  • 74
    • 20444430784 scopus 로고    scopus 로고
    • Is Alzheimer's disease preceded by neurodegeneration or cerebral hypoperfusion?
    • J.C. de la Torre Is Alzheimer's disease preceded by neurodegeneration or cerebral hypoperfusion? Ann Neurol 57 2005 783 784
    • (2005) Ann Neurol , vol.57 , pp. 783-784
    • De La Torre, J.C.1
  • 75
    • 0027426797 scopus 로고
    • Altered gene expression in cerebral ischemia
    • K. Kogure, and H. Kato Altered gene expression in cerebral ischemia Stroke 24 1993 2121 2127
    • (1993) Stroke , vol.24 , pp. 2121-2127
    • Kogure, K.1    Kato, H.2
  • 76
    • 33646712815 scopus 로고    scopus 로고
    • Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
    • M.S. Beeri, M. Rapp, J.M. Silverman, J. Schmeidler, H.T. Grossman, and J.T. Fallon Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers Neurology 66 2006 1399 1404
    • (2006) Neurology , vol.66 , pp. 1399-1404
    • Beeri, M.S.1    Rapp, M.2    Silverman, J.M.3    Schmeidler, J.4    Grossman, H.T.5    Fallon, J.T.6
  • 77
    • 33748928954 scopus 로고    scopus 로고
    • Cardiac risk factors and potential treatments in Alzheimer's disease
    • C. Bergmann, and M. Sano Cardiac risk factors and potential treatments in Alzheimer's disease Neurol Res 28 2006 595 604
    • (2006) Neurol Res , vol.28 , pp. 595-604
    • Bergmann, C.1    Sano, M.2
  • 78
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
    • S.M. de la Monte, and J.R. Wands Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease J Alzheimers Dis 9 2006 167 181
    • (2006) J Alzheimers Dis , vol.9 , pp. 167-181
    • De La Monte, S.M.1    Wands, J.R.2
  • 79
    • 10644276189 scopus 로고    scopus 로고
    • Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease
    • G. Aliev, M.A. Smith, J.C. de la Torre, and G. Perry Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease Mitochondrion 4 2004 649 663
    • (2004) Mitochondrion , vol.4 , pp. 649-663
    • Aliev, G.1    Smith, M.A.2    De La Torre, J.C.3    Perry, G.4
  • 80
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha(HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    • X. Zhang, K. Zhou, R. Wang, J. Cui, S.A. Lipton, and F.F. Liao Hypoxia-inducible factor 1 alpha(HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation J Biol Chem 15 2007 10873 10880
    • (2007) J Biol Chem , vol.15 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3    Cui, J.4    Lipton, S.A.5    Liao, F.F.6
  • 81
    • 41949086089 scopus 로고    scopus 로고
    • Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
    • W.S. Liang, E.M. Reiman, J. Valla, T. Dunckley, T.G. Beach, and A. Grover Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons Proc Natl Acad Sci U S A 105 2008 4441 4446
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4441-4446
    • Liang, W.S.1    Reiman, E.M.2    Valla, J.3    Dunckley, T.4    Beach, T.G.5    Grover, A.6
  • 82
    • 22144485957 scopus 로고    scopus 로고
    • ROS effects on neurodegeneration in Alzheimer's disease and related disorders: On environmental stresses of ionizing radiation
    • K.G. Manton, S. Volovik, and A. Kulminski ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation Curr Alzheimer Res 1 2004 277 293
    • (2004) Curr Alzheimer Res , vol.1 , pp. 277-293
    • Manton, K.G.1    Volovik, S.2    Kulminski, A.3
  • 84
    • 34249788738 scopus 로고    scopus 로고
    • Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
    • K. Sas, H. Robotka, J. Toldi, and L. Vécsei Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders J Neurol Sci 257 2007 221 239
    • (2007) J Neurol Sci , vol.257 , pp. 221-239
    • Sas, K.1    Robotka, H.2    Toldi, J.3    Vécsei, L.4
  • 85
    • 33750361106 scopus 로고    scopus 로고
    • Fluorescent advanced glycation endproducts in sera of Alzheimer's disease patients
    • J. Leszek, M. Ferens-Sieczkowska, and I. Ka̧tnik-Prastowska Fluorescent advanced glycation endproducts in sera of Alzheimer's disease patients Perspect Neurosci 2005 373 381
    • (2005) Perspect Neurosci , pp. 373-381
    • Leszek, J.1    Ferens-Sieczkowska, M.2    Ka̧tnik-Prastowska, I.3
  • 86
  • 87
    • 36049002393 scopus 로고    scopus 로고
    • Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse Alzheimer disease
    • J. Wang, L. Ho, L. Chen, Z. Zhao, W. Zhao, and X. Qian Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse Alzheimer disease J Clin Invest 117 2007 3393 3402
    • (2007) J Clin Invest , vol.117 , pp. 3393-3402
    • Wang, J.1    Ho, L.2    Chen, L.3    Zhao, Z.4    Zhao, W.5    Qian, X.6
  • 88
    • 85059107699 scopus 로고    scopus 로고
    • Spotlighting hypertension and the brain: Does controlling blood pressure reduce the risk of recurrent stroke and dementia? What we know about hypertension and dementia: Mechanisms and interventions
    • [Wednesday, May 15,4:00 pm-6:00 pm]
    • [Wednesday, May 15,4:00 pm-6:00 pm] P.B. Gorelick Spotlighting hypertension and the brain: does controlling blood pressure reduce the risk of recurrent stroke and dementia? What we know about hypertension and dementia: mechanisms and interventions Am J Hypertens 15 2002 237A
    • (2002) Am J Hypertens , vol.15
    • Gorelick, P.B.1
  • 89
    • 33749015483 scopus 로고    scopus 로고
    • Update on hypertension and Alzheimer's disease
    • I. Skoog, and D. Gustafson Update on hypertension and Alzheimer's disease Neurol Res 28 2006 605 611
    • (2006) Neurol Res , vol.28 , pp. 605-611
    • Skoog, I.1    Gustafson, D.2
  • 90
    • 24744449326 scopus 로고    scopus 로고
    • Cerebrovascular damage as a cause for Alzheimer's disease
    • C. Humpel, and J. Marksteiner Cerebrovascular damage as a cause for Alzheimer's disease Curr Neurovasc Res 2 2005 341 347
    • (2005) Curr Neurovasc Res , vol.2 , pp. 341-347
    • Humpel, C.1    Marksteiner, J.2
  • 91
    • 0037462253 scopus 로고    scopus 로고
    • Relationship between blood pressure and Alzheimer's disease in Linxian country, China
    • C. Wu, D. Zhou, C. Wen, L. Zhang, P. Como, and Y. Qiao Relationship between blood pressure and Alzheimer's disease in Linxian country, China Life Sci 10 2003 1125 1133
    • (2003) Life Sci , vol.10 , pp. 1125-1133
    • Wu, C.1    Zhou, D.2    Wen, C.3    Zhang, L.4    Como, P.5    Qiao, Y.6
  • 93
    • 37549010689 scopus 로고    scopus 로고
    • Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer disease
    • H. Matsuda, N. Araki, I. Kuji, T. Ohkubo, E. Imabayashi, and K. Shimazu Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer disease Clin Nucl Med 33 2008 34 35
    • (2008) Clin Nucl Med , vol.33 , pp. 34-35
    • Matsuda, H.1    Araki, N.2    Kuji, I.3    Ohkubo, T.4    Imabayashi, E.5    Shimazu, K.6
  • 94
    • 30344479822 scopus 로고    scopus 로고
    • Pharmacological strategies for the prevention of Alzheimer's disease
    • P.M. Doraiswamy, and G.L. Xiong Pharmacological strategies for the prevention of Alzheimer's disease Expert Opin Pharmacother 7 2006 1 10
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 1-10
    • Doraiswamy, P.M.1    Xiong, G.L.2
  • 95
    • 79958766982 scopus 로고    scopus 로고
    • Toward an integrated genetic and epigenetic approach to Alzheimer's disease
    • J. Mill Toward an integrated genetic and epigenetic approach to Alzheimer's disease Neurobiol Aging 32 2011 1188 1191
    • (2011) Neurobiol Aging , vol.32 , pp. 1188-1191
    • Mill, J.1
  • 96
    • 79960144202 scopus 로고    scopus 로고
    • Epigenetics: Principles and practice
    • J.P. Hamilton Epigenetics: principles and practice Dig Dis 29 2011 130 135
    • (2011) Dig Dis , vol.29 , pp. 130-135
    • Hamilton, J.P.1
  • 97
    • 79958038559 scopus 로고    scopus 로고
    • Epigenetic mechanisms in cognition
    • J.J. Day, and J.D. Sweatt Epigenetic mechanisms in cognition Neuron 70 2011 813 829
    • (2011) Neuron , vol.70 , pp. 813-829
    • Day, J.J.1    Sweatt, J.D.2
  • 98
    • 84855261953 scopus 로고    scopus 로고
    • Potential peripheral biomarkers for the diagnosis of Alzheimer's disease
    • S. Patel, R.J. Shah, P. Coleman, and M. Sabbagh Potential peripheral biomarkers for the diagnosis of Alzheimer's disease Int J Alzheimers Dis 2011 2011 572495
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 572495
    • Patel, S.1    Shah, R.J.2    Coleman, P.3    Sabbagh, M.4
  • 99
    • 75649094081 scopus 로고    scopus 로고
    • Pharmacology of epigenetics in brain disorders
    • P. Narayan, and M. Dragunow Pharmacology of epigenetics in brain disorders Br J Pharmacol 159 2010 285 303
    • (2010) Br J Pharmacol , vol.159 , pp. 285-303
    • Narayan, P.1    Dragunow, M.2
  • 101
    • 84857734021 scopus 로고    scopus 로고
    • Epigenetics and etiology of neurodegenerative diseases
    • B.M. Gruber Epigenetics and etiology of neurodegenerative diseases Postepy Hig Med Dosw 65 2011 542 551
    • (2011) Postepy Hig Med Dosw , vol.65 , pp. 542-551
    • Gruber, B.M.1
  • 102
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • D. Mastroeni, A. McKee, A. Grover, J. Rogers, and P.D. Coleman Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease PLoS One 4 2009 e6617
    • (2009) PLoS One , vol.4 , pp. 6617
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 103
    • 49949108971 scopus 로고    scopus 로고
    • Age specific epigenetic drift in late-onset Alzheimer's disease
    • S.C. Wang, B. Oelze, and A. Schumacher Age specific epigenetic drift in late-onset Alzheimer's disease PLoS One 3 2008 e2698
    • (2008) PLoS One , vol.3 , pp. 2698
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 105
    • 79960688688 scopus 로고    scopus 로고
    • Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease
    • M. Pietrzak, G. Rempala, P.T. Nelson, J.J. Zheng, and M. Hetman Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease PLoS One 6 2011 e22585
    • (2011) PLoS One , vol.6 , pp. 22585
    • Pietrzak, M.1    Rempala, G.2    Nelson, P.T.3    Zheng, J.J.4    Hetman, M.5
  • 106
    • 27144494994 scopus 로고    scopus 로고
    • Ribosome dysfunction is an early event in Alzheimer's disease
    • Q. Ding, W.R. Markesbery, Q. Chen, F. Li, and J.N. Keller Ribosome dysfunction is an early event in Alzheimer's disease J Neurosci 25 2005 9171 9175
    • (2005) J Neurosci , vol.25 , pp. 9171-9175
    • Ding, Q.1    Markesbery, W.R.2    Chen, Q.3    Li, F.4    Keller, J.N.5
  • 107
    • 34249874344 scopus 로고    scopus 로고
    • RNA in brain disease: No longer just the messenger in the middle
    • P.T. Nelson, and J.N. Keller RNA in brain disease: no longer just the messenger in the middle J Neuropathol Exp Neurol 66 2007 461 468
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 461-468
    • Nelson, P.T.1    Keller, J.N.2
  • 108
    • 44649134044 scopus 로고    scopus 로고
    • Epigenetic codes in cognition and behaviour
    • J. Gräff, and I.M. Mansuy Epigenetic codes in cognition and behaviour Behav Brain Res 192 2008 70 87
    • (2008) Behav Brain Res , vol.192 , pp. 70-87
    • Gräff, J.1    Mansuy, I.M.2
  • 109
    • 79959521749 scopus 로고    scopus 로고
    • The redox basis of epigenetic modifications: From mechanisms to functional consequences
    • A.R. Cyr, and F.E. Domann The redox basis of epigenetic modifications: from mechanisms to functional consequences Antioxid Redox Signal 15 2011 551 589
    • (2011) Antioxid Redox Signal , vol.15 , pp. 551-589
    • Cyr, A.R.1    Domann, F.E.2
  • 112
    • 79958763443 scopus 로고    scopus 로고
    • Epigenetic mechanisms in Alzheimer's disease: Progress but much to do
    • R. Balazs, J. Vernon, and J. Hardy Epigenetic mechanisms in Alzheimer's disease: progress but much to do Neurobiol Aging 32 2011 1181 1187
    • (2011) Neurobiol Aging , vol.32 , pp. 1181-1187
    • Balazs, R.1    Vernon, J.2    Hardy, J.3
  • 113
    • 79953216758 scopus 로고    scopus 로고
    • Chromatin acetylation, β-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair
    • I. Szumiel, and N. Foray Chromatin acetylation, β-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair Acta Biochim Pol 58 2011 11 18
    • (2011) Acta Biochim Pol , vol.58 , pp. 11-18
    • Szumiel, I.1    Foray, N.2
  • 114
    • 70350018325 scopus 로고    scopus 로고
    • Multiple roles of HDAC inhibition in neurodegenerative conditions
    • D.M. Chuang, Y. Leng, Z. Marinova, H.J. Kim, and C.T. Chiu Multiple roles of HDAC inhibition in neurodegenerative conditions Trends Neurosci 32 2009 591 601
    • (2009) Trends Neurosci , vol.32 , pp. 591-601
    • Chuang, D.M.1    Leng, Y.2    Marinova, Z.3    Kim, H.J.4    Chiu, C.T.5
  • 115
    • 79958001269 scopus 로고    scopus 로고
    • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease
    • R.M. Stilling, and A. Fischer The role of histone acetylation in age-associated memory impairment and Alzheimer's disease Neurobiol Learn Mem 96 2011 19 26
    • (2011) Neurobiol Learn Mem , vol.96 , pp. 19-26
    • Stilling, R.M.1    Fischer, A.2
  • 116
    • 78650723554 scopus 로고    scopus 로고
    • Alzheimer's disease: Aging, insomnia and epigenetics
    • T.Y. Wu, C.P. Chen, and T.R. Jinn Alzheimer's disease: aging, insomnia and epigenetics Taiwan J Obstet Gynecol 49 2010 468 472
    • (2010) Taiwan J Obstet Gynecol , vol.49 , pp. 468-472
    • Wu, T.Y.1    Chen, C.P.2    Jinn, T.R.3
  • 117
    • 77954130059 scopus 로고    scopus 로고
    • Emerging themes in epigenetics: Implications for understanding and treating nervous system disorders
    • I.A. Qureshi, and M.F. Mehler Emerging themes in epigenetics: implications for understanding and treating nervous system disorders Epigenomics 2 2010 345 349
    • (2010) Epigenomics , vol.2 , pp. 345-349
    • Qureshi, I.A.1    Mehler, M.F.2
  • 118
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
    • S.S. Hebert, J. Horre, and L. Nicolai Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression PNAS 105 2008 6415 6420
    • (2008) PNAS , vol.105 , pp. 6415-6420
    • Hebert, S.S.1    Horre, J.2    Nicolai, L.3
  • 119
    • 54049150793 scopus 로고    scopus 로고
    • MicroRNAs: Tiny regulators of synapse function in development and disease
    • S. Bicker, and G. Schratt MicroRNAs: tiny regulators of synapse function in development and disease J Cell Mol Med 12 2008 1466 1476
    • (2008) J Cell Mol Med , vol.12 , pp. 1466-1476
    • Bicker, S.1    Schratt, G.2
  • 120
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • W.X. Wang, B.W. Rajeev, A.J. Stromberg, N. Ren, G. Tang, and Q. Huang The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J Neurosci 28 2008 1213 1223
    • (2008) J Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6
  • 121
    • 68649092030 scopus 로고    scopus 로고
    • MicroRNA: Implications for Alzheimer disease and other human CNS disorders
    • O.C. Maes, H.M. Chertkow, E. Wang, and H.M. Schipper MicroRNA: implications for Alzheimer disease and other human CNS disorders Curr Genomics 10 2009 154 168
    • (2009) Curr Genomics , vol.10 , pp. 154-168
    • Maes, O.C.1    Chertkow, H.M.2    Wang, E.3    Schipper, H.M.4
  • 123
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • W.J. Lukiw Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus Neuroreport 18 2007 297 300
    • (2007) Neuroreport , vol.18 , pp. 297-300
    • Lukiw, W.J.1
  • 124
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • J.P. Cogswell, J. Ward, I.A. Taylor, M. Waters, Y. Shi, and B. Cannon Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways J Alzheimers Dis 14 2008 27 41
    • (2008) J Alzheimers Dis , vol.14 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 127
    • 56049100240 scopus 로고    scopus 로고
    • Early-life events may trigger biochemical pathways for Alzheimer's disease: The LEARn model
    • D.K. Lahiri, N.H. Zawia, N.H. Greig, K. Sambamurti, and B. Maloney Early-life events may trigger biochemical pathways for Alzheimer's disease: the LEARn model Biogerontology 9 2008 375 379
    • (2008) Biogerontology , vol.9 , pp. 375-379
    • Lahiri, D.K.1    Zawia, N.H.2    Greig, N.H.3    Sambamurti, K.4    Maloney, B.5
  • 128
    • 77649339701 scopus 로고    scopus 로고
    • The LEARn (latent early-life associated regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposed remedial steps
    • D.K. Lahiri, and B. Maloney The LEARn (latent early-life associated regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposed remedial steps Exp Gerontol 45 2010 291 296
    • (2010) Exp Gerontol , vol.45 , pp. 291-296
    • Lahiri, D.K.1    Maloney, B.2
  • 129
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • T. Lu, Y. Pan, S.Y. Kao, C. Li, L. Kohane, and J. Chan Gene regulation and DNA damage in the ageing human brain Nature 429 2004 883 891
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.Y.3    Li, C.4    Kohane, L.5    Chan, J.6
  • 130
    • 33646236916 scopus 로고    scopus 로고
    • Exposure to lead and the developmental origin of oxidative DNA damage in aging brain
    • C.M. Bolin, R. Basha, D. Cox, N.H. Zawia, B. Maloney, and D.K. Lahiri Exposure to lead and the developmental origin of oxidative DNA damage in aging brain FASEB J 20 2006 788 790
    • (2006) FASEB J , vol.20 , pp. 788-790
    • Bolin, C.M.1    Basha, R.2    Cox, D.3    Zawia, N.H.4    Maloney, B.5    Lahiri, D.K.6
  • 131
    • 70349256260 scopus 로고    scopus 로고
    • Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage
    • O. Campuzano, M.M. Castillo-Ruiz, L. Acarin, B. Castellano, and B. Gonzales Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage J Neurosci Res 87 2009 2484 2497
    • (2009) J Neurosci Res , vol.87 , pp. 2484-2497
    • Campuzano, O.1    Castillo-Ruiz, M.M.2    Acarin, L.3    Castellano, B.4    Gonzales, B.5
  • 132
    • 70350674919 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: An epigenetic model of obesity and the metabolic syndrome
    • A. Plagemann, T. Harder, M. Brunn, A. Harder, K. Roepke, and M. Wittrock-Staar Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome J Physiol 587 2009 4963 4976
    • (2009) J Physiol , vol.587 , pp. 4963-4976
    • Plagemann, A.1    Harder, T.2    Brunn, M.3    Harder, A.4    Roepke, K.5    Wittrock-Staar, M.6
  • 135
    • 48249127225 scopus 로고    scopus 로고
    • Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
    • L.M. Villeneuve, M.A. Reddy, L.L. Lanting, M. Wang, L. Meng, and R. Natarajan Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes PNAS 105 2008 9047 9052
    • (2008) PNAS , vol.105 , pp. 9047-9052
    • Villeneuve, L.M.1    Reddy, M.A.2    Lanting, L.L.3    Wang, M.4    Meng, L.5    Natarajan, R.6
  • 136
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered genome expression during subsequent normoglycemia
    • A. El-Osta, D. Brasacchio, D. Yao, A. Pocai, P.L. Jones, and R.G. Roeder Transient high glucose causes persistent epigenetic changes and altered genome expression during subsequent normoglycemia J Exp Med 205 2008 2409 2417
    • (2008) J Exp Med , vol.205 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3    Pocai, A.4    Jones, P.L.5    Roeder, R.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.