Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease

Neurotoxicity Research

Volumn 5, Issue 7, 2003, Pages 491-504

  Aliev, Gjumrakch ^a   Smith, Mark A ^a   Obrenovich, Mark E ^a   De La Torre, Jack C ^a   Perry, George ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Free radicals; Metabolism; Mitochondria; Neurodegeneration; Oxidative stress; Vascular hypoperfusion

Indexed keywords

AMYLOID;

ALZHEIMER DISEASE; ANIMAL; BLOOD VESSEL; CEREBROVASCULAR DISEASE; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; MOUSE; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; BLOOD VESSELS; CEREBROVASCULAR DISORDERS; HUMANS; MICE; MITOCHONDRIA; OXIDATIVE STRESS;

EID: 1342285214     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033159     Document Type: Review

References (99)

1. Acuna-Castroviejo D, M Martin, M Macias, G Escames, J Leon, H Khaldy and RJ Reiter (2001) Melatonin, mitochondria, and cellular bioenergetics. J. Pineal Res. 30, 65-74.
2. Al Abdulla NA and LJ Martin (1998) Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus. Am. J. Pathol. 153, 447-456.
3. Aliev G (2002) Is non-genetic Alzheimer's disease a vascular disorder with neurodegenerative consequences?. J. Alzheimer's Disease 4, 513-516.
4. Aliev G and G Burnstock (1998) Watanabe rabbits with heritable hypercholesterolaemia: A model of atherosclerosis. Histol. Histopathol. 13, 797-817.
5. Aliev G, R Cirillo, E Salvatico, M Paro and M Prosdocimi (1993) Changes in vessel ultrastructure during ischemia and reperfusion of rabbit hindlimb: Implications for therapeutic intervention. Microvasc. Res. 46, 65-76.
6. Aliev G, P Bodin and G Burnstock (1998) Free radical generators cause changes in endothelial and inducible nitric oxide synthases and endothelin-1 immunoreactivity in endothelial cells from hyperlipidemic rabbits. Mol. Genet. Metab. 63, 191-197.
7. Aliev G, MA Smith, H Vinters, AB Johnson, A Nunomura and G Perry (1999) Mitochondria abnormalities mark vulnerable neurons in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 58, 511.
8. Aliev G, J Shi, JC Lamanna, BT Lamb and RP Friedland (2000a) Atherosclerotic-like changes of the wall of cerebral microvessels in transgenic mice overexpressing amyloid β. Neurobiol Aging 21, 1S, S267, p. 1224.
9. Aliev G, J Shi, G Perry, BT Lamb, JC Lamanna and RP Friedland (2000b) Neuronal mitochondrial abnormalities in yeast artificial chromosome (YAC) transgenic mice overexpressing amyloid precursor protein (APP). Soc. Neurosci. Abstr. 30, 26: 301.4.
10. Aliev G, J Shi, G Perry, RP Friedland and JC Lamanna (2000c) Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet. Anat. Rec. 260, 16-25.
11. Aliev G, G Perry, BT Lamb, D Seyidova, ML Neal, SL Siedlak, JC LaManna, MA Smith and RP Friedland (2001a) Aged YAC AbPP transgenic mice develop atherosclerotic lesions and mitochondria DNA deletions in brain microvessels without exogenous cholesterol supplementation. Soc. Neurosci. Abstr. 752.12 (Abstr.)
12. Aliev G, MA Smith, M Turmaine, ML Neal, TV Zimina, RP Friedland, G Perry, JC Lamanna and G Burnstock (2001b) Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits. Exp. Mol. Pathol. 71, 40-54.
13. Aliev G, G Perry, D Seyidova, BT Lamb, ML Neal, SL Siedlak, MA Smith, JC LaManna and RP Friedland (2002a) The role of mitochondria failure in the development of AD-like pathology in an aged transgenic mouse model of AD. Neurobiol. Aging 23, S414-P.P.-1525.
14. Aliev G, D Seyidova, BT Lamb, ML Neal, SL Siedlak, H Vinters, JC LaManna, RP Friedland, E Head, G Perry and CW Cotman (2002b) Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in a aged YAC AβPP transgenic mice. Ann. NY Acad. Sci. 977, 45-64.
15. Aliev G, MA Smith, D Seyidova, ML Neal, BT Lamb, A Nunomura, EK Gasimov, HV Vinters, G Perry, JC Lamanna and RP Friedland (2002c) The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol. 12, 21-35.
16. Aliev G, MA Smith, D Seyidova, ML Neal, J Shi, M Loizidou, M Turmaine, RP Friedland, I Taylor, G Burnstock, G Perry and JC Lamanna (2002d) Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. J. Submicrosy. Cytol. Pathol. 34, 37-50.
17. Aliev G, D Seyidova, BT Lamb, ME Obrenovich, SL Siedlak, H Vinters, JC LaManna, MA Smith and G Perry (2003a) Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Res. 25, 665-674.
18. Aliev G, D Seyidova, AK Raina, ME Obrenovich, ML Neal, SL Siedlak, BT Lamb, H Vinters, JC LaManna, MA Smith and G Perry (2003b) Vascular hypoperfusion, mitochondria failure and oxidative stress in Alzheimer disease. Proc. Indian Natl. Science Academy B69, 209-238.
19. Baggio G, S Donazzan, D Monti, D Mari, S Martini, C Gabelli, VM Dalla, L Previato, M Guido, S Pigozzo, I Cortella, G Crepaldi and C Franceschi (1998) Lipoprotein(a) and lipoprotein profile in healthy centenarians: A reappraisal of vascular risk factors. FASEB J. 12, 433-437.
20. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
21. Beckman KB and BN Ames (1998a) Mitochondrial aging: Open questions. Ann. NY Acad. Sci. 854, 118-127.
22. Beckman KB and BN Ames (1998b) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
23. Beckman KB and BN Ames (1999) Endogenous oxidative damage of mtDNA. Mutat. Res. 424, 51-58.
24. Bonilla E, K Tanji, M Hirano, TH Vu, S DiMauro and EA Schon (1999) Mitochondrial involvement in Alzheimer's disease. Biochim. Biophys. Acta 1410, 171-182.
25. Cash AD, G Aliev, SL Siedlak, H Fujioka, HV Vinters, M Tabaton, AB Johnson, M Paula-Barbosa, J Avila, PK Jones, MA Smith and G Perry (2003) Microtubule reduction in Alzheimer disease and aging is independent of TAU filament formation. Am. J. Pathol. 162, 1623-1627.
26. Castellani R, K Hirai, G Aliev, KL Drew, A Nunomura, A Takeda, AD Cash, ME Obrenovich, G Perry and MA Smith (2002) Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res. 70, 357-360.
27. Chen G, KS Chen, J Knox, J Inglis, A Bernard, SJ Martin, A Justice L McConlogue, D Games, SB Freedman and RG Morris (2000) A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408, 975-979.
28. Cirillo R, E Salvatico, G Aliev and M Prosdocimi (1992) Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury. J. Cardiovasc. Pharmacol. 20, 969-975.
29. Cirillo R, G Aliev, EJ Hornby and M Prosdocimi (1994) Endothelium as a therapeutical target in peripheral occlusive arterial diseases: consideration for pharmacological interventions. Pharmacol. Res. 29, 293-311.
30. Coria F, E Castano, F Prelli, M Larrondo-Lillo, S van Duinen, ML Shelanski and B Frangione (1988) Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab. Invest. 58, 454-458.
31. Cormier A, C Morin, R Zini, J Tillement and G Lagrue (2001) In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation. Brain Res. 900, 72-79.
32. Coyle JT and P Puttfarcken (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
33. De Jong GI, RA De Vos, EN Steur and PG Luiten (1997) Cerebrovascular hypoperfusion: A risk factor for Alzheimer's disease? Animal model and postmortem human studies. Ann. NY Acad. Sci. 826, 56-74.
34. de la Torre JC (1997) Hemodynamic consequences of deformed microvessels in the brain in Alzheimer's disease. Ann. NY Acad. Sci. 826, 75-91.
35. de la Torre JC (2000) Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer's pathogenesis. Neurobiol. Aging 21, 331-342.
36. de la Torre JC (2002a) Alzheimer's disease: How does it start?. J. Alzheimer's Disease 4, 497-512.
37. de la Torre JC (2002b) Alzheimer disease as a vascular disorder: nosological evidence. Stroke 33, 1152-1162.
38. de la Torre JC (2002c) Vascular basis of Alzheimer's pathogenesis. Ann. NY Acad. Sci. 977, 196-215.
39. de la Torre JC and GB Stefano (2000) Evidence that Alzheimer's disease is a microvascular disorder: The role of constitutive nitric oxide. Brain Res. Brain Res. Rev. 34, 119-136.
40. Duff K (1998) Transgenic models for Alzheimer's disease. Neuropathol. Appl. Neurobiol. 24, 101-103.
41. Etiene D, J Kraft, N Ganju, T Gomez-Isla, B Gemelli, BT Hyman, T Hedley-Whyte, JR Wands and SM de la Monte (1998) Cerebrovascular pathology contributes to the heterogeneity of Alzheimer's disease. J. Alzheimer's Disease 1, 119-134.
42. Fiskum G, AN Murphy and MF Beal (1999) Mitochondria in neurodegeneration: Acute ischemia and chronic neurodegenerative diseases. J. Cereb. Blood Flow Metab. 19, 351-369.
43. Friston KJ and RS Frackowiak (1991) Cerebral function in aging and Alzheimer's disease: The role of PET. Electroencephalogr. Clin. Neurophysiol. Suppl. 42, 355-365.
44. Granger DN, JN Benoit, M Suzuki and MB Grisham (1989) Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am. J. Physiol. 257, G683-G688.
45. Grant DN (1997) Dietary links to Alzheimer's disease. Alzheimer's Disease Rev. 2, 42-55.
46. Hirai K, G Aliev, A Nunomura, H Fujioka, RL Russell, CS Atwood, AB Johnson, Y Kress, HV Vinters, M Tabaton, S Shimohama, AD Cash, SL Siedlak, PL Harris, PK Jones, RB Petersen, G Perry and MA Smith (2001) Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21, 3017-3023.
47. Hock BJJ and BT Lamb (2001) Transgenic mouse models of Alzheimer's disease. Trends. Genet. 17, S7-S12.
48. Jakobovits A, BT Lamb and KR Peterson (2000) Production of transgenic mice with yeast artificial chromosomes. Methods Mol. Biol. 136, 435-453.
49. Joachim CL, JH Morris and DJ Selkoe (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am. J. Pathol. 135, 309-319.
50. Kalaria RN (1999) The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann. NY Acad. Sci. 893, 113-125.
51. Kalaria RN (2000) The role of cerebral ischemia in Alzheimer's disease. Neurobiol. Aging 21, 321-330.
52. Kalaria RN and C Ballard (1999) Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis. Assoc. Disord. 13 Suppl. 3, S115-S123.
53. Kawai M, RN Kalaria, SI Harik and G Perry (1990) The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am. J. Pathol. 137, 1435-1446.
54. Knebl J, P DeFazio, MB Clearfield, L Little, WJ McConathy, R McPherson and AG Lacko (1994) Plasma lipids and cholesterol esterification in Alzheimer's disease. Mech. Ageing Dev. 73, 69-77.
55. Koudinov AR, TT Berezov and NV Koudinova (1998) Alzheimer's amyloid beta and lipid metabolism: A missing link?. FASEB J. 12, 1097-1099.
56. Kulnane LS and BT Lamb (2001) Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiol. Dis. 8, 982-992.
57. Kulnane LS, EJ Lehman, BJ Hock, KD Tsuchiya and BT Lamb (2002) Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts. Mamm. Genome 13, 223-226.
58. Kumar A, MB Schapiro, JV Haxby, CL Grady and RP Friedland (1990) Cerebral metabolic and cognitive studies in dementia with frontal lobe behavioral features. J. Psychiatr. Res. 24, 97-109.
59. Kuo, YM, MR Emmerling, CL Bisgaier, AD Essenburg, HC Lampert, D Drumm and AE Roher (1998) Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels. Biochem. Biophys. Res. Commun. 252, 711-715.
60. Lamb BT, LM Call, HH Slunt, KA Bardel, AM Lawler, CB Eckman, SG Younkin, G Holtz, SL Wagner, DL Price, SS Sisodia and JD Gearhart (1997) Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum. Mol. Genet. 6, 1535-1541.
61. Lamb BT, KA Bardel, LS Kulnane, JJ Anderson, G Holtz, SL Wagner, SS Sisodia and EJ Hoeger (1999) Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat. Neurosci. 2, 695-697
62. Lin B, MD Ginsberg and R Busto (2001) Hyperglycemic but not normoglycemic global ischemia induces marked early intraneuronal expression of beta-amyloid precursor protein. Brain Res. 888, 107-116.
63. Lovell MA, C Xie and WR Markesbery (1998) Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology 51, 1562-1566.
64. Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23, 134-147.
65. Markesbery WR and JM Carney (1999) Oxidative alterations in Alzheimer's disease. Brain Pathol. 9, 133-146.
66. Mecocci P, U MacGarvey, AE Kaufman, D Koontz, JM Shoffner, DC Wallace and MF Beal (1993) Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34, 609-616.
67. Mecocci P, U MacGarvey and MF Beal (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747-751.
68. Mecocci P, MF Beal, R Cecchetti, MC Polidori, A Cherubini, F Chionne, L Avellini, G Romano and U Senin (1997) Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol. Chem. Neuropathol. 31, 53-64.
69. Meguro K, X Blaizot, Y Kondoh, C Le Mestric, JC Baron and C Chavoix (1999) Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer's disease. Brain 122, 1519-1531.
70. Montine TJ, KS Montine and LL Swift (1997) Central nervous system lipoproteins in Alzheimer's disease. Am. J. Pathol. 151, 1571-1575.
71. Neve RL and NK Robakis (1998) Alzheimer's disease: A re-examination of the amyloid hypothesis. Trends Neurosci. 21, 15-19.
72. Nunomura A, G Perry, K Hirai, G Aliev, A Takeda, S Chiba and MA Smith (1999a) Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Ann. NY Acad. Sci. 893, 362-364.
73. Nunomura A, G Perry, MA Pappolla, R Wade, K Hirai, S Chiba and MA Smith (1999b) RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 19, 1959-1964.
74. Nunomura A, G Perry, G Aliev, K Hirai, A Takeda, EK Balraj, PK Jones, H Ghanbari, T Wataya, S Shimohama, S Chiba, CS Atwood, RB Petersen and MA Smith (2001) Oxidative damage is the carliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759-767.
75. Perry G, A Nunomura, K Hirai, A Takeda, G Aliev and MA Smith (2000) Oxidative damage in Alzheimer's disease: The metabolic dimension. Int. J. Dev. Neurosci. 18, 417-421.
76. Prasad MR, MA Lovell, M Yatin, H Dhillon and WR Markesbery (1998) Regional membrane phospholipid alterations in Alzheimer's disease. Neurochem. Res. 23, 81-88.
77. Puglielli L, RE Tanzi and DM Kovacs (2003) Alzheimer's disease: The cholesterol connection. Nat. Neurosci. 6, 345-351.
78. Refolo LM, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, R Wang, GS Tint, K Sambamurti and K Duff (2000) Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321-331.
79. Sala A, GM Aliev, G Rossoni, F Berti, C Buccellati, G Burnstock, G Folco and J Maclouf (1996) Morphological and functional changes of coronary vasculature caused by transcellular biosynthesis of sulfidopeptide leukotrienes in isolated heart of rabbit. Blood 87, 1824-1832.
80. Salvatico E, GM Aliev, D Novello and M Prosdocimi (1994) Functional depression of isolated perfused rat heart mediated by activated leukocytes: Protective effect of cloricromene. J. Cardiovasc. Pharmacol. 24, 638-647.
81. Sayre LM, DA Zelasko, PL Harris, G Perry, RG Salomon and MA Smith (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68, 2092-2097.
82. Schulz JB, RT Matthews, T Klockgether, J Dichgans and MF Beal (1997) The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Mol. Cell Biochem. 174, 193-197.
83. Shankar A, M Loizidou, G Aliev, S Fredericks, D Holt, PB Boulos, G Burnstock and I Taylor (1998) Raised endothelin 1 levels in patients with colorectal liver metastases. Br. J. Surg. 85, 502-506.
84. Shi J, G Perry, G Aliev, MA Smith, KH Ashe and RP Friedland (1999) Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model. Neuroreport 10, 3229-3232.
85. Shi J, G Perry, MS Berridge, G Aliev, SL Siedlak, MA Smith, JC Lamanna and RP Friedland (2002a) Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J. Nucl. Med. 43, 1044-1051.
86. Shi J, D Seyidova, G Perry, ML Neal, SL Siedlak, MA Smith, JC LaManna, RP Friedland and G Aliev (2002b) Neuronal mitochondria abnormalities in a transgenic mouse model overex-pressing amyloid beta. Soc. Neurosci. Abstr. 295.20.
87. Smith MA, S Taneda, PL Richey, S Miyata, SD Yan, D Stern, LM Sayre, VM Monnier and G Perry (1994) Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA 91, 5710-5714.
88. Smith MA, G Perry, PL Richey, LM Sayre, VE Anderson, MF Beal and N Kowall (1996a) Oxidative damage in Alzheimer's. Nature 382, 120-121.
89. Smith MA, LM Sayre and G Perry (1996b) Is Alzheimer's disease of oxidative stress? Alzheimer's Disease Rev. 1, 63-67.
90. Smith MA, GJ Petot and G Perry (1997a) Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer's disease. Alzheimer's Disease Rev. 2, 58-60.
91. Smith MA, PL Richey Harris, LM Sayre, JS Beckman and G Perry (1997b) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17, 2653-2657.
92. Smith MA, CA Rottkamp, A Nunomura, AK Raina and G Perry (2000) Oxidative stress in Alzheimer's disease. Biochim. Biophys. Acta 1502, 139-144.
93. Sparks DL (1997) Coronary artery disease, hypertension, ApoE, and cholesterol: A link to Alzheimer's disease? Ann. NY Acad. Sci. 826, 128-146.
94. Sparks DL, YM Kuo, A Roher, T Martin and RJ Lukas (2000) Alterations of Alzheimer's disease in the cholesterol-fed rabbit. including vascular inflammation. Preliminary observations. Ann. NY Acad. Sci. 903, 335-344.
95. Stewart PA, K Hayakawa, MA Akers and HV Vinters (1992) A morphometric study of the blood-brain barrier in Alzheimer's disease. Lab. Invest. 67, 734-742.
96. Tagliavini F, J Ghiso, WF Timmers, G Giaccone, O Bugiani and B Frangione (1990) Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls. Lab. Invest. 62, 761-767.
97. Wallace DC (1997) Mitochondrial DNA in aging and disease. Sci. Am. 277, 40-47.
98. Wallace DC (1999) Mitochondrial diseases in man and mouse. Science 283, 1482-1488.
99. Wong PC, H Cai, DR Borchelt and DL Price (2002) Genetically engenired mouse models of neurodegenerative diseases. Nat. Neurosci. 5, 633-639.