Neuropsychological, psychiatric, and cerebral perfusion correlates of leukoaraiosis in Alzheimer's disease

Journal of Neurology Neurosurgery and Psychiatry

Volumn 63, Issue 1, 1997, Pages 66-73

  Starkstein, S E ^a,b,c   Sabe, L ^a   Vazquez S ^a   Di Lorenzo, G ^c   Martinez A ^c   Petracca, G ^a   Teson A ^a   Chemerinski, E ^a   Leiguarda, R ^b  

^a Department of Behavioral Neurology ^*

^b Departments of Clinical Neurology   (Argentina)

^c Instituto de Investigaciones Neurologicas Raul Carrera   (Argentina)

Author keywords

Alzheimer's disease; Frontal lobes; Leukoaraiosis

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

AGED; ALZHEIMER DISEASE; APATHY; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; CLINICAL ARTICLE; DELUSION; DEPRESSION; EXTRAPYRAMIDAL SYMPTOM; FEMALE; FRONTAL LOBE; HUMAN; LEUKOARAIOSIS; MALE; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RATING SCALE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

EID: 0030739152     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.63.1.66     Document Type: Article

References (42)

1. Hachinski VC, Potter P, Merskey H. Leukoaraiosis. Arch Neurol 1987;44:21-3.
2. Scheltens P, Barkhof F, Leys D, Wolters EC, Ravid R, Kamphorst W. Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging. Neurology 1995;45:883-8.
3. Scheltens P, Weinstein HC, Leys D. Neuroimaging in the diagnosis of Alzheimer's disease. I. Computer tomography and magnetic resonance imaging. Clin Neurol Neurosurg 1992;94:277-89.
4. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. AJNR Am J Neuroradiol 1987; 8:421-6.
5. Marder K, Richards M, Bello J, Bell K, Sano M, Miller L, et al. Clinical correlates of Alzheimer's disease with and without silent radiographic abnormalities. Arch Neurol 1995;52: 146-51.
6. Diaz JF, Merskey H, Hachinski VC, Lee DH, Boniferro M, Wong CJ, et al. Improved recognition of leukoaraiosis and cognitive impairment in Alzheimer's disease. Arch Neurol 1991;48:1022-5.
7. Lopez OL, Becker JT, Rezek D, Wess J, Boller F, Reynolds CF, Panisset M. Neuropsychiatric correlates of cerebral white-matter radiolucencies in probable Alzheimer's disease. Arch Neurol 1992;49:828-34.
8. Almkvist O, Wahlund LO, Andersson G, Basun H, Backman L. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging. Arch Neurol 1992;49:626-32.
9. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, Lechner H. White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 1988;19: 1285-8.
10. Kawamura J, Meyer JS, Ichijo M, Kobari M, Terayama Y, Weathers S. Correlations of leuko-araiosis with cerebral atrophy and perfusion in elderly normal subjects and demented patients. J Neurol Neurosurg Psychiatry 1993;56: 182-7.
11. Waldemar G, Christiansen P, Larsson HBW, Hogh P, Laursen H, Lassen NA, Paulson OB. White matter magnetic resonance hyperintensities in dementia of the Alzheimer type: morphological and cerebral blood flow correlates. J Neurol Neurosurg Psychiatry 1994;57:1458-65.
12. Herholz K, Heindel W, Rackl A, Neubauer I, Steinbrich W, Pietrzyk U, et al. Regional cerebral blood flow in patients with leuko-araiosis and atherosclerotic carotid artery disease. Arch Neurol 1990;47:392-6.
13. Sultzer DL, Mahler ME, Cummings JL, Van Gorp WG, Hinkin CH, Brown C. Cortical abnormalities associated with subcortical lesions in vascular dementia: clinical and positron emission tomographic findings. Arch Neurol 1995; 52:773-80.
14. McKhann G, Drachman D, Folstein MF, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34: 939-44.
15. Hachinski VC, Iliff LD, Zilhka L, Du Boulay GH, McAllister VL, Marshall J, et al. Cerebral blood flow in dementia. Arch Neurol 1975;40:97-103.
16. Fahn S, Elton E. UPDRS Development Committee. Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Goldstein M, Calne CD, eds. Recent developments in Parkinson's disease. Florham Park, NJ: Macmillan, 1987:153-63.
17. Spitzer RL, Williams JBW, Gibbon M, First MB. The structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description. Arch Gen Psychiatry 1992;49: 624-9.
18. Hamilton MA. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
19. Migliorelli R, Teson A, Sabe L, Petracca G, Petracchi M, Leiguarda R, Starkstein SE. Anosognosia in Alzheimer's disease: a study of associated factors. J Neuropsychiatry Clin Neurosci 1995;7:338-44.
20. Migliorelli R, Petracca G, Teson A, Sabe L, Leiguarda R, Starkstein SE. Neuropsychiatric and neuropsychological correlates of delusions in Alzheimer's disease. Psychol Med 1995;25:505-13.
21. Starkstein SE, Migliorelli R, Teson A, Petracca G, Chemerinski E, Manes F, Leiguarda R. Prevalence and correlates of pathological affective display in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1995;59:55-60.
22. Starkstein SE, Migliorelli R, Manes F, Teson A, Petracca G, Chemerinski E, et al. The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease. European Journal of Neurology 1995;2:540-6.
23. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
24. Raven JC, Court JH, Raven J. Manual for Raven's progressive matrices and vocabulary scales. London: HK Lewis, 1986.
25. Nelson HE. A modified card sorting test sensitive to frontal lobe defects. Cortex 1976;12:313-24.
26. Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychology 1968;6:53-60.
27. Wechsler D. Wechsler adult intelligence scale manual. New York: Psychological Corporation, 1955.
28. Buschke H, Fuld PA. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974;24:1019-25.
29. Benton AL. The revised visual retention test. 4th ed. New York: The Psychological Corporation, 1974.
30. De Renzi E, Faglioni P. Development of a shortened version of the token test. Cortex 1978;14:41-9.
31. Kaplan EF, Goodglass H, Weintraub S. The Boston naming test. Philadelphia: Lea and Febiger, 1983.
32. Matsui T, Hirano A. An atlas for the human train for computerized tomography. New York: Igaku-Shoin, 1978.
33. Burns A, Philpot MP, Costa DC, EII PJ, Levy R. The investigation of Alzheimer's disease with single photon emission tomography. J Neurol Neurosurg Psychiatry 1989;12:248-53.
34. Starkstein SE, Migliorelli R, Sabe L, Teson A, Vazquez S, Leiguarda R. A SPECT study of anosognosia in Alzheimer's disease. Arch Neurol 1995;52:415-20.
35. Scheltens Ph, Barkhof F, Valk J, Algra PR, Van der Hoop RG, Nauta J, Wolters Ch. White matter lesions on magnetic resonance imaging in clinically diagnosed Alzheimer's disease: evidence for heterogeneity. Brain 1992;115: 735-48.
36. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991;3:243-54.
37. Stuss D, Benson DF. The frontal lobes. New York: Raven Press, 1986.
38. Starkstein SE, Fedoroff JP, Price TR, Leiguarda R, Robinson RG. Apathy following cerebrovascular lesions. Stroke 1993;24;1625-31.
39. Merello M, Sabe L, Teson A, Migliorelli R, Petracchi M, Leiguarda R, Starkstein SE. Extrapyramidalism in Alzheimer's disease: prevalence, psychiatric, and neuropsychological correlates. J Neurol Neurosurg Psychiatry 1994;57: 1103-10.
40. Starkstein SE, Vazquez S, Merello M, Teson A, Petracchi M, Leiguarda R. A SPECT study of parkinsonism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 1995;7:308-13.
41. Brooks DJ. Functional imaging in relation to parkinsonian syndrome. J Neurol Sci 1993;115:1-17.
42. 18F-dopa uptake: difference in Parkinson's disease and atypical parkinsonism. J Neurol Neurosurg Psychiatry 1991; 54:898-904.