Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2547-2550

  Fan, Yun Hua ^a   Chen, Han ^a   Natarajan, Amarnath ^a   Guo, Yuhong ^a   Harbinski, Fred ^a   Iyasere, Julia ^a   Christ, William ^a   Aktas, Huseyin ^a   Halperin, Jose A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Intracellular calcium; Thiazolidinediones; Troglitazone

Indexed keywords

TROGLITAZONE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROLIFERATION; DEPLETION; ENDOPLASMIC RETICULUM; IN VITRO STUDY; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRANSLATION INITIATION;

ANTINEOPLASTIC AGENTS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 1942534528     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.087     Document Type: Article

References (24)

1. Berridge M.J., Lipp P., Bootman M.D. Nat. Rev. 1:2000;11.
2. Koch G.L.E. BioEssays. 12:1990;527.
3. Li J. Frontiers of Biotechnology and Pharmaceuticals. 3:2002;110.
4. Soboloff J., Berger S.A. J. Biol. Chem. 277:2002;13812.
5. Brostrom M.A., Brostrom C.O. Cell Calcium. 34:2003;345.
6. Harper J.L., Daly J.W. Drug Dev. Res. 4:1999;107.
7. Kimball S.R., Clemens M.J., Tileray V.J., Wek R.C., Horetsky R.L., Jefferson L.S. Biochem. Biophys. Res. Commun. 280:2001;293-300.
8. Alcazar A., del la Vega C.M., Bazan E., Fando J.L., Salinas M. J. Neurochem. 69:1997;1703.
9. Prostko C.R., Dholakia J.N., Brostrom M.A., Brostrom C.O. J. Biol. Chem. 270:1995;6211.
10. Alcazar A., Bazan E., Ribera J., Salinas M. Neurosci. Lett. 201:1995;215.
11. Prostko C.R., Brostrom M.A., Brostrom C.O. Mol. Cell. Biochem. 127/128:1993;255.
12. Palakurthi S.S., Fluckiger R., Aktas H., Changolkar A.K., Shahsafaei Al., Harneit S., Kilic E., Halperin J.A. Cancer Res. 60:2000;2919.
13. Palakurthi S.S., Aktas H., Grubissich L.M., Mortensen R.M., Halperin J.A. Cancer Res. 61:2001;6213.
14. Aktas H., Fluckiger R., Acosta J.A., Savage J.M., Palakurthi S.S., Halperin J.A. Proc. Natl. Acad. Sci. U.S.A. 95:1998;8280.
15. Demetri G.D., Fletcher C.D.M., Mueller E., Sarraf P., Naujoks R., Campbell N., Spiegelman B.M., Singer S. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3951.
16. Sugimura A., Kiriyama Y., Nochi H., Tsuchiya H., Tamoto K., Sakurada Y., Ui M., Tokumitsu Y. Biochem. Biophys. Res. Commun. 261:1999;833.
17. Debrock G., Vanhentenrijk V., Sciot R., Debiec-Rychter M., Oyen R., Oosterom A.V. Brit. J. Cancer. 89:2003;1409.
18. +): m/z 319.80 (M+H).
19. Egusa K., Fukase K., Kusumoto S. Synlett. 1997;675.
20. Carpenter D.E., Imbordino R.J., Maloney M.T., Moeslein J.A., Reder M.R., Scott A. Org. Process Res. Dev. 6:2002;721.
21. Clementi E., Scheer H., Zacchetti D., Fasolato C., Pozzan T., Meldolesi J. J. Biol. Chem. 267:1992;2164.
22. Monks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J., Boyd M. J. Natl. Cancer Inst. 83:1991;757.
23. Reddy K.A., Lohray B.B., Bhushan V., Reddy A.S., Rao Mamidi N.V.S., Reddy P.P., Saibaba V., Reddy N.J., Suryaprakash A., Misra P., Vikramadithyan R.K., Rajagopalan R. J. Med. Chem. 42:1999;3265.
24. Fischer M.J.E., Paulussen J.J.C., Tollenaere J.P., De Mol N.J., Janssen L.H.M. Eur. J. Pharmacol. 350:1998;353.