Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2038-2043

  Gouveia, Frederico L ^a   de Oliveira, Renata M B ^a   de Oliveira, Tatiane B ^a   da Silva, Ivanildo M ^a   do Nascimento, Silene C ^a   de Sena, Kêsia X F R ^a   de Albuquerque, Julianna F C ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

4 Thioxothiazolidinones; Antimicrobial activity; Benzylidene derivatives; Cytotoxic activity

Indexed keywords

5 (2 BROMOBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (2 CHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (2 FLUOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (2,3,5 TRICHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (2,4 DICHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (2,6 DICHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (3 BROMOBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (3 CHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (3 FLUOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (3,4 DICHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (4 BROMOBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (4 CHLOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; 5 (4 FLUOROBENZYLIDENE) 4 THIOXO THIAZOLIDINE 2 ONE; AMPICILLIN; ANTIINFECTIVE AGENT; CARBONYL DERIVATIVE; CEFALEXIN; KANAMYCIN; KETOCONAZOLE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; HEP 2 CELL; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-POSITIVE BACTERIA; HUMANS; KETONES; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 62549150309     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.006     Document Type: Article

References (32)

1. Tenover F.C. Clin. Infect. Dis. 33 Suppl. 3 (2001) S108-S115
2. Hooper D.C. Clin. Infect. Dis. 33 Suppl. 3 (2001) S157-S160
3. Nagai K., Davies T.A., Jacobs M.R., and Appelbaum P.C. Antimicrob. Agents Chemother. 46 (2002) 1273-1280
4. Pfeltz R.F., and Wilkinson B.J. Curr. Drug Targets Infect. Disord. 4 (2004) 273-294
5. Salama H.M., Labouta I.M., and Moustafa M.A. Alex. J. Pharm. Sci. 4 (1990) 44-46
6. Bonde C.G., and Gaikwad N.J. Bioorg. Med. Chem. 12 (2004) 2151-2161
7. Ottanà R., Carotti S., Maccari R., Landini I., Chiricosta G., Caciagli B., Vigorita M.G., and Mini E. Bioorg. Med. Chem. Lett. 15 (2005) 3930-3933
8. Li W., Lu Y., Wang Z., Dalton J.T., and Miller D.D. Bioorg. Med. Chem. Lett. 17 (2007) 4113-4117
9. Babaoglu K., Page M.A., Jones V.C., McNeil M.R., Dong C., Naismith J.H., and Lee R.E. Bioorg. Med. Chem. Lett. 13 (2003) 3227-3230
10. Yanagisawa H., Takamura M., Yamada E., Fujita S., Fujiwara T., Yachi M., Isobe A., and Hagisawa Y. Bioorg. Med. Chem. Lett. 10 (2000) 373-375
11. Ottanà R., Maccari R., Barreca M.L., Bruno G., Rotondo A., Rossi A., Chiricosta G., Paola R.D., Sautebin L., Cuzzocrea S., and Vigorita M.G. Bioorg. Med. Chem. 13 (2005) 4243-4252
12. Verma A., and Saraf S.K. Eur. J. Med. Chem. 43 (2008) 897-905
13. Vicini P., Geronikaki A., Anastasia K., Incerti M., and Zani F. Bioorg. Med. Chem. 14 (2006) 3859-3864
14. Mandlik J.V., Patwardhan V.A., and Nargund K.S. J. Univ. Poona. Sci. Technol. 32 (1966) 43
15. Chem. Abstr. 68 (1968) 87228
16. Tunçbilek M., and Altanlar N. Il Farmaco 54 (1999) 475-478
17. Albrecht U., Gördes D., Schmidt E., Thurow K., Lalk M., and Langer P. Bioorg. Med. Chem. 13 (2005) 4402-4407
18. Bozdaǧ-Dündar O., Özgen O., Menteşe A., Altanlar N., Atli{dotless} O., Kendi E., and Ertan R. Bioorg. Med. Chem. 15 (2007) 6012-6017
19. Libermann D., Himbert J., and Hengl L. Bull. Soc. Chim. Fr. 15 (1948) 1120-1124
20. Albuquerque J.F.C., Galdino S.L., Cantegrel J., Thomasson F., Pitta I.R., and Luu-Duc C. Ann. Pharm. Fr. 55 (1997) 201-205
21. Tan S.F., Ang K.P., and Fong Y.F. J. Chem. Soc., Perkin Trans. 2 (1986) 1941-1944
22. Albuquerque J.F.C., Albuquerque A., Azevedo C.C., Thomasson F., Galdino L.S., Chantegrel J., Catanho M.T.J., Pitta I.R., and Luu-Duc C. Pharmazie 50 (1995) 387-389
23. Vögeli U., Philipsborn W., Nagarajan K., and Nair M.D. Helv. Chim. Acta 61 (1978) 607-617
24. Bruno G., Costantino L., Curinga C., Maccari R., Monforte F., Nicolò F., Ottanà R., and Vigorita M.G. Bioorg. Med. Chem. 10 (2002) 1077-1084
25. Ishida T., In Y., Inoue M., Tanaka C., and Hamanaka N. J. Chem. Soc., Perkin Trans. 2 (1990) 1085-1091
26. Mosmann T. J. Immunol. Methods 65 (1983) 55-63
27. Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., and Boyd M.R. Cancer Res. 48 (1988) 589-601
28. Zhou H., Wu S., Zhai S., Liu A., Sun Y., Li R., Zhang Y., Ekins S., Swaan P.W., Fang B., Zhang B., and Yan B. J. Med. Chem. 51 (2008) 1242-1251
29. Gududuru V., Hurh E., Dalton J.T., and Miller D.D. J. Med. Chem. 48 (2005) 2584-2588
30. Clinical and Laboratory Standards Institute, Performance Standards for Antimicrobial Disk Susceptibility Tests, Approved Standard M2-A8, Clinical and Laboratory Standards Institute, Wayne, PA, USA; 2003.
31. Clinical and Laboratory Standards Institute, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Approved Standard M7-A6, Clinical and Laboratory Standards Institute, Wayne, PA, USA; 2003.
32. Clinical and Laboratory Standards Institute, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, Approved Standard M27-A2, Clinical and Laboratory Standards Institute, Wayne, PA, USA; 2002.