-
1
-
-
0038218405
-
Sphingosine 1-phosphate: an enigmatic signalling lipid
-
Spiegel S., and Milstien M. Sphingosine 1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 4 (2003) 397-407
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, M.2
-
2
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
-
3
-
-
0036303786
-
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
-
Kolesnick R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J. Clin. Invest. 110 (2002) 3-8
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 3-8
-
-
Kolesnick, R.1
-
4
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
-
Rosen H., and Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 5 (2005) 560-570
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
5
-
-
0141566600
-
Egress: a receptor-regulated step in lymphocyte trafficking
-
Rosen H., et al. Egress: a receptor-regulated step in lymphocyte trafficking. Immunol. Rev. 195 (2003) 160-177
-
(2003)
Immunol. Rev.
, vol.195
, pp. 160-177
-
-
Rosen, H.1
-
6
-
-
0043073128
-
Sphingosine 1-phosphate pathway therapeutics: a lipid-receptor paradigm
-
Rosen H., and Liao J. Sphingosine 1-phosphate pathway therapeutics: a lipid-receptor paradigm. Curr. Opin. Chem. Biol. 7 (2003) 461-468
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 461-468
-
-
Rosen, H.1
Liao, J.2
-
7
-
-
0034672133
-
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions
-
Murata N., et al. Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem. J. 352 (2000) 809-815
-
(2000)
Biochem. J.
, vol.352
, pp. 809-815
-
-
Murata, N.1
-
8
-
-
33746365908
-
1 antagonist in vivo
-
1 antagonist in vivo. Nat. Chem. Biol. 2 (2006) 434-441
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 434-441
-
-
Sanna, M.G.1
-
9
-
-
11144353922
-
3, respectively, regulate lymphocyte recirculation and heart rate
-
3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279 (2004) 13839-13848
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13839-13848
-
-
Sanna, M.G.1
-
10
-
-
11144355672
-
Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes
-
Forrest M., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. 309 (2004) 758-768
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, pp. 758-768
-
-
Forrest, M.1
-
11
-
-
0037162030
-
Sphingosine-1-phosphate receptors and the development of the vascular system
-
Allende M.L., and Proia R.L. Sphingosine-1-phosphate receptors and the development of the vascular system. Biochim. Biophys. Acta 1582 (2002) 222-227
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, pp. 222-227
-
-
Allende, M.L.1
Proia, R.L.2
-
12
-
-
0242411518
-
1 acts within endothelial cells to regulate vascular maturation
-
1 acts within endothelial cells to regulate vascular maturation. Blood 102 (2003) 3665-3667
-
(2003)
Blood
, vol.102
, pp. 3665-3667
-
-
Allende, M.L.1
-
13
-
-
30044441314
-
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
-
Wei S.H., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6 (2005) 1228-1235
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1228-1235
-
-
Wei, S.H.1
-
14
-
-
33747419124
-
Pulmonary and vascular pharmacology of sphingosine 1-phosphate
-
Brinkmann V., and Baumruker T. Pulmonary and vascular pharmacology of sphingosine 1-phosphate. Curr. Opin. Pharmacol. 6 (2006) 244-250
-
(2006)
Curr. Opin. Pharmacol.
, vol.6
, pp. 244-250
-
-
Brinkmann, V.1
Baumruker, T.2
-
15
-
-
7044241285
-
Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury
-
McVerry B.J., et al. Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am. J. Respir. Crit. Care Med. 170 (2004) 987-993
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.170
, pp. 987-993
-
-
McVerry, B.J.1
-
16
-
-
5644287793
-
In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights
-
McVerry B.J., and Garcia J. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell. Signal. 17 (2005) 131-139
-
(2005)
Cell. Signal.
, vol.17
, pp. 131-139
-
-
McVerry, B.J.1
Garcia, J.2
-
17
-
-
0033783522
-
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
-
Liu Y., et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106 (2000) 951-961
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 951-961
-
-
Liu, Y.1
-
18
-
-
28244456527
-
Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes
-
Singer I.I., et al. Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. J. Immunol. 175 (2005) 7151-7161
-
(2005)
J. Immunol.
, vol.175
, pp. 7151-7161
-
-
Singer, I.I.1
-
19
-
-
0344443651
-
Phosphorylation and action of the immunomodulator FTY720 inhibits VEGF-induced vascular permeability
-
Sanchez T., et al. Phosphorylation and action of the immunomodulator FTY720 inhibits VEGF-induced vascular permeability. J. Biol. Chem. 278 (2003) 47281-47290
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47281-47290
-
-
Sanchez, T.1
-
20
-
-
13244270031
-
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
-
Lo C.G., et al. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201 (2005) 291-301
-
(2005)
J. Exp. Med.
, vol.201
, pp. 291-301
-
-
Lo, C.G.1
-
21
-
-
33746324873
-
Lipid-induced phenotypes
-
Schultz C. Lipid-induced phenotypes. Nat. Chem. Biol. 2 (2006) 396-398
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 396-398
-
-
Schultz, C.1
-
22
-
-
15444373345
-
Sphingosine 1-phosphate analogs as receptor antagonists
-
Davis M.D., et al. Sphingosine 1-phosphate analogs as receptor antagonists. J. Biol. Chem. 280 (2005) 9833-9841
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9833-9841
-
-
Davis, M.D.1
-
23
-
-
0034671505
-
Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate
-
Parrill A.L., et al. Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. J. Biol. Chem. 275 (2000) 39379-39384
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39379-39384
-
-
Parrill, A.L.1
-
24
-
-
18444390571
-
Molecular basis for the lysophosphatidic acid receptor agonist selectivity
-
Sardar V.M., et al. Molecular basis for the lysophosphatidic acid receptor agonist selectivity. Biochim. Biophys. Acta 1582 (2002) 309-317
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, pp. 309-317
-
-
Sardar, V.M.1
-
25
-
-
0035966064
-
1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors
-
1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. J. Biol. Chem. 276 (2001) 49213-49220
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 49213-49220
-
-
Wang, D.A.1
-
26
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277 (2002) 21453-21457
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
-
27
-
-
0036773971
-
FTY720: targeting G-protein-coupled receptors for S1P in transplantation and autoimmunity
-
Brinkmann V., and Lynch K. FTY720: targeting G-protein-coupled receptors for S1P in transplantation and autoimmunity. Curr. Opin. Immunol. 14 (2002) 569-575
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 569-575
-
-
Brinkmann, V.1
Lynch, K.2
-
28
-
-
33751093316
-
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model
-
Pan S., et al. A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem. Biol. 13 (2006) 1227-1234
-
(2006)
Chem. Biol.
, vol.13
, pp. 1227-1234
-
-
Pan, S.1
-
29
-
-
33845296479
-
Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists
-
Foss F., et al. Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg. Med. Chem. 15 (2007) 663-677
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 663-677
-
-
Foss, F.1
-
31
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian M., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
-
32
-
-
24944535833
-
1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate
-
1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem. Biol. 12 (2005) 703-715
-
(2005)
Chem. Biol.
, vol.12
, pp. 703-715
-
-
Jo, E.1
-
33
-
-
33847154714
-
Modulating molecular gateways
-
Owens J. Modulating molecular gateways. Nature Rev. Drug Discov. 5 (2006) 633
-
(2006)
Nature Rev. Drug Discov.
, vol.5
, pp. 633
-
-
Owens, J.1
-
34
-
-
2442561611
-
1, on T-cells controls thymic emigration
-
1, on T-cells controls thymic emigration. J. Biol. Chem. 279 (2004) 15396-15401
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15396-15401
-
-
Allende, M.L.1
-
35
-
-
0141814654
-
Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist
-
Rosen H., et al. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 10907-10912
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10907-10912
-
-
Rosen, H.1
-
36
-
-
0034105487
-
Immunosuppressant FTY720 inhibits thymocyte emigration
-
Yagi H., et al. Immunosuppressant FTY720 inhibits thymocyte emigration. Eur. J. Immunol. 2000 (2000) 1435-1444
-
(2000)
Eur. J. Immunol.
, vol.2000
, pp. 1435-1444
-
-
Yagi, H.1
-
37
-
-
0035988219
-
A potential role for CD69 in thymocyte emigration
-
Feng C., et al. A potential role for CD69 in thymocyte emigration. Int. Immunol. 14 (2002) 535-544
-
(2002)
Int. Immunol.
, vol.14
, pp. 535-544
-
-
Feng, C.1
-
38
-
-
0036134843
-
The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression
-
Nakayama T., et al. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168 (2002) 87-94
-
(2002)
J. Immunol.
, vol.168
, pp. 87-94
-
-
Nakayama, T.1
-
39
-
-
33645289121
-
1 and lymphocyte egress from lymphoid organs
-
1 and lymphocyte egress from lymphoid organs. Nature 440 (2006) 540-544
-
(2006)
Nature
, vol.440
, pp. 540-544
-
-
Shiow, L.R.1
-
40
-
-
0037036142
-
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
-
Miller M.J., et al. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296 (2002) 1869-1873
-
(2002)
Science
, vol.296
, pp. 1869-1873
-
-
Miller, M.J.1
-
41
-
-
0141566612
-
A stochastic view of lymphocyte motility and trafficking within the lymph node
-
Wei S.H., et al. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol. Rev. 195 (2003) 136-159
-
(2003)
Immunol. Rev.
, vol.195
, pp. 136-159
-
-
Wei, S.H.1
-
42
-
-
33744460736
-
Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment
-
Tilley D.G., and Rockman H. Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment. Expert Rev. Cardiovasc. Ther. 4 (2006) 417-432
-
(2006)
Expert Rev. Cardiovasc. Ther.
, vol.4
, pp. 417-432
-
-
Tilley, D.G.1
Rockman, H.2
-
43
-
-
0036035993
-
The roles of sphingosine-1-phosphate in asthma
-
Jolly P.S., et al. The roles of sphingosine-1-phosphate in asthma. Mol. Immunol. 38 (2002) 1239-1245
-
(2002)
Mol. Immunol.
, vol.38
, pp. 1239-1245
-
-
Jolly, P.S.1
-
44
-
-
33645099042
-
The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2a receptor
-
Milojevic T., et al. The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2a receptor. Mol. Pharmacol. 69 (2006) 1083-1094
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1083-1094
-
-
Milojevic, T.1
-
45
-
-
30044447860
-
1D-adrenergic receptors form a single functional entity
-
1D-adrenergic receptors form a single functional entity. Mol. Pharmacol. 69 (2006) 45-55
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 45-55
-
-
Hague, C.1
-
46
-
-
28444464430
-
GPCR modulation by RAMPs
-
Hay D.L., et al. GPCR modulation by RAMPs. Pharmacol. Ther. 109 (2006) 173-197
-
(2006)
Pharmacol. Ther.
, vol.109
, pp. 173-197
-
-
Hay, D.L.1
-
47
-
-
33644861545
-
Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases
-
Chun J., and Rosen H. Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Curr. Pharm. Des. 12 (2006) 161-171
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 161-171
-
-
Chun, J.1
Rosen, H.2
-
48
-
-
33746514475
-
1) with high selectivity against all other known S1P receptor subtypes
-
1) with high selectivity against all other known S1P receptor subtypes. Bioorg. Med. Chem. Lett. 16 (2006) 3679-3683
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 3679-3683
-
-
Yan, L.1
-
49
-
-
19944432761
-
KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts
-
Shimizu H., et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation 111 (2005) 222-229
-
(2005)
Circulation
, vol.111
, pp. 222-229
-
-
Shimizu, H.1
-
50
-
-
0036434445
-
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
-
Osada M., et al. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem. Biophys. Res. Commun. 299 (2002) 483-487
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 483-487
-
-
Osada, M.1
-
51
-
-
0034887535
-
B2 sphingosine 1-phosphate receptor in neuronal excitability
-
B2 sphingosine 1-phosphate receptor in neuronal excitability. Eur. J. Neurosci. 14 (2001) 203-209
-
(2001)
Eur. J. Neurosci.
, vol.14
, pp. 203-209
-
-
MacLennan, A.J.1
-
52
-
-
33748310612
-
2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function
-
2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function. Hear. Res. 220 (2006) 38-48
-
(2006)
Hear. Res.
, vol.220
, pp. 38-48
-
-
MacLennan, A.J.1
-
53
-
-
0037067769
-
B3/EDG-3
-
B3/EDG-3. J. Biol. Chem. 277 (2002) 25152-25159
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25152-25159
-
-
Ishii, I.1
-
54
-
-
33847113358
-
-
Gonzalez-Cabrera, P.J. et al. Mapping pathways downstream of S1P1 by differential chemical perturbation and proteomics. J. Biol. Chem. (in press)
-
-
-
|