APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q

Cancer Biology and Therapy

Volumn 3, Issue 10, 2004, Pages 960-964

  Arnold, Christian N ^a,h   Goel, Ajay ^a,g   Niedzwiecki, Donna ^b   Dowell, Jeannette M ^b   Wasserman, Linda ^a   Compton, Carolyn ^d   Mayer, Robert J ^e   Bertagnolli, Monica M ^f   Boland, C Richard ^a,c,g  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b DUKE UNIVERSITY   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^h UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Adenomatous polyposis coli (APC); Colorectal cancer (CRC); Immunohistochemistry (IHC); Loss of heterozygosity (LOH)

Indexed keywords

APC PROTEIN; DNA;

ALLELE; ARTICLE; COLORECTAL CANCER; GENE LOCUS; HETEROZYGOSITY LOSS; HUMAN; METHYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; STAINING; TUMOR; CHROMOSOME 5; COLON; COLORECTAL TUMOR; COMPARATIVE STUDY; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; PATHOLOGY; RECTUM;

ADENOMATOUS POLYPOSIS COLI PROTEIN; CHROMOSOMES, HUMAN, PAIR 5; COLON; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LOSS OF HETEROZYGOSITY; PROMOTER REGIONS (GENETICS); RECTUM;

EID: 21244500864     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.10.1113     Document Type: Article

References (28)

1. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87:159-70.
2. Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, et al. APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci USA 1996; 93:9049-54.
3. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-9.
4. Fearnhead NS, Britton MP, Bodmer WF. The ABC of APC. Hum Mol Genet 2001; 10:721-33.
5. Hlsken J, Behrens J. The Wnt signalling pathway. J Cell Sci 2000; 113: 3545-52.
6. Morin PJ. β-catenin signaling and cancer. Bioessays 1999; 21:1021-30.
7. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science 1998; 281:1509-12.
8. He TC, Chan TA, Vogelstein B, Kinzler KW PPARΔ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999; 99:335-45.
9. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 1997; 275:1787-90.
10. Tetsu O, McCormick F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398:422-6.
11. Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000; 60:4366-71.
12. Knudson Jr AG, Overview: Genes that predispose to cancer. Mutat Res 1991; 247:185-90.
13. Esteller M. Epigenetic lesions causing genetic lesions in human cancer: Promoter hypermethylation of DNA repair genes. Eur J Cancer 2000; 36:2294-2300.
14. Goel A, Arnold CN, Niedzwiecki D, Chang DK, Ricciardiello L, Carethers JM, et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 2003; 63:1608-14.
15. Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med 1995; 1:902-9.
16. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93:9821-6.
17. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001; 10:087-92.
18. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001; 293:1068-70.
19. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61:3225-9.
20. Rashid A, Shen L, Morris JS, Issa JP, Hamilton SR. CpG island methylation in colorectal adenomas. Am J Pathol 2001; 159:1129-35.
21. Goel A, Arnold CN, Boland CR. Multistep progression of colorectal cancer in the setting of microsatellite instability: New details and novel insights. Gastroenterology 2001; 121:1497-1502.
22. Moreno-Bueno G, Hardisson D, Sanchez C, Sarrio D, Cassia R, Garcia-Rostan G, et al. Abnormalities of the APC/β-catenin pathway in endometrial cancer. Oncogene 2002; 21:7981-90.
23. Virmani AK, Rathi A, Sathyanarayana UG, Padar A, Huang CX, Cunnigham HT, et al. Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas. Clin Cancer Res 2001; 7:1998-2004.
24. Lamlum H, Papadopoulou A, Ilyas M, Rowan A, Gillet C, Hanby A, et al. APC mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci USA 2000; 97:2225-8.
25. Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, et al. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 2001; 20:5025-32.
26. Pao MM, Liang G, Tsai YC, Xiong Z, Laird PW, Jones PA. DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene 2000; 19:943-52.
27. Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, et al. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 2000; 404:1003-7.
28. Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, et al. Frequent inactivation of PTEN by promoter hypermethylation in micro satellite instability-high (MSI-H) sporadic colorectal cancer. Cancer Res 2004; 64:3014-21.