Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

Nature

Volumn 475, Issue 7354, 2011, Pages 53-59

  Langevin, Frédéric ^a   Crossan, Gerry P ^a   Rosado, Ivan V ^a   Arends, Mark J ^b   Patel, Ketan J ^a,c  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALDEHYDE; DNA;

ALDEHYDE; ANEMIA; BLOOD SYSTEM DISORDER; CANCER; CARCINOGEN; CATABOLISM; EMBRYO; ENZYME ACTIVITY; ETHANOL; GENOTOXICITY; MOLECULAR ANALYSIS; PROTEIN; RODENT; TOXICITY;

ACUTE LEUKEMIA; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DEPRESSION; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FANCONI ANEMIA; FETAL ALCOHOL SYNDROME; GENOTOXICITY; HISTOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDEHYDES; ALLELES; ANIMALS; B-LYMPHOCYTES; BONE MARROW; CELL LINE; CELL SURVIVAL; CHICKENS; CLONE CELLS; DNA DAMAGE; DNA REPAIR; EMBRYO LOSS; EMBRYO, MAMMALIAN; ETHANOL; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FEMALE; FETAL ALCOHOL SYNDROME; GENE DELETION; GENES, ESSENTIAL; HEMATOPOIESIS; MALE; MICE; MICE, INBRED C57BL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREGNANCY; TERATOGENS; WEANING;

MUS;

EID: 79960037006     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10192     Document Type: Article

References (43)

1. Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709-715 (1993). (Pubitemid 23125973)
2. Patel, K. J. & Joenje, H. Fanconi anemia and DNA replication repair. DNA Repair (Amst.) 6, 885-890 (2007). (Pubitemid 46880469)
3. O'Brien, P. J., Siraki, A. G. & Shangari, N. Aldehyde sources, metabolism,molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35, 609-662 (2005). (Pubitemid 41693601)
4. Wang, M. et al. Identification of DNA adducts of acetaldehyde. Chem. Res. Toxicol. 13, 1149-1157 (2000).
5. Stein, S., Lao, Y., Yang, I. Y., Hecht, S. S. & Moriya, M. Genotoxicity of acetaldehydeand crotonaldehyde-induced 1,N2- propanodeoxyguanosine DNA adducts in human cells. Mutat. Res. 608, 1-7 (2006). (Pubitemid 44280042)
6. Cheng, G. et al. Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chem. Res. Toxicol. 16, 145-152 (2003). (Pubitemid 36245864)
7. Vasiliou, V., Pappa, A. & Estey, T. Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism. Drug Metab. Rev. 36, 279-299 (2004). (Pubitemid 38807313)
8. Perez-Miller, S. et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Struct. Mol. Biol. 17, 159-164 (2010).
9. Ridpath, J. R. et al. Cells deficient in theFANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res. 67, 11117-11122 (2007). (Pubitemid 350248534)
10. Nagayoshi, H. et al. Increased formation of gastric N2-ethylidene-29- deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. Mutat. Res. 673, 74-77 (2009).
11. Matsuda, T. et al. Increased formation of hepatic N2-ethylidene-29- deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. Carcinogenesis 28, 2363-2366 (2007). (Pubitemid 350111595)
12. Seitz, H. K. & Stickel, F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Rev. Cancer 7, 599-612 (2007). (Pubitemid 47106631)
13. Chen, L. et al. Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation. Chem. Res. Toxicol. 20, 108-113 (2007). (Pubitemid 46220161)
14. Niedzwiedz, W. et al. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell 15, 607-620 (2004). (Pubitemid 39141787)
15. Alpi, A. et al. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol. Cell. Biol. 27, 8421-8430 (2007).
16. King, G. & Holmes, R. Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J. Exp. Zool. 282, 12-17 (1998). (Pubitemid 28395502)
17. Pappa, A., Estey, T., Manzer, R., Brown, D. & Vasiliou, V. Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in thecornea.Biochem. J.376, 615-623 (2003). (Pubitemid 38063115)
18. Riveros-Rosas, H., Julian-Sanchez, A. & Pina, E. Enzymology of ethanol and acetaldehyde metabolism in mammals. Arch. Med. Res. 28, 453-471 (1997). (Pubitemid 28014256)
19. Kunitoh, S. et al. Acetaldehyde as well as ethanol is metabolized by human CYP2E1. J. Pharmacol. Exp. Ther. 280, 527-532 (1997). (Pubitemid 27171309)
20. Parmar, K., D'Andrea, A. & Niedernhofer, L. J. Mouse models of Fanconi anemia. Mutat. Res. 668, 133-140 (2009).
21. Crossan, G. P. et al. Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nature Genet. 43, 147-152 (2011).
22. Marietta, C., Thompson, L. H., Lamerdin, J. E. & Brooks, P. J. Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis. Mutat. Res. 664, 77-83 (2009).
23. Yu, H. S. et al.Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockoutmice. Toxicol. Mech. Methods 19, 535-540 (2009).
24. Houghtaling, S. et al. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev. 17, 2021-2035 (2003). (Pubitemid 36999328)
25. Sulik, K. K., Johnston, M. C. & Webb, M. A. Fetal alcohol syndrome: embryogenesis in a mouse model. Science 214, 936-938 (1981). (Pubitemid 12220101)
26. Webster, W. S., Walsh, D. A., McEwen, S. E. & Lipson, A. H. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome. Teratology 27, 231-243 (1983). (Pubitemid 13088890)
27. O'Shea, K.S. & Kaufman, M. H.Theteratogenic effect of acetaldehyde:implications for the study of the fetal alcohol syndrome. J. Anat. 128, 65-76 (1979). (Pubitemid 9086879)
28. Michot, F. & Gut, J.Alcohol-inducedbonemarrowdamage.Abonemarrowstudy in alcohol-dependent individuals. Acta Haematol. 78, 252-257 (1987).
29. Nakao, S., Harada, M., Kondo, K., Mizushima, N. & Matsuda, T. Reversible bone marrow hypoplasia induced by alcohol. Am. J. Hematol. 37, 120-123 (1991).
30. Meagher, R. C., Sieber, F. & Spivak, J. L. Suppression of hematopoietic-progenitorcell proliferationbyethanolandacetaldehyde.N. Engl. J.Med.307,845-849(1982).
31. Marc, N., Fautrel, A., Damon, M., Guillouzo, A. & Corcos, L. Phenobarbital induction of aldehyde dehydrogenase type 2 mRNA in mouse liver: a candidate region on chromosome 7 for a putative regulatory gene. Biochem. Genet. 38, 297-308 (2000).
32. Vasiliou, V., Torronen, R., Malamas, M. & Marselos, M. Inducibility of liver cytosolic aldehyde dehydrogenase activity in various animal species. Comp. Biochem. Physiol. C 94, 671-675 (1989). (Pubitemid 20107563)
33. Chen, C.-H. et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321, 1493-1495 (2008).
34. Perez-Miller, S. et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Struct. Mol. Biol. 17, 159-164 (2010).
35. Knipscheer, P. et al. The Fanconi anemia pathway promotes replicationdependent DNA interstrand cross-link repair. Science 326, 1698-1701 (2009).
36. Abel, E. L. & Sokol, R. J. A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol. Clin. Exp. Res. 15, 514-524 (1991).
37. Latino-Martel, P. et al.Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis. Cancer Epidemiol. Biomarkers Prev. 19, 1238-1260 (2010).
38. MacArthur, A. C. et al. Risk of childhood leukemia associated withparentalsmoking and alcohol consumption prior to conception and during pregnancy: the cross- Canada childhood leukemia study. Cancer Causes Control 19, 283-295 (2008).
39. Brooks, P. J., Enoch, M. A., Goldman, D., Li, T. K. & Yokoyama, A. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 6, e50 (2009).
40. McKay, J. D. et al. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE Consortium. PLoS Genet. 7, e1001333 (2011).
41. Alter, B. P., Joenje, H., Oostra, A. B. & Pals, G. Fanconi anemia: adult head and neck cancer and hematopoietic mosaicism. Arch. Otolaryngol. Head Neck Surg. 131, 635-639 (2005). (Pubitemid 41058056)
42. Hazen, S. L., Hsu, F. F., d'Avignon, A. & Heinecke, J. W. Human neutrophils employ myeloperoxidase to convert a-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation. Biochemistry 37, 6864-6873 (1998). (Pubitemid 28228123)
43. O'Brien, P. J., Siraki, A. G. & Shangari, N. Aldehyde sources, metabolism,molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35, 609-662 (2005). (Pubitemid 41693601)