Ghrelin maintains the cardiovascular stability in severe sepsis

Journal of Surgical Research

Volumn 178, Issue 1, 2012, Pages 370-377

  Wu, Rongqian ^a   Chaung, Wayne W ^a   Dong, Weifeng ^a   Ji, Youxin ^a   Barrera, Rafael ^a   Nicastro, Jeffrey ^a   Molmenti, Ernesto P ^a   Coppa, Gene F ^a   Wang, Ping ^a  

^a DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

Author keywords

Ghrelin; Heart performance; Sepsis; Vascular endothelial cell function

Indexed keywords

ACETYLCHOLINE; BICARBONATE; GHRELIN; GLYCERYL TRINITRATE; HEMOGLOBIN; NORADRENALIN;

ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CARDIOMYOPATHY; CARDIOVASCULAR FUNCTION; CONFERENCE PAPER; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; HEART MUSCLE CONTRACTILITY; HEART PERFORMANCE; HEART RATE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE PRESSURE; HEMATOCRIT; IN VIVO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SEPSIS; THORACIC AORTA; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CECUM; DISEASE MODELS, ANIMAL; GHRELIN; HEMATOCRIT; HEMOGLOBINS; INFUSION PUMPS; MALE; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SEVERITY OF ILLNESS INDEX; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT; WOUNDS, STAB;

EID: 84868191115     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.12.021     Document Type: Conference Paper

References (46)

1. G.R. Bernard, J.L. Vincent, and P.F. Laterre Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 2001 699
2. G.S. Martin, D.M. Mannino, and S. Eaton The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 2003 1546
3. A.M. Esper, M. Moss, and C.A. Lewis The role of infection and comorbidity: Factors that influence disparities in sepsis Crit Care Med 34 2006 2576
4. P.A. Danai, S. Sinha, and M. Moss Seasonal variation in the epidemiology of sepsis Crit Care Med 35 2007 410
5. M.C. Strehlow, S.D. Emond, and N.I. Shapiro National study of emergency department visits for sepsis, 1992 to 2001 Ann Emerg Med 48 2006 326
6. D.C. Angus, W.T. Linde-Zwirble, and J. Lidicker Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303
7. P. Wang, M. Zhou, and M.W. Rana Differential alterations in microvascular perfusion in various organs during early and late sepsis Am J Physiol 263 1992 G38
8. P. Wang, Z.F. Ba, and I.H. Chaudry Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis Am J Physiol 269 1995 R988
9. P. Wang Adrenomedullin and cardiovascular responses in sepsis Peptides 22 2001 1835
10. M. Kojima, H. Hosoda, and Y. Date Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656
11. J. Isgaard, and R. Granata Ghrelin in cardiovascular disease and atherogenesis Mol Cell Endocrinol 340 2011 59
12. R. Wu, M. Zhou, and X. Cui Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis Am J Physiol Heart Circ Physiol 287 2004 H1296
13. R. Wu, W. Dong, and M. Zhou Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1 Cardiovasc Res 68 2005 318
14. R. Wu, W. Dong, and M. Zhou Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats Am J Respir Crit Care Med 176 2007 805
15. X. Cui, R. Wu, and M. Zhou Differential expression of cytochrome P450 isoforms in the lungs of septic animals Crit Care Med 32 2004 1186
16. R. Wu, W. Dong, and X. Cui Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve Ann Surg 245 2007 480
17. S. Krishnagopalan, A. Kumar, and J.E. Parrillo Myocardial dysfunction in the patient with sepsis Curr Opin Crit Care 8 2002 376
18. K.A. Wichterman, A.E. Baue, and I.H. Chaudry Sepsis and septic shock: A review of laboratory models and a proposal J Surg Res 29 1980 189
19. 2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis Crit Care Med 27 1999 959
20. V.K. Sharma, and R.P. Dellinger The International Sepsis Forum's controversies in sepsis: My initial vasopressor agent in septic shock is norepinephrine rather than dopamine Crit Care 7 2003 3 5 (Pubitemid 36204257)
21. R.M.J. Palmer The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis Arch Surg 128 1993 396
22. R.J. Levy, and C.S. Deutschman Evaluating myocardial depression in sepsis Shock 22 2004 1
23. N. Nagaya, M. Uematsu, and M. Kojima Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435 (Pubitemid 32880158)
24. N. Nagaya, K. Miyatake, and M. Uematsu Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure J Clin Endocrinol Metab 86 2001 5854
25. N. Nagaya, J. Moriya, and Y. Yasumura Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674
26. M. Miksa, P. Das, and M. Zhou Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis PLoS ONE 4 2009 e5504
27. R. Wu, S. Higuchi, and W. Dong Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein Mol Med 15 2009 28
28. K.R. Walley, P.C. Hebert, and Y. Wakai Decrease in left ventricular contractility after tumor necrosis factor-alpha infusion in dogs J Appl Physiol 76 1994 1060
29. D.R. Murray, and G.L. Freeman Tumor necrosis factor-α induces a biphasic effect on myocardial contractility in conscious dogs Circ Res 78 1996 154
30. R. Wu, M. Zhou, and W. Dong Ghrelin hyporesponsiveness contributes to age-related hyperinflammation in septic shock Ann Surg 250 2009 126
31. L. Chang, Y. Ren, and X. Liu Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart J Cardiovasc Pharmacol 43 2004 165
32. E. Rivers, B. Nguyen, and S. Havstad Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med 345 2001 1368
33. B. Chernow, T.G. Rainey, and C.R. Lake Endogenous and Exogenous catecholamines in critical care medicine Crit Care Med 10 1982 409
34. S. Greenberg, J. Xie, and Y. Wang Tumor necrosis factor-alpha inhibits endothelium-dependent relaxation J Appl Physiol 74 1993 2394
35. J. Xie, Y. Wang, and H. Lippton Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide Am Rev Respir Dis 148 1993 627
36. N. Aoki, M. Siegfried, and A.M. Lefer Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries Am J Physiol 256 1989 H1509
37. P. Wang, Z.F. Ba, and I.H. Chaudry Administration of tumor necrosis factor-α in vivo depresses endothelium-dependent relaxation Am J Physiol 266 1994 H2535
38. M. Tesauro, F. Schinzari, and M. Caramanti Cardiovascular and metabolic effects of ghrelin Curr Diabetes Rev 6 2010 228
39. Y. Xu, J.J. Zhu, and F. Cheng Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3 β/β -catenin signaling in neonatal rats J Mol Endocrinol 47 2011 33
40. M. Tesauro, F. Schinzari, and V. Rovella Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome Hypertension 54 2009 995
41. S. Taddei, and A. Virdis Exogenous ghrelin on nitric oxide-endothelin 1 imbalance in metabolic syndrome: Can we kill 2 birds with 1 stone? Hypertension 54 2009 960
42. K.B. Chow, C.H. Cheng, and H. Wise Anti-inflammatory activity of ghrelin in human carotid artery cells Inflammation 32 2009 402
43. Y. Wang, K. Narsinh, and L. Zhao Effects and mechanisms of ghrelin on cardiac microvascular endothelial cells in rats Cell Biol Int 35 2011 135
44. G. Baldanzi, N. Filigheddu, and S. Cutrupi Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT J Cell Biol 159 2002 1029
45. P. Wang, and I.H. Chaudry Mechanism of hepatocellular dysfunction during hyperdynamic sepsis Am J Physiol 270 1996 R927
46. S. Yang, W.G. Cioffi, and K.I. Bland Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis J Trauma 47 1999 706