Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa

Hormone and Metabolic Research

Volumn 42, Issue 8, 2010, Pages 595-598

  Koyama, K I ^a   Yasuhara, D ^a   Nakahara, T ^a   Harada, T ^a   Uehara, M ^a   Ushikai, M ^a   Asakawa, A ^a   Inui, A ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

eating disorders; energy intake; gut hormone; hospitalization

Indexed keywords

GHRELIN; GHRELIN, DES-N-OCTANOYL;

ADULT; ANOREXIA NERVOSA; ARTICLE; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; MENTAL DISEASE; NUTRITIONAL STATUS; PRIORITY JOURNAL; REFEEDING; TREATMENT DURATION; BLOOD; FEEDING BEHAVIOR; TIME; YOUNG ADULT;

ADULT; ANOREXIA NERVOSA; FEEDING BEHAVIOR; FEMALE; GHRELIN; HUMANS; INPATIENTS; TIME FACTORS; YOUNG ADULT;

EID: 77954229592     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0030-1252017     Document Type: Article

References (27)

1. th century. Am J Psychiatry 2002 159 1284-1293
2. Harada T, Nakahara T, Yasuhara D, Kojima S, Sagiyama K, Amitani H, Laviano A, Naruo T, Inui A. Obestatin, Acyl Ghrelin, and Des-acyl Ghrelin Responses to an Oral Glucose Tolerance Test in the Restricting Type of Anorexia Nervosa. Biol Psychiatry 2008 63 245-247
3. Yasuhara D, Naruo T, Nagai N, Muranaga T, Nakahara T, Tanaka M, Kojima S, Sagiyama K, Masuda A, Inui A. Glucose Tolerance Predicts Short-term Refeeding Outcome in Females With Anorexia Nervosa. Psychosom Med 2005 67 669-676
4. Yasuhara D, Naruo T, Nagai N, Tanaka M, Muranaga T, Nozoe S. Insulinogenic index at 15min as a marker of nutritional rehabilitation in anorexia nervosa. Am J Clin Nutr 2003 77 292-299
5. Inui A. Eating behavior in anorexia nervosa an excess of both orexigenic and anorexigenic signaling? Mol Psychiatry 2001 6 620-624
6. Yasuhara D, Hashiguchi T, Kawahara K, Nakahara T, Harada T, Taguchi H, Yamada S, Maruyama I, Inui A. High mobility group box 1 and refeeding-resistance in anorexia nervosa. Mol Psychiatry 2007 12 976-977
7. Bechtold DA, Ivanov TR, Luckman SM. Appetite-modifying actions of pro-neuromedin U-derived peptides. Am J Physiol Endocrinol Metab 2009 297 545-551
8. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 402 656-660
9. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000 85 4908-4911
10. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000 407 908-913
11. Inui A. Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001 2 551-560
12. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Kangawa K, Matsukura S. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002 87 240-244
13. Tanaka M, Tatebe Y, Nakahara T, Yasuhara D, Sagiyama K, Muranaga T, Ueno H, Nkazato M, Nozoe S, Naruo T. Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa. Clin Endocrinol (Oxf) 2003 59 574-579
14. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001 120 337-345
15. Molfino A, Laviano A, Chiappini MG, Rossi Fanelli F, Muscaritoli M. Is des-acyl ghrelin contributing to uremic anorexia? Am J Clin Nutr 2007 86 1550-1551
16. Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N, Takano K. Plasma level of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab 2004 89 5707-5712
17. Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, Oikawa S. Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology 2002 143 3268-3275
18. Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM, Kasuga M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005 54 18-24
19. Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, Ueno N, Fujimiya M. Des-acyl Ghrelin Acts by CRF Type 2 Receptors to Disrupt Fasted Stomach Motility in Conscious Rats. Gastroenterology 2005 129 8-25
20. Inhoff T, Mönnikes H, Noetzel S, Stengel A, Goebel M, Dinh QT, Riedl A, Bannert N, Wisser AS, Widenmann B, Klapp BF, Taché Y, Kobelt P. Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats. Peptides 2008 29 2159-2168
21. Stving RK, Andries A, Brixen K, Flyvbjerg A, Hrder K, Frystyk J. Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa. J Psychiatr Res 2009 43 671-679
22. Janas-Kozik M, Krupka-Matuszczyk I, Malinowska-Kolodziej I, Lewin-Kowalik J. Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. Regul Pept 2007 5; 140 43-46
23. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed (DSM-IV), Washington, DC 1994
24. Yasuhara D, Nakahara T, Harada T, Inui A. Olanzapine-induced hyperglycemia in anorexia nervosa. Am J Psychiatry 2007 164 528-529
25. Broom DR, Batterham RL, King JA, Stensel DJ. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integ Comp Physiol 2009 296 29-35
26. Kawai K, Yamanaka T, Yamashita S, Gondo M, Morita C, Arimura C, Nozaki T, Takii M, Kubo C. Somatic and psychological factors related to the body mass index of patients with anorexia nervosa. Eat Weight Disord 2008 13 198-204
27. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone. Cell 2008 8 387-396