메뉴 건너뛰기




Volumn 53, Issue 4, 2012, Pages 585-595

Ghrelin: An emerging new anticonvulsant neuropeptide

Author keywords

Epilepsy; Hippocampus; Memory; Peptide

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTICONVULSIVE AGENT; CARBAMAZEPINE; GALANIN; GALMIC; GALNON; GHRELIN; GHRELIN RECEPTOR; GHSR 1B RECEPTOR; HORMONE RECEPTOR; ION CHANNEL; MACIMORELIN; NEUROPEPTIDE Y; NEUROTRANSMITTER; OXCARBAZEPINE; PHENYTOIN; SOMATOSTATIN; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84859420695     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2012.03423.x     Document Type: Review
Times cited : (44)

References (87)
  • 3
    • 67650957574 scopus 로고    scopus 로고
    • The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat
    • Aslan A, Yildirim M, Ayyildiz M, Guven A, Agar E. (2009) The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat. Neuropeptides 43:295-302.
    • (2009) Neuropeptides , vol.43 , pp. 295-302
    • Aslan, A.1    Yildirim, M.2    Ayyildiz, M.3    Guven, A.4    Agar, E.5
  • 4
  • 7
    • 79958082780 scopus 로고    scopus 로고
    • The effects of ghrelin on inflammation and the immune system
    • Baatar D, Patel K, Taub DD. (2011) The effects of ghrelin on inflammation and the immune system. Mol Cell Endocrinol 340:44-58.
    • (2011) Mol Cell Endocrinol , vol.340 , pp. 44-58
    • Baatar, D.1    Patel, K.2    Taub, D.D.3
  • 8
    • 20444365165 scopus 로고    scopus 로고
    • Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice
    • DOI 10.1016/j.npep.2004.12.010, PII S0143417904001507
    • Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T. (2005) Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39:249-251. (Pubitemid 40804593)
    • (2005) Neuropeptides , vol.39 , Issue.3 , pp. 249-251
    • Badie-Mahdavi, H.1    Behrens, M.M.2    Rebek, J.3    Bartfai, T.4
  • 9
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • DOI 10.1124/jpet.102.034827
    • Banks WA, Tschop M, Robinson SM, Heiman ML. (2002) Extent and direction of ghrelin transport across the blood - brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822-827. (Pubitemid 34787253)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.302 , Issue.2 , pp. 822-827
    • Banks, W.A.1    Tschop, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 12
    • 70349692982 scopus 로고    scopus 로고
    • Seizures beget seizures in temporal lobe epilepsies: The boomerang effects of newly formed aberrant kainatergic synapses
    • Ben-Ari Y, Crepel V, Represa A. (2008) Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses. Epilepsy Curr 8:68-72.
    • (2008) Epilepsy Curr , vol.8 , pp. 68-72
    • Ben-Ari, Y.1    Crepel, V.2    Represa, A.3
  • 13
    • 32044468920 scopus 로고    scopus 로고
    • Serum ghrelin levels are enhanced in patients with epilepsy
    • DOI 10.1016/j.seizure.2005.11.008, PII S1059131105002220
    • Berilgen MS, Mungen B, Ustundag B, Demir C. (2006) Serum ghrelin levels are enhanced in patients with epilepsy. Seizure 15:106-111. (Pubitemid 43192420)
    • (2006) Seizure , vol.15 , Issue.2 , pp. 106-111
    • Berilgen, M.S.1    Mungen, B.2    Ustundag, B.3    Demir, C.4
  • 16
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • DOI 10.1038/361031a0
    • Bliss TV, Collingridge GL. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39. (Pubitemid 23020772)
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.P.1    Collingridge, G.L.2
  • 17
    • 33644863678 scopus 로고    scopus 로고
    • Cell biology of the ghrelin receptor
    • Camina JP. (2006) Cell biology of the ghrelin receptor. J Neuroendocrinol 18:65-76.
    • (2006) J Neuroendocrinol , vol.18 , pp. 65-76
    • Camina, J.P.1
  • 19
    • 79960554651 scopus 로고    scopus 로고
    • Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate
    • Cansu A, Serdaroglu A, Camurdan O, Hirfanoglu T, Cinaz P. (2011a) Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate. Horm Res Paediatr 76:65-71.
    • (2011) Horm Res Paediatr , vol.76 , pp. 65-71
    • Cansu, A.1    Serdaroglu, A.2    Camurdan, O.3    Hirfanoglu, T.4    Cinaz, P.5
  • 20
    • 81855193935 scopus 로고    scopus 로고
    • Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving oxcarbazepine
    • Cansu A, Serdaroglu A, Cinaz P. (2011b) Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving oxcarbazepine. Eur J Paediatr Neurol 15:527-531.
    • (2011) Eur J Paediatr Neurol , vol.15 , pp. 527-531
    • Cansu, A.1    Serdaroglu, A.2    Cinaz, P.3
  • 22
    • 78651424438 scopus 로고    scopus 로고
    • Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats
    • Chen L, Xing T, Wang M, Miao Y, Tang M, Chen J, Li G, Ruan DY. (2011) Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats. Eur J Neurosci 33:266-275.
    • (2011) Eur J Neurosci , vol.33 , pp. 266-275
    • Chen, L.1    Xing, T.2    Wang, M.3    Miao, Y.4    Tang, M.5    Chen, J.6    Li, G.7    Ruan, D.Y.8
  • 23
    • 79952157408 scopus 로고    scopus 로고
    • Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve
    • Cheyuo C, Wu R, Zhou M, Jacob A, Coppa G, Wang P. (2011) Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve. Shock 35:258-265.
    • (2011) Shock , vol.35 , pp. 258-265
    • Cheyuo, C.1    Wu, R.2    Zhou, M.3    Jacob, A.4    Coppa, G.5    Wang, P.6
  • 24
    • 33847716287 scopus 로고    scopus 로고
    • Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity
    • DOI 10.1016/j.biocel.2006.11.007, PII S135727250600327X
    • Chu KM, Chow KB, Leung PK, Lau PN, Chan CB, Cheng CH, Wise H. (2007) Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity. Int J Biochem Cell Biol 39:752-764. (Pubitemid 46380278)
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , Issue.4 , pp. 752-764
    • Chu, K.-M.1    Chow, K.B.S.2    Leung, P.-K.3    Lau, P.-N.4    Chan, C.-B.5    Cheng, C.H.K.6    Wise, H.7
  • 25
    • 53349175016 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygenglucose deprivation-induced apoptosis in primary rat cortical neuronal cells
    • Chung H, Seo S, Moon M, Park S. (2008) Phosphatidylinositol-3-kinase/Akt/ glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygenglucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198:511-521.
    • (2008) J Endocrinol , vol.198 , pp. 511-521
    • Chung, H.1    Seo, S.2    Moon, M.3    Park, S.4
  • 26
    • 80052155324 scopus 로고    scopus 로고
    • Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity
    • July Epub ahead of print
    • Cifelli P, Grace AA. (2011) Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity. Int J Neuropsychopharmacol July 12 [Epub ahead of print].
    • (2011) Int J Neuropsychopharmacol , pp. 12
    • Cifelli, P.1    Grace, A.A.2
  • 27
    • 0037067070 scopus 로고    scopus 로고
    • The effects of galanin on long-term synaptic plasticity in the CA1 area of rodent hippocampus
    • DOI 10.1016/S0306-4522(02)00007-6, PII S0306452202000076
    • Coumis U, Davies CH. (2002) The effects of galanin on long-term synaptic plasticity in the CA1 area of rodent hippocampus. Neuroscience 112:173-182. (Pubitemid 34603508)
    • (2002) Neuroscience , vol.112 , Issue.1 , pp. 173-182
    • Coumis, U.1    Davies, C.H.2
  • 29
    • 77951257038 scopus 로고    scopus 로고
    • Alteration in chromogranin A, obestatin and total ghrelin levels of saliva and serum in epilepsy cases
    • Dag E, Aydin S, Ozkan Y, Erman F, Dagli AF, Gurger M. (2010) Alteration in chromogranin A, obestatin and total ghrelin levels of saliva and serum in epilepsy cases. Peptides 31:932-937.
    • (2010) Peptides , vol.31 , pp. 932-937
    • Dag, E.1    Aydin, S.2    Ozkan, Y.3    Erman, F.4    Dagli, A.F.5    Gurger, M.6
  • 32
    • 4043124791 scopus 로고    scopus 로고
    • Nitric oxide and brain hyperexcitability
    • Ferraro G, Sardo P. (2004) Nitric oxide and brain hyperexcitability. In Vivo 18:357-366. (Pubitemid 39069752)
    • (2004) In Vivo , vol.18 , Issue.3 , pp. 357-366
    • Ferraro, G.1    Sardo, P.2
  • 35
    • 0041929602 scopus 로고    scopus 로고
    • Ghrelin-induced feeding is dependent on nitric oxide
    • DOI 10.1016/S0196-9781(03)00160-8
    • Gaskin FS, Farr SA, Banks WA, Kumar VB, Morley JE. (2003) Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24:913-918. (Pubitemid 37011439)
    • (2003) Peptides , vol.24 , Issue.6 , pp. 913-918
    • Gaskin, F.S.1    Farr, S.A.2    Banks, W.A.3    Kumar, V.B.4    Morley, J.E.5
  • 36
    • 12944304591 scopus 로고    scopus 로고
    • Ghrelin: More than a natural GH secretagogue and/or an orexigenic factor
    • DOI 10.1111/j.1365-2265.2004.02160.x
    • Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G. (2005) Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol (Oxf) 62:1-17. (Pubitemid 40175277)
    • (2005) Clinical Endocrinology , vol.62 , Issue.1 , pp. 1-17
    • Ghigo, E.1    Broglio, F.2    Arvat, E.3    Maccario, M.4    Papotti, M.5    Muccioli, G.6
  • 37
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: Involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • DOI 10.1210/en.2006-0266
    • Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghe C, Isgaard J, Papotti M, Ghigo E, Muccioli G. (2007) Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling. Endocrinology 148:512-529. (Pubitemid 46143157)
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5    Bertuzzi, F.6    Destefanis, S.7    Annunziata, M.8    Martinetti, M.9    Catapano, F.10    Ghe, C.11    Isgaard, J.12    Papotti, M.13    Ghigo, E.14    Muccioli, G.15
  • 38
    • 33645064880 scopus 로고    scopus 로고
    • Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid
    • Greco R, Latini G, Chiarelli F, Iannetti P, Verrotti A. (2005) Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid. Neurology 65:1808-1809.
    • (2005) Neurology , vol.65 , pp. 1808-1809
    • Greco, R.1    Latini, G.2    Chiarelli, F.3    Iannetti, P.4    Verrotti, A.5
  • 39
    • 77957293457 scopus 로고    scopus 로고
    • Introduction of lipidizationcationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities
    • Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. (2010) Introduction of lipidizationcationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. J Pept Sci 16:486-495.
    • (2010) J Pept Sci , vol.16 , pp. 486-495
    • Green, B.R.1    White, K.L.2    McDougle, D.R.3    Zhang, L.4    Klein, B.5    Scholl, E.A.6    Pruess, T.H.7    White, H.S.8    Bulaj, G.9
  • 40
    • 36749087648 scopus 로고    scopus 로고
    • The role of ghrelin in weight gain and growth in epileptic children using valproate
    • DOI 10.1177/0883073807307096
    • Gungor S, Yucel G, Akinci A, Tabel Y, Ozerol IH, Yologlu S. (2007) The role of ghrelin in weight gain and growth in epileptic children using valproate. J Child Neurol 22:1384-1388. (Pubitemid 350214777)
    • (2007) Journal of Child Neurology , vol.22 , Issue.12 , pp. 1384-1388
    • Gungor, S.1    Yucel, G.2    Akinci, A.3    Tabel, Y.4    Ozerol, I.H.5    Yologlu, S.6
  • 42
    • 0038714965 scopus 로고    scopus 로고
    • Neuropeptides: Opportunities for drug discovery
    • DOI 10.1016/S1474-4422(03)00482-4
    • Hokfelt T, Bartfai T, Bloom F. (2003) Neuropeptides: opportunities for drug discovery. Lancet Neurol 2:463-472. (Pubitemid 36876103)
    • (2003) Lancet Neurology , vol.2 , Issue.8 , pp. 463-472
    • Hokfelt, T.1    Bartfai, T.2    Bloom, F.3
  • 43
    • 0242330291 scopus 로고    scopus 로고
    • High Constitutive Signaling of the Ghrelin Receptor - Identification of a Potent Inverse Agonist
    • DOI 10.1210/me.2003-0069
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. (2003) High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 17:2201-2210. (Pubitemid 37352532)
    • (2003) Molecular Endocrinology , vol.17 , Issue.11 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 44
    • 72849148304 scopus 로고    scopus 로고
    • Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet
    • Honors MA, Davenport BM, Kinzig KP. (2009) Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet. Nutr Metab (Lond) 6:46.
    • (2009) Nutr Metab (Lond) , vol.6 , pp. 46
    • Honors, M.A.1    Davenport, B.M.2    Kinzig, K.P.3
  • 46
    • 33748362868 scopus 로고    scopus 로고
    • Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: Implications for its involvement in brain reward
    • DOI 10.1111/j.1369-1600.2006.00002.x
    • Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L, Engel JA. (2006) Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict Biol 11:45-54. (Pubitemid 46696736)
    • (2006) Addiction Biology , vol.11 , Issue.1 , pp. 45-54
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Andersson, M.4    Svensson, L.5    Engel, J.A.6
  • 47
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    • DOI 10.1210/me.2005-0084
    • Jiang H, Betancourt L, Smith RG. (2006) Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 20:1772-1785. (Pubitemid 44148083)
    • (2006) Molecular Endocrinology , vol.20 , Issue.8 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 48
    • 42149154487 scopus 로고    scopus 로고
    • Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity
    • DOI 10.1101/lm.793008
    • Kluge C, Stoppel C, Szinyei C, Stork O, Pape HC. (2008) Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity. Learn Mem 15:252-260. (Pubitemid 351544223)
    • (2008) Learning and Memory , vol.15 , Issue.4 , pp. 252-260
    • Kluge, C.1    Stoppel, C.2    Szinyei, C.3    Stork, O.4    Pape, H.-C.5
  • 49
    • 37349007443 scopus 로고    scopus 로고
    • The discovery of ghrelin - A personal memory
    • Kojima M. (2008) The discovery of ghrelin - a personal memory. Regul Pept 145:2-6.
    • (2008) Regul Pept , vol.145 , pp. 2-6
    • Kojima, M.1
  • 50
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • DOI 10.1152/physrev.00012.2004
    • Kojima M, Kangawa K. (2005) Ghrelin: structure and function. Physiol Rev 85:495-522. (Pubitemid 40404635)
    • (2005) Physiological Reviews , vol.85 , Issue.2 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 51
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660. (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 52
    • 0035724867 scopus 로고    scopus 로고
    • Intrahippocampal injections of somatostatin dissociate acquisition from the flexible use of place responses
    • DOI 10.1046/j.0953-816X.2001.01672.x
    • Lamirault L, Guillou JL, Micheau J, Jaffard R. (2001) Intrahippocampal injections of somatostatin dissociate acquisition from the flexible use of place responses. Eur J Neurosci 14:567-570. (Pubitemid 34203465)
    • (2001) European Journal of Neuroscience , vol.14 , Issue.3 , pp. 567-570
    • Lamirault, L.1    Guillou, J.-L.2    Micheau, J.3    Jaffard, R.4
  • 54
    • 77952576252 scopus 로고    scopus 로고
    • Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
    • Lee J, Lim E, Kim Y, Li E, Park S. (2010) Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol 205:263-270.
    • (2010) J Endocrinol , vol.205 , pp. 263-270
    • Lee, J.1    Lim, E.2    Kim, Y.3    Li, E.4    Park, S.5
  • 55
    • 0033815978 scopus 로고    scopus 로고
    • Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats
    • Lehmann TN, Gabriel S, Kovacs R, Eilers A, Kivi A, Schulze K, Lanksch WR, Meencke HJ, Heinemann U. (2000) Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats. Epilepsia 41(Suppl. 6):S190-S194.
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 6
    • Lehmann, T.N.1    Gabriel, S.2    Kovacs, R.3    Eilers, A.4    Kivi, A.5    Schulze, K.6    Lanksch, W.R.7    Meencke, H.J.8    Heinemann, U.9
  • 56
    • 33947301456 scopus 로고    scopus 로고
    • The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor
    • DOI 10.1016/j.cellsig.2006.11.011, PII S0898656806003032
    • Leung PK, Chow KB, Lau PN, Chu KM, Chan CB, Cheng CH, Wise H. (2007) The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal 19:1011-1022. (Pubitemid 46437436)
    • (2007) Cellular Signalling , vol.19 , Issue.5 , pp. 1011-1022
    • Leung, P.-K.1    Chow, K.B.S.2    Lau, P.-N.3    Chu, K.-M.4    Chan, C.-B.5    Cheng, C.H.K.6    Wise, H.7
  • 57
    • 80054866128 scopus 로고    scopus 로고
    • The ghrelin/GOAT/GHS-R system and energy metabolism
    • Lim CT, Kola B, Korbonits M. (2011) The ghrelin/GOAT/GHS-R system and energy metabolism. Rev Endocr Metab Disord 12:173-186.
    • (2011) Rev Endocr Metab Disord , vol.12 , pp. 173-186
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 61
    • 0037064229 scopus 로고    scopus 로고
    • Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus
    • Mazarati A, Wasterlain CG. (2002) Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett 331:123-127.
    • (2002) Neurosci Lett , vol.331 , pp. 123-127
    • Mazarati, A.1    Wasterlain, C.G.2
  • 62
    • 18844446206 scopus 로고    scopus 로고
    • Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach
    • DOI 10.1210/en.2004-0645
    • Nishi Y, Hiejima H, Mifune H, Sato T, Kangawa K, Kojima M. (2005) Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach. Endocrinology 146:2709-2715. (Pubitemid 40695574)
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2709-2715
    • Nishi, Y.1    Hiejima, H.2    Mifune, H.3    Sato, T.4    Kangawa, K.5    Kojima, M.6
  • 63
  • 64
    • 34249694588 scopus 로고    scopus 로고
    • Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats
    • DOI 10.1016/j.peptides.2007.04.003, PII S0196978107001222
    • Obay BD, Tasdemir E, Tumer C, Bilgin HM, Sermet A. (2007) Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 28:1214-1219. (Pubitemid 46843389)
    • (2007) Peptides , vol.28 , Issue.6 , pp. 1214-1219
    • Obay, B.D.1    Tasdemir, E.2    Tumer, C.3    Bilgin, H.M.4    Sermet, A.5
  • 65
    • 39649099593 scopus 로고    scopus 로고
    • Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model
    • Obay BD, Tasdemir E, Tumer C, Bilgin HM, Atmaca M. (2008) Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29:448-455.
    • (2008) Peptides , vol.29 , pp. 448-455
    • Obay, B.D.1    Tasdemir, E.2    Tumer, C.3    Bilgin, H.M.4    Atmaca, M.5
  • 67
    • 36248960540 scopus 로고    scopus 로고
    • Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin
    • DOI 10.1016/j.ygcen.2007.05.016, PII S0016648007001761
    • Olsson C, Holbrook JD, Bompadre G, Jonsson E, Hoyle CH, Sanger GJ, Holmgren S, Andrews PL. (2008) Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. Gen Comp Endocrinol 155:217-226. (Pubitemid 350130249)
    • (2008) General and Comparative Endocrinology , vol.155 , Issue.1 , pp. 217-226
    • Olsson, C.1    Holbrook, J.D.2    Bompadre, G.3    Jonsson, E.4    Hoyle, C.H.V.5    Sanger, G.J.6    Holmgren, S.7    Andrews, P.L.R.8
  • 72
    • 79957807767 scopus 로고    scopus 로고
    • Inflammation and prevention of epileptogenesis
    • Ravizza T, Balosso S, Vezzani A. (2011) Inflammation and prevention of epileptogenesis. Neurosci Lett 497:223-230.
    • (2011) Neurosci Lett , vol.497 , pp. 223-230
    • Ravizza, T.1    Balosso, S.2    Vezzani, A.3
  • 75
    • 44649098808 scopus 로고    scopus 로고
    • Ghrelin, des-acyl ghrelin and obestatin: Three pieces of the same puzzle
    • Soares JB, Leite-Moreira AF. (2008) Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 29:1255-1270.
    • (2008) Peptides , vol.29 , pp. 1255-1270
    • Soares, J.B.1    Leite-Moreira, A.F.2
  • 78
    • 7044253172 scopus 로고    scopus 로고
    • The ketogenic diet does not alter brain expression of orexigenic neuropeptides
    • DOI 10.1016/j.eplepsyres.2004.08.002, PII S0920121104001512
    • Tabb K, Szot P, White SS, Liles LC, Weinshenker D. (2004) The ketogenic diet does not alter brain expression of orexigenic neuropeptides. Epilepsy Res 62:35-39. (Pubitemid 39424189)
    • (2004) Epilepsy Research , vol.62 , Issue.1 , pp. 35-39
    • Tabb, K.1    Szot, P.2    White, S.S.3    Liles, L.C.4    Weinshenker, D.5
  • 79
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • Tena-Sempere M. (2008) Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 4:666-674.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 80
    • 33747872325 scopus 로고    scopus 로고
    • Global and focal aspects of absence epilepsy: The contribution of genetic models
    • DOI 10.1016/j.neubiorev.2006.03.002, PII S0149763406000170
    • van Luijtelaar G, Sitnikova E. (2006) Global and focal aspects of absence epilepsy: the contribution of genetic models. Neurosci Biobehav Rev 30:983-1003. (Pubitemid 44292854)
    • (2006) Neuroscience and Biobehavioral Reviews , vol.30 , Issue.7 , pp. 983-1003
    • Van Luijtelaar, G.1    Sitnikova, E.2
  • 81
    • 0020514703 scopus 로고
    • Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats
    • DOI 10.1016/0196-9781(83)90135-3
    • Vecsei L, Bollok I, Telegdy G. (1983) Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats. Peptides 4:293-295. (Pubitemid 13051287)
    • (1983) Peptides , vol.4 , Issue.3 , pp. 293-295
    • Vecsel, L.1    Bollok, I.2    Telegdy, G.3
  • 82
    • 35748961971 scopus 로고    scopus 로고
    • Neuroprotection in epilepsy
    • Walker M. (2007) Neuroprotection in epilepsy. Epilepsia 48(Suppl. 8):66-68.
    • (2007) Epilepsia , vol.48 , Issue.SUPPL. 8 , pp. 66-68
    • Walker, M.1
  • 83
    • 55349124022 scopus 로고    scopus 로고
    • The contribution of norepinephrine and orexigenic neuropeptides to the anticonvulsant effect of the ketogenic diet
    • Weinshenker D. (2008) The contribution of norepinephrine and orexigenic neuropeptides to the anticonvulsant effect of the ketogenic diet. Epilepsia 49(Suppl. 8):104-107.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 8 , pp. 104-107
    • Weinshenker, D.1
  • 84
    • 0242320248 scopus 로고    scopus 로고
    • Ghrelin concentrations in healthy children and adolescents
    • DOI 10.1046/j.1365-2265.2003.01903.x
    • Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE. (2003) Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 59:649-654. (Pubitemid 37357628)
    • (2003) Clinical Endocrinology , vol.59 , Issue.5 , pp. 649-654
    • Whatmore, A.J.1    Hall, C.M.2    Jones, J.3    Westwood, M.4    Clayton, P.E.5
  • 85
    • 47949094078 scopus 로고    scopus 로고
    • Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation
    • Xu X, Jhun BS, Ha CH, Jin ZG. (2008) Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology 149:4183-4192.
    • (2008) Endocrinology , vol.149 , pp. 4183-4192
    • Xu, X.1    Jhun, B.S.2    Ha, C.H.3    Jin, Z.G.4
  • 86
    • 61349154154 scopus 로고    scopus 로고
    • Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats
    • Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z. (2009) Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453:58-61.
    • (2009) Neurosci Lett , vol.453 , pp. 58-61
    • Xu, J.1    Wang, S.2    Lin, Y.3    Cao, L.4    Wang, R.5    Chi, Z.6
  • 87
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
    • DOI 10.1016/j.cell.2008.01.017, PII S0092867408001177
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132:387-396. (Pubitemid 351192001)
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.